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1 ransferase that methylates 1,7-paraxanthine, is down-regulated.
2 curs after anaphase onset when CDK1 activity is down-regulated.
3 reas epithelial markers, such as E-cadherin, are down-regulated.
4 undant even though their corresponding mRNAs are down-regulated.
5 tion-reduction and steroid metabolic process are down-regulated.
6 rs of oil-added ducks, while the C12:0 ratio was down-regulated.
7 expression of pri-miRNA161 and pri-miRNA173 was down-regulated.
8 lf5/cyclin D1 axis was up-regulated and Klf4 was down-regulated.
9 ctural genes involved in eugenol production, was down-regulated.
10 rylation of one cluster of modified residues was down-regulated.
11 Mmp2 were up-regulated whereas p21 (Cdkn1a) was down-regulated.
12 ith U373MG glioblastoma cells in which Rap1A was down-regulated.
13 ucer, adenosine-5'-phosphosulfate reductase, was down-regulated.
14 se was up-regulated, whereas pyruvate kinase was down-regulated.
15 ressed collaterals including miRNA-352 which was down-regulated.
16 e of six mitochondrion-related nuclear genes was down-regulated.
17 e) and 107 (microwaved sample) protein spots were down regulated.
18 phA3 cytokine/tyrosine-kinase (TK) receptors were down regulated.
19 rticipate in the Alzheimer's disease pathway were down-regulated.
20 were elevated, while neuroinflammatory genes were down-regulated.
21 ry and field, while creb and pka transcripts were down-regulated.
22 7(-/-) mice, whereas DNA damage repair genes were down-regulated.
23 ion-channel transport and cardiac conduction were down-regulated.
24 , while the other sulfite network components were down-regulated.
25 ially expressed: 71 were up-regulated and 45 were down-regulated.
26 , cell cycle and reproduction (cdc20, ccnb1) were down-regulated.
27 in kinase phosphatase-1 messenger RNA levels were down-regulated.
28 t levels of IRF5 mRNA and protein expression were down-regulated.
29 sed proteins a V-ATPase and a 14-3-3 protein were down-regulated.
30 over, both alpha- and gamma-ENaC transcripts were down-regulated.
31 key iron transporters (AfuA, FhuC, and FhuD) being down-regulated.
33 ceptor beta and insulin receptor substrate 1 were down-regulated 2-fold by Kcne2 deletion, characteri
34 der anaerobic conditions, both Id1 and c-Myc are down-regulated (50-70%), and overexpression of oxyge
35 a), and its metabolic and angiogenic targets are down-regulated (50-85%) in skeletal muscles of mdx m
36 lin protein/78-kDa glucose-regulated protein was down-regulated, activating transcription factor 6, a
37 contractions in the guinea pig ileum, which are down-regulated after chronic, but not acute, exposur
38 ly of transcription factors, Sox4 and Sox11, are down-regulated after the epoch of hair cell developm
43 imary human hepatocytes, SIRT1 messenger RNA was down-regulated after GCA treatment, potentially thro
45 Particularly photosynthesis-related genes are down-regulated and genes belonging to the functional
46 mples revealed that both ts-3676 and ts-4521 are down-regulated and mutated in patient tumor samples.
47 ferentiation genes (KRT1, KRT10, DSC1, DSG1) being down-regulated and late differentiation genes (SPR
48 In this study we determined that autophagy is down-regulated and inversely correlated with miR-224
50 thylarginine dimethylaminohydrolase activity is down-regulated and PRMT1 protein expression is up-reg
51 cence the canonical miRNA biogenesis pathway is down-regulated and specific miRNAs are generated by a
52 osis occurs under conditions where cyclin D1 is down-regulated and the cell cycle arrested in G2 phas
53 tion, CD86 expressed by transitional B-cells was down regulated and T-cell proliferation was reduced.
