ライフサイエンスコーパス: be important for

1 n of nascent RNA by poly(A) polymerase (PAP) is important for 3' end maturation of almost all eukaryo

2 es in response to variations in temperature, are important for a number of aerospace, optical, energy

3 This new perspective on Katz centrality is important for a more comprehensive analysis of direct

4 g that uptake of miR-155-containing exosomes is important for a proper LPS response.

5 akaryoblastic MEG-01 cells showed that DREAM is important for A23187-induced Ca(2+) mobilization and

6 n regions support action category codes that are important for action recognition and action understa

7 ic residues at the N terminus of the channel are important for activation by PtdIns(3,5)P2 and inhibi

8 mal CPC, we suggest that spindle association is important for active Ipl1/Aurora B complexes to prefe

9 disrupts multiple output pathways thought to be important for activity rhythms, including PDF accumul

10 the TGFbeta pathway, indicated that they may be important for adhesion.

11 Protection from these ADP factors may be important for aging without significant ADP.

12 inhibitors, we observed that platelet DREAM is important for alpha-granule secretion, Ca(2+) mobiliz

13 at CD44V6 then sustains ERK signaling, which is important for AP-1 activity in lung fibroblasts.

14 ncer cells, ASM-mediated ceramide production is important for apoptosis, cell proliferation, and immu

15 lip on surface ruptures during an earthquake is important for assessing fault displacement, defining

16 Reproducible research is important for assessing the integrity of findings and

17 Our study demonstrates that Treg cells are important for B-cell differentiation from HSCs by ma

18 kin 6 (IL-6) gene encoding the cytokine that is important for B- and T-cell differentiation was knock

19 in host bacteria and which has been shown to be important for bacterial viability.

20 Epigenetic mechanisms are thought to be important for balancing effector and memory different

21 oteins are cell wall lipid transporters that are important for basic mycobacterial physiology and Myc

22 We found that MAVS is important for boosting optimal primary CD4(+) T cell

23 anoclusters with tailored surface structures are important for both fundamental studies and practical

24 ding to other microenvironmental cues, which is important for both normal and disease processes.

25 obe communication via small molecule signals is important for both symbiotic and pathogenic relations

26 f the 2-methyl-3-butyn-2-ol (alkynol) moiety was important for both biochemical and antimicrobial act

27 ure phospholipid of mitochondrial membranes, is important for cardiovascular health, and perturbation

28 Microbes produce metabolic resources that are important for cell growth yet leak into the environm

29 ure that organizes centrosomes and cilia and is important for cell signaling, cell cycle progression,

30 Maintaining genome integrity is important for cells and damaged DNA triggers autoimmu

31 Stress fibers-contractile actomyosin bundles-are important for cellular force production and adaptati

32 involving intrinsically disordered proteins are important for cellular function and common in all or

33 anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclea

34 Loss of function analysis revealed that Aire was important for centrosome number regulation and spind

35 rophyll synthesis revealed that this pathway is important for chlorophyll accumulation under a cycled

36 eres are found at the end of chromosomes and are important for chromosome stability.

37 proapoptotic function, Bim has been shown to be important for clonal deletion in several model system

38 ower phase, suggesting that the S4-S5 linker is important for communications between the pore gate an

39 Interneurons are important for computation in the brain, in particula

40 Taken together, FgSRP1 is important for conidiation, and pathogenesis and alter

41 Understanding source-sink dynamics is important for conservation management, particularly w

42 e of antiretroviral therapy during pregnancy is important for control of maternal human immunodeficie

43 identify target molecules in cell types that are important for controlling a variety of behaviors in

44 SK-3 pathway is a novel regulatory axis that is important for controlling the decision between T cell

45 ins suppress the levels of miR-424, and this is important for controlling the levels of CHK1, which p

46 Long-distance signalling is important for coordinating plant responses to the env

47 tion, which demonstrates that both processes are important for cry1 function.

