ライフサイエンスコーパス: be identified that

1 Publications were identified that (1) described the relationship betw

2 e compounds, T5424837, T5550585 and T5660138 were identified that ablated FX-mediated Ad5 transductio

3 Although numerous signaling mechanisms have been identified that act directly on axons to regulate t

4 It has also been identified that actin provides rest stops for Cx43

5 No studies were identified that addressed the other outcomes.

6 At least two genes have been identified that affect number of vertebrae in pigs

7 Four loci have been identified that affect stem length (Dw1-Dw4).

8 ted to the host, virus, and environment have been identified that affect the severity of RV infection

9 Multiple mutations were identified that affected the same pathways, includi

10 y analyses, and advanced MRI techniques have been identified that aid in the diagnosis of natalizumab

11 Moreover, several miRNAs have been identified that aid the formation of inducible plur

12 total of 36 types of insertions or deletions were identified that all cause a frameshift to the same

13 a metabolomics approach, single metabolites are identified that allow a good, albeit at about 14% fa

14 reducing agent, and reaction conditions have been identified that allow alteration in the rate- and r

15 Cytogenetic abnormalities have been identified that allow differentiation of endometria

16 mutations located on the surface of NC have been identified that allow NC maturation but block its e

17 Numerous related defects have recently been identified that allow T cell development but that c

18 efficient and salt concentration, conditions were identified that allowed the diffusion length to alw

19 One compound was identified that also prevented DEPTOR-mTOR binding i

20 Twenty-one grazing responsive pathways were identified that also exhibited differential express

21 of hydrophobic residues, key positions have been identified that alter the NTD equilibrium; these li

22 However, in an earlier related work , it was identified that an important trapping mechanism, res

23 ndependent classes of BR-regulated COR genes are identified that are regulated in a BR- and CES-depen

24 oversimplification, a subset of proteins can be identified that are likely targets for adaptive evolu

25 de (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working

26 Few small molecule compounds have been identified that are active in cell-based or animal

27 and atopic dermatitis, common variants have been identified that are associated with disease, and th

28 a series of hereditary UGT1A1 mutations have been identified that are associated with UGT1A1 deficien

29 Cortical and subcortical networks have been identified that are commonly associated with attent

30 Three mammalian IMP paralogs (IMP1-3) have been identified that are expressed in most organs during

31 dentified, but no molecular alterations have been identified that are in common to these diseases.

32 More than 375 genes have been identified that are involved in regulating skin pig

33 e electrical and episodic disorders have now been identified that are not defects in the ion channel

34 Recently, lipids have been identified that are released from tissues and act l

35 Mutations in several genes have been identified that are responsible for 25% of families

36 rks of CRC, and epigenetic driver genes have been identified that are thought to be involved in early

37 act via various targets, some of which have been identified, that are triggered according to the con

38 From this effort, three compounds were identified that are 10-fold more potent toward Cif

39 r this study, hundreds of intergenic LncRNAs were identified that are expressed in myoblasts and regu

40 s, during the mobile surveys, many gas leaks were identified that are not included in the inventories

41 Twenty-six variants were identified that are private to a family, alter prot

42 Two nonconserved active site residues were identified that are responsible for the different r

43 Several risk factors among survivors have been identified that assist in defining high-risk subgro

44 Ten proteasome-specific chaperones have been identified that assist in this process.

45 n recent years, numerous feedback loops have been identified that attenuate PI3K/PDK1/Akt-dependent s

46 No subgroup could be identified that benefited from oxygen.

47 ity, several innovative farming systems have been identified that better balance multiple sustainabil

48 Potent inhibitors of bacterial IMPDHs have been identified that bind in a structurally distinct poc

49 Several different receptor proteins have been identified that bind monomeric, oligomeric, or fibr

50 Hexapeptides have been identified that bind to junctions and inhibit vario

51 ry anti-C1 monoclonal antibodies (mAbs) have been identified that bind to putative phospholipid and v

