ライフサイエンスコーパス: be important in

1 Dynamic networks are important in a number of scenarios.

2 al's ferroelectric nature, can, but need not be important in a PV cell at room temperature.

3 py (nCRT) in esophageal cancer (EC) patients is important in a more personalized treatment.

4 Multiphase flow in porous media is important in a number of environmental and industrial

5 Autophagy is important in a variety of cellular and pathophysiolog

6 High-temperature tolerance in plants is important in a warming world, with extreme heat waves

7 Demographic factors shown to be important in access to eye care likely influence PNVI

8 capillary EC barrier function that may also be important in acquired systemic capillary leak associa

9 mals.SIGNIFICANCE STATEMENT Brain plasticity is important in adaptation and brain repair.

10 e strongly connected signaling pathways that are important in advanced CRC.

11 ertheless, the development of guidelines has been important in advancing this evolving field.

12 at spatial and temporal ecological variation is important in affecting upper trophic-level productivi

13 f the Wnt pathway/beta-catenin signaling may be important in aldosterone-producing adenoma (APA).

14 uggest that effective cognitive segmentation is important in all organized behavior, explaining the b

15 ide of the host and are thus hypothesized to be important in an undefined extrahost reservoir.

16 nergy surface studies indicated that Asp-168 is important in anchoring Arg-155 for ligand binding but

17 in addition to their cytolytic activity that is important in antimicrobial defense, MAIT cells have i

18 Plasmacytoid dendritic cells (pDCs) are important in antiviral immunity and in maintaining t

19 ansfer between a surface and impacting drops is important in applications ranging from industrial spr

20 e water sorption behavior of protein powders is important in applications such as the preservation of

21 These interactions are important in archetypal RNA processes such as transc

22 l reactions and interface engineering, which are important in areas ranging from optoelectronic devic

23 ous cell states and across timescales, which is important in areas including physiology, cancer resea

24 the chemokines and chemokine receptors that are important in asthma, food allergies, and atopic derm

25 es, activate an LPC-induced inflammasome and are important in astrogliosis and microgliosis.

26 epithelial cells (rather than myeloid cells) was important in attenuating inflammation.

27 ype, and glutamate cotransmission appears to be important in attribution of motivational salience.

28 altered expression of Pdx1-bound genes that are important in beta-cell replication, endoplasmic reti

29 the fibro-slime protein previously found to be important in binding to crystalline cellulose.

30 Detecting such genes is important in biomedical research, e.g. when identifyi

31 nd that accounting for this connectivity may be important in bleaching predictions.

32 glycoprotein abundant on the virion surface, is important in both influenza A virus assembly and entr

33 l invasion across basement membrane barriers is important in both normal development and cancer metas

34 Dysregulation of miRNAs is important in breast cancer initiation and malignant p

35 were most consistent for processes known to be important in cancer, implicating both selection and a

36 While size effects may be important in cases, silver nanoparticles have been fo

37 The Ras family of GTPases are important in cell signaling and frequently mutated i

38 we showed that ARHGAP18 in endothelial cells is important in cell junctions.

39 cle-associated membrane protein (MoVam7), as being important in cellular transport and pathogenicity.

40 y by ATP-independent phospholipid scrambling is important in cellular signaling, but its mechanism re

41 ta2 nicotinic acetylcholine receptor (nAChR) is important in central nervous system physiology and in

42 lative safety of ranibizumab and bevacizumab is important in choosing an anti-VEGF drug for the hundr

43 e immunoglobulin heavy-chain variable region are important in clinical management of chronic lymphocy

44 one base mutations in nucleic acid sequences is important in clinical applications.

