ライフサイエンスコーパス: be essential for

1 ding of fear-extinction learning in children is essential for (1) detecting the source of development

2 omain and Zinc finger motifs in human hUTP23 are essential for 18S rRNA maturation.

3 ) are key transcriptional co-activators that are essential for a multitude of cellular processes, and

4 tanding changes in precipitation variability is essential for a complete explanation of the hydrologi

5 nic patch and a unique hydrophobic loop-that are essential for accessing SM in bile salt micelles.

6 In this study, T-cadherin was essential for accumulation of adiponectin in the neo

7 ROS are essential for activation of T cells, but how ROS inf

8 ine group with the conserved active-site Asp is essential for activity and likely dictates its orient

9 Cox4i2 is essential for acute but not chronic pulmonary oxygen

10 tional forces generated during cell motility are essential for adaptive T-cell immunity against infec

11 d4 controls cell identity gene induction and is essential for adipogenesis and myogenesis.

12 Communication is essential for all domains of life.

13 This transit in axons is essential for alphaherpesviruses to establish latency

14 re that while the central DNA binding domain is essential for anchoring at parS, this interaction is

15 cial morphology in electrochemical processes is essential for applications ranging from nanomanufactu

16 embryo-specific promoter is ideal it may not be essential for assembling an effective TSS as tTA can

17 at position 5 (E5) of mature (pseudo)pilins is essential for assembly.

18 rved catalytic interface that was thought to be essential for ATP synthesis, and cannot convert gamma

19 Although CML38 was essential for AtRALF1-mediated root inhibition, it a

20 m Xanthomonas citri subsp. malvacearum (Xcm) are essential for bacterial blight of cotton (BBC).

21 e resistance-nodulation-division family that is essential for bacterial resistance to drugs and toxic

22 Rather, our results demonstrate that the PVT is essential for balancing conflicting behavioral tenden

23 er in the intracellular domain of E-Cadherin is essential for binding to beta-Catenin in vitro In cul

24 viviruses, maps onto one of these motifs and is essential for binding to neuroblastoma cells, with th

25 g of the clinical benefits relative to costs is essential for both appropriate clinical use and ratio

26 ous to the substrate in ascorbate peroxidase is essential for both decarboxylations, while a lysine t

27 l signalling between axons and Schwann cells is essential for both the development and maintenance of

28 es usually have a mushroom-like shape, which is essential for brain functions, because aberrant spine

29 ding intergenic RNA)-Nkx2.1 gene duplex that is essential for buffering Nkx2.1 expression, lung epith

30 rotic cytokines, such as TNFalpha and IL-13, are essential for C. muridarum to induce tubal fibrosis;

31 The mitochondrial calcium uniporter complex is essential for calcium (Ca(2+)) uptake into mitochondr

32 ely, the alternative initiation factor eIF2A is essential for cancer progression, during which it med

33 p proximal to the dimer-dimer interface that is essential for catalysis (i.e. the "activation loop").

34 within this putative DNA-binding cleft that are essential for catalytic activity.

35 The inactive PRMT paralog, TbPRMT1(PRO), is essential for catalytic activity of the TbPRMT1(ENZ)

36 Spatially organized macromolecular complexes are essential for cell and tissue function, but the mech

37 osomes [known as spindle pole bodies (SPBs)] are essential for cell division.

38 llectively, these results support that Usp36 is essential for cell and organism viability because of

39 SspA is essential for cell survival during acid-induced stres

40 Further, we show that RECQL5 is essential for cell survival in the absence of WRN.

41 Proper cell size is essential for cellular function.

42 racellular degradation/recycling system that is essential for cellular homeostasis but is dysregulate

43 It appears as an adaptation mechanism that is essential for cellular homeostasis in response to var

44 substrate of polo-like kinase (TbPLK), which is essential for centrin arm and FAZ duplication.