52 Increasingly, HIV bnAbs are being identified that bind to the N-linked glycans coati

53 onse in T lymphocytes, a class of inhibitors was identified that bind to and stabilize the pseudokina

54 ently, two potent taccalonolides, AF and AJ, were identified that bind to tubulin directly and enhanc

55 A stable heterohexameric complex was identified that binds to GPCRs with interactions tha

56 p (SAR) study, novel irreversible inhibitors were identified that block the transamidation activity o

57 n each example, certain community structures are identified that can be extrapolated to larger collec

58 Distinct configurations are identified that can be steered towards entities pred

59 opment, yet few patient characteristics have been identified that can be mechanistically linked to th

60 Dozens of small molecules have been identified that can functionally replace reprogramm

61 Thioether ancillary ligands have been identified that can greatly accelerate the C-H alke

62 Recently, compounds have been identified that can reverse HIV-1 latency in vivo.

63 A set of non-native peptides was identified that can inhibit all four of the AgrC rec

64 f poor metastatic outcome and CNA signatures were identified that can add a specific HR value for cla

65 eas, and octanol/water partition coefficient were identified that can contribute to the development o

66 Indeed, several volatile compounds were identified that can influence mosquito behaviour, i

67 It is shown that no physical property can be identified that carries significantly less informatio

68 combination with a single acetyl transferase was identified that catalyzes the conversion of 13R-mano

69 ee main genes (SCN1A, SCN1B and GABRG2) have been identified that cause febrile seizures with or with

70 Previously, two mutant forms of PCNA were identified that cause defects in MMR with little, i

71 spots matching to 23, 13 and 31 unique genes were identified that changed at least 1.5 fold (p < 0.05

72 Five predominant mutational subtypes were identified that clustered PDAC into 4 major subtype

73 l influence between the research communities were identified that combine the benefits of individual

74 While some pathways have been identified that communicate information from the en

75 ases, tract-based spatial statistics studies were identified that compared fractional anisotropy (FA;

76 a subclass of weak non-canonical terminators was identified that completely depend on NusA for effect

77 However no studies have been identified that comprehensively explore both the qu

78 a total set of 3661 direct p53 target genes is identified that comprise 3509 potential targets from

79 6), t(14;20), nonhyperdiploidy, and gain(1q) were identified that confer poor prognosis.

80 A point mutation in secY was identified that conferred smooth colony morphology t

81 Two mutations were identified that conferred low vein density.

82 Two groups of processing mechanisms are identified that conjointly adopt the particular powe

83 hybrid approach was carried on and a protein was identified that contained a Universal stress protein

84 ch viral contig, at least one fungal isolate was identified that contained each virus.

85 Eleven unique D. v. virgifera BEL elements were identified that contained full-length gag-pol codin

86 A unique MyoB light chain (MLC-B) was identified that contains a calmodulin-like domain at

87 urthermore, other genetic polymorphisms have been identified that contribute to risk or severity of m

88 share common pathways, and risk factors have been identified that contribute to the initiation and pr

89 teria, and a remarkable number of genes have been identified that contribute to the regulation of thi

90 , regulatory components, and mechanisms have been identified that control the initiation, morphogenes

91 Three drugs (CT3, SAB378 and SAD448) were identified that control spasticity via action on th

92 In addition, several molecular traits have been identified that correlate with site-specific mutati

93 An innate profile was identified that correlated with disease progression

94 Potential coaching pitfalls are identified that could interfere with each of the 3 r

95 ithin countries vary widely, and factors can be identified that could be modified to reduce the risk

96 odels a number of epigenetic mechanisms have been identified that could mediate vertical transmission

97 r distinct clusters of patients with AD have been identified that could represent endotypes with uniq

98 Polymeric substrates are being identified that could permit translation of human

99 ntly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (s

100 ng cancer subtypes and a list of new markers were identified that could be lineage-specifically assoc

101 DENV-1 and DENV-3 strains were identified that could be used to test for protectio

102 neutralization sensitive, although mutations were identified that could confer CD4-independent infect

