ライフサイエンスコーパス: be established as

1 as administered to 32 patients, and the RP2D was established as 0.7 mg/m(2) infused over 10 minutes.

2 ine butyrate in combination with ganciclovir was established as 1000 mg/(kg/day).

3 The maximum tolerated dose of ixazomib was established as 2.97 mg/m(2) and the recommended phas

4 The MTD was established as 225 mg twice per day orally over 2.5

5 s well tolerated; the maximum tolerated dose was established as 300 mg/day when two of three patients

6 e diagnostic ranges for sulfate OH stretches are established as 3580-3600 cm(-1) and can thus be dist

7 The MTD was established as 36 mg/m(2).

8 The absolute stereochemistry of 1 was established as 3S,3'S by a combination of X-ray diff

9 on, the absolute configuration of compound 5 was established as 3S,4R,7S,8S,11R,12S,13R by applicatio

10 abepilone as a 1-hour infusion every 3 weeks was established as 50 mg/m2.

11 clophosphamide, and rituximab (FCR) together are established as a standard first-line treatment of yo

12 s conditions, requires further assessment to be established as a biomarker of xenoestrogen exposure.

13 and unfavorable prognostic marker that could be established as a new grading parameter for LSCC.

14 the future, the here described protease may be established as a powerful tool for production strateg

15 measure of visual field loss, but has yet to be established as a reliable diagnostic tool.

16 However, economic demand has not yet been established as a biomarker of addiction-like behavi

17 ) is a novel metabolite of NADP that has now been established as a Ca(2+) messenger in many cellular

18 DNA damage has long been established as a cause of cancer development throug

19 owever, SHANK3 overexpression per se has not been established as a cause of human disorders because 2

20 virus (ZIKV) infection in pregnant women has been established as a cause of microcephaly in newborns.

21 main and mucin domain (TIM)-3 has previously been established as a central regulator of Th1 responses

22 noprotected chiral amino acids have recently been established as a class of ligand scaffolds for effe

23 ort in the 1980s, transmethylation has never been established as a component of eukaryotic cell chemo

24 he other class XIV myosin in Plasmodium, has been established as a component of the glideosome comple

25 an amine, commonly called A(3)-coupling, has been established as a convenient and general approach to

26 The PI3K/PTEN/Akt pathway has been established as a core signaling pathway that is cru

27 hough vascular endothelial growth factor has been established as a critical regulator of tumor angiog

28 ases to rectify MTs is prevalent, it has not been established as a design methodology in conjunction

29 ropropyl)-1-propylxanthine ((18)F-CPFPX) has been established as a highly selective and affine PET li

30 Estrogen receptor status has been established as a key factor in breast cancer progno

31 tide (CGRP) from the trigeminal ganglion has been established as a key player in the pathogenesis of

32 Hippocampal theta activity has been established as a key predictor of acquisition rate

33 The miR-200 family has been established as a key regulator of epithelial phenot

34 endent DEX(H/D) family of RNA helicases, has been established as a major cellular quadruplex resolvas

35 ns such as lungs, liver, and kidney has long been established as a marker of progressive fibrosis.

36 CD45, identified as CD45.1 and CD45.2, have been established as a marker system to track haematopoie

37 ilencing through RNA interference (RNAi) has been established as a means of conducting reverse geneti

38 RNA-primed DNA synthesis has been established as a mechanism for replicating the circ

39 However, NAD(P)H FLIM has not been established as a metabolic proxy in bacteria.

40 e span (RLS) of Saccharomyces cerevisiae has been established as a model for the genetic regulation o

41 Drosophila melanogaster has been established as a model organism for investigating t

42 ioid tolerance in mesencephalic cultures has been established as a model system for evaluating neuron

43 Despite these limitations, MUC16 has been established as a molecule of significant applicatio

44 c process is of high importance since it has been established as a most promising target for the deve

45 catalyst and a carboxylic acid has recently been established as a new activation mode in Bronsted ac

46 ng the past decade, mantle-cell lymphoma has been established as a new disease entity.