54 (mCaROCK1), we found that irisin production was down-regulated and the mice developed obesity and in
55 due to the fact that both p70S6K and Smurf1 were down-regulated and negatively correlated with TRIB2
56 in human breast tumors, PTTG1 protein levels were down-regulated and the reduction was significantly
57 In mom1-3 ovules, both SUF4 and EC1 genes are down-regulated, and EC1 genes show higher levels of
59 which is mainly stabilized by Cx43 in vivo, was down-regulated, and its characteristic staining rema
60 ant Htt neurons, fission genes Drp1 and Fis1 were down-regulated, and fusion genes Mfn1, Mfn2 and Opa
61 il-treated mutant Htt neurons, fission genes were down-regulated, and fusion genes were up-regulated,
62 known KCNE3 partners KCNC4 and KCNH2 (mERG) were down-regulated, and KCNK4 (TRAAK) was up-regulated
63 mature: 99% of them during early maturation were down-regulated, and preferentially associated with
65 1 accumulated, W1-COE and its paralog W2-COE were down-regulated, and the phenotype was nonglaucous a
67 (HS), critical to establish CCL21 gradients, was down-regulated around lymphatics by anti-VEGFR-3 and
69 uding the S6 ribosomal protein (S6rp), which is down-regulated at the onset of myelination, and N-myc
70 and describe a novel mechanism by which CYLD is down-regulated at the transcriptional level in MOLF/E
73 receptor expressions studied in mouse aortas were down-regulated at 6 and 18 hours in endotoxemic mic
76 ally by GABA release: Axonal GABAA receptors are down-regulated but dendritic receptors are up-regula
77 report here that Krt17 expression initially is down-regulated but later is strongly up-regulated by
78 levels and inhibitors of apoptosis proteins were down-regulated, but force production remained norma
83 In this study, we showed that MIF expression is down-regulated by 0.75 +/- 0.10-fold of the control i
84 2 in an autocrine manner, and PGE2 secretion is down-regulated by cell-to-cell contact, attenuating i
85 In most Brachypodium accessions BdODDSOC2 is down-regulated by cold, and in one of the winter acce
87 hyaluronic acid-CD44 independent manner that is down-regulated by inhibitors of the JAK/STAT pathway
88 nd CCNJ, a protein controlling cell mitosis, is down-regulated by miR-98 via targeting 3'-untranslate
90 by which protein synthesis in starved cells is down-regulated by phosphorylation of the universally
94 CD2AP.Cbl-3/c complex, suggesting that Ret9 was down-regulated by a fundamentally different mechanis
95 loop in prostate cancer: miR-190a expression was down-regulated by AR activation; YB-1 functions are
97 methylation showed that LOC146880 expression was down-regulated by DNA methylation in its promoter.
98 owed that leaf hydraulic conductance (Kleaf) was down-regulated by exogenous ABA, with strong variati
101 mitochondrial permeability transition pore, was down-regulated by miR-7 through targeting 3'-untrans
102 Oskn2:beta-glucuronidase reporter expression was down-regulated by OsGRF3 and OsGRF10 in vivo, sugges
111 he beta-catenin signaling target connexin-43 were down-regulated by FH535, and functional blockade of
112 xtent by PKA-CQR and of the transcripts that were down-regulated by FSH, 76% were also down-regulated
113 mponents of the circadian central oscillator were down-regulated by NF and LPS, suggesting that a roo
118 l to identify multiple neuronal tissues that are down-regulated due to pathogen infection in C. elega
119 xposure or beta3-adrenergic stimulation, and is down-regulated during brown adipocyte differentiation
120 p protein EZH2 (enhancer of zeste homolog 2) is down-regulated during osteoblastic differentiation of
122 Expression of the precursors of the miR393 was down-regulated during mycorrhization in three differ
123 synthase, biosynthesis, and Hym hydrogenase were down-regulated during C2H2 inhibition, consistent w
125 roapoptotic tumor suppressor gene DPPIV/CD26 was down-regulated, followed by an increase in extracell
127 ant morphological changes and one week later were down-regulated gradually, while those in Modules 2
128 As were up regulated (>2 fold) and 35 miRNAs were down regulated (>2fold) compared to controls.
129 mMRP-5 (all orthologs of HRGs in C. elegans) are down-regulated in heme-treated B. malayi, as compare
130 Finally, we demonstrate that Rheb levels are down-regulated in the AD brain, which is consistent
131 are up-regulated and downstream SRF targets are down-regulated in the hearts of MCKCUG-BP1 mice, whi
134 miR-214, and LHX6 expression was detected to be down-regulated in erlotinib-resistant HCC827 cells.