103 of human-centered problems in communication were identified that could provide the motivation for a

104 Two major retinotopic maps were identified that cover PL and PIcl, the dorsal one i

105 Several conserved amino acids were identified that create a hydrophobic binding pocket

106 Several interaction partners of alpha-Nrxn are identified that depend on alternative splicing, incl

107 One set of molecules was identified that, depending on the concentrations, in

108 Six steps were identified that determine steady state cell surface

109 nts of mouse cytomegalovirus (MCMV) a mutant was identified that did not elicit cell rounding and lac

110 Nevertheless, to date, very few ligands have been identified that directly interact with histidine ki

111 of the signaling cascade; however, none have been identified that directly target active beta-catenin

112 Six clusters of between 5 and 7 transcripts were identified that discriminated between stroke and co

113 ious anticancer drugs, a series of compounds were identified that displayed potent cytotoxicity towar

114 Sixty-six classifier genes were identified that distinguished infants with and with

115 specific regulatory B cell subsets recently were identified that downregulate adaptive and innate im

116 A plethora of genetic factors have been identified that drive the degeneration of motor neu

117 To date, no pyrophosphatase has been identified that employs an arginine finger fulfilli

118 Several additional important subgroups are identified that enable an estimate of the specific c

119 ures, critical enzyme-substrate interactions were identified that enable tight binding of MurNAc-alph

120 A modular Cu/ABNO catalyst system has been identified that enables efficient aerobic oxidative

121 reaction of 1,2-diketones with amidines has been identified that enables their transformation into i

122 l genes (nf2152, nf2215, nf2523, and pr2455) were identified that encode family 39 glycoside hydrolas

123 Ten studies were identified that evaluated ICD use in patients with

124 A number of Zur-regulated genes were identified that exhibit increased expression both w

125 ough comparative analyses genes and pathways were identified that exhibit unique genetic changes and

126 Two groups of elements were identified that exhibited different responses.

127 No studies were identified that explicitly investigated the costs o

128 However, many cells were identified that fired in bursts unrelated to the an

129 he last two decades, more than 20 genes have been identified that function in SJ biogenesis in Drosop

130 r toxin/antitoxin (TA) systems, no toxin has been identified that functions by cleaving DNA.

131 2,3-dihydroxypropyl cysteine at position 190 was identified that had significantly increased activity

132 Among a predictive set of 80 SNPs, 6 loci were identified that had a significant degree of functio

133 within the transmembrane domain (TM) regions were identified that had differential effects on acetyle

134 amilies (including 75,724 total individuals) were identified that had no individuals with an ASD diag

135 tworks, from which 12 resting-state networks were identified that had significant voxel-wise function

136 Two papers were identified that had sufficiently similar study desi

137 wever, several shortcomings of OECD 308 have been identified that hamper data evaluation and interpre

138 ver, to date, no human-derived substrate has been identified that has the capacity to interact with t

139 ma compounds from different substance groups were identified that have hitherto not been described in

140 In this study, two key factors were identified that have important and counterbalancing

141 of the country's development experience can be identified that help explain its unexpected health tr

142 pression between SCs, a total of 1,384 genes were identified that highly differentiated the SCs at an

143 An additional 1193 markers were identified that illuminated genomic regions exhibit

144 Several conserved bacterial riboregulators were identified that impacted this response.

145 Seventy-one relevant articles were identified that included a total of 387,569 partici

146 Two equivalent protocols were identified that included both BS and respective WC

147 Chlamydomonas reinhardtii, and 243 compounds were identified that increase triacylglyceride (TAG) acc

148 Two tir1 mutations were identified that increased interaction with Aux/IAAs

149 those, a mutation in the viral hemagglutinin was identified that increases 2009 pandemic H1N1 virus b

150 growing number of transcription factors have been identified that influence the EMT/MET processes.