47 ategy for fragment-based de novo design, has been established as a new type of fragment-based inhibit

48 Ischemia-reperfusion injury has been established as a nonimmunologic risk factor for the

49 of CD19 antigen on leukemic cells, which has been established as a novel mechanism to escape CD19-spe

50 Mutations causing a gating pore current have been established as a pathomechanism for hypokalaemic pe

51 ripheral benzodiazepine receptor ligand, has been established as a potent hCAR deactivator in immorta

52 itogen-activated protein kinase) cascade has been established as a potent regulator of gene transcrip

53 rine salvage enzyme in this parasite and has been established as a potential chemotherapeutic target

54 Mass spectrometry has been established as a powerful and versatile technique f

55 f 25-hydroxyvitamin D [25(OH)D] has recently been established as a predictor of treatment response.

56 cGAS/STING DNA sensing complex has recently been established as a predominant pathogen recognition r

57 The fruit fly Drosophila melanogaster has been established as a premier experimental model system

58 No gold standard has been established as a primary endpoint in trials of init

59 The National Quality Forum (NQF) has been established as a private, not-for-profit, open memb

60 TFAP2C has been established as a prognostic factor in human breast

61 bolic profiling of cancer cells has recently been established as a promising tool for the development

62 Although Sgo1 has clearly been established as a protector of centromere cohesion i

63 Viscoelastic coagulation tests have been established as a rapid and reliable method to asses

64 Although the zebrafish has been established as a research tool over the past two to

65 Although Mdm2 has been established as a RING finger ubiquitin ligase, MdmX

66 sk human papilloma-virus (HPV) infection has been established as a risk factor for developing head an

67 ulates dendrite and spine morphogenesis, has been established as a risk gene for ASD.

68 NPAS3 has been established as a robust genetic risk factor in majo

69 However, no method has, so far, been established as a routine method for the analysis of

70 f a unique C,N-chelated dilithio dianion has been established as a solvated monomeric species using a

71 termediate hematopoietic progenitors has not been established as a source of HIV-associated hematopoi

72 h effective in shrinking tumors, has not yet been established as a standalone treatment for cancer.

73 ecurrent deletions at the 22q11.2 locus have been established as a strong genetic risk factor for the

74 ogression-free survival (PFS) has previously been established as a surrogate for overall survival (OS

75 However, only COX17 has been established as a target of Puf3p-mediated deadenyla

76 uced acoustic desorption (LIAD) has recently been established as a tool for analytical chemistry.

77 Photorhabdus bacteria have recently been established as a tool for investigating immune reco

78 ody motion of transmembrane (TM) helices has been established as a unifying mechanism in the activati

79 In addition, (18)F has been established as a useful positron emitting isotope f

80 te binding domain of EBA-175, RII, which has been established as a vaccine candidate.

81 When used appropriately, CCTA has been established as a valid noninvasive imaging alternat

82 Thus, PMCA has been established as a valuable analytical tool in prion

83 Ferrets have been established as a valuable in vivo model of influenz

84 imensional infrared spectroscopy (2D IR) has been established as a versatile tool that can uniquely p

85 1) Periodontal regeneration has been established as a viable therapeutic option for the

86 Transplant has been established as a viable treatment of HCC measuring

87 uxR and two luxI homologs, each of which has been established as a virulence factor.

88 biochemically recurrent prostate cancer has been established as a widely accepted clinical indicatio

89 persistent postweaning social isolation has been established as a widely used animal model with tran

90 bly into a range of mesophase structures has been established as a widespread phenomenon.

91 w discoveries have led to prevention science being established as a discipline designed to mitigate t

92 Despite SHS being established as a risk factor for lung cancer devel

93 e antigen 1 (AMA-1) of Plasmodium merozoites is established as a candidate molecule for inclusion in

94 Thus, UBP1 is established as a component of dynamically assembled c

95 t points (CPs) made by each motor neuron and is established as a consequence of pruning that occurs d

96 papillomavirus infections, the viral genome is established as a double-stranded DNA episome.