45 Visualizing ocular vasculature is important in clinical ophthalmology because ocular ci

46 Various TGF-beta superfamily members are important in colorectal cancer metastasis, but their

47 This is important in conditions where understanding the relat

48 at low NR2B subunit expression in adult LMAN is important in conserving features of stereotyped adult

49 xperiments tested the hypothesis that the PL is important in context-dependent responding learned dur

50 position as a function of land cover and may be important in controlling the fate of cotransported po

51 rom canonical to noncanonical autophagy that is important in controlling B cell differentiation and f

52 ue embedded in a hydrophobic pocket of HdeA, is important in controlling HdeA stabilization and thus

53 Diffusion is important in controlling local solute transport and r

54 ng the role of interleukin-17 (IL-17), which is important in controlling other fungal infections, hav

55 Host nitric oxide (NO) is important in controlling TB infection.

56 ipose tissue and formation of lipid crystals is important in Cryo-procedures such as Selective Cryoli

57 he clinician to understand features that may be important in daily practice, whereas researchers need

58 teria affiliated with the Nitrospinae phylum are important in dark ocean chemoautotrophy.

59 Cold tolerance is important in defining the distribution of insects.

60 cts including electron-electron interactions are important in describing the electronic transport.

61 ocity manipulation by anisotropy engineering is important in designing novel magnetic information dev

62 ing the genotoxic potential of viral vectors is important in designing safe and efficacious vectors f

63 netic variants, population-specific variants are important in determining plasma B12 concentrations.

64 Clinicopathological studies are important in determining the brain lesions underlyin

65 rtantly, the specific K:R ratio is likely to be important in determining helical stability in de novo

66 H, rather than absolute bile production, may be important in determining the likelihood of posttransp

67 increased freshwater output from Antarctica is important in determining sea level rise, the fate of

68 Such information will be important in developing our understanding of the chem

69 Modulation of MCs may be important in developing therapeutics for cholangiopat

70 echanism of complement activation that could be important in disease pathogenesis and therapeutic int

71 e regulatory regions of associated genes may be important in disease pathogenesis.

72 e the biomechanical behavior of the eye, and are important in diseases such as glaucoma and myopia.

73 he maintenance of gene silencing, while H2AX is important in DNA damage repair.

74 that both function and population structure are important in driving irreversible dependence between

75 The internal temperature of faeces was important in driving the rate of change in the E. co

76 It has been suggested that the cerebellum is important in dual-tasking.

77 le in epigenetic regulation, a role that may be important in early-stage digit development.

78 n from single-cell to multicellular behavior is important in early development but rarely studied.

79 uggests MALT1-dependent NF-kappaB activation is important in EGFR-associated solid-tumor progression.

80 Digestion of plant cell wall polysaccharides is important in energy capture in the gastrointestinal t

81 rity of the macromolecular protein assembly, is important in enforcing the accumulation of the BRCA1-

82 These may be important in ensuring that excessive chloride secreti

83 Trace organic compounds are important in environmental analysis because they imp

84 These results indicate that HAT-L4 is important in epidermal barrier function to prevent bo

85 wth transition at early postnatal age, which is important in establishing normal physiological functi

86 anced burial of organic matter seems to have been important in eventually sequestering the released c

87 Social interactions are important in everyday life for primates and many oth

88 tor modelling shows 4 groups of variables to be important in experience of past-year sexual and/or ph

89 hrough cloud formation and precipitation can be important in facilitating continental-scale moisture

90 and knowledge of these substitutions in AIVs is important in facilitating antiviral susceptibility mo

91 PRK4 and PRK5, and that PRK kinase activity is important in facilitating its interaction with NET2A.

92 These results demonstrate that CYP2E1 is important in fast food-mediated liver fibrosis by pro

93 actor receptor beta (PDGFRbeta) are known to be important in fibrosis of organs such as the liver and

94 Personality differences are known to be important in foraging behaviour but also in the trade

95 st that the evolutionary history of a cancer is important in forecasting clinical outlook.

96 honomic processes affecting bone post mortem are important in forensic, archaeological and palaeontol

97 titative measurements of spinal cord atrophy are important in fully characterizing these and other sp

98 o guide avenues of future research that will be important in fully understanding the role of glycerol

99 ased symptoms, suggesting that other factors are important in future assessments of inflammation's ro

100 y during past glaciations, and are likely to be important in future climate change.

