ライフサイエンスコーパス: be exacerbated by

1 d by a slowly transcribing Pol II mutant and are exacerbated by a faster-transcribing Pol II mutant.

2 mon causes of death; risks of these outcomes are exacerbated by a prothrombotic diathesis and hypokal

3 In these cases, thrombus formation may be exacerbated by a hyperthrombogenic state present in p

4 on after intracerebral hemorrhage, which can be exacerbated by a pharmacologic reduction of MAP.

5 Lipid status can be exacerbated by a variety of factors in the posttransp

6 d impaired fatty acid oxidation (FAO), which is exacerbated by a high-lipid (Western) diet (WD).

7 ) exhibit both steatosis and fibrosis, which is exacerbated by a high-transfat/fructose diet.

8 moderate primary hypertriglyceridaemia that is exacerbated by a secondary cause.

9 c syndromes, the suffering of these patients is exacerbated by a self-perpetuating, self-validating c

10 in vivo passive systemic anaphylactic model, is exacerbated by a single dose and is attenuated by rep

11 This abnormal lipolytic response is exacerbated by a state of positive energy balance in

12 sh per brood-year vs 373 for wild fish), and was exacerbated by a high variance in broodstock reprodu

13 The growth defect of the double mutant was exacerbated by a null mutation in the chromosome par

14 This phenotype was exacerbated by a simultaneous reduction of LMNA/C.

15 h the biochemical data, these growth defects were exacerbated by a combination of certain mutations i

16 These phenotypes were exacerbated by a pspG null mutation.

17 ties in defining disease etiology, which can be exacerbated by abiotic factors, have limited progress

18 ly by defective VEGF-A signalling in RGCs or are exacerbated by abnormal vascular morphology.

19 I cell stage to the small pre-BII cell stage was exacerbated by abnormal cytokine signaling and repet

20 stic kidney disease (ADPKD) cyst enlargement is exacerbated by accumulation of fluid within the lumen

21 ystic kidney disease (PKD) has been shown to be exacerbated by acidosis or a low potassium intake, an

22 ibited a moderate defect in cell fusion that was exacerbated by activated alleles of Pkc1p or loss of

23 insulin secretion and that this defect would be exacerbated by acute free fatty acid (FFA)-induced in

24 However, the adverse events had been exacerbated by administration of a near-maximum imm

25 or obesity and phenotypic adiposity measures is exacerbated by adverse sleeping characteristics.

26 ssness at postnatal day 5, and the phenotype is exacerbated by age.

27 ri VacA protein, that induced by V. cholerae was exacerbated by agents that block vacuolar proton pum

28 Protein misfolding and aggregation are exacerbated by aging and diseases of protein conform

29 ctions are common in early childhood and may be exacerbated by air pollution.

30 phrenia even without alcoholism, although it was exacerbated by alcoholism.

31 This pneumonia was exacerbated by allogeneic BMT but was ameliorated by

32 Finally, PPI deficits were exacerbated by allopregnanolone (10 mg/kg, IP) and

33 This scenario will be exacerbated by an expansion in rice cultivation neede

34 The current species extinction crisis is being exacerbated by an increased rate of emergence of e

35 5, or amyloid precursor protein gene dosage, is exacerbated by an insufficient or missing antioxidant

36 True-lumen collapse was induced and was exacerbated by an increase in the size of the entry

37 This was exacerbated by an independent effect of CTCF loss th

38 tin expression and macrophage content, which were exacerbated by AngII infusion.

39 This overall state of affairs is likely to be exacerbated by anthropogenic climate change and in pa

40 ximately 20% in alpha1alpha2(lox/lox), which was exacerbated by approximately 2-fold in alpha1alpha2(

41 ve stress that is causative in apoptosis and is exacerbated by ATM/G6PD inhibition.

42 rresponds to an unwinding of the helix, that is exacerbated by binding of the topoisomerase and by bi

43 Toxicity of SNAP to BS neurons was exacerbated by blocking NF-kappaB activation with SN

44 n a chronic state of oxidative stress, which is exacerbated by blood feeding, resulting in increased

45 of lancinating pain in the right breast that was exacerbated by blunt pressure and cold temperature.