45 (mGluR1) function in Purkinje neurons (PNs) is essential for cerebellar development and for motor le

46 work demonstrates that ultrasensitive assays are essential for characterizing human cytokines in heal

47 tative and thorough study of skin permeation is essential for chemical exposure assessment and transd

48 design exploits a lysyl residue in EGFP that is essential for chromophore maturation, and is also an

49 rily conserved multisubunit protein complex, is essential for chromosome condensation during cell div

50 Microglia are essential for CNS homeostasis and innate neuroimmune

51 DC and PC Cx26 expression is essential for cochlear amplification in the stiff bas

52 tassium channels of the KCNQ (Kv7) subfamily are essential for control of cellular excitability and r

53 at both conformational rigidity and dynamics are essential for controlling protein activity.

54 n the harsh food environment and sporulation is essential for CPE production.

55 r previous work demonstrates that HIF-2alpha is essential for CRC growth and progression.

56 Dentin sialoprotein (DSP) is essential for dentinogenesis and processed into fragm

57 fic intrinsically disordered proteins (TDPs) are essential for desiccation tolerance.

58 polymorphs with differing cytotoxic effects is essential for determining how the aggregation reactio

59 long-distance transport of natural resources is essential for determining the impacts of past human a

60 e knowledge acquired in the present research is essential for developing effective remediation strate

61 The coordinated control of Ca(2+) signaling is essential for development in eukaryotes.

62 bolism, and find that its pre-lignin pathway is essential for development.

63 Ethylene gas is essential for developmental processes and stress resp

64 MYC/BCL2/BCL6 in high-grade B-cell lymphomas are essential for diagnosis.

65 It is essential for differentiation and early embryonic dev

66 tracellularly in macrophages, a process that is essential for disease progression.

67 for decades that optimal levels of dopamine are essential for dlPFC working memory function, with ma

68 lls, we show that actin dynamics and formins are essential for DNA replication.

69 The Star-PAP-mediated APA of PTEN is essential for DNA damage-induced increase of PTEN pro

70 and Cks2, share an overlapping function that is essential for early development.

71 as the T3SS needle pore protein EspD, which is essential for effector protein translocation into hos

72 that a transmembrane embedded lysine residue is essential for electrogenic transport in Na(+)/H(+) an

73 is a cellular quality-control pathway, which is essential for elimination of unhealthy mitochondria.

74 s a Cu(+) transporter for Cu acquisition and is essential for embryonic development, a homologous pro

75 human Y chromosome, the chicken W chromosome is essential for embryonic viability of the heterogameti

76 The ability to colonize the small intestine is essential for enterotoxigenic Escherichia coli (ETEC)

77 aberrant secretion of lamellar bodies, which are essential for epidermal barrier formation.

78 ndrial enzymes associated with the TCA cycle are essential for epigenetic remodeling and are transien

79 Mechanical coherence of cell layers is essential for epithelia to function as tissue barrier

80 in KRAS mutated pancreatic cancer cells and was essential for ER homoeostasis.

81 dation of the critical dPCR assumptions that are essential for establishing the SI traceability of la

82 suggest that coordinated firing during sleep is essential for establishing sparse activation patterns

83 characterizing nanoparticle biodistribution is essential for evaluating their efficacy and safety.

84 cus and inhibited Foxp3 transcription, which is essential for fate determination towards TH17 cells.

85 cromolar affinity in vitro, and its function was essential for fatty acid export in cells lacking the

86 ractions between FCSCs and endothelial cells are essential for FCSC-derived vascularized bone formati

87 A total of 331 homologous gene clusters were essential for fitness during in vitro growth in thr

88 Lymphangiogenesis is essential for fluid homeostasis in vascularized tissu

89 ating the memory about the perturbation that is essential for forelimb motor adaptation.

90 ion of MMP7 by FOXC1 and the WNT5A-MMP7 axis is essential for FOXC1-induced invasiveness of TNBC cell

91 e Notch receptor on multiple EGF repeats and are essential for full Notch function.

92 gration of GABAergic inhibitory interneurons are essential for functional neural circuits in the brai

93 en studied, recent findings indicate that it is essential for functions apart from mitochondrial bioe

94 onships during male reproductive development is essential for fundamental biology and crop breeding.

95 extrafollicular area, whereas downregulation is essential for GC formation.

96 how principles of developmental biology have been essential for generating human organoids in vitro,

97 und that the presence of BamD, but not BamE, is essential for gonococcal viability.

