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1 f HMPA in more complex systems are likely to be fraught with a high degree of uncertainty.
2 layed over the helical scaffold such that it is fraught with a huge steric strain to undergo required
3 lity to cross-couple secondary alkyl centers is fraught with a number of problems, including difficul
4  with the most efficient regimens available, is fraught with a substantial proportion of failures to
5 pheral percutaneous transluminal angioplasty is fraught with a substantial risk of restenosis and rei
6 isting reprogramming methodologies, however, are fraught with caveats, including a heavy reliance on
7  the management of anophthalmia in the child is fraught with challenges and nuances, the principal ai
8     Learning their structure and intricacies is fraught with challenges, and often side-stepped in fa
9 relationships after termination of treatment are fraught with complexities and are the subject of ong
10 healing following third-degree burn injuries are fraught with complications, often resulting in long-
11 main the mainstay of care for IOI, their use is fraught with complications and side-effects, suggesti
12  vitro evaluation of colistin susceptibility is fraught with complications, due in part to the inhere
13 clarified the nature of PTLD, the literature is fraught with conflicting experience and outcomes with
14    For membrane proteins, the extrapolations are fraught with considerable uncertainty as the denatur
15 c target genes, particularly in cancer, have been fraught with dead ends and context-specific functio
16    However, all elements of informed consent are fraught with difficulties due to the unique nature o
17 ffective in releasing the drug rapidly, they are fraught with difficulties inherent in processing par
18        However, use of the Tet-On system has been fraught with difficulties, including high backgroun
19 r, attempts at targeting these pathways have been fraught with difficulties.
20 ing this pre-biomineralization fossil record is fraught with difficulties, leading to controversial a
21 using RPM might seem straightforward, but it is fraught with difficulties.
22 nodes of the webs and the links between them is fraught with difficulties.
23 election in experimentally derived sequences is fraught with difficulties.
24  practice or clinical research, however, has been fraught with difficulty.
25 TA induction is extremely important, but has been fraught with difficulty.
26                           Replication of DNA is fraught with difficulty and chromosomes contain many
27                        Predicting the future is fraught with difficulty; nonetheless, it is apparent
28 g direct links across phenotypic hierarchies is fraught with difficulty; we identify issues complicat
29                 Although testing of mAbs has been fraught with failure and confusing results, the exp
30 t strategies for reconstructing bony defects are fraught with inadequacies.
31 ses, the randomized trials used for analysis are fraught with inconsistencies, including the availabi
32                      However, the literature is fraught with inconsistent accounts as to whether vari
33             Yet, such sophisticated analyses are fraught with interpretive difficulties.
34                                      Staples are fraught with limitations including high-localized ti
35 e modification may be helpful, but even this is fraught with limited efficacy and potential complicat
36 st has been colon; however, most series have been fraught with major complications and conduit loss.
37            The history of ALS drug discovery is fraught with many stops and starts.
38 hough studies of trauma system effectiveness are fraught with methodologic difficulties, several type
39 e evidence base is limited, and most studies are fraught with methodologic limitations, including cro
40 tween studies, because quantification of AEA is fraught with methodological difficulties.
41 roup and neighboring phosphoglyceryl complex were fraught with obstacles.
42 , eliciting reliable responses from newborns is fraught with operational difficulties, and studies wi
43 nomic characters means that using these data is fraught with potential difficulties, leading to error
44 iagnosis of some infectious diseases and yet is fraught with potential pitfalls.
45 gainst infection, and current drug therapies are fraught with problems, predominantly because of the
46                                Clearly, both are fraught with problems.
47  Emergency airway management in children can be fraught with problems.
48 o map the genes for psychotic illnesses have been fraught with problems.
49                      Travel into outer space is fraught with risk of exposure to energetic heavy ion
50 nistration of such myeloablative transplants is fraught with risks, some of which are related to the
51 , present methods to measure telomere length are fraught with shortcomings that limit their use.
52 t the road to integration and acceptance has been fraught with skepticism and technical hurdles.
53 stic category guiding translational research is fraught with so many problems that the validity of re
54 tandard therapy for Wegener's granulomatosis is fraught with substantial toxicity and not always effe
55 ion of HCV replication in extrahepatic sites is fraught with technical challenges, and in vitro syste
56 primary tumors, however, the analysis of LOH is fraught with technical problems that have limited its
57 g MYC expression in hepatocellular carcinoma are fraught with the theoretical possibility of injuring
58 tion in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the ag
59                       The study of virulence is fraught with the paradox that virulence, despite bein
60 re many effective choices, but as a class it is fraught with the risk of serious peptic ulcer disease
61  will go functionally extinct in the future, are fraught with uncertainty.
62 nce current treatment methods for KS and PEL are fraught with unwanted side effects and low efficienc

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