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3 ression of an ERBB3-binding protein 1 (EBP1) is downregulated in 8-day old hamster ovaries concurrent
4 rotein levels of Notch receptors and ligands are downregulated in a time- and learning-specific manne
5 t nuclear receptor binding protein 1 (NRBP1) is downregulated in a range of human tumours, where low
7 D21A transcript, protein and activity levels were downregulated in a largely ERFVII-dependent manner.
9 tabolic pathways, and OXPHOS proteins in SAT are downregulated in acquired obesity, and are associate
13 asthmatic patients (P < .05), whereas PGES2 was downregulated in AEC-HLF cocultures (2.2-fold, P < .
15 ocaine- and amphetamine-regulated transcript was downregulated), in alignment with leptin suppression
16 factor 1 (WIF1), a secreted Wnt antagonist, is downregulated in all human primary cervical tumors an
23 ferator-activated receptor gamma (PPARgamma) is downregulated in APCs isolated from the lungs of emph
25 viously unknown, primate-specific miRNA that is downregulated in ASD and that regulates the epidermal
27 ant and malignant skin neoplasia, E-cadherin is downregulated in association with reduced XPC and DDB
28 Several genes that oppose T cell activation were downregulated in asthma, suggesting enhanced activa
29 d that the expression of miR-145/143 cluster was downregulated in astrocytic tumors compared to norma
30 ses in expression of the miRNA miR30a, which is downregulated in ATC compared with differentiated thy
35 pha7 nAChR-dependent calcium signal cascades are downregulated in both 15q13.3 deletion and duplicati
36 al structures, including multiple mRNAs that are downregulated in both inhibitory GABAergic and excit
41 of the prosurvival Bcl-2 family member Mcl-1 was downregulated in both mir-125a-overexpressing IEC-6
43 hat the highly conserved brain miRNA miR-219 is downregulated in brain tissue taken at autopsy from p
45 B4 (zinc-finger and BTB domain containing 4) is downregulated in breast cancer patients, and that its
46 ential cellular functions, Pfn1's expression is downregulated in breast cancer, the significance of w
49 identified one Wnt target gene, Pitx2, that was downregulated in Brg1 mutant endothelial cells but w
52 , a protein expressed in cardiomyocytes that was downregulated in cardiac hypertrophy and human heart
53 at PPM1F messenger RNA levels in human blood were downregulated in cases with symptoms of comorbid PT
54 ways and functions of the measured cytokines were downregulated in cases, except cell death pathways,
55 h the adult prostate or CD133-PrEC, and RBM3 is downregulated in cells cultured in soft agar or expos
57 e expression of 10 DNA damage response genes was downregulated in cells treated with etoposide and si
58 erently expressed, 2 were upregulated and 14 were downregulated in children with active CMA compared
62 were enriched in cancer-related pathways and were downregulated in clinical metastatic versus localiz
64 er regulator class II transactivator (CIITA) are downregulated in CML compared with non-CML stem/prog
70 n the colon and are consistently reported as being downregulated in colorectal and other cancers.
