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1 piratory viruses--the "common cold" viruses--are implicated as a principal cause, there is little evi
3 these conditions, sorting nexin 9 (Snx9) can be implicated as a specific adaptor that replaces toca-1
7 Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, the
10 previously reported, FMD has not previously been implicated as a cause of MP, and the massive extent
12 equent following acute brain injury and have been implicated as a cause of secondary brain injury, bu
14 ) from burning "smoky" (bituminous) coal has been implicated as a cause of the high lung cancer incid
16 lly, mutagenic action of mismatch repair has been implicated as a cause of triplet repeat expansions
18 In the years since its discovery, IL-23 has been implicated as a central pathogenic factor in multip
19 se to an oxidative insult, wild-type p53 has been implicated as a central regulatory component of the
20 e repeat-containing protein alpha (SGTA) has been implicated as a co-chaperone and regulator of andro
21 liver cancer, and the HBV X protein (pX) has been implicated as a cofactor in hepatocyte transformati
23 Greater preference for immediate reward has been implicated as a component of several psychiatric di
24 scription factor Forkhead box N1 (FOXN1) has been implicated as a component of the mechanism regulati
27 transcription factor mesogenin 1 (Msgn1) has been implicated as a cooperative regulator working in co
28 EBV origin of plasmid replication (OriP) has been implicated as a critical control element for viral
30 on of nuclear factor-kappaB (NF-kappaB), has been implicated as a critical molecular link between inf
35 ithelial-to-mesenchymal transition (EMT) has been implicated as a drug resistance mechanism in multip
38 or secretory product of human mast cells has been implicated as a key mediator of allergic inflammati
45 al cues from the surrounding environment has been implicated as a key regulator of cell differentiati
48 ated phosphorylation of serine 36 in p66 has been implicated as a key regulatory step preceding mitoc
57 )-hyper-inflammatory monocytic phenotype has been implicated as a mechanism of exacerbated tissue des
58 ion to its role in anaphylaxis, PAF has also been implicated as a mediator in both allergic and nonal
60 expressed on variety of immune cells and has been implicated as a mediator of diverse inflammatory di
62 arvation-induced stress, COPII vesicles have been implicated as a membrane source for autophagosomes,
63 m in the monoamine oxidase A (MAOA) gene has been implicated as a moderating factor in the relationsh
64 SAMHD1 is a dGTP-activated dNTPase that has been implicated as a modulator of the innate immune resp
66 PilY1 protein of Pseudomonas aeruginosa has been implicated as a novel mechanosensor that stimulates
67 avity, is both common and modifiable and has been implicated as a novel potential CKD risk factor.
69 Promyelocytic leukemia protein (PML) has been implicated as a participant in multiple cellular pr
70 and systemic inflammatory responses and have been implicated as a pathogenic factor in necrotizing en
74 RNA (dsRNA) virus Leishmaniavirus (LRV1) has been implicated as a pathogenicity factor for leishmania
75 with pathogen- and self-derived peptides has been implicated as a pathway involved in the development
77 iptional modification of RNA nucleosides has been implicated as a pivotal regulator of mRNA biology.