46 ract during transcription, a phenomenon that is exacerbated by both superhelical stress and increased

47 E OF REVIEW: Preexisting corneal disease can be exacerbated by cataract surgery and may prevent well

48 Moreover, the growth defect of abd1 mutants is exacerbated by cdc34-2.

49 duced bone mineral density, which appears to be exacerbated by certain HIV protease inhibitors (PIs).

50 Impacts may be exacerbated by chronic effects and interactions with

51 d multifocal areas of necrosis when sickling was exacerbated by chronic hypoxic conditions.

52 ulmonary vasculopathic changes, all of which were exacerbated by chronic hypoxia.

53 their effects on wildlife populations could be exacerbated by climate change, especially in species

54 to weather and climate extremes, which would be exacerbated by climate change.

55 transitions are occurring globally, and may be exacerbated by climate change.

56 -IL-10 receptor (IL-10R) monoclonal antibody was exacerbated by co-administration of anti-IL-17A mono

57 ncrease in monocyte adhesion and trafficking is exacerbated by cocaine abuse.

58 lated genes, and the severity of this defect was exacerbated by codeletion of the Gcn5 acetyltransfer

59 ered a motor disorder, motor signs of PD can be exacerbated by cognitive dysfunction.

60 rulence defect of DeltahapX on tomato plants is exacerbated by coinoculation of roots with a biocontr

61 propyzamide and oryzalin, and right skewing is exacerbated by cold treatment.

62 Uroporphyria in Uro-D+/- animals was exacerbated by combinations of the homozygous Hfe-nu

63 It may be exacerbated by common medications, especially cortico

64 illness is a global health problem that may be exacerbated by concurrent infection.

65 egulation in APP expression and Abeta levels is exacerbated by concurrent disturbances in APP process

66 otype that might be the direct result of, or be exacerbated by, concussion.

67 her alternatively spliced transcripts, which is exacerbated by cool temperatures.

68 We discuss how their effects might be exacerbated by current and future therapies.

69 Intestinal inflammation is exacerbated by defects in the epithelial barrier and

70 ad altered call repertoires, and this effect was exacerbated by deficiency in Apoer2.

71 reduced number of PrE cells, an effect that was exacerbated by delaying implantation.

72 to colitis-associated cancer (CAC) and both are exacerbated by deletion of Sphk2.

73 human keratoconjunctivitis sicca (KCS) that are exacerbated by desiccating environmental stress.

74 uded proximal LCA intimal hyperplasia, which was exacerbated by diet-induced obesity.

75 ere under stressful, high-UVR conditions and is exacerbated by dietary insufficiency.

76 ious studies have shown that Mn accumulation is exacerbated by dietary iron deficiency (ID) and distu

77 Rather, individual anxiety may be exacerbated by disrupted sleep.

78 Aflatoxin production by Aspergillus flavus is exacerbated by drought stress in the field and by oxi

79 is a major global public health problem that is exacerbated by drug resistance.

80 Neuropathogenesis of HIV-1 is exacerbated by drugs of abuse such as methamphetamine

81 typically observed in unlesioned P301S mice were exacerbated by DSP-4, and mortality was also accele

82 and hypofibrinolytic effects of obesity may be exacerbated by dysregulated expression and secretion

83 The sensitivity to iron is exacerbated by ectopic expression of the iron transpo

84 hypertriglyceridemia due to VLDLr deficiency is exacerbated by either LpL deficiency or VLDL overprod

85 mediated alterations in LV compliance, which are exacerbated by elevated intrapericardial pressure.

86 cted consequence of stand development, which was exacerbated by elevated CO(2).

87 tent with an injury model in which hypoxemia is exacerbated by endotoxin-mediated failure of hypoxic

88 pression, a common event in SCC development, is exacerbated by enhanced E-cadherin degradation induce

89 ting evidence that inbreeding depression can be exacerbated by environmental stresses such as starvat

90 thematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma.

91 surfaces in CF patients, and this condition is exacerbated by excessive Na(+) absorption.

92 This problem is exacerbated by exchange of resistance genes between p

93 aired by statin therapy, and this effect may be exacerbated by exercise.

94 This growth inhibition was exacerbated by exposing the cells to either hydroxyu

95 This activity was exacerbated by exposure to a novel environment.

96 by growth in limiting N, and that reduction was exacerbated by exposure to elevated O(3).