101 Rodent models have been important in gaining a better understanding of the

102 protein isoforms from the same gene and thus is important in gene expression regulation.

103 inner ear melanin, and cochlear melanocytes are important in generating the endocochlear potential.

104 by the reactive infiltration instability and is important in geologic carbon storage where the dissol

105 ther infochemical in signalling pathways(4), is important in global sulfur cycling(2) and affects the

106 ng and suggest that a decrease in ADP levels is important in GSIS.

107 aling in G protein-coupled receptors (GPCRs) is important in guiding design of therapeutics and under

108 This information is important in guiding the development of vaccine candi

109 itochondrial calcium uptake and release that are important in healthy and diseased myocardium.

110 Natural killer (NK) cells are important in host defense against pathogens, and the

111 echanisms, suggesting that extrusion of NETs is important in host defence.

112 ms of DC regulation in the mouse which could be important in human asthma.

113 Thus, CD48 might be important in human asthma.

114 Both types of killing are important in humans, although proactive killing appe

115 These predictions could be important in identifying new brain target areas for f

116 AEC) mitochondrial dysfunction and apoptosis are important in idiopathic pulmonary fibrosis and asbes

117 form caspase-1-activating inflammasomes that are important in immunity to cytosolic bacteria, DNA vir

118 ages and polymorphonuclear neutrophils (PMN) are important in inducing GN, as anti-CD11b and -ICAM-1

119 Surfaces with patterned wettability contrast are important in industrial applications such as heat tr

120 Ethylene is important in industry and biological signaling.

121 ow that possession of both terminal oxidases is important in infection.

122 Correlation matrices are important in inferring relationships and networks be

123 tatin is a putative glycosyltransferase that is important in intestinal colonization of cattle by EHE

124 vation and microbial translocation appear to be important in IRIS pathogenesis.

125 cytokine triggered by inflammasome activity, is important in its own right.

126 CD2AP is important in kidney dysfunction that is accompanied b

127 d in large quantities at coral reefs and may be important in larval orientation.

128 Cholinergic innervation of the basal ganglia is important in learning and memory.

129 in amyloid-beta (Abeta) deposition over time is important in longitudinal studies, particularly in an

130 ed to include disease-causing serotypes that are important in low-income and middle-income countries.

131 ily, Hoxa5, Hoxb5, and Hoxc5, genes known to be important in lung development within mesenchymal cell

132 We previously demonstrated that SCD1 is important in lung cancer stem cells survival and prop

133 y, we found that the TGFbeta1/CD44V6 pathway is important in lung myofibroblast collagen-1 and alpha-

134 is, other than systematic cholesterol level, is important in lung tumorigenesis, and LXR activation m

135 that vesicular or transcellular pathways may be important in lymphatic solute transport.

136 complex and reveals unique interactions that are important in maintaining the S. pombe telomere in a

137 with cell cycle progression is considered to be important in maintaining cell function during growth

138 GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis.

139 our findings show that intestinal PPARdelta is important in maintaining metabolic homeostasis and su

140 Transforming growth factor beta (TGFbeta) is important in maintaining self-tolerance and inhibits

141 The phasic release of neuronal d-serine is important in maintaining synaptic function, and defic

142 both Valpha/Vbeta interface and CDR residues were important in maintaining binding to MART-1.HLA-A2,

143 HDC/histamine/leptin signaling may be important in managing obesity-induced biliary damage.

144 Silica nanostructured materials are important in many fields, including catalysis, imagi

145 Multinucleated cells are important in many organisms, but the mechanisms gove

146 amic surfaces, including biological tissues, is important in many fields but has proven to be extreme

147 f a spontaneous electric polarization, which is important in many practical applications, has rarely

148 s of two-phase fluid flow in permeable media is important in many processes such as water infiltratio

149 Development of the gut microbiota in infancy is important in maturation of the immune system.

150 and assembly, then the sites involved likely are important in mediating these processes.