98 xidant challenge, termed oxidative eustress, is essential for governing life processes through redox

99 that acidic residues in the BAZ2B PHD domain are essential for H3 binding and that BAZ2B PHD-BRD esta

100 Furthermore, the enzymatic activity of LSD1 is essential for H3K9me2 demethylation at cell cycle gen

101 Hda make contact with the beta clamp, which is essential for Hda function in RIDA.

102 ACT: The maintenance of skeletal muscle mass is essential for health and quality of life.

103 rs of the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection, but

104 ensional atomic layered p-n heterostructures are essential for high-performance integrated optoelectr

105 The lateral prefrontal cortex (LPFC) is essential for higher-level cognition, but the nature

106 To find an appropriate NIR-absorbing BHJ is essential for highly efficient, organic, photovoltaic

107 te a large-scale Mediator rearrangement that is essential for holoenzyme formation.

108 The latter is essential for human health.

109 arly activation of Lyn by FcepsilonRI, which is essential for human MC responses and provides the bas

110 orm hyphae has suggested that cAMP signaling is essential for hyphal growth.

111 drug interaction, and evolutionary processes is essential for identifying best intervention strategie

112 nary endothelial cells during cardiac repair is essential for identifying improved approaches to reva

113 genome and its variation across individuals is essential for identifying the cellular mechanisms tha

114 ic understanding of early organoid formation is essential for improving the robustness of these metho

115 of transmembrane receptor integrin by talin is essential for inducing cell adhesion.

116 with the plastid-encoded RNA polymerase, and is essential for inducing the plastomic photosynthetic g

117 ne-to-alanine mutation at residue 76 (Y76A), were essential for infectious virus production and filam

118 lated expression of glycolytic machinery and is essential for inflammatory responses to myelin.

119 ncipal PAT for Glut4 and that this mechanism is essential for insulin-regulated glucose homeostasis.

120 s indicate that the extreme C terminus of K2 is essential for integrin co-activation and highlight th

121 INTU is essential for intraflagellar transport A complex asse

122 aphyloferrin B (SB) of Staphylococcus aureus are essential for iron acquisition in the iron-restricte

123 Both PX and BAR domains of MoVps17 are essential for its endosomal localization and functio

124 entify a region of the TRIOBP-1 protein that is essential for its aggregation to occur.

125 p130Cas targeting to FAs is essential for its tyrosine phosphorylation and downst

126 bryos demonstrating that the HP1 interaction is essential for KDM2A function.

127 ETGE motifs, not just the motifs themselves, are essential for KEAP1-mediated degradation.

128 Yeast Nop15 is an RRM protein that is essential for large ribosomal subunit biogenesis.

129 her brain that influence innate behavior and are essential for learned responses to taste compounds.

130 ng an outer (OM) and an inner (IM) membrane, is essential for life.

131 on molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate Tfh-B cell intera

132 In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos,

133 bility to suppress host macrophage apoptosis is essential for M. tuberculosis (Mtb) to replicate intr

134 Autophagy is essential for maintaining cellular homeostasis and su

135 IsaR1 is essential for maintaining physiological levels of Fe/

136 TPase cycle of the Hsp90 molecular chaperone is essential for maintaining the stability of numerous c

137 Moreover, both FOXM1 and AURKA were essential for maintaining the BCSC population.

138 This transport is essential for maintenance of axonal growth-cone dynam

139 Sophisticated and interactive visualizations are essential for making sense of the intricate 3D struc

140 rt of the sperm nucleus, the acrosome, which is essential for male fertility.

141 1 (PD-1) and the PD-1 ligands (PD-L1, PD-L2) is essential for malignant Hodgkin Reed-Sternberg (HRS)

142 ich regulate extensive splicing programs and are essential for mammalian organogenesis.

143 As sPPases are essential for many metabolic pathways in eukaryotic

144 Thus, characterizing the zeta potential is essential for many applications, but available measur

145 mans Because the purine biosynthesis pathway is essential for many metabolic processes, such as synth

146 In adult mosquitoes, it is essential for maturation of the ovary and normal male

147 about the synthesis of phospholipids, which is essential for membrane biogenesis in cancer cells.

148 he mitochondrial pyrimidine salvage pathway, is essential for mitochondrial DNA (mtDNA) maintenance.