97 this disorder is unknown, although symptoms are exacerbated by factors that trigger innate immune re

98 This was exacerbated by feeding mice a high-cholesterol diet

99 amage associated with retinal vein occlusion is exacerbated by fluid extravasation and hemorrhage, wh

100 ed in vitamin B12 depletion, and this effect was exacerbated by folate depletion.

101 This immobilization is exacerbated by frequent administration of sedative ag

102 This suggests a lack of capacity that would be exacerbated by further network narrowing.Accurate phy

103 the first postnatal week, and the phenotypes were exacerbated by further additive conditional knock-o

104 nt a significant global burden whose effects are exacerbated by gaps in diagnosis and service provisi

105 haracteristic neointima formation, which can be exacerbated by genetic depletion of caveolin-1 or hem

106 Depression risk is exacerbated by genetic factors and stress exposure; h

107 ive disease, and neuronal degeneration in RP is exacerbated by glial activation.

108 be globally distributed, and its effects may be exacerbated by global warming.

109 stressors such as food deprivation, which is being exacerbated by global warming.

110 duced calcium mobilization and neurotoxicity are exacerbated by glucocorticoids, the adrenal steroids

111 previously shown that this neurotoxicity can be exacerbated by glucocorticoids (GCs), the stress horm

112 euronal degeneration, and the decline in ATP was exacerbated by glutamate.

113 These pex1-2 defects were exacerbated by growth at high temperature and ameli

114 cted the phenotype of Scn1a (+/-) mice would be exacerbated by GS967, a potent, unconventional sodium

115 fter either syngeneic or allogeneic BMT, but is exacerbated by GVHD.

116 sing in low- and middle-income countries and are exacerbated by health care systems that are ill-equi

117 Respiratory failure and dyspnea may be exacerbated by heart failure, pulmonary embolism, and

118 This effect is exacerbated by high temperature.

119 re associated with insulin resistance, which is exacerbated by high-fat diet.

120 id atherosclerosis in humans, an effect that was exacerbated by high dietary AA but mitigated by high

121 ice resulted in increased body weight, which was exacerbated by high fat diet and driven by increased

122 es compared with gld mice, and these effects were exacerbated by high cholesterol diet.

123 of fatty acid oxidation, with syndromes that are exacerbated by hyperthermia.

124 oduction in PML +/+ MEF, and this difference is exacerbated by IFN treatment that upregulates PML exp

125 Cutaneous bacterial infection in mice was exacerbated by IL-4 signaling and improved with IL-4

126 s due to the eight human herpesviruses (HHV) are exacerbated by immunosuppression in organ transplant

127 eleterious effect of these comorbidities may be exacerbated by impaired access to secondary preventio

128 The problem has been exacerbated by inadequate economic incentives for p

129 sensitive to H(2)O(2), and this sensitivity is exacerbated by increased O(2) concentrations.

130 g studies to rule out deep venous thrombosis is exacerbated by increased susceptibility that critical

131 age-related spatial working memory deficits were exacerbated by increased HPA activity.

132 ural context and whether such problems would be exacerbated by increases in task difficulty.

133 This scenario is exacerbated by increases in antibiotic resistance and

134 ining breeders is costly and that such costs are exacerbated by increasing group size.

135 nt or silencing of transgenes may occur, and is exacerbated by increasing numbers of transgenic loci

136 ted hydrolysis and oxidation byproducts that were exacerbated by increasing temperatures.

137 toimmune diseases such as glomerulonephritis are exacerbated by infection.

138 Glomerulonephritis can be exacerbated by infection.

139 al tissue damage after an ischemic event can be exacerbated by inflammation and thrombosis.

140 s the kynurenine pathway, an effect that may be exacerbated by inflammatory responses in immunocompet

141 prevented by IDEC-131 alone or with ATG, and was exacerbated by infusion of donor bone marrow (n=8).

142 fibroblasts in multiple organs and that this is exacerbated by injury and occurs in a mouse tumor mod

143 t, lung, and kidney and that this phenomenon is exacerbated by injury.

144 undamental difficulties in such a separation are exacerbated by instrumental distortions of the signa

145 t components and biophysics, these responses are exacerbated by IRD.

146 may result from the use of docetaxel and may be exacerbated by its combination with vinorelbine.

147 ued partially by overproduction of Bem3p and is exacerbated by its absence.