151 RN1], VRN2, and FLOWERING LOCUS T [FT]) have been identified that influence the vernalization require

152 complexes were performed, and a key residue was identified that influences the plant PPO's acceptanc

153 n anonymous gene variant in C14ORF39/SIX6OS1 was identified that influences the recombination rate in

154 To date, small-molecule inhibitors have been identified that inhibit HIV-1 capsid assembly and/o

155 vitro, and a number of small molecules have been identified that inhibit Tau fibril formation.

156 Two mutants were identified that inhibit F-mediated fusion by stabil

157 g approach, a series of benzopyran compounds was identified that inhibited the catalytic activity of

158 Compounds structurally related to the hits were identified that inhibited the E. coli SC and SC-med

159 Furthermore, various proteins have been identified that interact with APP and modulate its

160 Six phages were identified that interacted exclusively with Rhodoba

161 Several core groups of cellular proteins were identified that interacted with each viral protein

162 Eight cross-sectional studies were identified that investigated the effect of dietary

163 Two potential modes of activation have been identified that involve donation of electron densit

164 lecule soluble in an aprotic electrolyte can be identified that is stable for repeated cycling and do

165 A pyridazinone series has been identified that is significantly more THR-beta sele

166 inding site remote from the catalytic center was identified that is distinct from one reported for th

167 and cell assays, a promising lead candidate was identified that is efficiently processed and has hig

168 of-function AKT2 coding variant (p.Pro50Thr) was identified that is nearly specific to Finns (frequen

169 n's disease, a disease-specific physiomarker was identified that is now used to investigate adaptive

170 c analyses, a set of nearly 600 polypeptides was identified that is present in green algae and flower

171 A common motif in each NELF was identified that is required for full activity of bot

172 ors, biological and genetic differences have been identified that lead to differential disease course

173 et genes in the heart are the first genes to be identified that likely play an important role in medi

174 istical, economic, and regulatory deterrents were identified that limit the performance of AR researc

175 A key regulator of ciliary shape has now been identified that links the establishment of neuronal

176 Key amino acid residue substitutions were identified that make rabbit recombinant PrP suscept

177 In addition, avenues are identified that may be exploited for photosynthesis

178 Along with IMGT VH 50, other positions are identified that may help to promote a TCR-like orien

179 ndothelium that impairs insulin movement has been identified that may contribute to type 2 diabetes p

180 pression and a related genetic variation has been identified that may predispose individuals for thes

181 New miR-21 targets were identified that may be important during PD fibrogen

182 netic alterations in specific pathways in MF were identified that may be viable, effective new target

183 stitutions associated with treatment failure were identified that may contribute to resistance of thi

184 Transcripts were identified that may control metabolic fluxes.

185 Several transcription factors were identified that may control these shared processes

186 Several sequence features were identified that may influence hotspot intensity and

187 Factors were identified that may prove useful in targeting those

188 Numerous potential benefits were identified that may result from nurses having a gre

189 r loci, A and B (renamed NIC1 and NIC2) have been identified that mediate JA-inducible nicotine forma

190 Six-clustered gene products have been identified that mediate sequential catalysis of DHN

191 Nine genes linked to Actin dynamics were identified that mediate invasion in situ.

192 However, no Mediator subunit has yet been identified that mediates WRI1 transcriptional activ

193 Thirteen studies were identified that met the inclusion criteria for revi

194 improvements in preclinical study design can be identified that might also increase the likelihood of

195 Some interventions have been identified that modestly slow progression and prolo

196 for an approach by which small molecules can be identified that modulate IL-18 activity.

197 Recently, several metabolites have been identified that modulate ageing; however, the molec

198 In addition, a variety of compounds have been identified that modulate agonist-evoked responses o

199 c infection phenotypes, some regulators have been identified that modulate multiple virulence mechani

200 several novel influenza virus proteins have been identified that modulate viral infections in vitro

201 A number of conditions were identified that modulate the onset of anaphylaxis s

202 a range of limitations and factors have also been identified that must be taken into consideration wh

203 ected, but no individual system has hitherto been identified that must have been formed by migration.