81 gh historically reactive oxygen species have been implicated as a potential cause of ageing, recent e
82 r immediate over larger delayed rewards, has been implicated as a potential intermediate phenotype (e
84 abotropic glutamate receptor 5 (mGluR5) have been implicated as a potential pharmacotherapy for a num
85 e and polymorphism in the human ID3 gene has been implicated as a potential risk marker of atheroscle
86 or of a number of signaling pathways and has been implicated as a potential target for oncology and d
90 abinoid type 2 receptor (CB2) has previously been implicated as a regulator of tumor growth, bone rem
91 g to the heme cofactor of H-NOX proteins has been implicated as a regulatory mechanism for processes
94 is an inflammatory chronic disease that has been implicated as a risk factor for cardiovascular dise
96 y homologue of a human gene, BTBD9, that has been implicated as a risk factor for restless legs displ
98 The lateral intraparietal area (LIP) has been implicated as a salience map for control of saccadi
100 bolism during fasting and starvation and has been implicated as a signal connecting nutrition, growth
102 hydrogen peroxide, a diffusible ROS that has been implicated as a signaling molecule, alleviated hepa
103 biosynthesis of the NAD cofactor, which has been implicated as a target for developing new antimycob
105 ngosine 1-phosphate (S1P) lyase has recently been implicated as a therapeutic target for the treatmen
106 al sensor for pH/bicarbonate/CO2, and it has been implicated as a therapeutic target, e.g. for diabet
112 ient receptor potential 3 (TRPV3), which has been implicated as a warmth detector, becomes responsive
115 tin, a potent activator of GnRH neurons that is implicated as a critical permissive signal triggering
119 end of an intergenic region on Chr11p13 that is implicated as a modifier of cystic fibrosis airway di
122 s (DCN) following intense sound exposure and is implicated as a possible neural correlate of noise-in
123 dependent cysteine protease calpain 1 (Cal1) is implicated as a primary or secondary pathological eve
127 pressed in myeloid and bone marrow cells and was implicated as a checkpoint regulator of inflammatory
129 Macrophage colony stimulating factor (M-CSF) was implicated as a contributing upstream activator of m
131 ular chaperone heat shock protein 90 (Hsp90) was implicated as a major regulator of temperature-depen
132 , which is decreased in Alzheimer's disease, was implicated as a potential mediator of long-term chol
134 orylation-regulated kinase 1 A (DYRK1A) gene was implicated as a risk factor for autism spectrum diso
137 a interferon (IFN-alpha/beta) responses, has been implicated as an EBOV-encoded factor that contribut
138 regulated by transcription factor HSF-1 has been implicated as an effector mechanism, the role and p
140 nase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis a
142 ingolipid, ceramide 1-phosphate (C-1-P), has been implicated as an extracellular chemotactic agent di
144 ncompletely understood, oxidative stress has been implicated as an important contributor in the devel
145 ing via the IL-6 signal transducer GP130 has been implicated as an important driver of MM pathogenesi
146 ed derivative of 5-methylcytosine (5mC), has been implicated as an important epigenetic regulator of
147 ological diseases, including autism, and has been implicated as an important gene in human-specific e
148 ng is increased in menopausal women, and has been implicated as an important mediator of hot flushes.
149 C-type lectin expressed in renal tissue, has been implicated as an important trigger of complement ac
153 tally determined structure of Abeta that has been implicated as an intermediate in the aggregation pa
154 it of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcino
160 of methylated cytosines, a modification that is implicated as an initiating step of mitosis-independe
161 Flavonols are plant metabolites that have been implicated as antioxidants; however, their antioxid
164 ids and inorganic polyphosphate (polyP) have been implicated as being important (patho)physiologicall
166 mmalian target of rapamycin (mTOR) signaling was implicated as being involved in the regulation of mi
167 ement of the orphan receptor Tie1, which has been implicated as both a positive and negative regulato
172 though polar biotransformation products have been implicated as causative genotoxic agents, no specif
173 tion with other deletions in the region have been implicated as causative of the 5q- syndrome phenoty
174 Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality.
175 Cockroach and mouse allergens have both been implicated as causes in inner-city asthma morbidity
176 impaired clearance of apoptotic cells, have been implicated as causes of failure to resolve gut infl
177 Increasingly, nonfecal sources of FIB have been implicated as causes of poor microbial water qualit
178 rus and Heartland virus, which have recently been implicated as causing severe acute febrile illnesse
180 lular nonreceptor tyrosine kinase, which has been implicated as central immune modulator promoting al
181 rotein (APP) into Abeta peptides, which have been implicated as central players in the pathology of A
182 ome arms 1p and 19q (1p/19q codeletion) have been implicated as clinically relevant markers of lower-
183 plexes, the Tic110 and 1 MDa complexes, have been implicated as constituents of the TIC translocon, a
184 bute to impaired beta-cell function and have been implicated as contributing factors to this disease.
