ライフサイエンスコーパス: be downregulated by

1 miR-133a expression was downregulated by 0.7- and 0.5-fold at 2 and 4 weeks

2 -infection of macrophages but the expression was downregulated by 12 h post-infection.

3 t receptor in HCE cells up to 30 minutes and was downregulated by 2 hours.

4 Podocalyxin was downregulated by 20% in newborn kidneys but not in k

5 pressed from birth through 8years of age and is downregulated by 20years of age to low levels that ar

6 ong which maternally expressed gene 3 (MEG3) was downregulated by 210-fold relative to expression in

7 phosphatases, we found that calcineurin/PP2B was downregulated by 30% in pre-symptomatic and 50% in s

8 mRNA expression of interleukin (IL)-1beta was downregulated by 42.5 +/- 4.7% (p < .05) and transfo

9 in several malignancies, including melanoma, was downregulated by 5.6-fold following MUC18 silencing.

10 cell-cycle regulatory activity, was shown to be downregulated by 50% following androgen stimulation.

11 f total), and (b) in heart failure alpha-MHC was downregulated (by 67-84%) and beta-MHC gene expressi

12 DAPK1 expression of the CLL allele is downregulated by 75% in germline cells due to increas

13 y contrast, partially complementary messages are downregulated by a combination of translational repr

14 ion of the kinetochore complex subunit Ndc80 is downregulated by a 5' extended long undecoded NDC80 t

15 enes, 1088 genes were induced and 3828 genes were downregulated by a log(2) factor of 2.

16 Sclerostin (Sost) expression was downregulated by about 90% and SOST protein was unde

17 alkalinizing SC pH, whereas this antiporter was downregulated by acidifying SC pH, independent of ch

18 models of NSCLC, we found that Cyp2c44 could be downregulated by activating the transcription factor

19 An IL-1beta-induced set of 27 genes was downregulated by an NF-kappaB inhibitor, leading to

20 ding 4-coumarate:coenzyme A ligase (4CL) has been downregulated by antisense inhibition.

21 Cardiac Kv4.3 channel gene expression was downregulated by approximately 3- to 5-fold, both at

22 (HAT1), which catalyzes H4K5ac and H4K12ac, was downregulated by ascorbate mainly via the TET-mediat

23 n (CLU) gene, which is related to apoptosis, was downregulated by ascorbate.

24 phosphatase, protein phosphatase 2A (PP2A), is downregulated by ATM-mediated phosphorylation.

25 s a key regulator of anabolic metabolism and is downregulated by axotomy.

26 Using CML mouse model, we show that Msr1 is downregulated by BCR-ABL and this down-regulation is

27 in which the SpSoxB1 transcription regulator is downregulated by beta-catenin-dependent gene products

28 rgest functional group (n = 45) all of which were downregulated by bile exposure.

29 of the translation initiation complex eIF4F, is downregulated by binding the negative-acting factor 4

30 Subunits of the Arp2/3 complex were downregulated by BLOC-1 loss of function, thus affe

31 c genes (for example, BCL2, BCL-XL and DAD1) was downregulated by BTK short hairpin RNA.

32 t the majority of these genes carried by pCD were downregulated by Ca2+.

33 The PrgX protein, prgX RNA, and the Qa RNA were downregulated by cCF10 induction; however, prgX gen

34 In turn, CD2-stimulated adhesion is downregulated by CD2BP1, apparently through coupling

35 Cdk2/CyclinE acts downstream of ATM and is downregulated by Cdk2 phosphorylation on tyrosine 15.

36 d on these results, it appears that the SERT is downregulated by chronic administration of SSRIs but

37 psychotic actions by neuroleptic treatments, was downregulated by chronic treatment with the two pote

38 R2A encodes the serotonin 2A receptor, which is downregulated by citalopram.

39 core components of the beta-catenin pathway, is downregulated by clofibrate.

40 e brain, and has been previously reported to be downregulated by cocaine.

41 that about 70% of the genes induced by Wnt3a were downregulated by combined FGF treatment.

42 responses to bacterial challenge or TNFalpha are downregulated by CsA.

43 mely miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further

44 Ct-Rac1 expression is downregulated by DARas under limiting nutrition.

45 sion, a time at which many maternal proteins are downregulated by deadenylation and destabilization o

46 We show that Cpe expression is downregulated by diet-induced obesity and that FoxO1

47 is a p53-targeting E3 ubiquitin ligase that is downregulated by DNA damage through mechanisms that r

48 In colorectal cancer cells, AP4 was downregulated by DNA damage in a p53-dependent manne

49 T-type Ca(2+) channels were downregulated by dopamine receptor activation actin

50 iverse HDACs, and lamina-associated proteins were downregulated by dsRNA.

