ライフサイエンスコーパス: be disrupted by

1 Importantly, LATS1 signaling was disrupted by 17-AAG in tumor cell lines in vitro and

2 Endothelial cell barrier functions are disrupted by a number of viruses that cause hemorrha

3 vealed that tertiary contacts within the PDZ are disrupted by a partial unfolding transition that ena

4 We hypothesize that RGTA2 function might be disrupted by a 12-amino acid insertion in a conserved

5 interacts with BBS-5 and the interaction can be disrupted by a conserved mutation identified in human

6 s - the function of a gene is less likely to be disrupted by a mutation close to the distal ends.

7 Clusters of functionally related genes can be disrupted by a single copy number variant (CNV).

8 unctional unit required for activity and can be disrupted by a single point mutation.

9 ming a motor task, the fast motor memory can be disrupted by a task that engages declarative memory,

10 Vascular barrier integrity can be disrupted by a variety of soluble permeability factor

11 he Disrupted in Schizophrenia 1 (DISC1) gene is disrupted by a balanced chromosomal translocation (1;

12 The inhibitory interaction is disrupted by a constitutively activating mutation (M3

13 Intriguingly, binding of each PIP is disrupted by a different subset of mutations.

14 When vimentin organization is disrupted by a dominant-negative mutant or by silenci

15 in the active E form, and the oxyanion hole is disrupted by a flip of the Glu(192)-Gly(193) peptide

16 Nine Mile reference isolate, where the gene is disrupted by a frameshift mutation, resulting in a ps

17 Their minus-strand origin is disrupted by a large cassette that simultaneously con

18 To determine if NK cell function is disrupted by a model of human shift-work and jet-lag,

19 aptic termini, and this function of dynactin is disrupted by a mutation that causes motor neuron dise

20 inding is cooperative, but the cooperativity is disrupted by a phospho-mimic mutation S249D in the 4.

21 , the intron is crippled and the target gene is disrupted by a series of stop codons.

22 ative geotaxis in flies, scored as climbing, is disrupted by a static EMF, and this is mediated by cr

23 This delicate balance in the liver is disrupted by a variety of pathological states includi

24 alcium-binding aspartate residue, Asp307Ala, was disrupted by a c.920A>C change in one family that pr

25 A 200-km large asteroid was disrupted by a collision in the Main Asteroid Belt,

26 d both nucleotide binding domains (NBDs) and was disrupted by a cystic fibrosis mutation in NBD1 (G55

27 virus (ADinUL79(stop)) in which the UL79 ORF was disrupted by a stop codon mutation and found that AD

28 In 1 case, CUX1 was disrupted by a translocation, resulting in a loss-of

29 associations with foot shock or food reward were disrupted by a highly-specific actin cycling inhibi

30 Moreover, these various forms of plasticity were disrupted by Abeta exposure.

31 on via a lysine-phosphate salt bridge, which was disrupted by acetyl-Lys resulting in backbone flexib

32 everal alternative nucleosomal arrays, which are disrupted by activation.

33 ma membrane population of PLCbeta2.PLCdelta1 is disrupted by activation of heterotrimeric G proteins,

34 This interaction is disrupted by activation of NMDA receptors in cultured

35 dependent on the Psl polysaccharide and can be disrupted by adding mannose, a key structural compone

36 ated with the I(Ks)-Yotiao complex and could be disrupted by addition of the AC9 N terminus.

37 the functions of these circadian oscillators are disrupted by age, environment, or genetic mutation,

38 f these proteins and their DNA binding sites are disrupted by AHLs in vitro.

39 Ca(2+) homeostasis is disrupted by alpha-synuclein (alpha-syn), a small lip

40 Interestingly, this interaction was disrupted by AMPylation.

41 point to a gephyrin-dependent mechanism that is disrupted by an autism-associated mutation at R705 an

42 Although HIV latency is disrupted by an initial VOR dose, the effect of subse

43 mouse model in which IL-1R1 gene expression is disrupted by an intronic insertion of a loxP flanked

44 inant virus SMin92, in which pM92 expression was disrupted by an insertional/frameshift mutation.