97 g, which uses the putative 7TMR, Smoothened, is established as a fundamental pathway in development,

98 Intraduplex DNA-mediated reduction is established as a general mechanism for the reduction

99 While DLK is established as a key regulator of axonal responses to

100 Reversible protein acetylation is established as a modification of major regulatory sig

101 all, the transition metal-semiquinoid system is established as a particularly promising scaffold for

102 calcium-dependent binding to phosphocholine, is established as a pentraxin species distinct from all

103 The coupled assay is established as a rapid, convenient and safe method wh

104 beta1 integrin (encoded by Itgb1) is established as a regulator of angiogenesis based upon

105 n plants, systemic acquired resistance (SAR) is established as a result of NPR1-regulated expression

106 Hymeglusin (1233A, F244, L-659-699) is established as a specific beta-lactone inhibitor of e

107 In this context, SL is established as a versatile approach for the controlle

108 her, carbonylation of disubstituted epoxides is established as a viable and economical entry into syn

109 ne transmission was confirmed and Zika virus was established as a cause of severe neurological compli

110 udies to Evaluate Resistance (PASER) network was established as a collaborative partnership of clinic

111 e-mediated, NFAT-controlled, GFP expression) was established as a direct approach for cloning T cell-

112 Using luciferase assay and ChIP, KLF6 was established as a direct transcriptional activator of

113 al distance from the furcation (CDF) of 4 mm was established as a landmark under which, if surgery wa

114 40 mg/m2 for 6 weeks in combination with RT was established as a new standard for the treatment of l

115 The SRA was established as a public repository for the next-gene

116 Near infrared spectroscopy was established as a rapid and effective tool to obtain

117 In this work, the predicted Etnk2 cDNA was established as a soluble protein with ethanolamine-s

118 Immunization Systems Management Group (IMG) was established as a time-limited entity, responsible fo

119 It was established as a valuable resource for counter scree

120 Whereas the vast majority of body plans were established as a result of the CE, taxonomic increa

121 oreover, stable hyperplastic outgrowth lines were established as a tool to study premalignant PyV-mT-

122 The recommended phase II dose was established as abexinostat 45 mg/m(2) twice a day ad

123 A new record coordination number is established, as AcHe17(3+) , ThHe17(4+) , and PaHe17(

124 o deltahedral Zintl ions such as Ge9(n-) has been established as addition of anionic nucleophiles.

125 etes, dyslipidemia, and hyperhomocysteinemia were established as aggravating factors for the aortic c

126 Alkynyl-lambda(3)-iodanes have been established as alkynyl cation equivalents for the a

127 rapeutic enzyme is L-asparaginase, which has been established as an antileukemic protein drug for mor

128 n bulk thermoelectric materials has recently been established as an effective approach to scatter pho

129 my in the presence of metastatic disease has been established as an effective procedure for select pa

130 Cardiac rehabilitation has been established as an effective treatment for patients

131 f plasma-derived C1-inhibitor (pdC1-INH) has been established as an effective treatment.

132 No medication has been established as an efficacious treatment for cocaine

133 pper-catalyzed arylation of nucleophiles has been established as an efficient methodology for the for

134 arylation polymerization (DHAP) has recently been established as an environmentally benign method for

135 proteins named the evening complex (EC) has been established as an essential component of the circad

136 NK cells have been established as an important effector of innate immu

137 Akt is a serine-threonine kinase that has been established as an important intracellular signaling

138 riments, the p38alpha MAP kinase isoform has been established as an important regulator of immune and

139 mall ubiquitin-like modifier 1 (SUMO-1), has been established as an important regulatory mechanism.

140 The serine-threonine kinase Akt has been established as an important signaling intermediate

141 f TGF-beta signaling in T cells, and has now been established as an important suppressor of leukemoge

142 Cerebral microbleeds (CMBs) have been established as an independent predictor of cerebral

143 ed fibroblast specific protein 1 (FSP1) have been established as an inducer of metastasis and indicat

144 ninvolved serum free light chains (dFLC) has been established as an invaluable hematologic parameter

145 e degree to which the stimulus dimension has been established as an unreliable predictor of reinforce

146 transbronchial needle aspiration (EBUS-TBNA) is established as an alternative to mediastinoscopy in p

147 m Escherichia coli, and the function of CapP is established as an ATP-dependent capuramycin phosphotr

148 e free fatty acid receptor 1 (FFA1 or GPR40) is established as an interesting potential target for tr

149 Here, pachymetry was established as an additional tool and used to conduc

150 hibian Xenopus laevis and Frog Virus 3 (FV3) were established as an experimental platform for investi

151 ogens, as well as several proteins that have been established as antigens.