48 egulated the malate-aspartate shuttle, which is important for cytoplasmic NAD(+) regeneration that su

49 orylation of S687 and S510, S512 and/or S514 are important for damage bypass and cell survival after

50 tal cortex activity related to choice values is important for decision-making we conducted an additio

51 In contrast, TLR7 was important for defense against disease in the lungs.

52 These findings are important for designing early intervention strategie

53 derstanding of the electrochemical interface is important for designing better electrochemical system

54 hese results suggest that these three traits are important for determining drought tolerance, and are

55 and insights derived from this study should be important for developing new analytical methods that

56 tion between H. schachtii and its host plant is important for developing a sustainable management sys

57 the excess burden of cardiovascular disease is important for developing effective strategies to impr

58 l the processes involved in HCMV replication is important for developing novel treatments.

59 sms governing Treg homeostasis may therefore be important for development of effective tumor immunoth

60 transmembrane helix 4 (TM4) that is known to be important for dimerization.

61 gether, these results suggest that the dlPFC is important for discrimination during elevated anxiety

62 gnal through the JAK/STAT signalling pathway are important for disease, informing the pathogenetic fu

63 , we (1) review methodological advances that are important for dissociating conscious experience from

64 ng' by human repair enzymes is considered to be important for DNA damage detection.

65 om the seed by the suberin and tannin layers is important for dormancy imposition.

66 ensation, since DNA sequence motifs shown to be important for dosage compensation complex (DCC) recru

67 te the analysis of these transporters, which is important for drug safety and physiological studies,

68 t pathways drive hygrosensory behavior: each is important for dry-seeking by hydrated flies and toget

69 Structural retinal imaging biomarkers are important for early recognition and monitoring of in

70 acrophages and NK cells, cell types known to be important for early defenses against L. monocytogenes

71 propose that Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithe

72 ubstantial evidence demonstrating that TIM-1 is important for efficient infection by hepatitis C viru

73 igase TRIM6 promotes VP35 ubiquitination and is important for efficient virus replication.

74 Understanding how Ras proteins are regulated is important for elucidating cell signaling pathways and

75 dulation of the amygdala by serotonin (5-HT) is important for emotional regulation and is implicated

76 The insights we obtain are important for engineering opto-spintronic devices th

77 The metabolism of glycerol-3-phosphate (G3P) is important for environmental stress responses by eukar

78 T-mTOR-mediated attenuation of IRE1 activity is important for ER remodelling dynamics and cell surviv

79 nd the ACC has motor areas and is thought to be important for error detection, the dialogue between t

80 ge and two loci on chromosomes 7D and 7H(ch) are important for esterification.

81 Ionotropic glutamate receptors are important for estradiol feedback, but it is not know

82 protein) class of E3 ubiquitin ligases that are important for eukaryotic protein degradation.

83 esin-3 family member KIF1A has been shown to be important for experience dependent neuroplasticity.

84 ate that both physical and climatic features are important for explaining the observed patterns of ge

85 t, deliver cargo and alter the fate of HSPCs is important for exploring such applications.

86 sion of other transcription factors known to be important for expression of IL-10, including Jun fami

87 tion and survival, indicating that androgens are important for extended survival.

88 eat LIZ contributed to TM-TM association and is important for F protein function and pre-fusion stabi

89 ation of subtype co-infection, was likely to be important for FIVPle transmission for the two major s

90 Therefore, authentication of food is important for food processors, retailers and consumer

91 Understanding the fate of gravel is important for forecasting the response of rivers to l

92 These observations are important for further informing Ebola vaccine and th

93 of indicators, and analytic standardization is important for further improvements in iron status ass

94 netic fields of nanoscale write heads, which is important for future miniaturization of these devices

95 red bees learn visual stimuli, a result that is important for future neurobiological studies in virtu

96 We find that lysine 104 is important for GEF recognition, because mutations at t

97 hogen Borrelia burgdorferi has been shown to be important for generating an inflammatory response to

98 gether, our data indicate that VPS4 activity is important for generating exosomes and ectosomes, ther

99 ir and single-strand break repair (SSBR) and is important for genetic integrity and normal neurologic

100 e protein kinase PskA was also identified as being important for glucose metabolism.