45 along traditional routes, many of which have been disrupted by anthropogenic disturbances.

46 at binding was associated with the TfR as it was disrupted by anti-TfR antibodies.

47 nd inhibition of calcium currents by galanin were disrupted by anti-G(o)2alpha antibodies.

48 ssion of B1R and CPM-E264Q in the same cell, was disrupted by antibody that dissociates CPM from B1R,

49 present forces; this organization can easily be disrupted by any small external stimuli.

50 Organization of F-actin in appressoria is disrupted by application of antioxidants, whereas lat

51 is an important ecological process that can be disrupted by artificial lighting.

52 apping this phosphorylation site and binding is disrupted by Aurora phosphorylation.

53 These results demonstrate that neural timing is disrupted by background noise and that greater disrup

54 This comparison suggests that repeat folding is disrupted by base pairing in the duplex arms and by p

55 ider how this mutator-nonmutator balance can be disrupted by beneficial mutations and analyze the cir

56 he physical interaction between TAP2 and TPN is disrupted by benzene, a compound known to interfere w

57 les form stable complexes with HLA-DM, which are disrupted by binding of high-affinity peptide.

58 e cGMP-induced enhancement of LTP and memory was disrupted by blockade of Abeta, suggesting that the

59 Galphaq/11 interactions in endothelial cells are disrupted by both competitive inhibition and HS degr

60 ive, suggesting neural connections to the PV were disrupted by both PV isolation and GP ablation.

61 repair pathway, translesion synthesis (TLS), is disrupted by BPLF1, which deubiquitinates the DNA pro

62 or understanding how this DNA repair process is disrupted by BRCA2 mutations, which lead to chromosom

63 tramolecular electrostatic interactions that are disrupted by calcium.

64 interaction between TRIP8b and the HCN1 CNBD was disrupted by cAMP and that TRIP8b binding to the CNB

65 d conscious awareness and have been shown to be disrupted by cannabinoids in animal studies.

66 When these interactions are disrupted by cationic antimicrobial peptides, or by

67 ed to catalyze these events when replication is disrupted by certain impediments in vivo.

68 vels and targets of methylation are known to be disrupted by chemicals and are therefore of great int

69 After DNA damage, the MDMX-CK1alpha complex is disrupted by Chk2-mediated phosphorylation of MDMX at

70 on of JNK by TGF-beta in the absence of Dab2 is disrupted by cholesterol depletion.

71 g-related shift in novel environments should be disrupted by cholinergic antagonism; and (3) in famil

72 t role in nicotine reward and their function is disrupted by chronic nicotine exposure, suggesting ni

73 regulated and evolves; and how splicing can be disrupted by cis- and trans-acting mutations leading

74 coevolved plant-pollinator relationships to be disrupted by climatic warming.

75 inding protein as protein.heme complexes can be disrupted by contact with an apoprotein (e.g. apomyog

76 e consolidated memory for the experience can be disrupted; by contrast, protein synthesis inhibition

77 RNA isoform transitions and are predicted to be disrupted by CUG(exp)-associated mechanisms in utero.

78 on microscopy shows that the Abeta42 fibrils are disrupted by curcumin.

79 This interaction can be disrupted by CXCR4 antagonists.

80 These inherently mechanical processes are disrupted by cyclic stretch (CS), but the specific s

81 ic similarity to aversive LTM in that it can be disrupted by cycloheximide, the dCreb2-b transcriptio

82 mplex, TMC1 and TMC2, and these interactions are disrupted by deafness-causing Cib2 mutations.

83 in injectoporated hair cells, a pattern that is disrupted by deafness-associated PJVK mutations.

84 regulates tip-link assembly, a process that is disrupted by deafness-causing Tmhs mutations.

