ライフサイエンスコーパス: be exacerbated in

1 ested the hypotheses that EAE severity would be exacerbated in 12/15-LO-deficient mice and attenuated

2 elevated levels of Mn(II), and these effects are exacerbated in a mneP mneS double mutant.

3 dent cardiac mast cells, a process likely to be exacerbated in a chronic inflammatory background.

4 This reduction requires (p)ppGpp and is exacerbated in a gppA mutant with increased pppGpp le

5 presumed to transport Ca2+ into the vacuole, is exacerbated in a hum1 mutant strain background.

6 Interestingly, this phenotype is exacerbated in a p53(+/-) background and the tumorige

7 ology and accelerated clinical course, which is exacerbated in a significant proportion of cases by t

8 This activation is exacerbated in a strain lacking the gene encoding Co,

9 This doubt was exacerbated in a few cases as families were uninform

10 l retinal neovascularization during ischemia was exacerbated in adiponectin-knockout (APN-KO) mice co

11 uced damage to hippocampal pyramidal neurons was exacerbated in adult gelsolin-deficient mice.

12 These effects were exacerbated in aged AD mice with marked Abeta plaqu

13 ar anticoagulants, a process that appears to be exacerbated in aging, a well-known risk factor for th

14 This was exacerbated in aHUS by genetic abnormalities associa

15 In the absence of Rpl22, ER stress is exacerbated in alphabeta, but not gammadelta, T cell

16 ature-dependent failure to accumulate VirB10 is exacerbated in an attachment-deficient mutant strain

17 UPR induction in low zinc is exacerbated in an msc2 mutant.

18 ndings suggest that malaria transmission may be exacerbated in areas of high antibiotic usage, and th

19 of wound healing in chronic schistosomiasis, was exacerbated in Batf3(-/-) mice infected with Schisto

20 In sharp contrast, spontaneous diabetes is exacerbated in both B7-1/B7-2-deficient and CD28-defi

21 -17-dependent pathology in Zc3h12a(+/-) mice was exacerbated in both EAE and pulmonary inflammation.

22 the second week of infection, this swelling was exacerbated in C3H IFN-gamma degrees mice.

23 Hyperglycolysis was exacerbated in CA1 and CA3 hippocampus after TBI in

24 fect on EAE, experimental autoimmune uveitis is exacerbated in CD4-IRF8KO mice and disease enhancemen

25 The effect of L-dopa on PP2A and p-Tau was exacerbated in cells exposed to folate deficiency.

26 visible in untreated cells, but the defects were exacerbated in cells forced to filament by inactiva

27 These challenges are exacerbated in coastal communities, where population

28 inflammation associated with HIV-1 infection is exacerbated in cocaine-abusing, HIV+ individuals.

29 Notably, this blockage is exacerbated in Cockayne Syndrome and xeroderma pigmen

30 Loss of RPE in yap mutants is exacerbated in combination with taz (wwtr1) mutant al

31 This cone defect was exacerbated in conditions of low levels of 11-cis-re

32 e, the aneuploidy of tumor endothelial cells is exacerbated in culture suggesting that these cells ar

33 tion of reactive oxygen species (ROS), which is exacerbated in diabetes and may affect placental deve

34 eneration, sarcolemma integrity and fibrosis were exacerbated in DKO mice and were remarkably similar

35 Injury signatures were exacerbated in DMPA users who also practiced vagina

36 This response was exacerbated in egr-1(-/-) mice.

37 rythrocytes with VC induced hemolysis, which was exacerbated in erythrocytes from glucose-6-phosphate

38 LKC was exacerbated in euthymic mice depleted of CD4(+)CD25(

39 n social approach behavior, a phenotype that is exacerbated in female Pten(+/-); Slc6a4(+/-) mice.

40 Likewise, renal IRI was exacerbated in female estrogen receptor alpha-KO mic

41 defects in JAK/STAT or EGF-R signalling and were exacerbated in flies heterozygous for either the d-

42 diet-induced obesity and insulin resistance are exacerbated in GFRAL-deficient mice, suggesting a ho

43 t times of peak behavioural sensitivity that is exacerbated in gp120+ddC as compared to either treatm

44 ux through SM synthase also increases, which is exacerbated in HepG2-SMS1 cells.

45 vels increased progressively with age, which was exacerbated in Hfe-deficient mice.

