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4 comparable control group, cognitive function was impaired in 4 of the 6 cognitive domains tested (med
5 neumococcal polysaccharide antibody response was impaired in 87% of patients (ie, antibody titer abov
7 d mechanism for dendrite establishment might be impaired in a human genetic epilepsy syndrome, polyhy
12 GIPR, GLP-1-mediated GLP-1R internalization was impaired in a GIPR concentration-dependent manner.
13 ANK-associated RH domain-interacting protein was impaired in a male fetus with IP, leading to defecti
14 tion and secretion of SBT3 in vivo Secretion was impaired in a propeptide-deletion mutant but could b
17 w that patients with cerebellar degeneration are impaired in adapting feedforward control of speech b
19 type in recycling membrane lipids to TAG but being impaired in additional de novo synthesis of TAG du
20 defects and communication with immune cells are impaired in aged keratinocytes, diminishing their ef
21 ffinity between Sesn2 and AMPK upstream LKB1 is impaired in aged hearts during ischemia (P < 0.05 vs.
23 lated by the Sesn2-AMPK complex in the heart-is impaired in aging that sensitizes the heart to ischem
24 opic glutamate receptor-dependent plasticity is impaired in AIDA-1 cKO mice, further supporting a rol
26 alcohol as wild-type animals; however, they were impaired in alcohol seeking during the motivation t
28 BCR-mediated canonical NF-kappaB signaling was impaired in all mature naive CVID-derived B cells.
30 Furthermore, repression of cryptic exons was impaired in ALS-FTD cases, suggesting that this spli
33 diated ubiquitination and degradation, which is impaired in approximately 6% of diffuse large B-cell
35 tioning studies revealed that remobilization is impaired in atg12 plants, which significantly decreas
37 matin and identified mutants of cohesin that are impaired in ATPase activity but remarkably confer ro
38 ed for cell fission and infectivity, BB0323, is impaired in BbhtrA mutants grown at 37 degrees C, whi
41 phospho-mimetic residue Asp at this position is impaired in both signalling and Myddosome assembly.
42 to increase vulnerability to drug addiction-was impaired in both adolescent mice and adult mice with
45 r (mGluR)-induced dendritic spine regulation was impaired in both Fmr1(-/y) and Cyfip2(+/-) cortical
48 cation fork stalling, as replication-restart was impaired in both SMI#9-pretreated and RAD6B-silenced
49 cGMP- and Ca(2+)-mediated inhibition of NHE3 was impaired in both the internal and the C-terminal PBM
52 gnaling response in peripheral blood T cells is impaired in breast cancer patients and is associated
53 ate to terminate inflammation, and which may be impaired in C1q-deficient patients with autoimmune di
54 In human arterioles, H2O2-induced dilation is impaired in CAD, which is associated with a transitio
57 activation of insulin, and PI3K-Akt pathways were impaired in CCR5 and CCL5 deficient hypothalamus.
58 f-ubiquitination and proteasomal degradation is impaired in Cd28(-/-) T cells, the defective developm
59 orphology in response to anti-CD40 plus IL-4 were impaired in Cdc42-deficient B cells compared with W
64 pacitance decay following strong stimulation is impaired in cKO; the rapid capacitance changes immedi
65 c theories assume such metacognitive insight is impaired in compulsivity, though this is supported by
67 ound that fetal monocyte maturation into AMs was impaired in Cre(+)5(f/f) mice, and we also confirmed
69 king the type I IFN signaling molecule STAT2 are impaired in cross-presenting tumor Ags to CD8(+) T c
72 innate defense mechanism in airways, and it is impaired in cystic fibrosis (CF) and other obstructiv
73 maturation and that phagosomal acidification was impaired in DCs in which the gene encoding TFEB was
78 This work demonstrates that PKA signaling is impaired in diabetes and suggests that treating hyper
81 ed binding of the UBXD1 adaptor protein that is impaired in disease; this underlies the potential for
82 understood transient brain oscillation that is impaired in disorders such as Alzheimer's disease and
84 docytosis of the thrombopoietin receptor Mpl was impaired in Dnm2-null platelets, causing constitutiv
85 signaling in response to replication stress is impaired in DONSON-deficient cells, resulting in decr
88 e response to adenosine receptor stimulation was impaired in eKO mice in single cells in patch clamp
91 to the NER proteome and DNA excision repair is impaired in extracts prepared from FICZ/UVA-treated c
92 and associated auditory cortical plasticity are impaired in female Mecp2(het) mice, a model of Rett
94 uced formation of NEMO-containing structures was impaired in fibroblasts from patients with IP carryi
96 iating leukocyte slow rolling and emigration are impaired in Gal-3(-/-) mice, which could be because
102 tissue factor-triggered thrombin generation was impaired in GPVI-deficient patients and reduced by t