85 The clustering can be disrupted by deletion of various proteins in mice, in

86 istent with a tethering role for GARP, which is disrupted by deletion of the Vps53 C-terminal region.

87 r of the two Cdc42 apical recycling pathways was disrupted by deletion of Rdi1, a guanine nucleotide

88 These effects of inflammatory stimuli were disrupted by deletion of inhibitor of NF-kappaB kin

89 Normal epigenetic states could be disrupted by detrimental mutations and expression alt

90 he molecular properties of alpha-crystallins are disrupted by diabetes and contribute to the loss of

91 th and homeostasis; however, these processes are disrupted by diabetes.

92 her these data suggest that nuclear position is disrupted by distinct mechanisms in EDMD and CNM.

93 Here we report that D loops can also be disrupted by DNA topoisomerase 3 (Top3), and this dis

94 ethylated on histones, but their recruitment is disrupted by DNA methylation.

95 CA1, E2F1, and Rb at the BRCA1 promoter that is disrupted by DNA-damaging agents to increase its tran

96 tion delocalization and Coulomb gap collapse are disrupted by doping-induced disorder, suppressing th

97 Inhibitory signals via KIR3DL1 are disrupted by downregulation of HLA class I ligands o

98 In summary, the BBB is disrupted by downregulation of the Shh pathway and br

99 Because the sphingolipid domains are disrupted by drugs that depolymerize the cells actin

100 hat localization of both nNOSmu and nNOSbeta is disrupted by dystrophin deficiency.

101 en this differential proliferation mechanism is disrupted by either ectopic overexpression or mutatio

102 This relationship is disrupted by elevated VDRE-BP, causing a form of here

103 But willpower can be disrupted by emotions and depleted over time.

104 ues in CytR and CRP (cAMP receptor protein), is disrupted by exogenous cytidine.

105 This interaction is disrupted by exogenous ligands, such as TCDD, to indu

106 target promoters and VirR : promoter binding was disrupted by exogenous addition of the signalling mo

107 get tissue after the blood brain barrier has been disrupted by exposure to a hyperosmolar mannitol so

108 This is disrupted by expression of K-Ras V12 or B-Raf V600E b

109 Repression required both proteins and was disrupted by FBF-2 alleles that failed to bind CPB-1

110 complementation assay, and this association is disrupted by flagellin treatment.

111 h the skin occurs when skin barrier function is disrupted by, for example, genetic predisposition, me

112 e in TMP metabolism, mitochondrial membranes were disrupted by freezing and thawing.

113 he brain parenchyma in regions where the BBB is disrupted by FUS and MBs.

114 sm and that PLCbeta2.PLCdelta1 complexes can be disrupted by Gbetagamma subunits.

115 Physcomitrella patens when both HY2 and PUBS were disrupted by gene targeting.

116 Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why

117 ntly reduced in mice in which CRHR1 activity was disrupted by genetic deletion or with an antagonist,

118 The activities of CRHR1 and CRHR2 were disrupted by genetic deletion in mice or with selec

119 e line (Gad1(-/-)) in which GAD67 expression is disrupted by genomic insertion of the green fluoresce

120 This complex is disrupted by genotoxic stress, resulting in the displ

121 n the blood-rich marginal zone and follicles is disrupted by GRK2 deficiency and by mutation of an S1

122 unique biphasic developmental cycle that can be disrupted by growth in the presence of IFN-gamma and

123 Theory suggests these cycles can be disrupted by high amplitude seasonal fluctuations in

124 in with H3K4 unmethylated histone tails that is disrupted by histone H3K4 methylation and histone ace

125 nscription factor coexpression profiles that is disrupted by HIV infection and suggest a role for HIV

126 a highly complex collection of proteins that is disrupted by hundreds of gene mutations causing over

127 when the vertical migration of phytoplankton was disrupted by hydrodynamic shear.