136 analyzed miR-133b expression and found it to be down-regulated in HCC patient samples and induced in
138 tein claudin 1 (Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatit
139 Importantly, we show that iso3, known to be down-regulated in several cancers, competes with RBBP
146 oplasmic tRNAs tK(UUU), tQ(UUG) and tE(UUC), is down-regulated in a proteasomal dependent fashion.
148 and qPCR indicated that the expression of FT is down-regulated in both OsbHLH068-overexpressing Arabi
152 mediated by the DNA methylase, DNMT3A, which is down-regulated in cells lacking p38alpha, but once re
154 g ducts of mice and rats, and its expression is down-regulated in Dahl salt-sensitive rats fed a high
155 anscript; miR-198 expression in healthy skin is down-regulated in favor of FSTL1 upon wounding, which
157 contrast to other cancers, PICK1 expression is down-regulated in grade IV astrocytic tumor cell line
163 rce this result, we also show that Tif1gamma is down-regulated in HSCs during aging in 20-mo-old wild
164 We also found that expression of miRNA-200b is down-regulated in human breast cancer during lymph no
166 glandin E2 (PGE2), through its receptor EP4, is down-regulated in human systemic inflammatory disease
168 Muscular secreted frizzled-related protein 2 is down-regulated in ICU-acquired weakness patients and
172 xpressed in many cancers, including RCC, and is down-regulated in metastatic versus primary ccRCC.
173 e 2 of the gibberellin biosynthesis pathway, is down-regulated in OsbZIP48(OE) and up-regulated in Os
175 olved in gametogenesis in Chlamydomonas pCRY is down-regulated in pregametes and gametes, and in the
178 deacetylase and activator of fat oxidation, is down-regulated in response to high fat feeding, the r
179 hich surface expression of the Vbeta5(+) TCR is down-regulated in response to Mtv-8 and recombination
184 the most widely characterized family member, is down-regulated in the depressed brain and plays a pro
185 in 3 (Ucn3), a marker for mature beta cells, is down-regulated in the early stages of T2D in mice and
186 transforming growth factor-beta1 expression is down-regulated in the Lamc3(-/-) retina, and SMAD sig
187 es with a QTL for rice blast resistance, and is down-regulated in the ospal4 mutant line; this may ex
188 an endothelial-specific, proangiogenic miR, is down-regulated in the peripheral muscles of patients
189 rticoid regulated kinase 1 (SGK1) expression is down-regulated in the postmortem PFC of PTSD subjects
195 We found that expression of miR-3189-3p was down-regulated in astrocytoma and glioblastoma clini
196 e 3 (Sec14l3) - a putative target of Creb1 - was down-regulated in both asthma models and in NHBE cel
199 ferator-activated receptor-gamma (PPARgamma) was down-regulated in control animals after AMI and up-r
207 defense priming in systemic plant immunity, was down-regulated in leaves by joint stress and conferr
208 IRF5 in HCV-induced HCC, as IRF5 expression was down-regulated in livers from HCV-positive versus HC
213 nuclear factor 4A-driven gene network, which was down-regulated in mouse hepatocyte nuclear factor 4A
214 The functionally essential sGC beta1-subunit was down-regulated in patients with COPD and in CS-expos
219 primary methyltransferase acting on H3K9me2, was down-regulated in response to (*)NO, and changes in
221 ntified a serine protein kinase, SRPK3, that was down-regulated in RMS cells and found that expressio
223 ibitor, secreted frizzled-related protein 2, was down-regulated in skeletal muscle of ICU-acquired we
227 ation found that BMP/Smad4 signaling pathway was down-regulated in the K14-cre;Bmp2(f/f);Bmp4(f/f)ame
231 xpression of multiple enamel matrix proteins was down-regulated in the mutant ameloblasts, the cleava
232 e expression of synapsin genes SYN1 and SYN2 was down-regulated in vivo and in vitro by alphaSyn olig
234 ression status, and the majority of the rest were down-regulated in abiotic stresses and up-regulated
235 mma (PPAR-gamma) and downstream target genes were down-regulated in adipose tissue from participants
236 iogenesis, including c-MYC, c-MYB, and VEGF, were down-regulated in association with a decline in hyp
239 ral drug metabolism and BA transporter genes were down-regulated in Cic-L(-/-) liver, and that BA was
240 teractions and NK cell-mediated cytotoxicity were down-regulated in cKO decidua compared with control
243 In addition, Camta1, Camta2, and Nkx2-2 were down-regulated in GK rat islets, and knockdown of C
248 TGFbeta pathway, including pSMAD2 and pERK, were down-regulated in LTBP4 mutant human dermal fibrobl
249 in A, and Growth factor-independent 1 (Gfi1) were down-regulated in Mtgr1(-/-) whole intestines and M
250 ies in PGK mutants showed that PGK1 and PGK3 were down-regulated in pgk3.2 and pgk1.1, respectively.