101 Here we show that HIF-1alpha is important for glucose metabolism and insulin action i

102 d central core of the trimeric interface and are important for GP-alphaDG interaction.

103 arch for genes within ExPEC isolate F11 that are important for growth in intestinal mucus, which is t

104 ure we showed that IGF-1 receptor activation is important for growth cone assembly and axonal formati

105 sa quiC1 gene knock-out demonstrates that it is important for growth on either quinate or shikimate.

106 mass, consisting mostly of skeletal muscle, is important for healthy aging.

107 A) generated from glucose and acetate uptake is important for histone acetylation and gene expression

108 bstrate, AMP-dependent protein kinase (AMPK) are important for HNK-mediated inhibition of pluripotenc

109 e, and continuously available water services are important for human development and health yet many

110 These findings are important for hydrology study in observation scarce

111 WD3 recruitment to stalled replication forks is important for ICL repair.

112 emonstrate that protein quantity and quality are important for improving energy balance.

113 This new approach will be important for improving estimates of species distribu

114 Although DCs are important for inducing both immunity and tolerance,

115 Th1/Th2 (IFN-gamma/ELISA antibodies) assays are important for infection detection, but cannot reliab

116 that the hydroxyl groups of (2S)-hesperetin are important for inhibition, in particular the phenyl-c

117 Whereas IL-6 classic signaling is important for innate and acquired immunity, IL-6 tran

118 simultaneously in a single integrated system is important for interpreting behavioral shifts of eithe

119 Together, our data suggest that SK1 is important for islet revascularization following trans

120 d hydrophobic groove on its surface that may be important for its function.

121 n, and pathogenesis and alternative splicing is important for its normal functions.

122 harge carriers in nanoscale titanium dioxide is important for its use in solar energy conversion, pho

123 ugh transcriptional regulation has proven to be important for keratinocyte differentiation, little is

124 Although in the epidermis Blimp1 is important for keratinocyte and sebocyte differentiati

125 e drivers of stability across spatial scales is important for land management and policy decisions.

126 are associated with memory reactivation and are important for learning, but their specific memory fu

127 This suggests that GluA1 may be important for learning that is sensitive to the tempo

128 is activated by Leishmania and this pathway is important for Leishmania amazonensis infection.

129 osine kinase receptor that has been shown to be important for lens development and to contribute to b

130 cation of key residues of the receptors that are important for ligand functionality and selectivity.

131 ns, along with an additional site, which may be important for lipid binding, show increased stability

132 itional cellular contributors beyond B cells are important for lupus pathogenesis.

133 3 pathway during L. amazonensis phagocytosis is important for macrophage restriction of the parasite

134 in regulates synaptic transmission and might be important for maintaining energy homeostasis.

135 ial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis an

136 transcription, whereas in +1 nucleosomes, it is important for maintaining the activity of some genes.

137 together, PknG-mediated GarA phosphorylation is important for maintenance of both mycobacterial physi

138 dioxygenase-related N-terminal domain, which is important for MCM loading, but not for subsequent rep

139 at the lateral borders of the sarcomere and is important for mechanical stability and contractility

140 h suggest that the hormone oxytocin (OT) may be important for metabolic regulation.

141 t, and determined that serum response factor is important for MFG-E8 production in myofibroblasts.

142 Evidence exists that shows glucagon is important for minute-to-minute regulation of postpran

143 crotubule-binding capacity of the SAH domain is important for mitotic arrest in conditions of suppres

144 on-induced calcium responses are believed to be important for modulating downstream bioeffects such a

145 e cortex (ACC, areas 24a and 24b) appears to be important for mood disorders and constitutes a neuroa

146 well established that climbing fibre signals are important for motor coordination, the mechanisms by

147 ic head domains with ATP bound at both sites is important for MRN functions in eukaryotic cells.