152 cid, 1,2,2-trimethylpropyl ester), which has been established as approximately 0.8 mg m(-3).

153 Although no genes are established as associated with AD + P, the first gen

154 These seeking-circuits are established as associations are formed between drug-

155 of a two-partner secretion system, and HrpA is established as being important to adherence and intra

156 The temporal requirement for Fgf signalling was established as being between 60% epiboly and tailbud

157 HEL/CLAVATA (WUS/CLV) negative feedback loop was established as being essential for regulating the si

158 (PAD) without intermittent claudication have been established as beneficial.

159 complex patterning in which individual faces are established as biochemically distinct domains by end

160 Tumours from 12 patients were established as BRCA wild-type, but could not be cla

161 Air-stable Ni(PPh3)2Cl2 has also been established as catalyst precursor, and highly activ

162 colon, vagina, and oral cavity, but have not been established as causes of human disease.

163 Epithelial cells isolated from these tumors were established as cell strains in culture.

164 requency) between the basilar papilla and NM is established as cochlear nerve axons arrive in the NM

165 mal growth factor receptor (EGFR/ErbB1) have been established as collaborators in cellular signaling

166 pathways to form in the vertebrate forebrain are established as commissural and retinal axons cross t

167 feasibility and utility of these assays has been established as concerns about specificity and sensi

168 rotein post-translational modifications have been established as contributors but still cannot comple

169 lthough Jun upregulation and activation have been established as critical to oncogenesis, the relevan

170 ytometry (FC) and FC-based cell sorting have been established as critical tools in modern cell and de

171 inant group of membrane fatty acids and have been established as crucial determinants in resistance a

172 Retinoids have long been established as crucial for several essential life p

173 mapping and sentinel lymph node biopsy have been established as definitive procedures for the stagin

174 Chimerism was established as described before.

175 erved in nonexpressed genes and of these 120 were established as differentially expressed in dwarf mi

176 (A = Ca, Sr, Ba, or rare earth element) have been established as Dirac materials.

177 actor beta [TGFbeta]-binding protein 4) have been established as DMD modifiers.

178 ndary for fossil hydrocarbons has previously been established as double-bond equivalents (i.e., DBE =

179 sruptive mutations in coding genes that have been established as 'drivers' of cancer in large somatic

180 nhancer chromatin marks H3K4me1 and H3K27ac, are established as early as blastula stage and that Smad

181 ri-implant soft tissue clinical maturity may be established as early as 4 weeks following implant pla

182 A discrete apical domain is established as early as the first cell division and b

183 Viruses have been established as ecologically important infectious ag

184 and well-tolerated BH3-mimetic drug that has been established as effective.

185 Cognitive behavior therapy (CBT) has been established as efficacious for obsessive-compulsive

186 uman keratinocytes, mutant E2(Y131A) genomes were established as episomes, but at a markedly lower co

187 The lysA gene of M. tuberculosis H37Rv has been established as essential for bacterial survival in

188 CnnC is established as essential for functional centrosomes,

189 in sensitized recipients when allochimerism was established, as evidenced by the acceptance of secon

190 Carbon quantum dots (CQDs) are established as excellent photosensitizers in combina

191 Two subcohorts were established as follows: (1) users of a LABA plus lo

192 m disorder (ASD) risk, but few variants have been established as functional.

193 eless, it is unclear how this directionality is established as Glass bottom boat (Gbb), the known BMP

194 zed to the inner mitochondrial membrane have been established as GSH transporters in liver and kidney

195 mp implanted in the mother; cell birth dates were established as having occurred before or after pump

196 Involvement of HS1 in T cell regulation has been established, as HS1 is required for the formation o

197 Scaffold proteins have been established as important mediators of signal transd

198 )--deletions and duplications--have recently been established as important risk factors for both gene

199 the same time trend for new steady states to be established as in Michel and Phillips' experiments.