149 pted us to investigate whether IGF signaling is essential for mitochondrial maintenance in cancer cel

150 myelination in the peripheral nervous system is essential for motor function, and uncontrolled SC pro

151 trial designs and interpretation of results is essential for moving forward.

152 synthase (PKS) gene PfmaE and showed that it is essential for multicellular conidial pigmentation and

153 r they differentiate at embryonic day 12 and is essential for multiple aspects of postnatal visual sy

154 Accordingly, DNA polymerase zeta activity was essential for mutagenesis in cisplatin-treated rad1D

155 CIL has been proven to be essential for NC migration in amphibians and zebrafis

156 hly dynamic beta-tubulin isoform in neurons, is essential for netrin-1/UNC5C-promoted axon repulsion.

157 GABAergic interneurons are essential for neural circuit function, and their los

158 is, increases oxidative phosphorylation, and is essential for neutrophil maturation.

159 ecognized as key organizers of synapses that are essential for normal brain function.

160 These data support that SMN:HuD complexes are essential for normal motoneuron development and indi

161 ning the 2m:1p genome ratio in the endosperm is essential for normal grain development in rice and ot

162 nt of pancreatic beta cell mass before birth is essential for normal growth of the fetus and for long

163 hepatocyte nuclear factor-1beta (HNF-1beta) is essential for normal kidney development and function.

164 Integrity of the airway epithelium is essential for normal lung function.

165 o large variations in maternal supplies, and is essential for normal progression of embryogenesis.

166 firm the concept that normal stroma function is essential for normal tubular differentiation.

167 v1, cav3, and cavin1b, we show that caveolae are essential for notochord integrity.

168 abel olfactory sensory neurons (OSNs), which are essential for olfaction (Figure 1).

169 nce of protein background-a whitening filter are essential for optimal detection, in particular for i

170 administration and meticulous intensive care are essential for optimal outcome.

171 Thus, AlyA1 appears to be essential for optimal attack of alginate in intact ce

172 th relapsed/refractory Hodgkin lymphoma (HL) is essential for optimizing therapy with risk-adapted ap

173 CR-independent Treg proliferation per se, it is essential for optimum IL-2 production by Teff cells.

174 balance of inhibitory and activating signals is essential for orchestrating appropriate inflammatory

175 Although ARG was found to be essential for ornithine and polyamine synthesis, orni

176 We conclude that ATM activity is essential for p21-dependent and p21-independent mecha

177 protein complex called the glideosome, which is essential for parasite motility and includes the MyoA

178 A region encompassing KOW4 and KOW5 of Spt5 is essential for pausing, and mutations in KOW5 specific

179 Importantly, although catalytic activity was essential for Pck1 function, Pck2 remained partially

180 choline biosynthesis, that were not known to be essential for phototrophic growth.

181 The GTPase dynamin-related protein 1 (Drp1) is essential for physiological and pathophysiological mi

182 The unfolded protein response (UPR) is essential for physiological growth as well as managem

183 plays critical roles during development and is essential for plant-specific responses to abiotic and

184 les phosphatidylinositol between organelles, is essential for platelet-mediated tumor metastasis.

185 ing physiological levels of mTORC1 signaling is essential for postnatal tendon development and matura

186 oxyl moieties in the flavone A-ring backbone are essential for potent inhibition of LasR/RhlR.

187 Papilla formation at the site of attack is essential for preinvasive immunity; in postinvasive i

188 is part of an immune checkpoint system that is essential for preventing autoimmunity and cancer.

189 NCE STATEMENT: The DNA damage response (DDR) is essential for prevention of a broad spectrum of diffe

190 This effect is essential for priming of CD8(+) T cells that mediate

191 Thus, ARG is essential for proliferation of promastigotes but not

192 RNA-protein interactions are essential for proper gene expression regulation, par

193 TMEM16A is shown to be essential for proper activation and membrane expressi

194 These signals are thought to be essential for proper biogenesis and function of the p

195 Our results show that CM Tln2 is essential for proper beta1D-integrin expression and t

196 Sleep is essential for proper brain function in mammals and in

197 or disease and provides evidence that ZC3H14 is essential for proper brain function.

198 We also show that the presence of barr2 is essential for proper CAMKII function in beta-cells.

199 protein MTSs and their receptor site on SecA are essential for protein secretion.