51 boule expression is downregulated by ecdysone in MB neurons at the onset

52 d rabbit model, FasL expression was shown to be downregulated by elevations in serum cholesterol, whi

53 ectant that decreases with advancing age and is downregulated by estrogen treatment.

54 of both the EXO-GUS and the native EXO genes is downregulated by exogenous cytokinin.

55 AtMYB4 expression is downregulated by exposure to UV-B light, indicating t

56 ity; (c) PPAR gamma 1 and gamma 2 expression is downregulated by fasting and insulin-deficient diabet

57 ed that neural activity in other systems may be downregulated by food deprivation.

58 Expression of all 14 genes was downregulated by GA and upregulated by DELLA.

59 enin, a member of the Wnt signaling pathway, is downregulated by glycogen synthase kinase-3beta (GSK-

60 s was upregulated and expression of 61 genes was downregulated by >1.5-fold at both E12.5 and E13.5 i

61 were consistently upregulated, and 14 genes were downregulated, by >50%.

62 required for OIS in primary fibroblasts but is downregulated by H-Ras(V12) in immortalized NIH 3T3 c

63 positive regulator of E-cadherin expression, was downregulated by HBx in HepG2X cells and tissue sect

64 as an HCV entry host dependence factor that is downregulated by HCV infection in a cell culture mode

65 and insulin- stimulable GS and PP1 activity are downregulated by high glucose in fibroblasts and thi

66 1 and cdc25A as direct miR-503 targets which are downregulated by high glucose/low growth factors in

67 HLA-E protein expression on cell surface is downregulated by high-risk HPV16 and HPV18 E7 express

68 CITED2 was the target of miR-200b and was downregulated by high glucose.

69 re is a growing number of genes known, which are downregulated by histone deacetylase (HDAC) inhibito

70 Meiotic recombination 11 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDAC

71 ER and PR in LAM cells appear to be downregulated by hormonal therapy.

72 tring profiling identified 14 microRNAs that are downregulated by hPMR1, including all five members o

73 We discover that microRNA-203 is downregulated by Hras(G12V).

74 s, the yeast alpha-factor pheromone receptor is downregulated by hyperphosphorylation, ubiquitination

75 ases in key IgE signaling molecules known to be downregulated by IL-10.

76 t of airway epithelial barrier function that is downregulated by IL-13 and that claudin-18 deficiency

77 fic genes, Sox9 and collagen type IIa, which were downregulated by IL-1beta.

78 trating that miR-23b cluster and miR-125a-5p are downregulated by increased expression of PDGFR-alpha

79 Protein kinase C (PKC) was downregulated by incubating acini overnight, with or

80 Hepatitis B virus (HBV) RNA is downregulated by inflammatory cytokines induced in th

81 However, all four prosurvival proteins were downregulated by inhibition of NF-kappaB in MCF-7/E

82 growth regulators in the retina and RPE that are downregulated by injury, to allow tissue repair.

83 Our novel findings reveal that omentin-1 is downregulated by insulin and glucose.

84 LK-1, a conserved regulator of regeneration, is downregulated by insulin/IGF1 signaling, bound by DAF

85 specifically expressed within these domains are downregulated by interference with SoxB1 expression,

86 olved in P. gingivalis invasion of GECs, may be downregulated by internalized P. gingivalis.

87 e homologs of Drosophila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated

88 s, iron, and bone morphogenetic proteins and is downregulated by iron deficiency, ineffective erythro

89 is highly sensitive to stress conditions and is downregulated by iron depletion and gamma-irradiation

90 phenomenon in which the expression of a gene is downregulated by its protein product.

91 Interestingly, SnoN itself is downregulated by Lats2 that is activated by the Scrib

92 Namely, expression of UDA is downregulated by let-7 microRNA, whereas the predomin

93 However, expression is downregulated by lipopolysaccharide and rIL-1beta in

94 that the basic helix-loop-helix factor Ascl1 is downregulated by loss of Smad4 and that Ascl1 regulat

95 ssed the expression of eight genes that also were downregulated by low temperature, indicating that i

96 es demonstrate that murine GHR transcription is downregulated by LPS, primarily via TNF-alpha-depende

97 that show constitutive macropinocytosis that was downregulated by LPS treatment.

98 Exopolysaccharide production is downregulated by Ltp1 through transcriptional regulat

99 Similarly, CA9 promoter activity was downregulated by MC in HCT 116 p53(+/+) but not the

100 g pathway, including mTOR, eIF4A, and eIF4E, are downregulated by mf, suggesting that mf target this

101 ient and that Fgf2 and its receptor, Fgfr-1, are downregulated by mid to late stages of neurogenesis.

102 factor-kappaB (NF-kappaB), was identified to be downregulated by miR-7 using quantitative proteomic a

103 tin-interacting protein 1-related (HIP1R) as being downregulated by miR-23b/-27b.