200 Diabetes and obesity have been established as independent risk factors for the dev

201 nt of proline (Pro) hydroxylation has yet to be established, as it is largely unexplored in bacteria.

202 PSD-95/Dlg proteins have been established as key components of the postsynapse.

203 of the Wnt family of secreted molecules have been established as key factors in determining cell fate

204 MicroRNAs (miRNAs) recently have been established as key regulators of transcriptome repr

205 MicroRNAs (miRNAs) have been established as key regulators of various biological

206 PURPOSE OF REVIEW: Cognitive abilities are established as major deficits in those with schizoph

207 LD) and its product, phosphatidic acid, have been established as mediators of mitogenic activation of

208 tures derived from retinoblastoma tumors can be established as non-adherent tumorspheres when grown i

209 ed responses when conditioned stimuli had to be established as nonpredictive for an outcome, whereas

210 of the dissipation of a single molecule has been established as not exceeding 310(-7)kg/s.

211 THz spectroscopy of aqueous solutions has been established as of recently to be a valuable and com

212 adation mechanisms at the microscale has not been established, as of yet.

213 gnetic resonance (NMR) spectroscopy has long been established as offering unique atomic-scale and ele

214 lthough the ubiquitin-proteasome pathway has been established as one mechanism of inactivating Smad4

215 Consequently, resistance to apoptosis has been established as one of the mechanisms responsible fo

216 pruce (Picea glauca), a gymnosperm tree, has been established as one of the models for conifer genomi

217 ilable, the diarylprolinol silyl ethers have been established as one of the most frequently used in a

218 Dissolved organic matter is established as one of the most relevant photosensitiz

219 ensing and afferent endocrine signaling have been established as parallel systems communicating metab

220 Embryonic stem (ES) cells have been established as permanent lines of undifferentiated

221 ected with HPV, only 10 to 20% of infections are established as persistent infections.

222 Glycosylation has been established as playing a pivotal role in various as

223 Dopaminergic signalling is established as playing an important role in novelty r

224 imetic divalent ligands, which have recently been established as powerful tools for acute perturbatio

225 ed responses when conditioned stimuli had to be established as predictive.

226 Primary culture of MRECs was established as previously described and was used to

227 with currently available theoretical methods are established as primary targets for crystallographic

228 Although enzymatic techniques have been established as promising tools in biofuel productio

229 These imaging modalities are being established as promising tools in high-risk cardio

230 Prostaglandin D2 has been established as promoting the resolution of inflamma

231 (CL) and Cell Line Ontology (CLO) have long been established as reference ontologies in the OBO fram

232 s where infection-prevention bundles of care are established as routine practice.

233 Such innovative methodologies need to be established as routine testing procedures to detect a

234 ch allows the C-20 and C-21 configuration to be established as S and R, respectively.

235 methods to investigate MRD because they have been established as sensitive and specific enough to all

236 Finally, the relevance of SF2 function was established, as SF2 strongly correlated with cyclin

237 NDINGS: Although hypomethylating agents have been established as standard of therapy for MDS in the n

238 Preoperative chemoradiotherapy (CRT) has been established as standard treatment for locally advan

239 d clearance of different Abeta isoforms have been established as targets of proposed disease-modifyin

240 ging the success of the calibration transfer are established as the standard error of prediction (SEP

241 A recommendation that the 4 materials be established as the first World Health Organization In

242 inear relationship between J and deltamu can be established as the linear flux-force relation in irre

243 e activity of the BCR-ABL fusion protein has been established as the causative molecular event in chr

244 of this species to the west of Eurasia have been established as the cause of the unjustified allocat

245 Halonium ions have long been established as the critical intermediates in haloge

246 philic, motile, spiral-shaped bacterium, has been established as the etiologic agent of gastritis and

247 erpesvirus (KSHV) or human herpesvirus 8 has been established as the etiological agent of Kaposi's sa

248 2)](3)(-)(,4)(-) (M = Mo (2), V), which have been established as the first structural (topological) a

249 ve behavior therapy for insomnia (CBT-I) has been established as the first-line recommendation for th

250 lesions by fractional flow reserve (FFR) has been established as the gold standard.