200 contributes to a 1-carbon metabolism, which is essential for purine biosynthesis and methionine recy

201 he biological underpinnings of such features is essential for rational vaccine development.

202 al species across the surface of a substrate is essential for realizing lab-on-chip technologies.

203 g) is experimentally observed and appears to be essential for receptor activation.

204 One of the proteins, VP35, is essential for replication of the viral genome and for

205 Histone H3 lysine-9 (H3K9) methylation is essential for retinoblastoma protein (RB)-mediated he

206 ic nucleosides across cellular membranes and are essential for salvage nucleotide synthesis and purin

207 with PCG and showed that ANGPT/TEK signaling is essential for SC development.

208 We conclude that seed coat suberin is essential for seed dormancy imposition by low tempera

209 scription factor Klf4 in differentiated SMCs is essential for SMC reprogramming in vivo, whereas in v

210 Audiovisual (AV) integration is essential for speech comprehension, especially in adv

211 The calcium channel of sperm (CatSper) is essential for sperm hyperactivated motility and ferti

212 Here, we show that copper is essential for spore germination in Schizosaccharomyce

213 the conserved portion of the Orai N terminus is essential for STIM1, as it fine-tunes the open Orai c

214 This is essential for studying the basic principles in order

215 al tract (GIT) and its associated microbiota are essential for survival and milk production, as this

216 llectively, our results show that PI3K delta is essential for survival during sepsis.

217 muli with positive or negative reinforcement is essential for survival, but a complete wiring diagram

218 the thermosensors, the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious

219 tween neurexins (Nrxs) and neuroligins (NLs) are essential for synapse structure, stability, and func

220 The TF BACH2 is essential for T and B lymphocytes and is associated w

221 We report that GSH is essential for T cell effector functions through its r

222 ain Ca(2+) influx pathway in lymphocytes and is essential for T cell function and adaptive immunity.

223 However, subtelomere integrity is essential for T. brucei viability.

224 The transmembrane segments of RHD3 are essential for targeting and retention of RHD3 in the

225 urthermore, we found that such modifications were essential for targeting to the mycomembrane and suf

226 The intact TIR domain was essential for TcpB to subvert the non-canonical infl

227 ltaneous transcripts and protein measurement are essential for the appropriate analysis of T cell res

228 has latent and lytic replication phases that are essential for the development of KSHV-associated can

229 both diffusion and phonon drag contributions are essential for the hole surface carriers.

230 alian model, we demonstrate that macrophages are essential for the regeneration process.

231 in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of uracil.

232 lved 18 times independently over 550 MYA and are essential for the success of the Gastropoda.

233 conserved eukaryotic signalling modules that are essential for the virulence of human pathogenic fung

234 onal freedom of the FMN domain is thought to be essential for the electron transfer (ET) reactions in

235 articular, we showed that the PB2 627 domain is essential for the accumulation of the cRNA replicativ

236 r, it has been assumed that the pilin domain is essential for the allosteric propagation within the l

237 The Dot/Icm-type IVB secretion system is essential for the biogenesis of the CCV and the intra

238 The nuclease ARTEMIS is essential for the development of B and T lymphocytes.

239 the oxygen evolution reaction (OER) function is essential for the development of efficient energy-sto

240 Sustained angiogenesis is essential for the development of solid tumors and met

241 the periphery can influence brain processes is essential for the development of therapies to prevent

242 Tracking disease progression in vivo is essential for the development of treatments against b

243 Access to high-quality reference data is essential for the development, validation, and implem

244 TCR-signal-induced transcription factor Irf4 is essential for the differentiation of Bcl6-expressing

245 Cellular cytotoxicity is essential for the elimination of virus-infected and c

246 nding of normal structural brain development is essential for the examination of brain-behavior relat

247 The medial temporal-lobe system is essential for the formation and retrieval of episodic

248 hich was not visible in previous studies and is essential for the formation of a functional replicati

249 ese data demonstrate that the SMC5/6 complex is essential for the formation of segregation-competent

250 Binding to LC3s/GABARAPs is essential for the fragmentation of ER tubules and the

251 and that preserved synthesis of glutathione is essential for the full development of this response.