46 gh levels of IFN-gamma are secreted, disease is exacerbated in IFN-gamma or IFN-gamma receptor-defici

47 N-gamma are secreted in CIA and EAE, disease is exacerbated in IFN-gamma- or IFN-gamma receptor-defic

48 shed reports of Th2-mediated protection, CIA was exacerbated in IL-2R beta/IL-4R alpha chimeric recep

49 The severity of PGIA was exacerbated in IL-4Ralpha(-/-) and LysM(cre)IL-4Ralp

50 These effects may be exacerbated in infants because they are able to absor

51 s in development and cytokine secretion that are exacerbated in Itk/Txk double-knockout mice.

52 Cajal hyperplasia and mast cell hyperplasia were exacerbated in Kit(V558;T669I/+) mice.

53 model, aberrant mitochondrial bioenergetics was exacerbated in KO myocytes.

54 ed in SD-OBx hamsters; LPS-induced anhedonia was exacerbated in LD-OBx hamsters; and photoperiodic di

55 but not self-directed, repetitive behaviors were exacerbated in lesioned mice.

56 Lastly, LPS-induced sepsis is exacerbated in LysMCre-SOCS3(fl/fl) mice and is assoc

57 Interestingly, the mutant's growth defect was exacerbated in macrophages that had been depleted of

58 The cardiomyopathic phenotype was exacerbated in MHC-PPAR mice fed a diet enriched in

59 (DSS)-induced inflammation-associated cancer is exacerbated in mice lacking Axl and Mer.

60 prevented in mice lacking both isoforms but is exacerbated in mice lacking fructokinase A.

61 1)-dependent autoantibody-mediated arthritis is exacerbated in mice lacking IAPs, and is reduced by d

62 This was exacerbated in mice deficient in IFN pathways, leadi

63 Inflammation was exacerbated in mice in which CRHR2 activity was inhi

64 Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared

65 These phenotypes were exacerbated in mice with only a single copy of p300

66 nits and translation initiation defects that are exacerbated in minimal medium.

67 d NF-kappaB nuclear translocation in WT mice was exacerbated in MIOX-TG mice but absent in MIOX(-/-)

68 of hyperlipidemia, such that atherosclerosis was exacerbated in Mir126(-/-) mice.

69 PCD was found to be exacerbated in MNs expressing ALS-linked superoxide d

70 NAC-induced G(1) arrest is exacerbated in MnSOD heterozygous fibroblasts.

71 These effects of acetate were exacerbated in mutants with slowed electron transfe

72 These phenotypes were all found to be exacerbated in myb108 myb24 double mutants, which als

73 Unexpectedly, the inflammatory response was exacerbated in MyD88(-/-) mice, with enhanced neutro

74 iated with normal aging and is postulated to be exacerbated in neurodegenerative disorders.

75 generating an inward current (IH), which may be exacerbated in NKA-subunit mutations associated with

76 Notably, autoimmune diabetes was exacerbated in NOD.MerTK(KD/KD) versus NOD mice expr

77 role because PGN-triggered eye inflammation was exacerbated in NOD2 KO mice.

78 Although these problems are exacerbated in numerous neurological and psychiatric

79 ed gammadelta T cells on epidermal structure is exacerbated in obesity as E-cadherin localization and

80 ces of prenatal viral-like immune activation are exacerbated in offspring with genetic predisposition

81 This effect could be exacerbated in overweight individuals because DHA met

82 These phenotypes were exacerbated in p53-deficient cultures exhibiting in

83 receptors, whereas the hepatocellular damage was exacerbated in PACAP-deficient mice.

84 ressed membrane potential occur in parallel, are exacerbated in parallel by exogenous free fatty acid

85 leak occurs via ryanodine receptors and can be exacerbated in pathological states such as heart fail

86 determine which pathophysiological pathways are exacerbated in patients with HF, reduced ejection fr

87 Colitis is exacerbated in patients with concurrent cytomegalovir

88 long-term, chronic inflammatory disease that is exacerbated in patients with diabetes.

89 Intimal proliferation was exacerbated in PECAM-1 grafts (57+/-5% for PECAM-1 v

90 t has been hypothesised that the effect will be exacerbated in polygamous species with higher levels

91 ) mice are macrocephalic, and this phenotype is exacerbated in Pten(+/-); Slc6a4(+/-) mice.