103 approximately half had >/=3 comorbidities or were impaired in >/=1 aspect that significantly interfer
105 ing the actin-related protein6 mutant, which is impaired in H2A.Z deposition, and by H2A.Z profiling
110 triguingly, the function of this zinc finger is impaired in high-altitude-adapted Tibetans, suggestin
112 berculosis-specific CD4 T cell immunity that are impaired in HIV-infected individuals with LTBI, whic
117 d IFN-lambda1 antiviral activity against HCV was impaired in IL28B T/T infected hepatocytes compared
118 N-gamma production and microbicidal activity were impaired in individuals with diabetes mellitus (DM)
120 to maintain skeletal muscle mass appears to be impaired in insulin-resistant conditions, such as typ
122 plants grown under iron-deficient conditions was impaired in iron-regulated transporter1 and ferric c
123 lucosyl-transferase, STARCH SYNTHASE 4 (SS4) is impaired in its ability to initiate starch granules;
124 spastic paraplegia mutant, ATL1-F151S, that is impaired in its nucleotide-hydrolysis cycle but can s
125 ts of crude total lipids revealed that roc40 was impaired in its ability to increase the accumulation
126 , capillarization of the infarct border zone was impaired in KO mice, and the animals developed large
128 efective in TCR-dependent NFkappaB signaling were impaired in late expression of Pim-1, Eomes, and CD
129 ts with combined manipulation of OFC and NAC were impaired in learning to use environmental cues to w
133 rophils and inflammatory cytokine production are impaired in M-ILK-deficient mice, and activation of
135 y we found that invitro efferocytosis of ACM was impaired in macrophages from db/db (diabetic) mice.
136 plication of the PF74-resistant HIV-1 mutant was impaired in macrophages, likely owing to altered int
140 We found that glutamate release in the brain was impaired in mice lacking low-density lipoprotein rec
142 and thus initiation of liver tumorigenesis, were impaired in mice harboring a MYC mutant unable to a
143 ) mice), we show that long-term potentiation is impaired in MKP-2(-/-) mice compared with MKP-2(+/+)
148 ary acidic protein in the hippocampus, which was impaired in Morris water maze-trained IL-4- and IL-1
149 ke receptor (TLR) 9-induced B-cell responses are impaired in most patients with common variable immun
150 e function and reward system neural activity are impaired in most psychiatric disorders, it is unknow
151 ese reasons, the growth of a DeltaICP0 virus is impaired in most cells, except cells of the human ost
152 hermore, we demonstrate that the in vivo HSR is impaired in mouse models of Huntington's disease but
153 ates the expression of amino acid permeases, are impaired in multiple aspects of fungus-macrophage in
155 anelle that is essential for the Hh pathway, was impaired in mutant dermal condensate cells, suggesti
156 HCM carrying MYBPC3 mutations, (2) autophagy is impaired in Mybpc3-targeted knockin mice, and (3) act
159 ortex (mPFC) serves executive functions that are impaired in neuropsychiatric disorders and pain.
160 otor functions and cognitive processing that are impaired in neuropsychiatric disorders such as Parki
168 that rats with contralateral PER-POR lesions were impaired in object-context recognition but not in c
169 ory innervation of mesenteric arteries (MAs) is impaired in Old ( approximately 24 months) versus You
172 ulation when cytosolic Fe-S cluster assembly is impaired in order to maintain optimal iron levels for
174 RA reservoir and passive conduit functions are impaired in PAH, independent of RA size and pressure
175 the principal cellular degradative pathway, is impaired in pancreatitis, but it is unknown whether i
177 the recruitment of CD8+ T cells to the tumor is impaired, in part preventing containment or eliminati
178 In a community-based cohort, LA function was impaired in participants with prevalent HF, but ther
182 ) is a major airway host defence system that is impaired in patients with smoking-associated chronic
188 ial mechanism for why RBV antiviral activity is impaired in persistently HCV-infected cell cultures a
189 stomatosis virus-induced IL-1beta secretion was impaired in Pgam5(-/-) bone marrow-derived macrophag
191 or spoIIIAH mutants that complete engulfment are impaired in post-engulfment, forespore and mother ce
194 n and long-term potentiation-like plasticity were impaired in presymptomatic carriers, compared to he
195 that telomere length and telomerase activity are impaired in primary lymphocyte subsets from patients
196 he BCR, BAFFR, CXCR4, CXCR5, CD40, and TLR4, were impaired in promoting CD19 co-receptor activation a
198 shment of systemic acquired resistance (SAR) is impaired in proteasome mutants, suggesting that the p
203 ostatic regulation of intracellular chloride is impaired in pyramidal cells, yet how this dysregulati