71 evels of lipoprotein ApoA1 expression, which is downregulated in Crohn's disease patients and causall
74 in the nuclei of follicle cell epithelia and is downregulated in delaminating epithelia as expression
75 anistic target of rapamycin (mTOR) signaling is downregulated in dGBA knock-out flies, with a concomi
76 hanistic target of rapamycin (mTOR) activity is downregulated in dGBA-deficient flies and rapamycin a
78 cell survival through inhibition of FOXO3a, was downregulated in diabetic CD34(pos)-PCs and inversel
81 ls multiple tumour suppressive functions and is downregulated in diverse types of human cancers throu
83 example, ERO1LB, DOCK10, IGSF11, and PRR14L were downregulated in donors with hyperglycemia and corr
85 d in Klf5 knockout (KO) embryos at E3.0, and was downregulated in embryos overexpressing Klf5 Further
89 pidermal expression of complement components was downregulated in ex vivo injured skin lacking the st
91 colleagues demonstrate that AIRE expression is downregulated in females as the result of estrogen-me
92 d ECM proteins are targets for miR-29, which was downregulated in fibroblasts grown on IPF-derived EC
94 ether, these data suggest that, although BLM is downregulated in G1 phase in order to promote NHEJ-me
96 lity for small molecular tracers, and Cyp1b1 was downregulated in glioma vessels in which BBB functio
97 r (G-CSF) receptor-triggered granulopoiesis, is downregulated in granulocytic progenitors of severe c
99 I is an imprinted tumor-suppressor gene that is downregulated in >60% of ovarian cancers, and its los
100 ere, we demonstrated that expression of FBP1 was downregulated in HCC patient specimens and decreased
101 The expressions of miR-200c and miR-141 were downregulated in HCC-BDTT (4.5- and 4.8-fold decrea
104 expression of several of the same genes that were downregulated in HCT116 cells, including the MYC on
106 ived neurotrophic factor (BDNF), a gene that is downregulated in HD, in the presence of mutant Htt.
107 the most striking change was for TLR5, which was downregulated in healthy smokers (1.4-fold, p < 10(-
108 Ten genes important in cardiac metabolism were downregulated in heart failure, with SLC27A4 and KC
110 roduct, damaged DNA-binding protein (DDB)-2, is downregulated in high-grade colon cancers, and it pla
111 s robustly regulated by BDNF/TrkB signaling, is downregulated in hippocampus (male/female) and upregu
112 how that expression of the MHC class I genes is downregulated in HPV-positive keratinocytes in an E7-
113 oded in the same miR cluster (miR-23b/-27b), are downregulated in human metastatic prostate cancer co
114 m (CNS)-specific PGC-1alpha (CNS-PGC-1alpha) are downregulated in human PD brain, in A30P alpha-syn t
115 domain-containing 1 (PDZK1) was revealed to be downregulated in human clear cell renal cell carcinom
118 iovascular profile comparable to apelin, and is downregulated in human disease and rodent PAH models,
124 eceptor 1-related protein y/CD46) expression was downregulated in human and murine OB; and C3a, a mar
127 the transcriptional level and, like JunB, it was downregulated in human squamous cell carcinoma cells
129 We demonstrated that the level of PRDX3 was downregulated in ICP placentas as well as bile acids
130 tion indicated that mRNA for L-NFL and NF132 was downregulated in identified reticulospinal neurons b
131 nes, chemokines, and anti-microbial peptides were downregulated in Ikkepsilon-deficient tissues, subs
133 NA) expression profile identified genes that were downregulated in ILT3-induced human CD8(+) T suppre
137 in contrast to RGCs, neither c-myc nor mTOR was downregulated in injured peripheral sensory neurons.