252 mental disorders Joubert and MORM syndromes, is essential for the function of the primary cilium and

253 ate that the transcriptional regulator Runx1 is essential for the generation of ROR-gammat expressing

254 Timely and efficient access to hospital care is essential for the health and well-being of children.

255 C-terminus of Swc5, called Bucentaur (BCNT), is essential for the histone exchange activity of SWR, w

256 This strongly suggests that glycylation is essential for the homeostasis of primary cilia, which

257 CXCL13 recruits both Tfh and B cells, which is essential for the homing of Tfh cells and the develop

258 e peptide 1 (GLP-1) by the intestinal L cell is essential for the incretin effect after nutrient inge

259 as in vitro approaches demonstrate that Klf4 is essential for the maintenance of the AdvSca1 progenit

260 SYN present in dopaminergic nigral afferents is essential for the normal cycling and maintenance of n

261 Transport of fluid through a pipe is essential for the operation of macroscale machines an

262 ermore, we showed that ecdysteroid signaling is essential for the proper activation of matrix metallo

263 ing the functional polymerase complex, which is essential for the replication and transcription of in

264 DNA replication is essential for the rhythmic changes of nucleosome comp

265 PERK is essential for the survival and differentiation of act

266 rs.SIGNIFICANCE STATEMENT Ca(2+) homeostasis is essential for the survival and function of retinal ph

267 trosome-independent mitotic spindle assembly is essential for the survival and proliferation of SMARC

268 (unmodified graphene vs. oxidized graphenes) is essential for the translation of this material into c

269 echanotransduction channel in hair cells and is essential for the transport of some of these componen

270 NDPK-C was essential for the formation of an NDPK-B/G protein c

271 isms and endow many species with traits that are essential for their survival.

272 bearing a C-terminal hydrophobic domain that is essential for their membrane integration.

273 tenance of the antioxidant glutathione (GSH) is essential for their survival and proliferation.

274 edge of cells and extracellular Ca(2+) entry is essential for this reorganization.

275 irm that the precise geometry of these rings is essential for this synergistic activity.

276 F-actin has been shown to be essential for tip growth in an array of plant models,

277 ontrolled angiogenesis and lymphangiogenesis are essential for tissue development, function, and repa

278 y is a cell-to-cell signaling mechanism that is essential for tissue development and maintenance, and

279 mechanism comprising NF-kappaB and MMP7 that is essential for TNBC cell invasiveness, thereby providi

280 MO trafficking to the blood or the brain but was essential for trafficking within the brain parenchym

281 We demonstrate that PRMT5-MEP50 is essential for transcriptional regulation promoting ca

282 G protein-coupled receptors (GPCRs) are essential for transferring extracellular signals int

283 adherence of the biofilm to the flea foregut is essential for transmission.

284 DRD9 is dispensable for piRNA biogenesis but is essential for transposon silencing and male fertility

285 Opiates are essential for treating pain, but termination of opia

286 eport that IL-27 signaling in Foxp3(+) Tregs is essential for Tregs to control autoimmune inflammatio

287 ng presence of right ventricular dysfunction is essential for triage; however, comprehensive transtho

288 which predominantly localize to the AIS and are essential for tuning neuronal excitability.

289 High-resolution membrane protein structures are essential for understanding the molecular basis of d

290 ping neural circuits across defined synapses is essential for understanding brain function.

291 platinum surfaces under operando conditions is essential for understanding catalytic performance.

292 racterization of Ag-specific BCR repertoires is essential for understanding disease mechanisms involv

293 e intrapopulation variation in these shifts, is essential for understanding mechanisms driving altern

294 events in an unperturbed in vivo environment is essential for understanding the complex biology of li

295 y to modulate sensitivity in sensory systems is essential for useful information to be extracted from

296 Smooth muscle cell (SMC) differentiation is essential for vascular development, and TGF-beta sign

297 sue-specific properties in endothelial cells is essential for vascular function.

298 We found that PumA is essential for virulence and inhibits NF-kappaB, a pro

299 Cyclic-nucleotide-gated channels are essential for vision and olfaction.

300 ns are dispensable, whereas binding to CYK-4 is essential, for ZEN-4 function in polarity.