148 The attenuation in gag mRNA translation is exacerbated by K51A substitution in the Tat double-st

149 eficits were noted 48 h after CCAT and these were exacerbated by L-NAME treatment.

150 and progression of thrombotic disorders that are exacerbated by leukocyte-platelet aggregation.

151 tional studies demonstrated that rd3 disease is exacerbated by light but not protected by the absence

152 ions in Rhodopsin; in some animal models, RD is exacerbated by light.

153 verity of visual dysfunction and retinopathy was exacerbated by light but attenuated by treatment wit

154 determine which aspects of autoimmunity may be exacerbated by LMP1, we bred mCD40-LMP1tg mice to two

155 due to loss of de novo PE biosynthesis, but are exacerbated by loss of PS itself.

156 romatin missegregation, and these phenotypes are exacerbated by loss of the cell cycle regulator, p21

157 s and pericentromeric heterochromatin, which is exacerbated by loss of p53 and linked to ATM activati

158 large magnitude storms; these conditions may be exacerbated by low inorganic sediment content and hig

159 fficiency leads to muscle wasting, which may be exacerbated by low-protein diets prescribed to delay

160 h impact adult survival but also this impact was exacerbated by lower food availability in years foll

161 , but there was evidence that the impairment was exacerbated by manipulating stimulus selection diffi

162 Thus, pain is exacerbated by measures inhibiting the immigration of

163 cells destined to become neoplastic and may be exacerbated by Nf1 heterozygosity in other non-neopla

164 mice exhibit a vacuolating degeneration that is exacerbated by nicotine and ameliorated by null mutat

165 Th9 cells induced airway inflammation, which was exacerbated by NO and blocked by anti-IL-9 antibody.

166 dothelial cell angiotensin-converting enzyme was exacerbated by NO2-, illustrating the physiological

167 Hypertriglyceridaemia is exacerbated by non-genetic factors.

168 bition of cytokinesis by byr4 overexpression was exacerbated by null alleles of ras1 and scd1, sugges

169 Both effects are exacerbated by obesity.

170 tration, usually presents in middle age, and is exacerbated by obesity.

171 s biomechanical and inflammatory origins and is exacerbated by obesity.

172 Treatment-related symptoms were exacerbated by obesity, a large prostate size, a hi

173 oclasts and intracortical/calvarial porosity is exacerbated by overexpressing Sost and reversed by bl

174 overexpression of SPO12, YAK1, and SIC1 and is exacerbated by overproduction of the mitotic cyclin C

175 tress and innate immune gene activation that were exacerbated by p38 GOF and Bsk LOF, respectively.

176 ity to growth inhibition by 6-azauracil that was exacerbated by partial truncations of the Pol II CTD

177 The degree of aneuploidy was exacerbated by passage in culture.

178 that the oxidative stress after a blood meal is exacerbated by Plasmodium infection.

179 one marrow (BM), lesions in humoral immunity are exacerbated by poor engraftment of donor B cells.

180 in the indoxacarb-selected population, which was exacerbated by poor nutrition.

181 d in skinned myocardial tissues; this effect is exacerbated by pretreating with protein phosphatase 1

182 demonstrated evidence of liver injury, which was exacerbated by previous exposure to maternal obesity

183 dies have investigated whether these changes are exacerbated by prior episodes.

184 To explore how these effects may have been exacerbated by prior ecological changes, we used a

185 nt in monkeys with transection of the fornix is exacerbated by prior depletion of acetylcholine from

186 mammillary bodies, like fornix transection, was exacerbated by prior removal of temporal cortical ac

187 We therefore hypothesized that pain might be exacerbated by proinflammatory chemokines.

188 function by Abeta (which preceded apoptosis) was exacerbated by PS-1 mutations and was largely preven

189 hibition of Src family kinases (SFKs), which was exacerbated by PTP1B overexpression and largely prev

190 hemic injury in the beta(2)AR overexpressors was exacerbated by PTX treatment, implying that it was G

191 th mixed resistant and susceptible parasites are exacerbated by pyrimethamine in mice.

192 lities experienced by leg ulcer patients may be exacerbated by reduced access to guideline-based mana

193 f Rapgap1 induces a rough eye phenotype that is exacerbated by reducing Rap1 gene dosage.