251 Silicon has long been established as the material of choice for the micro

252 trials where no single efficacy endpoint has been established as the most important.

253 Strengths and Difficulties Questionnaire has been established as the most widely used instrument in c

254 pediatric) or 20 mg/m(2)/d (adolescent) have been established as the MTD/RPIID.

255 Glycan arrays have been established as the premier technical platform for a

256 apillomaviruses (HPVs), including HPV58, has been established as the primary cause of cervical cancer

257 Mammography has been established as the primary imaging screening method

258 These genetic variants have been established as the source of beta-casomorphins (BCM

259 luorescence In Situ Hybridization (FISH) has been established as the standard method for this purpose

260 bleomycin, vinblastine, and dacarbazine) has been established as the standard of care in patients wit

261 Although antibiotic therapy has been established as the standard of care in patients wit

262 rative portal vein embolization has thus far been established as the standard procedure for achieving

263 This nuclear signaling is established as the canonical or type 1 pathway for TH

264 Antiferromagnetism is established as the competing order, but the relations

265 bunit, the telomerase reverse transcriptase, is established as the dominant mechanism conferring the

266 oute from Golgi to basolateral membrane that is established as the epithelial monolayer matures.

267 e SET-induced biaryl cross-coupling reaction is established as the first example of a Grignard S(RN)1

268 Although the oligodendrocyte progenitor is established as the major source of remyelinating cell

269 est (in this case, phosphoenolpyruvate, PEP) is established as the objective function and time-varyin

270 Carotid stenting is established as the treatment of choice for certain hi

271 y of 78% and a specificity of 70%, 3.51 mg/L was established as the lower margin for the therapeutic

272 otein-stable isotope probing, the RuMP cycle was established as the main carbon assimilation pathway,

273 TNFR1 was established as the main receptor involved in IL-12p4

274 300 mg/day was established as the maximum tolerated dose.

275 d-foot syndrome, and 12.0 mg/m2/d for 5 days was established as the maximum-tolerated dose.

276 In the study, a sample mass of 400mg was established as the minimum mass required for analysi

277 Since 1+ or less was established as the most common MRSA carrier state, b

278 ue from Bacillus staerothermophilus (BstHPr) was established as the most thermostable homologue and a

279 ents were dose limiting, and 60 mug/m(2)/day was established as the MTD.

280 g thiazole rings and trifluoromethyl groups, was established as the optimal lead compound because of

281 cizumab 15 mg/kg intravenously every 21 days was established as the phase II dose, although no dose-l

282 36309 at 500 mg twice daily (n=6); this dose was established as the recommended phase 2 dose.

283 of these results, the segmented CT AC method was established as the silver standard for the segmented

284 eans of a concentration effect curve, 7 mg/L was established as the upper margin.

285 Normal ranges of interocular differences were established as the 2.5th and the 97.5th percentiles

286 3.1% and 1mg/ml for PC and F3, respectively, were established as the best entrapment protocol by resp

287 uvaol, and campestanol/Delta(7)-avenasterol were established as the indicators of variety of fresh o

288 e (6beta-hydroxyetiocholanolone) glucuronide were established as the structures for these metabolites

289 of the presented compounds in EC/EL devices is established, as they are applied as cross-linked elec

290 The MTD was established as topotecan 0.6 mg/m(2)/d and ABT-888 1

291 by a trimeric (Me-DuPhos)3Ni3(OAc)5I complex was established as turnover limiting followed by rapid c

292 nt of N-Acetylneuraminic acid (NANA) and EGF are established as unique indicators for the grades of E

293 Algae have also been established as unique biofactories for industrial,

294 Cysteine proteases have been established as valid targets for this purpose.

295 The maximum tolerated dose was established as vemurafenib 960 mg twice a day in com

296 ement deposition on Streptococcus pneumoniae are established as virulence features for invasive disea

297 nding of how specific developmental lineages are established as well as how cell fates can be manipul

298 to allow structure-function relationships to be established, as well as providing a repository of tis

299 l provide insight into how OB microcircuitry is established as well as adult neurogenesis.

300 the ways in which transcriptional direction is established as well as its functional implications.