92 The exencephaly phenotype is exacerbated in Rala(-/-);Ralb(+/-) embryos; embryos n

93 t treatment led to dermal fibrosis, and this was exacerbated in recipients of contrast-exposed marrow

94 Peroxisomal defects were exacerbated in RING peroxin double mutants, suggest

95 apoptosis in wild-type mice; these responses were exacerbated in RIP3(-/-) mice.

96 LPS-induced anorexia was exacerbated in SD-OBx hamsters; LPS-induced anhedoni

97 These changes were exacerbated in severe PH.

98 d in LA-laden macrophages in all strains but was exacerbated in SHHF rats.

99 above pathological and molecular alterations were exacerbated in skin cancer lesions that spontaneous

100 t SMN-dependent downstream molecular defects are exacerbated in SMA motor neurons.

101 This problem is exacerbated in some biological systems, such as muscl

102 dicate that the lysosomal degradation defect is exacerbated in some cells because of the accumulation

103 ect in root-to-shoot Fe translocation, which was exacerbated in spl7 and associated with a lack of fe

104 Importantly, tissue damage and fibrosis were exacerbated in SR-AI(-/-) mice following hepatic in

105 nt on MprAB-mediated signal transduction and is exacerbated in strains of M. tuberculosis producing a

106 Furthermore, the toxicity of many salts is exacerbated in strains with a defective vacuolar H(+)

107 The phenotypes of the BSH-deficient strains were exacerbated in strains lacking the Fe-S cluster car

108 These changes were exacerbated in Tg-S466L Cbs(-/-) mice with aging.

109 lmonary hypertension and vascular remodeling are exacerbated in the absence of COX-2 with enhanced ET

110 rmined that IFN-gamma (Th1) immune responses are exacerbated in the airways of individuals with SA, w

111 s display distinct degenerative defects that are exacerbated in the double homozygotes, we conclude t

112 assembly of the spore protective layers that are exacerbated in the presence of a functional GerA rec

113 pid deposition in the BMPR2-mutant RV, which are exacerbated in the presence of dietary lipids.

114 hat accompanies severe astrogliosis and this is exacerbated in the absence of either the hsf2 or hsf4

115 tic reduction in conidial germination, which is exacerbated in the absence of GNA-1.

116 pressed in vivo or in vitro, and this effect is exacerbated in the absence of IFN-gamma.

117 ssue damage caused by gut barrier disruption is exacerbated in the absence of NF-kappaB, with failure

118 t injury-induced systemic autoimmune disease is exacerbated in the absence of Ro52/Trim21 and is driv

119 This reduced core interaction is exacerbated in the presence of sigma70, which compete

120 This defect is exacerbated in the presence of Spi-1 haplo-insufficie

121 restingly, TNF-mediated intestinal pathology was exacerbated in the absence of MAPKAP kinase 2, yet s

122 Axonal demyelination was exacerbated in the absence of tPA or plasminogen, in

123 Accordingly, oxidation of KCNB1 channels was exacerbated in the brain of a triple transgenic mous

124 Cone cell loss was exacerbated in the inferior retinal region, with onl

125 ulted in formation of cysts, and this effect was exacerbated in the Pkd2(+/-) kidneys.

126 proach, anti-IgE produced acidification that was exacerbated in the presence of 100 microM Zn(2+).

127 Phase delay in this mutant on DD1 was exacerbated in the presence of a single functional a

128 antly with changes in ambient conditions: it was exacerbated in the presence of Mn(2+) or by increase

129 Ischemic stroke-induced brain injury was exacerbated in the presence of supraphysiologic brai

130 Heme protein deficiencies were exacerbated in the iron-loaded mitochondria, sugges

131 nome-wide DNA methylation alterations, which were exacerbated in the placenta compared to the embryo.

132 Outer hair cell losses were exacerbated in the same time frame ( approximately

133 jor role in excitotoxicity, it is thought to be exacerbated in this region by two forms of post-ischa

134 Furthermore, both neuronal and pSC injury were exacerbated in tissues from mice lacking the inhibi

135 cal cerebral ischemia and epileptic seizures was exacerbated in TNFR-KO mice, indicating that TNF ser

136 Spontaneous scratching was exacerbated in transgenic mice that overexpressed TR

137 r and humoral immune responses were found to be exacerbated in vaccinated iNOS-deficient mice, vaccin

138 Biliary-type liver injury is exacerbated in Vdr(-/-) mice by limited adaptive resp