194 asal level of chromosome missegregation that is exacerbated by reduction of CENP-E.

195 high levels of spontaneous MSI occur, which is exacerbated by replication inhibition.

196 rowing regions with poor soil fertility will be exacerbated by rising background O(3).

197 istribution of Nucella by the year 2100 that were exacerbated by rising greenhouse gas emissions.

198 alone on the skeletal muscle was minimal but was exacerbated by ryanodine-induced perturbation of int

199 ed in pronounced stress fiber formation that was exacerbated by S1P2 overexpression, partially blocke

200 n X-linked, degenerative muscle disease that is exacerbated by secondary inflammation.

201 d antiproliferative and proapoptotic effects were exacerbated by sepiapterin, a precursor of tetrahyd

202 nd other adverse effects with statin use can be exacerbated by several factors, including compromised

203 This process is exacerbated by significant changes to the microbiome,

204 en characterised by slower speeds, which may be exacerbated by situations that combine gait with a co

205 This problem is exacerbated by small sample sizes, nonequilibrium dem

206 laments more slowly than WT, and the slowing is exacerbated by smooth muscle tropomyosin.

207 stingly, many of these behavioral phenotypes are exacerbated by social isolation stress.

208 Many of these behaviors were exacerbated by social isolation stress.

209 , the effects of Sir2 or Sir3 overexpression are exacerbated by specific mutations in the N-terminus

210 Reduced torsion was found to be exacerbated by steeper HAs.

211 at corals experience viral infections, which are exacerbated by stress, and that herpes-like viruses

212 he most prevalent psychiatric conditions and are exacerbated by stress.

213 Acylcarnitine accumulation is exacerbated by stress such as influenza infection or

214 asculopathy with pulmonary hypertension that is exacerbated by SU5416.

215 lial apoptosis in B6 mice after DS, and this was exacerbated by subconjunctival IFN-gamma injection.

216 In particular, molecular weight analysis is exacerbated by such glycosylation.

217 yoderma gangrenosum, those in 8 (12 percent) were exacerbated by such treatment, and those in 15 (23

218 pairment with nonfermentable substrates that was exacerbated by sulfide, a precursor to mitochondrial

219 athway that is unique to spinal cord MNs and is exacerbated by superoxide dismutase (SOD) mutations.

220 lling and pain and difficulty breathing that was exacerbated by supine positioning; he had not had an

221 ation risk on neonates, an interaction which is exacerbated by susceptibility to climatic events.

222 age and neurological deficit 24 h after MCAo were exacerbated by systemic lipopolysaccharide (LPS) ad

223 (R+)/seronegative donor (D-) transplants and is exacerbated by T-cell depletion.

224 MT shows a high mutagenic bypass rate, which is exacerbated by TEFM (transcription elongation factor

225 ow that, paradoxically, these challenges can be exacerbated by temporary-sharing media-technologies t

226 the suppression of either DISC1 or BBS4 and are exacerbated by the concomitant suppression of both.

227 The consequent functional losses are exacerbated by the deterioration of other interactin

228 y in the extent to which their ADHD symptoms are exacerbated by the ingestion of food additives.

229 These issues are exacerbated by the lack of guidance on the use of su

230 ced sulfite reductase activity in particular are exacerbated by the need for glutathione in cobalt re

231 In males, such trade-offs are exacerbated by the resource requirements associated

232 chieving desired social outcomes in life may be exacerbated by the experience of childhood cancer, in

233 id bilayer and the exposure of PS, which can be exacerbated by the inhibition of aminophospholipid tr

234 associated with oxidative stress, which may be exacerbated by the presence of excess iron.

235 This putative rephasing might also be exacerbated by the rare CGA Arg codon in the second p

236 sive inflammatory response to polytrauma may be exacerbated by the transfusion of blood products.

237 to patient anti-idiotype responses which may be exacerbated by the unusually high number of basic res

238 bacteria is a global health problem that has been exacerbated by the dearth of novel classes of antib

239 The formation of dead zones has been exacerbated by the increase in primary production a

240 The toxicity associated with PAP I is exacerbated by the absence of either RNase T and/or R

241 lutionary history of mammals, a problem that is exacerbated by the absence of this vitamin from the p

242 hepatitis B virus (HBV), whose pathogenesis is exacerbated by the acquisition of mutations that acce

243 th problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco sm

244 h in low-zinc medium, and this growth defect is exacerbated by the additional presence of a yciC muta

245 The spindle defect in cut12.1 is exacerbated by the cdc25.22 mutation, and stf1.1 cell

246 to assemble into self-seeding fibrils, which is exacerbated by the disease mutations.

