ライフサイエンスコーパス: be inactivated by

1 ng AKT and mitogen-activated protein kinase, were inactivated by 17-AAG in the KIT-positive GIST line

2 Tau by expressing I2 (PP2A) in which the NLS was inactivated by (179)RKR(181) --> AAA along with (168

3 -hydroxylase encoded by the CYP27B1 gene and is inactivated by 24-hydroxylase encoded by the CYP24A1

4 indicating that the switch OFF-specific mRNA is inactivated by 3' to 5' degradation.

5 ance, l-aspartate aminotransferase (l-AspAT) is inactivated by 4-amino-4,5-dihydro-2-thiophenecarboxy

6 The enzyme requires Fe2+ as a cofactor and is inactivated by 4-chloro-3-hydroxyanthranilate.

7 These results demonstrate that hGST P1-1 is inactivated by 4-OHEN through two possible mechanisms

8 nandamide and 2-arachidonoyl glycerol (2-AG) are inactivated by a two-step mechanism.

9 (Kir1.1) family of epithelial K channels can be inactivated by a combination of low internal pH and l

10 vidence suggests that certain transgenes can be inactivated by a methylation independent mechanism.

11 ntal support for the hypothesis that HRP can be inactivated by a phenoxyl radical attack.

12 ed by our data showing that the BR3 gene had been inactivated by a discrete, approximately 4.7 kb gen

13 of mouse embryos in which the Tak1 gene has been inactivated by a genetrap insertion.

14 in which one copy of the murine Odc gene has been inactivated by a homologous recombination.

15 DM1 is a tumor suppressor gene in NKCLs that is inactivated by a combination of monoallelic deletion

16 Factor VIIIa is inactivated by a combination of two mechanisms.

17 conserved sequence CGGAUCCUGGGAAACAGG, (iv) is inactivated by a four-base duplication in this conser

18 In the presence of light, COP1 is inactivated by a mechanism which is not completely un

19 ion of autosomal tumor-suppressor genes, WTX is inactivated by a monoallelic "single-hit" event targe

20 Consistent with this notion, Cul3 is inactivated by a mutation in its conserved neddylatio

21 Thus, the IIp45 gene is inactivated by a tumor-specific alternative splicing

22 tumor suppressor homeodomain protein NKX3.1 is inactivated by a variety of mechanisms in the earlies

23 3OC12-HSL was inactivated by a cell-associated activity rather tha

24 This siaD gene was inactivated by a frameshift mutation at the poly(C)

25 heavy chain (MYH) expressed in these muscles was inactivated by a frameshifting mutation after the li

26 complex in which the glutaminase active site was inactivated by a glutamine analogue and the unstable

27 phosphotransferase system for glucose uptake was inactivated by a mutation in ptsI.

28 s overexpressing RD20, in which peroxygenase was inactivated by a point mutation of a catalytic histi

29 function in the phosphorylation site mutant was inactivated by a point mutation.

30 The osmU operon was inactivated by a site-directed deletion, which aboli

31 Furthermore, mice in which pRb was inactivated by a truncated T antigen in a p53 null b

32 ic expression of CrkII, a Rac activator that is inactivated by Abl-mediated tyrosine phosphorylation,

33 ii subsp. stewartii is a LuxR homologue that is inactivated by acyl-homoserine lactone (AHL).

34 When Cdc7-as3 is inactivated by addition of inhibitor to sporulation m

35 that the RGL2 repressor of seed germination is inactivated by after-ripening of sly1 mutant seeds.

36 at the Foxo proteins Foxo1 and Foxo3a, which are inactivated by Akt, drive Foxp3 expression.

37 tein FOXO3a (formerly termed FKHRL-1), which is inactivated by Akt, as a key regulator of ERalpha gen

38 of glycogen synthase kinase-3 (GSK-3), which is inactivated by AKT, for its role in the regulation of

39 anolamine phosphorylceramide (EPC) synthase, were inactivated by Ala substitutions of a conserved tri

40 which PKA phosphorylation site S2808 on RyR2 is inactivated by alanine substitution.

41 ure supernatants from Escherichia coli could be inactivated by alkali hydrolysis but not by PAF-AH.

42 TA was removed using an anti-LTA antibody or was inactivated by alkaline hydrolysis or platelet-activ

43 and Sezary syndrome and that these genes may be inactivated by allelic loss and aberrant promoter met

44 ss resistance, genes encoding those proteins were inactivated by allelic exchange mutagenesis.

45 volatile (Z)-3-hexenyl acetate, which might be inactivated by an esterase.

46 tions of thioether are present, the catalyst is inactivated by an irreversible formation of colloidal

47 Type I sulfatases are inactivated by aryl sulfamates in a time-dependent,

48 In the absence of EPS, the kinase is inactivated by autophosphorylation.

49 To prevent host suicide, colicins are inactivated by binding to immunity proteins.

50 PAKs are inactivated by blockage of the active site of the ki

51 Complex II activity was inactivated by blue light in mitochondria from strai

52 tert-butyl hydroperoxide, the mutant enzyme was inactivated by both 17EE and efavirenz.