148 promote myelination.Axon-glial communication is important for myelination.

149 o the central plaque from within the nucleus is important for NE insertion of the new SPB.

150 s and transition metal dichalcogenides which are important for next generation electronic devices.

151 l for thrombosis formation and pathways that are important for non-hemostatic functions.

152 Autophagy is important for normal cellular and organismal physiolo

153 re, information obtained from this study may be important for novel anti-HIV drug development.

154 lso suggest that GPD2 and GPD3 GPDH isoforms are important for nutrient starvation-induced TAG accumu

155 ol of ZIF nanocrystals are considered, which are important for optimizing the textural characteristic

156 al immune functions, they have been shown to be important for organogenesis, spermatogenesis, and mal

157 intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly, and

158 In contrast, revolatilization may be important for other SVOCs such as PCBs.

159 ain, elucidating how cells repair themselves is important for our mechanistic understanding of cell b

160 Understanding fluctuating selection is important for our understanding of patterns of spatia

161 The 6-cysteine protein P47, known to be important for P. berghei female gamete fertility, is

162 infected human tissue and that this pathway is important for parasite survival and progression of th

163 Limiting wasteful testing is important for patient safety.

164 The contentious pollen research should be important for patients with pollinosis in Japan.

165 ds found in K-Ras4B (K-Ras) but not in H-Ras are important for permanent K-Ras localization to the PM

166 ctions of microglial cells, the factors that are important for physiological microglial function, and

167 o utilize dissolved organic phosphorus (DOP) is important for phytoplankton to survive the scarcity o

168 on factor (TF) basic/Helix-Loop-Helix (bHLH) is important for plant growth, development, and stress r

169 so demonstrated that PLK2 polyubiquitination is important for PLK2.alpha-syn protein complex degradat

170 ation of PM 2.5 transmission characteristics is important for pollution control and policymaking.

171 In contrast, internal friction effects are important for polymers of modest length.

172 electronic properties of this material that are important for possible future applications.

173 showed porcine muscle satellite cells (PSCs) are important for postnatal skeletal muscle growth, and

174 Thus, it is important for practicing cardiologists to be knowledg

175 Characterizing this heterogeneity is important for precision diagnostics, personalized pre

176 ions interact with lipid membranes that will be important for predicting polycation-membrane interact

177 of VPDant suggests that atmospheric drought is important for predicting GPP under current and future

178 These receptors are important for prefrontal executive function because

179 Utilization of triplets is important for preparing organic light-emitting diodes

180 nvelope pentamer complex (PC) are thought to be important for preventing HCMV transmission from the m

181 tion through TLR signaling has been shown to be important for promoting T cell subset development and

182 Reference region selection is important for proper amyloid PET analysis, especially

183 As such, we hypothesized that Irf6 is important for proper development of salivary glands a

184 We show that MapZ is important for proper division plane selection; thus,

185 show that greater use of active surveillance is important for prostate cancer screening to be cost-ef

186 tailed characterization of interactions that are important for proteasome function, indicate ubiquiti

187 antibiotic resistance in bacterial pathogens is important for public health.

188 f nitrogen (N) and phosphorus (P) deposition are important for quantifying their impact on forest car

189 l a common structural scaffold of GPCRs that is important for receptor folding and activation.

190 Vif-A3F interfaces, with a small Vif region being important for recognition of both A3G and A3H.

191 Assessing liver health may be important for reducing the risk of future CHF events,

192 To explore whether this pathway is important for regulating alpha-cell activity and gluc

193 We argue that hormonal signaling is important for regulating immune system activity and,

194 ABSTRACT: Small transmembrane proteins are important for regulation of cellular ion transport.

195 Cutaneous reflexes are important for responding rapidly to perturbations, c

196 rve as building blocks for proteins but also are important for responses to stress and the biosynthes

197 sensitive detection of intracellular thiols is important for revealing cellular function.

198 ventral tegmental area (VTA) dopamine system is important for reward, motivation, emotion, learning,

199 -associated membrane proteins (LAMP) 1 and 2 are important for robust liver-stage P. berghei growth.