128 Bindings of both HDAC and PcG to Arf are disrupted by inactivation of p53 and can be restored

129 mer dilution, where WT receptor dimerization is disrupted by increasing expression of nonfunctional C

130 Maternal behavior in postpartum rats is disrupted by increasing norepinephrine release in the

131 stin assembly during the saccular stage that is disrupted by inflammatory signaling and could be amen

132 tions via protein-protein interaction, which is disrupted by inherited disease mutations.

133 n 10 nm of one another and that the clusters are disrupted by inhibition of Src and Syk family kinase

134 o-immunoprecipitates of arrestin-2 with PAR4 are disrupted by inhibitors of P2Y1 or P2Y12.

135 thogenesis, and suggest that T4P systems may be disrupted by inhibitors that do not preclude componen

136 lobal, potentiation is synapse specific, and is disrupted by inhibitors of calcineurin or Ca-calmodul

137 s, which revealed that vimentin localization is disrupted by inhibitors of signaling that belong to a

138 Furthermore, degradation can be disrupted by insertion of two N-terminal myc tags, im

139 jejuni genes encoding the putative adhesins were disrupted by insertional mutagenesis.

140 notypes of the DeltabinA mutant strain could be disrupted by insertions in genes in the bacterial cel

141 Oligomerization was disrupted by insertions located between residues 561

142 a (encoded by Pik3r2) form heterodimers that are disrupted by insulin treatment.

143 monstrate that cellular actions of metformin are disrupted by interference with its metal-binding pro

144 cts with the N-terminal domain of AR and can be disrupted by JQ1.

145 some phospholipid bilayer, the bilayer would be disrupted by laser irradiation so that drug release w

146 failed to reseal a plasma membrane that had been disrupted by laser irradiation.

147 precisely at this positionally cued line and are disrupted by Lgn.

148 slow fluctuations and neuronal synchronicity is disrupted by light general anesthesia.

149 ioning required extracellular prosaposin and was disrupted by lipid raft perturbation using methyl-be

150 In some individuals, mineral homeostasis can be disrupted by long-term therapy with certain antiepile

151 The transition to coordinated activity was disrupted by long-term optical inhibition of sporadi

152 n mechanisms that regulate osmotic stability are disrupted by loop diuretics in rats.

153 The stability is disrupted by low ionic strength or high pH, providing

154 Cholinergic input to the cortex was disrupted by making bilateral injections of the immu

155 We also find that these activity patterns are disrupted by manipulating cadherin or gap junction e

156 (3)R1 and TRPC3 channel spatial localization was disrupted by MbetaCD and a CSD peptide.

157 sults were observed when the potential motif was disrupted by means of an E495S mutation.

158 elopment of event-related neuronal responses was disrupted by MeCP2 mutation, suggesting that impaire

159 Mucin O-glycan biosynthesis in HCLE cells was disrupted by metabolic interference with benzyl-alph

160 prediction error and incentive value signals were disrupted by methamphetamine in the left nucleus ac

161 growth is a highly ordered process that can be disrupted by misalignment of individual amino acids a

162 The interaction between WT1 and TET2 is disrupted by multiple AML-derived TET2 mutations.

163 When droplet sequestration is disrupted by mutating Jabba, embryos display an eleva

164 lar, mostly electrostatic, interactions that were disrupted by mutating a positively charged (Lys-ric

165 54-465 as the main binding site, which could be disrupted by mutation.

166 This intramolecular interaction is disrupted by mutation of Tyr633 within the Mint1 auto

167 st if the structure of Lys(48)-linked chains is disrupted by mutation of ubiquitin or if chains are l

168 Moreover, if this normal folding nucleus is disrupted by mutation, the interdomain interface is s

169 588) of ATDC and the RING domain of RNF8 and was disrupted by mutation of ATDC Ser-550 to alanine.

170 cells that nucleolar localization of RPL23aA was disrupted by mutation of various combinations of fiv

171 Importantly, this action of PDZ-GEF1 was disrupted by mutation within its putative cyclic nuc

172 hat is largely not understood, but which can be disrupted by mutations.

