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2 layed over the helical scaffold such that it is fraught with a huge steric strain to undergo required
3 lity to cross-couple secondary alkyl centers is fraught with a number of problems, including difficul
4 with the most efficient regimens available, is fraught with a substantial proportion of failures to
5 pheral percutaneous transluminal angioplasty is fraught with a substantial risk of restenosis and rei
6 isting reprogramming methodologies, however, are fraught with caveats, including a heavy reliance on
7 the management of anophthalmia in the child is fraught with challenges and nuances, the principal ai
9 relationships after termination of treatment are fraught with complexities and are the subject of ong
10 healing following third-degree burn injuries are fraught with complications, often resulting in long-
11 main the mainstay of care for IOI, their use is fraught with complications and side-effects, suggesti
12 vitro evaluation of colistin susceptibility is fraught with complications, due in part to the inhere
13 clarified the nature of PTLD, the literature is fraught with conflicting experience and outcomes with
14 For membrane proteins, the extrapolations are fraught with considerable uncertainty as the denatur
15 c target genes, particularly in cancer, have been fraught with dead ends and context-specific functio
16 However, all elements of informed consent are fraught with difficulties due to the unique nature o
17 ffective in releasing the drug rapidly, they are fraught with difficulties inherent in processing par
20 ing this pre-biomineralization fossil record is fraught with difficulties, leading to controversial a
28 g direct links across phenotypic hierarchies is fraught with difficulty; we identify issues complicat
31 ses, the randomized trials used for analysis are fraught with inconsistencies, including the availabi
35 e modification may be helpful, but even this is fraught with limited efficacy and potential complicat
36 st has been colon; however, most series have been fraught with major complications and conduit loss.
38 hough studies of trauma system effectiveness are fraught with methodologic difficulties, several type
39 e evidence base is limited, and most studies are fraught with methodologic limitations, including cro
42 , eliciting reliable responses from newborns is fraught with operational difficulties, and studies wi
43 nomic characters means that using these data is fraught with potential difficulties, leading to error
45 gainst infection, and current drug therapies are fraught with problems, predominantly because of the
50 nistration of such myeloablative transplants is fraught with risks, some of which are related to the
53 stic category guiding translational research is fraught with so many problems that the validity of re
54 tandard therapy for Wegener's granulomatosis is fraught with substantial toxicity and not always effe
55 ion of HCV replication in extrahepatic sites is fraught with technical challenges, and in vitro syste
56 primary tumors, however, the analysis of LOH is fraught with technical problems that have limited its
57 g MYC expression in hepatocellular carcinoma are fraught with the theoretical possibility of injuring
58 tion in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the ag
60 re many effective choices, but as a class it is fraught with the risk of serious peptic ulcer disease
62 nce current treatment methods for KS and PEL are fraught with unwanted side effects and low efficienc
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