200 These findings are important for science policy and support the need fo

201 Light intensity, spectra, and timing are important for SCN synchronisation.

202 ratification, based on genomic drivers, will be important for selecting patients for clinical trials.

203 equipment, vehicles, or personnel proved to be important for several livestock epidemics.

204 se via cytokines revealed that dexamethasone was important for shifting the immune response away from

205 fected by cry1's C-terminal extension, which is important for signal transduction.

206 The intracellular ATP level was shown to be important for SimCell function.

207 Because these two molecules are important for social behavior, our study sheds light

208 e changes in evoked and spontaneous activity are important for sound perception.

209 physical division asymmetry, but nonetheless is important for specifying differential cell fate.

210 poral sulcus (pSTS), a brain region known to be important for speech perception, is complex, with som

211 strength of SPB-microtubule attachments may be important for spindle integrity in mitotic cells so t

212 ermore, both binding sites within the ISS-N1 are important for splicing repression and their contribu

213 pter proteins outside of the SH2/PTB domains are important for stabilizing the binding of Grb2 and Sh

214 ntifying sites of protein-ligand interaction is important for structure-based drug discovery and unde

215 Available and affordable medications are important for successfully controlling hypertension,

216 We found that immunoproteasomes were important for suppression of a caspase-independent

217 at MmpL11 and its cell wall lipid substrates are important for survival in the context of adaptive im

218 at editing by aminoacyl-tRNA synthetases may be important for survival under starvation/nutrient limi

219 l synapse, whose structure has been shown to be important for T cell activation.

220 armins, as well as the cytokine IL-15, which is important for T cell and NK cell homeostasis.

221 gy, and understanding how they are regulated is important for tailoring effective treatments.

222 part of the molecule, the region expected to be important for target binding.

223 Furthermore, p300/CBP are important for the acetylation of H3K27 at loci downr

224 , influence the water-membrane interface and are important for the bacterial attachment.

225 These findings are important for the development of strategies in aller

226 Wild mushrooms are important for the diet of some communities in Mexico

227 MO2/LDB1 complex to regulatory elements that are important for the establishment of the haematopoieti

228 Animal models of human disease are important for the exploration of underlying disease

229 als and spindle pole bodies (SPBs) in fungi, are important for the faithful distribution of chromosom

230 V S3-S4 loops of NaV channel voltage sensors are important for the interaction of Pre1a with NaV chan

231 To map the protein residues that are important for the interaction with this inhibitor, w

232 tTJs are important for the maintenance of barrier function, a

233 and vIL-6 interactions with GlucII and UGGT1 are important for the profolding activity of vIL-6, whic

234 ested that nonclassical targets of sorafenib are important for the propagation of RVFV.

235 home and the associated out-of-pocket costs are important for the saving decisions by individuals an

236 ata identify different receptor regions that are important for the stabilization of distinct conforma

237 The findings are important for the understanding of the pathogenesis

238 mmobilized-fibronectin, a finding that might be important for the anti-infective properties of B. sub

239 o-inflammatory molecule secretion, which may be important for the control of inflammatory responses i

240 rences in guard cell oscillator function may be important for the correct regulation of photoperiod p

241 These findings may be important for the designs of future secondary prevent

242 lergens, and ADAM10 has been demonstrated to be important for the development of adaptive responses.

243 o recognize these variable presentations can be important for the diagnosis of TSC.

244 s a unique N-terminus that has been shown to be important for the formation of amyloid-like aggregate

245 oiesis suggests that in-vivo this gene could be important for the regulation of platelet production.

246 nding of electron-dense material that should be important for the stiffness of the dendrite.