173 a compact platform-like architecture, which is disrupted by mutations implicated in developmental di

174 sary for the nucleolar targeting of NPM1 and is disrupted by mutations in AML with cytoplasmic NPM1.

175 level of Ribosomal Protein L27a (RPL27a) and is disrupted by mutations in the two paralogs RPL27aC an

176 anese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1.

177 membrane homeostasis, and that this function is disrupted by mutations that cause CMT4J and YVS.

178 rus-like particle Gag3, and this interaction was disrupted by mutations in the amino-terminal domain

179 ion in the human thymic epithelial cell line was disrupted by mutations in the homogenously staining

180 In contrast, axonal targeting of the VMAT2 was disrupted by neither dominant-negative SEC24C nor do

181 tion, is conserved in human development, and is disrupted by neurodegeneration.

182 ing respiration, posture and locomotion that are disrupted by neurodegenerative diseases such as amyo

183 e normal visual input during development and are disrupted by NMDAR blockade.

184 asure of hippocampus-dependent learning that is disrupted by nonselective mAChR antagonists.

185 Protection in females was disrupted by ovariectomy and restored by short-term

186 interaction between PER and CKIdelta/epsilon was disrupted by overexpressing the CKIdelta/epsilon bin

187 the normal asymmetric localization of Vangl2 was disrupted by overexpressing Vangl2 in clusters of ce

188 r Tks5 but decreased when XB130/Tks5 binding was disrupted by overexpression of XB130 N-terminal dele

189 ion factors exist in a latent state that may be disrupted by oxidative modifications that activate th

190 d that this wild-type/pathogenic heterodimer is disrupted by oxidative stress, leading to DJ-1/E163K

191 restore barrier integrity and function that are disrupted by PAO1 and 3O-C12-HSL.

192 anguage disorders, and that this interaction is disrupted by pathogenic mutations affecting either pr

193 resence of the distal coiled-coil domain and was disrupted by pathogenic missense mutations.

194 c pathways in addition to BDNF signaling may be disrupted by Pb(2+) exposure.

195 and ALX/FPR2 receptor-dependent manner that was disrupted by PDP1-specific antibodies.

196 plete picture of how hERG surface expression is disrupted by pentamidine at the cellular and molecula

197 ts generated a significant BRET signal, this was disrupted by peptide in all except for single-site m

198 ntrinsically active interface that could not be disrupted by peptides derived from the Nox4 C-terminu

199 yme required for normal lung development can be disrupted by perinatal inflammation in preterm infant

200 more, this match is activity-dependent as it is disrupted by perturbing pyramidal cell activity.

201 genome, representing a unified node that can be disrupted by pharmacologic inhibition.

202 clones and activated ex vivo CD8(+) T cells was disrupted by pharmacological inhibition, knockdown o

203 -1A-5RK/A mutant complex with SUR1 could not be disrupted by PIP2, consequently reducing PIP2 activat

204 The long-range order is disrupted by polycrystalline disorder and the variati

205 (LO) circuits: extracting targets from noise is disrupted by PPC stimulation, in contrast to judging

206 that the efficiency of A(H3N2)v transmission is disrupted by preexisting immunity induced by seasonal

207 he radial symmetry of spherulitic growth can be disrupted by preferentially selecting the molecular o

208 dolescence and furthermore that this process is disrupted by prenatal stress.

209 nnection was very strong at river sites, but was disrupted by processes occurring in rivermouths (the

210 These interactions are disrupted by proteolysis of the CA-SP1 junction duri

211 at skin temperature in a specific limb could be disrupted by psychologically disrupting the sense of

212 stablishment of a tolerant B cell repertoire is disrupted by PTPN22-R620W action during immature B ce

213 3 when its nuclear localization signal (NLS) was disrupted by R101S and R105S substitutions.

214 major cytosolic population of the complexes are disrupted by Rac1 activation.