151 ed with peripheral-central crosstalk and may be important in mediating depressive behaviours.

152 While Sphk1 is important in mediating vasoconstriction in hypertensi

153 isibility around the time of saccades, which is important in mediating visual stability; another is t

154 omyces cerevisiae is consequently thought to be important in Melatonin synthesis, but limited data an

155 lcitonin gene-related peptide (CGRP) pathway is important in migraine pathophysiology.

156 lankton and heterotrophic community dynamics are important in modelling carbon cycling and the impact

157 unctional replacement by new nuclear factors are important in models for the origin of eukaryotes, es

158 ith respect to both genotype and environment is important in models of cancer initiation and progress

159 addition, we demonstrate that ZEB1 and ITGB4 are important in modulating the histopathological phenot

160 DNA damage response, previously suggested to be important in modulating expansion of the repeat tract

161 8 T cells, suggesting that this cytokine may be important in modulating these CXCR5+ CD8 T cells in v

162 Copper and pH were important in modulating MeSH and EtSH accumulation

163 The IL-23/IL-17 pathway is important in multiple autoimmune diseases, but its ef

164 Electrochemical surface stress is important in nanomaterials because of their large sur

165 that the overlap between IgE and IgG4 might be important in natural tolerance acquisition.

166 traditional IKKbeta/NF-kappaB pathways that are important in normal immune responses.

167 ated protein kinase-retinoblastoma signaling is important in NSC proliferation and the reduction of t

168 eosides produces reactive intermediates that are important in nucleic acid oxidation.

169 Phase equilibria of fluid mixtures are important in numerous industrial applications and ar

170 through porous membranes and ionic channels is important in numerous applications ranging from energ

171 teorological patterns of contrasting seasons is important in order to gauge how environmental (and hu

172 hophysiology and its relationship to dry eye is important in order to optimize diagnosis and treatmen

173 disease-related molecular signatures and may be important in other human age-associated conditions.

174 m, leaving it unclear whether this signaling is important in other brain regions.

175 The activation of O2 is important in part because of its central role in the

176 Understanding demographic history is important in placing current population status into a

177 The accurate estimation of iron deficiency is important in planning and implementing interventions.

178 the prevalence of vitamin A deficiency (VAD) is important in planning and implementing interventions.

179 and showed that genetic variation in CDKN1A is important in POAG risk.

180 e suggests that specific characteristics may be important in predicting disease progression and outco

181 This will be important in predicting extrusion hotspots and dynami

182 Whereas acute illness factors may be important in prediction of hospital outcomes in veno-

183 xt of the hypoxic tumor microenvironment may be important in preventing or reverting malignant conver

184 This modulation could be important in preventing sensory signals from destabil

185 ting with mock communities and field samples is important in primer selection.

186 Thus, the PVN and its projection to rVLM are important in processing acupuncture modulation of el

187 e size distribution of PLGA NMP was shown to be important in producing a compact structure in bilayer

188 the CRDs and that the Wnt palmitoleoyl group is important in promoting these interactions.

189 tect primary human blood cells are likely to be important in protection against zoonotic infection wi

190 bstituent of the substrate was also found to be important in providing an efficient mode of molecular

191 Financial incentives might be important in raising engagement of providers and heal

192 or ultra-trace detection of glucose in blood is important in real-life sampling and analysis.

193 ma cholesterol lowering effect in humans and are important in reducing the risk of many chronic disea

194 n of NEIL1, demonstrating that these enzymes are important in regulating cellular NEIL1 steady state

195 Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy primary airway smooth

196 The micronutrient iron is now recognized to be important in regulating the magnitude and dynamics of

197 pathway mediated by GGA1 and retromer, which is important in regulating Abeta production.