204 cceptable for nurses and a number of aspects were identified that need to be considered prior to cond

205 Furthermore, aptamers were identified that not only bound with high affinity,

206 similar gene pairs with opposing codon bias were identified that not only manifest dichotomous prote

207 aB signaling, but small-molecule derivatives were identified that only marginally affected these path

208 However, several species have been identified that perform C(4) photosynthesis using d

209 es of hFXR, K122, K210, K339, and K460, have been identified that play a critical role in FXR target

210 t cells, a microtubule-dependent network has been identified that polarizes the distribution of signa

211 Several derivatives were identified that possess greater protective effect i

212 minishes.IMPORTANCE Multiple antibodies have been identified that potently neutralize a broad range o

213 Recently, a less toxic variant (BC194) was identified that potently inhibits angiogenesis.

214 nts," several medical conditions among youth were identified that predispose to accelerated atheroscl

215 Rotavirus (RV) strains have been identified that preferentially replicate in neonate

216 Regions of the pSTS were identified that preferred visually presented moving

217 c, which slow the proton translocation rate, are identified that prevent epsilon-deficient ATP syntha

218 ne called XPG-like endonuclease1 (GEN1) have been identified that process HJs in a manner analogous t

219 mutations in a growing number of genes have been identified that produce autosomal recessive forms o

220 o Medicago truncatula Tnt1-insertion mutants were identified that produced small nodules, which were

221 the roots, an oxidosqualene cyclase, OsONS1, was identified that produces alpha-onocerin from squalen

222 Cu/nitroxyl catalysts have been identified that promote highly efficient and select

223 e amongst older adults, and few factors have been identified that promote their resilience.

224 However, no neurobiological markers have been identified that prospectively predict MDD course tr

225 read between cells, but it has more recently been identified that protein effectors secreted by funga

226 five cross-validated consensus mutants could be identified that provide structural constraints for tr

227 ition, an array of CIB1 binding partners has been identified that provide important insight into how

228 Host biomarkers were identified that provide high predictive value under

229 Spinal afferent axons were identified that ramified extensively through many r

230 Multiple pan-ebolavirus antibodies were identified that react to the Ebola, Sudan, Bundibug

231 , cell-permeable naphthalene-based tetrazole was identified that reacts with acrylamide with the effe

232 Antisense oligonucleotides (ASOs) are identified that reduce GGGGCC-containing nuclear foc

233 nd no clinically relevant interventions have been identified that reduce the number of these HIV DNA-

234 ecently, a common human polymorphism (R287Q) was identified that reduces sEH hydrolase activity and i

235 Although many compounds have been identified that regulate glutamate receptor activit

236 chanisms originating within the plastid have been identified that regulate stromule activity, a criti

237 Several miRNAs have been identified that regulate the amplitude of the innat

238 asticity and a large number of proteins have been identified that regulate this complex process.

239 A total of 65 key lncRNAs were identified that regulate 20 significantly enriched

240 desmal-localized beta-1,3 glucanases (PdBGs) were identified that regulate callose accumulation and t

241 Overall, mechanisms were identified that regulate the multifaceted roles of

242 re than 13000 of these series, key compounds were identified that represented substitution sites of a

243 A mortality, and a novel obesity paradox has been identified that requires further investigation.

244 Multiple yeast prions have been identified that result from the structural conversi

245 Combination therapies were identified that resulted in complete and sustained

246 in the second family, a variant (c.1102G>C) was identified that results in a splicing defect leading

247 Several non-bactericidal compounds were identified that reversed intrinsic resistance to be

248 Cases have been identified that seem to be best suited for differen

249 Cases have been identified that seem to be best suited for differen

250 nonsense and HOXC11 S191F missense mutations were identified that segregate in clubfoot families.