215 , alpha(1)-AR- but not mGluR5- dependent LTD is disrupted by restraint stress.

216 This is disrupted by RNA interference silencing of Sdc1 but c

217 lexes, and demonstrate that this association is disrupted by S21 phosphorylation.

218 The SigT-clpPp interaction could be disrupted by secondary metabolites, giving rise to th

219 nt DNA methylation-driven gene silencing can be disrupted by selectively targeting this coiled-coil c

220 that oligomeric forms of defensin, which may be disrupted by serum, contribute to the anti-HIV-1 acti

221 ow that the interaction and SETX sumoylation are disrupted by SETX mutations associated with AOA2 but

222 t impaired cardiac autonomic phenotypes that are disrupted by several cardiovascular pathologies.

223 This novel interaction is disrupted by several cardiomyopathy-linked mutations

224 zed to anterior cell edges and this polarity was disrupted by several Wnt antagonists.

225 etained over the course of evolution and can be disrupted by simple amino acid substitutions.

226 omplex involve large scale dynamics that can be disrupted by single point mutations in both proteins.

227 This binding is disrupted by single mutations of non-cysteine amino a

228 Homologous TGB1 binding was disrupted by site-specific mutations in each of the

229 TFBS were disrupted by site-directed mutagenesis (SDM) to eva

230 pattern and predicts the invasion order can be disrupted by slower, less directional lead cells or b

231 drug discovery, and in a number of cases can be disrupted by small molecules.

232 h, the normal development of this region may be disrupted by social deprivation.

233 the pathophysiology of AD, synaptic function is disrupted by soluble Abeta oligomers, possibly throug

234 The intramolecular H-bonding is disrupted by solvents that support intermolecular H-b

235 lts suggest that mGluR1a signaling in cancer is disrupted by somatic mutations with multiple downstre

236 tion between the F box protein and substrate is disrupted by stress-induced phosphorylation.

237 ities shift across pregnancy, a process that is disrupted by stress.

238 osure dissociate extremely slowly and cannot be disrupted by strictly competitive inhibitors.

239 ly after training is so unstable that it can be disrupted by subsequent new learning until after pass

240 Gating in these K(+) channels can be disrupted by substitution of residues for the hinge g

241 This association is disrupted by substitution of a conserved arginine (R1

242 ins conserved despite the fact that it would be disrupted by synonymous mutations, which raises the p

243 acute illnesses where clock gene expression is disrupted by systemic inflammation.

244 ly related members of the DUF579 family have been disrupted by T-DNA insertions contain less xylose i

245 6/Eto2 is a transcriptional corepressor that is disrupted by t(16;21) in acute myeloid leukemia.

246 transmission of B. burgdorferi to humans can be disrupted by targeting 2 key elements in its enzootic

247 ion, and actin and microtubule assembly have been disrupted by targeting integrins.

248 tinoblastoma (pRb) tumor suppressor pathways are disrupted by the human papilloma virus (HPV) E6 and

249 ut it suggests that interdomain interactions are disrupted by the mutation.

250 re, we demonstrate that this interaction can be disrupted by the addition of an NCL binding aptamer (

251 delocalization in redox-active polymers may be disrupted by the heterogeneity of the environment tha

252 ydrolysis of plasma triglycerides by LPL can be disrupted by the protein angiopoietin-like 4 (ANGPTL4

253 Notably, this functional circuitry can be disrupted by the small-molecule kinase inhibitor pacr

254 This connectivity is increasingly being disrupted by the construction of dams, mining, lan

255 cal polarity complexes at the tight junction is disrupted by the adaptor protein Amot.

256 We previously reported that this association is disrupted by the binding of the second messenger Ap4A

257 rms prior to interaction with the intron and is disrupted by the DExD/H protein Prp5p during engageme

258 This behavior is disrupted by the disconnection of amygdala pathways t

259 ion is conferred by the LRRK2 Roc domain and is disrupted by the familial R1441G mutation and artific

260 c, requires the ZnF-UBP domain of USP22, and is disrupted by the inactivating H363Y mutation within S

261 ere it directly binds KLF11 in a manner that is disrupted by the MODY7 A347S variant.