138 xpression levels of the chIL-17RA transcript were downregulated in intestinal tissues from chickens i
140 ther small GTPases, including Rab3 and Rab7, was downregulated in kidneys from Ctns-/- mice and in hu
142 beta-ketoacyl CoA synthase gene (PotriKCS1) was downregulated in leaves from non-alkene-producing ac
143 of the stearoyl-CoA desaturase 1 (Scd1) gene is downregulated in LSCs and that Scd1 plays a tumor-sup
144 ruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have bee
147 gland-specific genes and mitochondrial genes were downregulated in males with resistant Y chromosomes
148 es a polycomb group protein that is known to be downregulated in many types of human cancers, althoug
149 apoptosis activators and tumor suppressors, being downregulated in many human cancers, although thei
150 r of cancer cell invasion and its expression is downregulated in many advanced, poorly differentiated
153 d that basic fibroblast growth factor (bFGF) was downregulated in MDA-MB-231-injected tibiae from the
154 ated receptor gamma (PPARG/Pparg) expression was downregulated in mDCs of smokers with emphysema and
155 order (MDD) have noted that the cAMP cascade is downregulated in MDD and upregulated by antidepressan
157 oded by the same miR cluster (miR-23b/-27b), are downregulated in metastatic, castration-resistant tu
159 wer in AS(-/-) mice than in AS(+/+) mice and was downregulated in mice of both genotypes in response
160 ing and TGFbeta-regulated genes encoding ECM are downregulated in Mkl2(-/-) ES cells and the vasculat
161 ied a putative STAT3 target gene, NR4A3 that was downregulated in MKN28 GC daughter cells overexpress
163 stem cells of 11 adults with ASD that MOCOS is downregulated in most of them when compared with 11 a
165 at ten-eleven translocation protein 1 (TET1) was downregulated in mouse nucleus accumbens (NAc), a ke
166 GAP is a critical tumor suppressor gene that is downregulated in multiple aggressive cancers, such as
168 omponents of the myostatin signaling pathway is downregulated in muscle wasting or atrophying disease
169 ion at baseline in fresolimumab nonimprovers were downregulated in mycophenolate mofetil improvers, s
171 proteins involved in fatty acid utilization were downregulated in myocardial samples from the failin
172 dditionally, we found that IQGAP1 expression was downregulated in myofibroblasts associated with huma
176 reast cancer metastasis suppressor 1 (BRMS1) is downregulated in non-small cell lung cancer (NSCLC),
178 cGK (cGMP-dependent protein kinase) activity was downregulated in Npr2(+/-) valves, and CNP triggered
180 sive role for human adipose tissue function, being downregulated in obesity and increased during diff
181 ation and restricted cell motility (SHROOM2) was downregulated in OE21 but upregulated in OE33 cells.
182 sion, Dpp signaling is extinguished, and Nos is downregulated in one daughter cell, causing it to swi
188 e found that the expression level of miR-19b is downregulated in patients with idiopathic rapid eye m
189 d by the histone demethylase JARID1B, MANTIS was downregulated in patients with idiopathic pulmonary
191 vation cohort, one of these miRNAs, miR-150, was downregulated in patients with remodeling (DeltaEDV>
194 cer of actin-depolymerizing factor activity, is downregulated in platelet messenger RNA (mRNA) from s
196 regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarc
199 on levels of the majority of imprinted genes are downregulated in primary tumors compared to normal c
201 which belongs to the largest RTK Eph family, was downregulated in primary B cells post-EBV infection
204 rget of rapamycin complex 1 (mTORC1) pathway was downregulated in proximal tubular cell lines derived
206 f the same genes were independently found to be downregulated in Q175 KI mice compared to WT (5.2e-7
207 d that miR-205 promotes radiosensitivity and is downregulated in radioresistant subpopulations of bre
208 19a-3p, broadly conserved among vertebrates, was downregulated in RAW264.7 macrophage cells of the M2
210 nt with these data, Gtl2-Dio3-encoded miRNAs are downregulated in regenerating Mef2a knockout muscle,
212 NC1 is specifically expressed in kidney, and is downregulated in renal cell carcinoma; also, its low
213 EM2, FRAS1 was absent and the other proteins were downregulated in rescued kidneys, consistent with a
214 ine pigment epithelium-derived factor (PEDF) is downregulated in resected human brain metastases of b
215 se in patients with breast cancer, and Par-4 is downregulated in residual tumor cells that survive ne
217 egulator of receptor tyrosine kinases (RTK), is downregulated in resistant derivatives of breast canc
218 medulloblastoma-specific GLI1 binding sites are downregulated in response to JQ1 treatment, supporti
220 ways, MAPK pathway, as well as redox enzymes were downregulated in response to disruption of glutamin
221 a microRNA predicted to target MDM4 (miR191) was downregulated in retinoblastoma relative to human fe
223 ich inhibit serotonin synthesis and release, are downregulated in SAD, and serotonin transporter avai
224 cl (Fanconi anemia, complementation group L) is downregulated in SALL4B Tg leukemic and pre-leukemic
226 s and bioinformatics analysis show that Ate1 is downregulated in several types of human cancer sample
227 responsive genes, which promote cell growth, were downregulated in shoot apices that accumulated incr
228 involved in cellular redox homeostasis which is downregulated in skeletal muscle differentiation.