253 many glycosylation sites on surface proteins were down-regulated in statin-treated cells compared to
254 s were up-regulated whereas 36% of LPE genes were down-regulated in the absence of this receptor.
255 Interestingly, these mitochondrial proteins were down-regulated in the CTX model thereby linking oxi
256 ins were differentially up-regulated and 400 were down-regulated in the fast muscle compared with slo
257 0.75, respectively; P < 0.05); both pathways were down-regulated in the greatest-ADG compared with le
258 script as well as protein levels, while they were down-regulated in the GSH-depleted phytoalexin defi
259 etylase sirtuin 1, a ChREBP-negative target, were down-regulated in the liver of alcohol-fed mice, th
260 f the beta cell transcriptional network that were down-regulated in the Nkx2.2(KO) mice, were maintai
262 le control and 9 genes involved in apoptosis were down-regulated in the treatment tumor tissues versu
263 sis and fatty acid biosynthesis; these genes were down-regulated in wild-type or WRI1-overexpressing
264 %) of S-palmitoylation sites on 254 proteins were down-regulated in Zdhhc13-deficient mice, represent
265 Genes involved in various metabolic pathways were down regulated, including genes involved in cell gr
266 Ninety genes were up-regulated and 18 genes were down-regulated, including genes with potential regu
267 and parathyroid hormone-like peptide (Pthlh) were down-regulated, indicating compromised Hh signaling
268 ts, but in aggressive osteosarcomas, miR-874 is down-regulated, leading to elevated CCNE1 expression
269 Interestingly, the majority of these genes are down-regulated, linking malignant transformation to
270 artery occlusion (MCAO) model of stroke, LSR was down-regulated, linking loss of LSR and pathological
271 l stages of development to define genes that are down-regulated or up-regulated by the lec1 mutation.
272 -miR-585-3p, hsa-miR-508-3p and hsa-miR-626) were down-regulated (P < 0.05; fold regulation </=-2) in
273 erogeneous nuclear ribonucleoproteins A2/B1, are down-regulated post-transcriptionally only in Tg-Ran
275 e nuclear factor of activated T cells (NFAT) was down-regulated progressively in accordance to the si
277 nd RORgammat are up-regulated, whereas FoxP3 is down-regulated, resulting in enhanced Th1 and Th17 ex
278 d expression of Bcl-2 and IAP family members were down-regulated, resulting in high levels of caspase
279 Results show pro-inflammatory cytokines were down-regulated significantly post antibiotic treatm
280 lved in flavonoid biosynthesis were found to be down-regulated specifically in the salinity tolerant
281 gnals such as CC chemokine receptor 7 (CCR7) are down-regulated, T cell intrinsic S1PR1 is the master
282 ge-sharing hypothesis, most young duplicates are down-regulated to match expression levels of single-
286 14-3-3 protein beta/alpha/YWHAB (14-3-3beta) is down-regulated upon miR-152 overexpression, although
287 normal human keratinocytes YIPF4 expression was down-regulated upon differentiation and this reducti
290 k, and Pi3K/Akt/mTor signaling pathway genes were down-regulated upon vitamin D supplementation.
291 production from an equivalent number of MSCs was down-regulated via gap junctional intercellular comm
294 , ferritin OsFER2 and ferredoxin OsFd1 mRNAs are down-regulated whereas the transcriptional iron regu
296 keletal organization, and cell proliferation were down-regulated, whereas stress-related proteins wer
297 2 days earlier than normal MT channels, and being down-regulated with the emergence of the normal ch
298 ing energy deficit, muscle protein synthesis is down-regulated with concomitant increases in ubiquiti
299 zed in HCC cells and anti-apoptotic proteins were down regulated with apoptosis in ~27% of the tumor
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