247 is associated with the inbred background and is exacerbated by the dominant spotting oncogene allele

248 This is exacerbated by the lack of appropriate adaptation opt

249 This problem is exacerbated by the lack of computational tools for RN

250 in mutants lacking PBP 5, and this phenotype is exacerbated by the loss of additional peptidoglycan e

251 This challenge is exacerbated by the paucity of suitable approaches to

252 nduction of N-linked N,N'-diacetylchitobiose is exacerbated by the removal of fetal bovine serum.

253 This problem is exacerbated by the removal of low-frequency polymorph

254 Ischemia-reperfusion injury is exacerbated by the thrombospondin-1-CD47 system throu

255 to ischemia-reperfusion injury (IRI), which is exacerbated by the thrombospondin-1/CD47 pathway thro

256 Liver injury is exacerbated by the transfusion of stored blood, prima

257 The fragility of Flex1 was exacerbated by the absence of Rad52 or the presence

258 he persistence defect of the Mtb mctB mutant was exacerbated by the addition of Cu to the diet.

259 l community composition and structure, which was exacerbated by the addition of organic matter, with

260 y attenuated in wa-2 fibroblast cells, which was exacerbated by the additional Shp-2 mutation.

261 , and myocardial injury occurred; the injury was exacerbated by the lower ischemia pH in these hearts

262 ive valence on appearance self-consciousness was exacerbated by the moderating effect increased salie

263 Mitochondrial ROS production was exacerbated by the use of antimycin A, which inhibit

264 hology defects associated with loss of PBP 1 were exacerbated by the additional loss of PBP 4 but not

265 all of these defects associated with Rb loss were exacerbated by the concomitant inactivation of E2f8

266 f Ca from watershed soils, but these effects were exacerbated by the long-term pattern.

267 arising in the individual E2f1 or E2f3 mice were exacerbated by the mutation of the other E2f.

268 These changes were exacerbated by the presence of cataract and were su

269 caemia-induced changes in ASL lactate and pH were exacerbated by the presence of P. aeruginosa and we

270 the clearance of 50nm lipid nanocapsules, or is exacerbated by their pulmonary administration.

271 the deleterious effects of I/R on the brain are exacerbated by this cardiovascular risk factor.

272 in rnp1 cells; (iv) the rnp1 Ts(-) phenotype is exacerbated by tif32-Delta6, which eliminates a bindi

273 Furthermore, both forms of disease are exacerbated by tobacco use.

274 the Kca agonist NS 1619; the effect of each was exacerbated by tPA.

275 ion with PM was higher in aged subjects, and was exacerbated by training, although it was not changed

276 eased after 48 hr of ischemia, this decrease being exacerbated by transplantation-reperfusion.

277 The growth defect within macrophages was exacerbated by treatment of the host cells with an i

278 as gliosis and huntingtin aggregates, which were exacerbated by treatment with GPA.

279 ises the issue of access to medicines, which is exacerbated by TRIPS-plus provisions, although many c

280 Tumorigenesis was exacerbated by Trp53 co-deletion (median age of onse

281 viors, and the deficiencies in Sk3(-/-) mice were exacerbated by Trpc2 knockout.

282 The severity of the spt5-DeltaCTD phenotype is exacerbated by truncation of the Pol II CTD and ameli

283 operative period and how these responses can be exacerbated by underlying cardiac pathology is critic

284 ition, although poorly defined, is likely to be exacerbated by undernutrition as well as being respon

285 opulations often have health conditions that are exacerbated by unnecessarily inadequate healthcare.

286 It is commonly acknowledged that asthma is exacerbated by viral infections.

287 th overfishing in this ecosystem will likely be exacerbated by warming, but this loss may be countera

288 This need is exacerbated by ways in which evolutionary and genetic

289 the application of macrophage precursors and was exacerbated by whole BM.

290 sting pulmonary hypertension, and whether it is exacerbated by worsening chronic obstructive pulmonar