104 We also identified MAFA as a target that is downregulated by miR-204.

105 truct containing the 3'-UTR of PKCvarepsilon was downregulated by miR-107 and mutations in the three

106 ture experiments showed that AIB1 expression was downregulated by Mir-17-5p, primarily through transl

107 Accordingly, global H3K27me3 levels were downregulated by miR combo treatment.

108 3'UTR and coding sequence and for genes that were downregulated by miR-200c overexpression.

109 pression of OBFC2A, a DNA-damage factor that is downregulated by miR17 and miR21 in HTLV-1-infected C

110 H4 gene transcription during differentiation is downregulated by modulating protein interaction at th

111 Only ESR1 was downregulated by more than two-fold in ER-positive c

112 We find that HLA-C is downregulated by most primary HIV-1 clones, including

113 In our model, the hedgehog pathway was downregulated by Mtb-stimulation, but Shh levels in

114 in cells in which the RhoA signaling pathway was downregulated by multiple experimental approaches.

115 In addition, the expression of Na(V)1.5 mRNA is downregulated by muscle activity, both at the NMJ and

116 rt that the tumor suppressor microRNA let-7i is downregulated by mutant p53 in multiple cell lines ex

117 Pump activity is downregulated by natriuretic hormones, such as dopami

118 g mediated by phospho-JNK and p38 expression was downregulated by NBP treatment in vitro and in vivo.

119 ich play critical roles for NCC development, was downregulated by NCC disruption of Smad4.

120 The NgR family is downregulated by neuronal activity, a response that m

121 The induction was downregulated by neutralizing IL-22.

122 epatic lipin 1beta and PGC-1alpha expression are downregulated by obesity and obesity-related metabol

123 lated protein 9 (CTRP9) is an adipokine that is downregulated by obesity.

124 ue of human Gravin/AKAP12), whose expression is downregulated by oncogenic Src and in many human canc

125 pression of transthyretin, which is known to be downregulated by oxidative stress.

126 The discovery that macrophage COX-2 is downregulated by oxidized low-density lipoprotein and

127 on, suggesting that PRC1 transcription could be downregulated by p53.

128 Similar to FOXM1, KIF20A expression is downregulated by paclitaxel in the sensitive MCF-7 br

129 Smpd3 expression in ATDC5 chondrogenic cells is downregulated by parathyroid hormone-related peptide

130 In addition, TGM-2 induced by CsA is downregulated by PD98059, LY294002, NAC, curcumin, EG

131 embers of the protein kinase C family, which are downregulated by phorbol esters, because it was stil

132 AID activity and its oncogenic potential can be downregulated by phosphorylation of serine 3 and that

133 on have suggested that c-Src kinase activity is downregulated by phosphorylation of a critical carbox

134 s steady state level during the light period are downregulated by phototropin, whereas the level of c

135 The level of ambient TNF is known to be downregulated by physical activity, exercise and adap

136 This mitochondrial activity of ATR is downregulated by Pin1 that isomerizes ATR from cis-is

137 or (NPR-C) expression in rat mesangial cells is downregulated by platelet-derived growth factor (PDGF

138 ee pathways which cross talk with each other were downregulated by POX: the cyclooxygenase-2 (COX-2)

139 osphorylated state under control conditions, are downregulated by PP2B upon stimulation, with the maj

140 late apoptotic human polymorphonuclear cells was downregulated by proinflammatory stimuli, including

141 Methods and Results-PKC was downregulated by prolonged (24-hour) treatment with

142 In cancer, expression of BNIP3 and BNIP3L is downregulated by promoter hypermethylation or by homo

143 the first report documenting that the WIF-1 is downregulated by promoter methylation and functions a

144 rized member of the family is RASSF1A, which is downregulated by promoter methylation in 40-90% of pr

145 miR-192 was downregulated by promoter methylation in both PDAC a

146 Expression of miR-193b in liposarcoma cells was downregulated by promoter methylation, resulting at

147 anine kidney cell taurine transporter (pNCT) is downregulated by protein kinase C (PKC) activation.

148 alpha7-nAChR levels are downregulated by reduced activity, whereas alpha3-nA

149 l transduction mechanisms that are likely to be downregulated by reelin deficiency in the brain of sc

150 cytes, the expression of alpha3(IV) collagen was downregulated by Rho-inhibition.

151 imulate motility of the cells, in which S6K1 was downregulated by RNAi.