198 Our findings demonstrate that OGT is important in regulating axonal maintenance in the per

199 nce between cell-cell and cell-ECM adhesions is important in regulating cell behaviors, force generat

200 Although purinegic signaling is important in regulating gastric physiological functio

201 t although insulin signaling in AgRP neurons is important in regulating glucose metabolism, insulin s

202 mmary, our study provides evidence that PFN1 is important in regulating NMJ morphology and influences

203 The results are important in revealing a CaV1.3-densin-CaMKII intera

204 er output necessary on an inclined treadmill was important in revealing altered activity in SOD1G93A

205 rticularly nucleobases, that bind metal ions is important in RNA catalysis.

206 by the action of xantphos-based ligands and is important in securing good yields for the beta-lactam

207 ed in tips with embedded materials of choice are important in separation science.

208 Interfacial electric fields are important in several areas of chemistry, materials s

209 strated that patterns of sensory information is important in shaping neural circuits during developme

210 h complex behavior of the electrical synapse is important in shaping the response of coupled neurons.

211 viously thought to be targets for collectins are important in shielding the more vulnerable sites in

212 This may be important in slowing disease progression and provides

213 e to Dobzhansky-Muller incompatibilities and be important in speciation.

214 ata suggested that positively charged Lys256 was important in stabilizing the pocket because it repel

215 s revealed that base-pair opening - known to be important in strand separation - was the best predict

216 ons show that the Glu361 and His447 residues are important in substrate binding.

217 he Mg(2+) binding loop and a P + 1 loop that is important in substrate binding.

218 nteractions between PB1 and PB2, which could be important in targeting sites for anti-influenza inter

219 Various lines of evidence suggest that DIET is important in terrestrial wetlands, which are an impor

220 five consecutive cycles.Antihydrogen studies are important in testing the fundamental principles of p

221 ts suggest that a number of immune mediators are important in the beiging response.

222 These findings are important in the context of Th1 driven diseases sinc

223 Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell proliferation, diff

224 T-helper (Th) 17 cells are important in the control of Streptococcus pneumoniae

225 with a thermally triggered phase transition are important in the design of materials for biological

226 esses of molybdenum-sulfide (Mo-S) compounds are important in the function of materials for various a

227 We agree that these additional ingredients are important in the long run and discuss prospects for

228 LDs are important in the maintenance of energy homeostasis,

229 l barrier leakiness (hyperpermeability) that are important in the pathogenesis of cardiovascular and

230 lthough weight control and physical activity are important in the prevention of both diseases, severa

231 Phospholipase A2 (PLA2)-dependent pathways are important in the regulation of cell proliferation, d

232 th direct contact and ICOS-ICOSL interaction are important in the regulation of ILC2 function.

233 rization interface, and the ATP-binding site are important in the signal transduction mechanism of Af

234 Mismatch and base-excision repair are important in the somatic expansion of repeated seque

235 Stress granules are important in the stress response and may contribute

236 unrecognized advanced weathering stages that are important in the ultimate transformation of spilled

237 t has been hypothesized that these PUFAs may be important in the aetiology of allergic diseases.

238 and monitoring of cognitive dysfunction may be important in the assessment of visual field progressi

239 g intramolecular hydrogen shifts-is known to be important in the combustion of organic materials.

240 s of immune response modulation, which could be important in the context of HIV vaccination or therap

241 osition suggest that microbial processes may be important in the cycling of not only C, but other ele

242 psin S-mediated activation of IL-36gamma may be important in the development of numerous IL-36gamma-d

243 The application of LCPs could also be important in the further development of new membrane

244 COO, within prospective clinical trials will be important in the future.

245 e temporal lobe white matter tracts known to be important in the generation and propagation of tempor

246 a hydrophobic triad W1L4L8 that is known to be important in the interaction with centrin.

247 uenza virus replication in mammals but might be important in the long-term adaptation of avian-origin

248 apy or targeting melatonin/miR-200b axis may be important in the management of biliary damage and liv

249 ata efficiency and compositionality that may be important in the path toward general artificial intel

250 astatic role of stromal signals suggested to be important in the PDAC microenvironment.