262 ysosomal positioning, and that this function is disrupted by the most common PD-causing LRRK2 mutatio

263 gesting that it may be gB-lipid binding that is disrupted by the mutations.

264 y interaction with the ARP2/3 complex, which is disrupted by the phosphorylation of Coro1B.

265 whereas at dusk EMF1 binding to FT chromatin is disrupted by the photoperiod pathway, leading to prop

266 The interaction is disrupted by the pol30-113 mutation that results in a

267 reversed by reassociation with PKAc, and it is disrupted by the presence of AKAP peptides, mutations

268 is the first to show that sodium regulation is disrupted by the presence of citrate-capped Ag NPs, a

269 s mutually exclusive with APPL1 binding, and is disrupted by the same missense mutations in the ASH-R

270 lved xenon in an aqueous liquid crystal that is disrupted by the shear forces of bubbling, and we obs

271 ia Nef's SMR motif and that this interaction is disrupted by the SMRwt peptide.

272 When the IHB is disrupted by the solvent or by substitution of the hy

273 When CKIepsilon activity was disrupted by the DN-CKIepsilon in the mutant MEFs, c

274 g that surface trafficking of CaValpha2delta was disrupted by the double mutation.

275 ular responses induced when gBcyt regulation was disrupted by the gB[Y881F] substitution.

276 ed on the extent to which normal social life was disrupted by the illness and depended on the age and

277 ly identified site between adjacent subunits was disrupted by the M3 G329I substitution, both propofo

278 The acquired motor learning was disrupted by the optical shrinkage of the potentiate

279 to discontinuous PrP epitopes, all of which were disrupted by the addition of 2-ME or DTT, which red

280 en turnover with adipogenesis or lipogenesis were disrupted by the associated decrease in collagen tu

281 The interactions were disrupted by the Cys694Arg mutation, which resulted

282 Strikingly, LRRK2-DVL1-3 interactions were disrupted by the familial PARK8 mutation Y1699C, wh

283 tein reveals that a common molecular process is disrupted by these mutations, implying an active role

284 ving the hypothalamus-pituitary-thyroid axis is disrupted by these stimulating autoantibodies.

285 aspect of the regulation of telomere length is disrupted by this POT1(DeltaOB) mutant protein.

286 he enzyme catalytic cycle (SAM regeneration) is disrupted by this single mutation.

287 to motoneurons (MNs) and Renshaw cells (RCs) is disrupted by thoracic spinal cord transection at post

288 , the 580-amino-acid UL25 open reading frame was disrupted by transposon mutagenesis.

289 with VDACs when the function of mitochondria is disrupted by treating cells with the proton uncoupler

290 ontaining PyVmT, p85 (PI3K), and ErbB3, that is disrupted by treatment with lapatinib.

291 A mutant protein in which the NLS motif was disrupted by triple mutation (RRR to AAA) was able t

292 ion experiments, PAR4 formed homodimers that were disrupted by unlabeled PAR4 in a concentration-depe

293 here is some structure near position 39 that is disrupted by urea.

294 The effects of Zn(2+) are disrupted by V228L, Y529A, and Y232A.

295 Rb in the DREAM complex and how the complex is disrupted by viral oncoproteins.

296 r genes, including cytokine regulators, that are disrupted by virus integration, and we determined me

297 regimes during early development that could be disrupted by warming.

298 ween the substrate- and product-side ligands are disrupted by water in nonprocessive cellulase clefts

299 The interaction of PACT with RIG-I is disrupted by wild-type VP35, but not by VP35 mutants

300 s with RIP2 via its BIR2 domain, which could be disrupted by XIAP antagonists SMAC and SMAC-mimicking