185 -body energy homeostasis; its disruption has been implicated as contributing to the development of in
187 ypes and bone marrow-derived fibrocytes have been implicated as contributors to fibrotic lesions beca
188 n (DC-SIGN) and heparan sulfate proteoglycan were implicated as coreceptors because only the combinat
191 enchymal-to-epithelial transition (MET), has been implicated as critical in the metastatic colonizati
192 regulatory factor (IRF) family members have been implicated as critical transcription factors that f
193 eference and stability of hemagglutinin have been implicated as crucial determinants of airborne tran
195 listic interactions among bacteria have also been implicated as determinants of the microbiota compos
196 es across the genome, and a small subset has been implicated as downstream effectors in oncogenic pat
198 r consequences for cerebrovascular function, are implicated as driving cognitive impairment during ag
200 hibition shunts the kynurenine pathway-which is implicated as dysfunctional in various psychiatric di
201 bon (C) with appropriate management and thus are implicated as effective tools in stabilizing climate
202 tein peptide-specific cytotoxic CD8+ T cells are implicated as effectors in a transgenic mouse model
203 ells of the monocyte/macrophage lineage have been implicated as effectors in acute allograft rejectio
204 not natural killer cells or CD8(+) T cells, were implicated as effectors of the vorinostat antitumor
206 ine 1-phosphate (S1P) from sphingosine, have been implicated as essential intracellular messengers in
207 d play a role in neutrophil chemotaxis, have been implicated as fluid shear stress sensors that contr
208 omponents of the retromer coat complex, have been implicated as genetic risk factors for sporadic and
211 es in the assembly process in vitro and have been implicated as important neurotoxic species in AD.
212 ets, neutrophils, and factor XII (FXII) have been implicated as important players in the pathophysiol
217 immune responders in the brain, glial cells are implicated as key players in the onset and progressi
219 r of G-protein signaling (RGS) proteins have been implicated as key inhibitors of 5-HT(1A)Rs, whose a
221 (III)-superoxo species (Fe(III)-O2(-.)) have been implicated as key intermediates in the catalytic cy
222 minal cobalt(IV)-oxo (Co(IV)-O) species have been implicated as key intermediates in various cobalt-m
224 horins are transmembrane proteins, they have been implicated as ligands in different aspects of neura
227 nresponsiveness in Foxp3(-) cells, have both been implicated as mechanisms to suppress dangerous immu
230 T: Small conductance K(+) (SK) channels have been implicated as modulators of spontaneous depolarizat
231 ion of diffusible oligomeric aggregates that are implicated as neurotoxic agents in Alzheimer's disea
232 vesicles, including exosomes, have recently been implicated as novel mediators of immune cell commun
233 Several genes, including GRAMD2 and STAM, were implicated as novel ASD risk genes when integrating
235 ate determinant, and its hyperactivation has been implicated as oncogenic in several cancers includin
240 onging to the Fgf, Wnt and Bmp families have been implicated as patterning factors of the posterior m
242 amine, and norepinephrine transporters) have been implicated as playing major roles in the actions of
244 Forkhead family transcription factors have been implicated as positive (forkhead box [Fox] transcri
247 tituents as well as the caffeine in tea have been implicated as potential cancer-preventive compounds
248 (D3R) partial agonists and antagonists have been implicated as potential medications for substance u
249 arrhythmias are frequently reported and have been implicated as potential pathomechanisms of Sudden U
251 e oligomers of the amyloid-beta peptide have been implicated as proximal neurotoxins in Alzheimer's d
256 , this is the first time specific pesticides are implicated as risk factors for aggressive prostate c
257 ly prevalent in sub-Saharan African and have been implicated as risk factors for HIV acquisition.
259 s of the candidate genes have not previously been implicated as RP modifiers and their functions are
260 regulation and lamin B1 down-regulation have been implicated as senescence effectors, functional inte
261 landular tissue (FGT) assessed with MRI have been implicated as sensitive imaging biomarkers for brea
264 Large genomic copy number variations have been implicated as strong risk factors for schizophrenia
266 astasis-associated transcripts that have not been implicated as targets, effectors or potential bioma
267 the brush border of the apical membrane has been implicated as the "receptor" mediating albumin tran
268 er butzleri is an emerging pathogen that has been implicated as the causative agent of persistent wat
270 Of the validly described species, many have been implicated as the cause of serious human infections
271 Protein misfolding and/or aggregation has been implicated as the cause of several human diseases,
275 -interglacial timescales, the deep ocean has been implicated as the likely location of carbon sequest
283 In both cases the Antarctic ice sheet has been implicated as the primary contributor, hinting at i
284 support robust HIV-1 transcription and have been implicated as the primary reservoir of latent HIV-1
288 izontal lineN(+) horizontal lineC(CH3)2 (17) is implicated as the immediate precursor of azabutadiene
293 rils are observed in disease tissue and have been implicated as toxic agents responsible for neurodeg
294 ons of the amyloid beta-peptide (Abeta) have been implicated as toxic events in the development and p
298 NF (mSWI/SNF or BAF) complexes have recently been implicated as tumor suppressors in human malignanci
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