251 This may be important in the prevention of adverse effects of ear

252 binding of transcription factors is known to be important in the regulation of gene expression progra

253 miR-24-dependent expression of menin may be important in the regulation of nonmalignant and CCA p

254 These unusual characteristics are likely to be important in the still incompletely understood physio

255 beta signalling, suggesting this pathway may be important in the transition from acute to chronic mid

256 in eukaryotic cells and has been reported to be important in the virulence of a number of microbial p

257 her nonflowering seed plant groups, and have been important in the evolution of seeds and cones at le

258 ticle aggregator and may, in this role, have been important in the initial colonization of land.

259 Generating various laser sources is important in the communication systems.

260 Understanding these networks is important in the contexts of the etiology, diagnosis,

261 ed activation of carbon-hydrogen bonds (C-H) is important in the development of synthetically useful

262 rate of mitochondrial oxidation of calories is important in the etiology of metabolic disease.

263 epithelial cells, indicating that the T6SS-5 is important in the host-pathogen interaction in these c

264 interact with the HLA peptide binding groove is important in the immunopathogenesis of T-cell mediate

265 ression studies indicate that vpr-1 activity is important in the nervous system, germ line and intest

266 f omega-3 polyunsaturated fatty acids (PUFA) is important in the oil industries.

267 as tacrolimus (TaC) and cyclosporin A (CsA), is important in the outpatient follow-up of kidney trans

268 Because impaired renal ammonium excretion is important in the pathogenesis of acidosis, urine ammo

269 loss of caveolae and HCN channels in ICCs-DM is important in the pathogenesis of DCP.

270 Innate immune signaling is important in the pathophysiology of ischemia/reperfus

271 peptide (IAPP) to form fibrils and oligomers is important in the progression of type 2 diabetes.

272 respect to the direction of principal stress is important in the promotion of cavity formation.

273 ence suggest that the activity of HA neurons is important in the regulation of vigilance despite the

274 Thus, by pinpointing a cellular protein that is important in the replication cycle of HCMV, we identi

275 itical determinant of excessive drinking, it was important in the acute sedative effects of alcohol.

276 The results suggested that 1,2-enolization was important in the interconversion of glucose and fruc

277 ne flow, rather than large-scale dispersals, was important in the Pleistocene evolutionary history of

278 areness for early detection and intervention are important in these traumas.

279 predictions that Hund's exchange interaction is important in these materials.

280 uggesting that factors other than C1-INH may be important in this process.

281 nally couples the DMN with a region known to be important in top-down executive control at rest (left

282 sociations between behavior and neurobiology is important in treatment development.

283 ts indicate that acceleration trade-offs can be important in two respects: (1) they can reduce the co

284 iated lymphoid tissue to boost Tr1 cells may be important in type 1 diabetes management.

285 the genetic basis of this heritability will be important in understanding the pathogenesis of IgAN.

286 This finding is important in understanding EV71-host cell interaction

287 r heterogeneity in protease secretion, which is important in understanding immune capability and the

288 rovides evidence that pathogen heterogeneity is important in understanding pathogen transmission, whi

289 e with Pepper & Nettle that personal control is important in understanding people's willingness to en

290 Viral interference is important in understanding respiratory viral circulat

291 AMR bacteria in-situ in complex environments is important in understanding the role of viable but non

292 dentification of these seven novel genes has been important in unravelling the molecular mechanisms u

293 expression quantitative trait loci or eQTLs) is important in unravelling the genetic basis of complex

294 Plants are important in urban environments for removing pathoge

295 Detection of reactive oxygen species (ROS) is important in varied biological processes, disease dia

296 gle crystal semiconductor nanomembranes (NM) are important in various applications such as heterogene

297 unctional properties of IFN-lambda4 that can be important in viral clearance and other clinical condi

298 Nude mice are important in vivo model for characterization of cell

299 ic behaviour under low energy conditions and is important in vivo.

300 ulates voluntary alcohol intake and thus may be important in vulnerability to developing alcohol use