247 me interconverts d- and l-lactic acid, which is important for the assembly of cell walls in many micr

248 the class III phosphatidylinositol 3-kinase, is important for the Cb-mediated recruitment of gephyrin

249 The cross-linking of polysaccharides is important for the cell wall structure and growth, and

250 Complement C3 is important for the classical, alternative, and lectin

251 It is important for the clinical laboratory to interpret th

252 sis and how those mechanisms change with age is important for the development of interventions to pro

253 portable fiber optic detection system, what is important for the development of low cost and portabl

254 The synthesis of stable organic polyradicals is important for the development of magnetic materials.

255 In conclusion, the ET-1 system is important for the development of tunicamycin-induced

256 iated dendritic compartmentalization in SACs is important for the functional output of direction-sele

257 mation of molecular halogen compounds, which is important for the global tropospheric ozone budget.

258 reduction, suggesting that cell cholesterol is important for the HSV-1 replicative cycle at a stage(

259 This study provides evidence that LPA1 is important for the maintenance of epithelial barrier i

260 Normal renin synthesis and secretion is important for the maintenance of juxtaglomerular appa

261 sis, rather than consumption of the polymer, is important for the mechanism by which polyP promotes c

262 nery is a constitutively active process that is important for the organization of the plasma membrane

263 cessary for maintaining HC morphology, which is important for the parasite's ability to take up molec

264 in NS5, rich in serotype-specific residues, is important for the recovery of replication fitness in

265 sA Arabidopsis lines showed that this region is important for the regulation of CAT2 promoter activit

266 ilepticus (SE) evoked chloride dysregulation is important for the remodeling of aberrant glutamatergi

267 man ether-a-go-go-related gene (hERG), which is important for the repolarization of the cardiac actio

268 eins of the mitochondrial outer membrane and is important for the structure-inspired design of tubuli

269 nding environmental influences on sex ratios is important for the study of the evolution of sex-deter

270 d that the controlled release of autoantigen was important for the suppression of clinical disease sy

271 Moreover, NagB activation by HPr was important for the utilization of amino sugars, and a

272 he extent to which different drug properties are important for these different uses.

273 ta argue that apical contractility gradients are important for tissue folding.

274 Sensitive detection of off-target effects is important for translating CRISPR-Cas9 nucleases into

275 ognition of these variable presentations can be important for TSC diagnosis.

276 ely spliced MBSs affecting transcript levels are important for understanding plant stress responses.

277 dynamic investigations of unfolded proteins are important for understanding protein-folding mechanis

278 ntered complex situations and more generally are important for understanding redox chains relying on

279 changes in near-infrared emission of SWCNTs are important for understanding the interaction between

280 complexity of climate-driven variables could be important for understanding the potential responses o

281 presence and location in proteins and cells is important for understanding biological function.

282 d triggering to the post-fusion conformation is important for understanding F protein function.

283 This model is important for understanding loss of tolerance to chol

284 ansition-metal complexes with dioxygen (O2 ) is important for understanding oxidation in biological a

285 The present review is important for understanding the effects of oxidation

286 mining the genetic constraints on Zika virus is important for understanding the factors affecting vir

287 ing behaviors of RNA-binding proteins (RBPs) is important for understanding their functional roles in

288 Reconstructing when this dichotomy arose is important for understanding when plate tectonics star

289 etitive-domain cysteine residue in 1Dx5 that was important for understanding the formation of dough v

290 nduced spatiotemporal control of Rok and Pkn is important for unequal cortical expansion, ensuring co

291 ntification of rare CFH variant carriers may be important for upcoming complement-inhibiting therapie

292 bmA to switch between open and closed states is important for V. cholerae biofilm formation, as RbmA

293 ther showed that maintenance of its function is important for vaccinia virus replication.

294 the release of Ca(2+) from organelles, which is important for various physiological processes, includ

295 CD8(+) T cells are important for viral clearance, and although often in

296 FV replication, indicating that this pathway is important for viral replication.

297 likely having roles in attenuation proved to be important for virulence.

298 Our results suggest that SsCP1 is important for virulence of S. sclerotiorum and that i

299 bnormal shapes, indicating that the vp3 gene is important for virus structure.

300 , active vision and behavioral context might be important for visual learning.