152 ith RREB confirmed that the p16 promoter can be downregulated by RREB, in a Ras- or Mek-dependent man

153 CI-AML3 cells revealed that the miRNA let-7a was downregulated by SDF-1alpha-mediated CXCR4 activatio

154 s evidence that presynaptic calcium channels are downregulated by second messenger pathways involving

155 VEGF was downregulated by SERPINA3K at the transcriptional le

156 We conclude that SHP is downregulated by several steatotic drugs and in advan

157 Fob1-mediated Ter-Ter interactions in trans are downregulated by Sir2.

158 tor Robo1 has proinflammatory properties and is downregulated by Slit2 via targeting of miR-218.

159 Apolipoprotein B100 was downregulated by statin therapy, consistent with it

160 e results show that TACE is a target of, and is downregulated by, sTNF-induced AP-2alpha transcriptio

161 have identified several additional RNAs that are downregulated by Su(s).

162 ypsin-like (CT-L) activity of the proteasome is downregulated by substrates of the peptidyl-glutamyl

163 Activity of an agpA::TnphoA fusion was downregulated by SyrA.

164 responses for both foreign and self antigens are downregulated by T cells that are specialised for th

165 llular levels of lumican and keratocan mRNAs were downregulated by TGF-beta1 and FBS.

166 These are downregulated by Th2 cytokines of the allergic respo

167 gely stress induced and TAF independent, and are downregulated by the coordinate action of a variety

168 r induced by androgen: 9 out of the 12 mRNAs are downregulated by the microRNA cluster.

169 enovirus expressing miR-145 (Ad-miR-145) but are downregulated by the miR-145 inhibitor 2'OMe-miR-145

170 roteins are upregulated and surface proteins are downregulated by the regulator, suggesting that mgrA

171 ansforming, we investigated whether it could be downregulated by the Cbl proteins.

172 LB2 transcription cluster have been known to be downregulated by the DNA damage checkpoint for many y

173 ell commitment and that Notch signaling must be downregulated by the double positive stage for proper

174 MYC, HIF1a, MTIF and CDKN1B) are reported to be downregulated by the loss of PRMT5, while their mRNA

175 However, activation of Akt appears to be downregulated by the receptor's carboxy-terminal regi

176 Src kinase activity is downregulated by the carboxy-terminal Src kinase (Csk

177 Robo repulsion is downregulated by the Commissureless (Comm) protein, a

178 rom thymus and secondary lymphoid organs and is downregulated by the immunosuppressive drug FTY720.

179 Furthermore, when the expression of nestin is downregulated by the nestin-specific small interferin

180 on of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR prot

181 charide (LPS)-induced monocyte TF expression is downregulated by the nuclear hormone all-trans retino

182 virus saimiri, whereby ORF 50a transcription is downregulated by the ORF 57 gene product, a gene whic

183 this study, we show that Claspin expression is downregulated by the proteasome-mediated degradation

184 Dab1 is downregulated by the Reln signal in neurons in the ab

185 show for the first time that activated c-Abl is downregulated by the ubiquitin-dependent degradation

186 In summary, ENaC was downregulated by the activation of P2X2, P2X(2/6), P

187 ut factor VIII, in which thrombin generation was downregulated by the addition of protein C and throm

188 RGS4 was downregulated by the master regulator of LEC differe

189 -) T cells as was mTOR, and their expression was downregulated by the overexpression of miR-15b/16.

190 RA two-component sensory transduction system was downregulated by the presence of FCS.

191 A-DRalpha, a member of the MHC-II molecules, was downregulated by the replication and transcription a

192 The gene was downregulated by the syrA gene product and also by g

193 mune response and inflammation pathway genes were downregulated by thiazolidinedione treatment, beta-

194 (atypical protein kinase C [aPKC]-PAR6-PAR3) were downregulated by TNF-alpha signaling in intestinal

195 microRNAs (miRs), miR-126 and miR-126*, that are downregulated by TNFalpha and IFNgamma in a human br

196 The expression of survivin was downregulated by TP.

197 HER2-overexpressing breast cancer cell lines was downregulated by transfection with HER2 small interf

198 y, similar to c-Myc, the expression of Gfi-1 is downregulated by transforming growth factor-beta (TGF

199 itutive expression of NF-kappaB in NHL-B can be downregulated by treatment with antibodies to CD40 or

200 tive pathways regulating cell migration that are downregulated by tumor suppressor PTEN: one involves

201 thelial NO synthase (eNOS), whose expression is downregulated by tumor necrosis factor (TNF)-alpha at

202 d by twofold or greater, and 173 genes (51%) were downregulated by twofold or greater.

203 Here we demonstrate that Smo is downregulated by ubiquitin-mediated endocytosis and d

204 y expressed IL-15 mRNA, and IL-15 expression was downregulated by ultraviolet B radiation in cultured

205 rived growth factor-b, and S100A4 in R-cells were downregulated by valproic acid and suberoylanilide

206 oth muscle cells (VSMCs), and its expression is downregulated by vascular injury or other conditions

207 localized to the nucleus, and its expression was downregulated by water stress.