230 we show that expression of Baf60c and Deptor was downregulated in skeletal muscle in obesity, accompa
231 c basis for previous observations that SRPK1 is downregulated in some cancer contexts and upregulated
233 -beta and guanylate-binding proteins (GBPs), are downregulated in STING knockout (KO) macrophages inf
234 A, a key enzyme in cAMP and cGMP catabolism, is downregulated in striatal projections to entopeduncul
236 volved in the development of hemopathies and is downregulated in T-lymphomas, such as anaplastic larg
238 roduction and subsequent T cell recruitment, is downregulated in TAMs through Mer tyrosine kinase-dep
240 orthologue (14-3-3 protein zeta/YWHAZ) that was downregulated in temporary ponds in both species.
243 egulators, including cyclin D1 and survivin, are downregulated in the germinative zone of the MAPK1-d
245 itories in the mouse, as E-cadherin needs to be downregulated in the primitive streak and in the epib
246 in-mitochondria), was uniquely identified as being downregulated in the DeltaHog1 background during g
247 itis, an animal model of multiple sclerosis, is downregulated in the brain at onset and peak of disea
249 xcellent study revealing that MPL expression is downregulated in the context of the mutant protein, J
257 transmembrane ligand for the NOTCH receptor, is downregulated in the PTEN-null fibroblasts leading to
259 tures compared with the Fgmcm1 mutant, which was downregulated in the expression of genes involved in
260 oreover, CD55 was upregulated, whereas RANKL was downregulated in the gingival tissue of the 10 mug/k
262 After seroconversion, perforin expression was downregulated in the lamina propria, but not in the
263 lectin, critical for T-cell entry into skin, was downregulated in the majority (52%) of MCCs (n=56),
264 Sonic hedgehog (Shh) signal transduction was downregulated in the mutant forebrain, consistent wi
265 sion of genes for several thylakoid proteins was downregulated in the mutants, but the relative level
270 hich 46 genes were upregulated and 200 genes were downregulated in the fibrotic cell lines compared t
271 microarray analysis revealed that 152 genes were downregulated in the hippocampal dentate gyrus regi
273 ole in regulating free fatty acid metabolism were downregulated in the livers, but not in the adipose
274 inal mucus showed that 60% of the genes that were downregulated in the luxO mutant were involved in a
275 ceptor (PPAR)-gamma coactivator (PGC)-1beta, were downregulated in the M-ERRalpha(-/-) muscles at the
278 t, the ETEC colonization factors CS1 and CS3 were downregulated in the presence of bile, consistent w
279 enes known to be involved in spermatogenesis were downregulated in the testes of knock-out mice, as w
280 gulated and miR-122, miR-296-5p and miR-503# were downregulated in the uninvolved colonic mucosa of A
284 s, p-mTOR (p=0.03) and PI3K-alpha (P = 0.04) were downregulated in treatment responsive residual tumo
286 ure products of MIR-491 (miR-491-5p and -3p) are downregulated in tumors compared with the normal bra
290 ugh earlier reports showed that BR signaling is downregulated in twd1, how TWD1 is integrated in BR s
291 ough expression of CRTH2 on blood leukocytes is downregulated in UC, CRTH2 is present in colon tissue
292 inal epithelium and that SERPINA1 and Elafin were downregulated in vaginal tissues from women with PO
295 changes in mitochondrial membrane potential, is downregulated in vascular smooth muscle cells in cult
297 ) modulates S1P-dependent responses; and (3) is downregulated in vitro and in vivo by tumor necrosis
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