206 t patients who received anterior cingulotomy were impaired in recognizing negative facial affect expr
207 domain produces channels that bind Hax-1 but are impaired in recruiting Arp2/3 to the plasma membrane
209 he circadian photoresponse to constant light was impaired in rh7 mutant flies, especially under dim l
210 n of the hypo-methylated nrpe1 mutant, which is impaired in RNA-directed DNA methylation, and the hyp
211 A-MPK3/sid2 and CA-MPK3/ein2-50 lines, which are impaired in SA synthesis and ethylene signaling, res
216 Visuospatial working memory (vsWM), which is impaired in schizophrenia, requires information trans
219 at developmental plasticity and connectivity are impaired in sensory systems in DS model mice, that s
220 a key role in cognition, and working memory is impaired in several neurological and psychiatric diso
221 is a core aspect of cognition, and one that is impaired in several neuropsychiatric diseases, includ
225 the first to show that immune tolerance may be impaired in spaceflight, leading to excessive inflamm
228 he hypothesis that gliovascular interactions are impaired in subjects with high burdens of white matt
229 ing, MMN, and P300 have been demonstrated to be impaired in subjects clinically at risk of developing
231 from patients with CF or from Cftr(-/-) mice were impaired in suppressing conventional T cells, an ef
234 percepts and decoding of integrated percepts are impaired in tandem, while leaving feedforward repres
236 ate and adaptive antibacterial host defenses are impaired in the context of preceding influenza virus
240 ived from patients with Ruijs-Aalfs syndrome are impaired in the resolution of covalent DPCs in vivo.
241 activity) of identified midbrain DA neurons are impaired in the ventral tegmental area (VTA), but no
245 fG1-4, whereas secretion of the inhibitor(s) is impaired in the biofilm-forming mutant, leading to sy
246 ein Tau, because its microtubule interaction is impaired in the course of Alzheimer's disease and sev
247 The observation that the BDNF/TrkB pathway is impaired in the dmNTS during CHF provides a novel mec
252 rformance in the single pellet reaching task was impaired in the AAV1/2-A53T-aSyn-injected stim-OFF g
253 rably reduced by phr1 and phl1 mutations and was impaired in the ABA-deficient aba2-3 and ABA-insensi
254 and evasion of lysosomal fusion, the mutant was impaired in the ability to initiate replication betw
258 ere initially decreased, whereas DF function was impaired in the beta2ARag-treated porcine wound bed.
260 Our results showed that auxin signaling was impaired in the gsnor1-3 mutant as revealed by signi
265 script cleavage and translational repression were impaired in the AGO3 mutant background, indicating
266 mmitment and oligodendrocyte differentiation were impaired in the corpus callosum of Olig1-null mice,
267 ptor 1/2 (TLR1/2), TLR2/6, and TLR4 agonists were impaired in the fibroblasts and leukocytes of all T
269 endent effects on some clock gene expression were impaired in the liver of mice deficient for BMAL1,
270 ight ventricular effective refractory period were impaired in the mutant mice, whereas sinus nodal fu
271 region or arm-like P-domain of calreticulin are impaired in their abilities to induce apoptotic cell
272 e formation of antibody-toxin complexes that are impaired in their ability to access host cell recept
273 mouse model that NanA-deficient pneumococci are impaired in their ability to cause both nasal coloni
274 th more mature but still naive T cells, RTEs are impaired in their ability to perform aerobic glycoly
275 om subjects with established type 1 diabetes were impaired in their ability to produce CCL3 and CCL4.
276 and macrophages lacking type I IFN signaling were impaired in their ability to promote IL-18 inductio
277 gs deficient for expression of CCL3 and CCL4 were impaired in their ability to suppress experimental
278 nt to the CD4(+)CD8(-) single-positive stage are impaired in Themis(-/-) mice, suggesting that Themis
286 may explain how peripheral immune tolerance is impaired in tissues under autoimmune attack, includin
289 the pro-apoptotic mediators CamkII and Stat1 was impaired in Trpc3-deficient M1 cells, gathering insi
290 eries of cognitive and social tasks known to be impaired in two different 16p11.2 deletion mouse mode
291 suggest that retinoid metabolism in the eye is impaired in type 1 diabetes, which leads to deficient
295 1K mutation, we show that hnRNP K expression is impaired in urea soluble extracts from mutant TDP-43
296 A new study shows that Parkinson patients are impaired in using their prior knowledge leading to s
298 ogical sensory attenuation has been shown to be impaired in various patient groups, so understanding
300 Here we show that polarization of node cells is impaired in Wnt5a(-/-)Wnt5b(-/-) and Sfrp mutant embr
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