251 LMNB2, a novel homozygous missense mutation was identified that segregated with the PME in the famil

252 Two main clusters were identified that segregated controls from all other

253 tion, structural modifications of compound 2 were identified that segregated Hsp90 inhibition from MA

254 Three main clusters were identified that separated the control and chronic p

255 ic, Mediterranean, and Southern Ocean waters were identified that share a substantial percentage of r

256 hemical probes, BI-7273 (1) and BI-9564 (2), were identified that should prove to be useful in furthe

257 A version of 5c8 with a mutated IgG1 tail was identified that showed minimal FcgammaR binding and

258 Correlations between 34 gene loci were identified that showed concordant variations in gen

259 (n = 21), Round (n = 7) and Spindle (n = 12) were identified that showed distinct biological and mole

260 ven cytosine guanine dinucleotide (CpG) loci were identified that showed no significant temporal chan

261 tational modeling, potent pan-JNK inhibitors were identified that showed submicromolar activity in a

262 However, individual CC lines were identified that showed type 2 diabetes mellitus (t2

263 portant, several risk gene variants have now been identified that significantly contribute to ASD sus

264 o determine whether distinct PD patterns can be identified that, similar to electrographic seizures,

265 e intimately connected, and several TFs have been identified that simultaneously control both process

266 A limited number of unique mutations are identified that stabilize the prefusion conformation

267 xpected for a tegument protein, interactions were identified that suggest distinct roles for pUL103 a

268 One hundred eighty two GIS genes were identified that suppressed GCR formation.

269 nal haplotypes, and current depression score were identified that survived correction for multiple te

270 Several toxins from venomous animals have been identified that target ASICs with high specificity

271 promising therapeutic candidates for FD have been identified that target the underlying mRNA splicing

272 fied by the compound nucleozin, has recently been identified that targets the viral nucleoprotein (NP

273 In Arabidopsis, a genetic toolbox has been identified that tightly controls stomatal developme

274 tein-peptide interaction, and four mutations were identified that together improved the affinity for

275 al positions in the ECL3s of GCGR and GLP-1R were identified that tolerate SphK mutagenesis and subse

276 Short ciliary targeting sequences (CTS) have been identified that trigger the transport of ciliary pr

277 A variety of fluorescent proteins have been identified that undergo shifts in spectral emission

278 a collection of host virus resistance genes was identified that, upon silencing, increased polioviru

279 HIV/macaque model, HIV-1 Env proteins should be identified that use mCD4 as a functional receptor and

280 lausible region of the simulator input space was identified that was 10(11) times smaller than the or

281 , a pool of biotinylatable membrane proteins was identified that was sufficient to resupply flagella

282 Rather, a hybrid pathway was identified that we call the modified K-R (MK-R) path

283 to the phylogenetics of RSV, emergent clades were identified that we termed High Titre (HiT) clades o

284 Echocardiographic mechanistic features were identified that were associated with improvement in

285 Within the population, 4 growth patterns were identified that were each characterized by worsenin

286 ing assays, 466 highly promiscuous compounds were identified that were examined for known pan-assay i

287 ext-generation sequencing, 96 SHFV body TRSs were identified that were functional in both infected MA

288 n modules (four modules totaling 8398 genes) were identified that were highly preserved across divers

289 By conditioning on this variable, biomarkers were identified that were more likely to be effective in

290 Two ent-steroids were identified that were more potent than the anestheti

291 Combinations of Ab responses were identified that were more strongly associated with

292 Another 438 cooperatively acting GIS genes were identified that were not GIS genes, but suppressed

293 Several drug-sensitive shRNAs were identified that were selectively depleted in the pr

294 Several growth-related proteins were identified that were ubiquitinated and degraded mor

295 nd tissue inhibitor of metalloproteinases 1) were identified that, when combined through a classifica

296 Characteristic "ion groups" and "key ions" were identified that, when combined with their CAD produ

297 Within this loop, four residues were identified that, when mutated, resulted in the appe

298 e no naturally tool-using congeners have yet been identified that would enable informative comparison

299 s, multiple preserved communication pathways were identified that would allow such long-range signali

300 Thirteen low concentration PSs were identified that would otherwise not have been disti