53 b5 the variant readily metabolized 17EE and was inactivated by both 17EE and efavirenz.

54 es and accumulation of oxidized Pdi1p, Ero1p was inactivated by both autonomous oxidation and Pdi1p-m

55 erestingly, p(open) for a channel model that is inactivated by Ca(2+) also increases as a function of

56 ing function, i.e., inhibition of apoptosis, is inactivated by caspase cleavage.

57 IL-33 is inactivated by caspase-3 and -7 to prevent an inappro

58 hat ICD-1 apoptosis-suppressing activity may be inactivated by caspases.

59 by a CRM1-dependent mechanism unless the NES is inactivated by CDK phosphorylation.

60 duced apoptosis, further suggesting that YAP was inactivated by Cdk1 phosphorylation.

61 tants of Rb (PSM7LP and PSM9-Rb) that cannot be inactivated by cdks can be targeted by Fas and p38 ki

62 Nitric oxide (NO) is inactivated by cell-free hemoglobin in a dioxygenatio

63 bohydrate-dependent receptor-mediated uptake was inactivated by chemical modification.

64 In this system, complementary 10-23 variants were inactivated by circularization, creating deoxyriboz

65 modified proteins when SHV-1 beta-lactamase is inactivated by clavulanate.

66 ation did not prevent the C475S variant from being inactivated by clopidogrel.

67 t a target containing a recognition site can be inactivated by coexpressed TEV protease.

68 malignant cells with mdm2 amplification can be inactivated by continued association of DNA-bound p53

69 To achieve this, Otx2 was inactivated by Cre recombinase under the transcripti

70 Neu-Cre-ErbB4(flox/null) mice in which ErbB4 was inactivated by Cre-lox-mediated recombination in the

71 hrough the generation of mice in which Dnmt1 was inactivated by Cre/loxP-mediated deletion at sequent

72 Additionally, integrins can be inactivated by CSPGs, and this inhibition can be over

73 ease if components are missing or if ORC has been inactivated by cyclin-dependent kinase phosphorylat

74 aken together, these data indicate that p107 is inactivated by cyclin D1/Cdk4 via direct phosphorylat

75 S112C, Y117C, S126C), most EL1 mutants (64%) were inactivated by cysteine mutation, suggesting a func

76 ost-translationally repair proteins that had been inactivated by deleterious insertions or extensions

77 PTEN is a phosphoinositide phosphatase that is inactivated by deletion and/or mutation in diverse hu

78 at, in an rne mutant in which autoregulation is inactivated by deletion of most of the 5' untranslate

79 In all cases studied, both BLIMP1 alleles were inactivated by deletions or mutations.

80 The plant kinase was inactivated by dephosphorylation and reactivated by

81 mplemented mutant when the classical pathway was inactivated by depleting NHS of C1q and was increase

82 ype K(+) current in spinal CPG neurons which is inactivated by depolarization and de-inactivated by h

83 s insensitive to imipramine or KB-R7943, but is inactivated by depolarization.

84 The enzyme was inactivated by dialysis against 1,10-phenanthroline

85 to show that, under conditions in which cAPK is inactivated by diamide, it is also readily thiolated.

86 tB expression when major digestive proteases are inactivated by dietary scN, which is presumably an a

87 hat elucidate the molecular basis of how p53 is inactivated by different types of cancer mutation.

88 5-Fluorouracil is inactivated by dihydropyrimidine dehydrogenase and ta

89 rsely, in bright conditions, sodium channels were inactivated by dopamine released from amacrine cell

90 HER2-HER3 signaling can be inactivated by doses of lapatinib that fully inactiva

91 al transduction in all eukaryotic organisms, are inactivated by dual specificity MAPK phosphatases (M

92 us genomes: a critical MRN-ATM DDR that must be inactivated by E1B-55K/E4-ORF3 viral oncoproteins and

93 ed in this concatemer formation and how they are inactivated by E4 products during a wild-type infect

94 nding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or prot

95 f the CYP2B6 wild-type (WT) protein that had been inactivated by either clopidogrel or 2-oxo-clopidog

96 time viral DNA accumulates, the MRN complex is inactivated by either of the E4-induced mechanisms an

97 In vitro, GAPC1 was inactivated by either nitric oxide donors or hydroge

98 its activity as a negative regulator of CpxA is inactivated by envelope stress.

99 BLIMP1 gene, and suggest that the same gene is inactivated by epigenetic mechanisms in an additional

100 , C3 is cleaved to form active C3b, then C3b is inactivated by Factor I and Factor H to form the C3c

101 The CaCHS1 gene was inactivated by first disrupting one allele using the

102 be a classic tumor suppressor gene that can be inactivated by frequent point mutations.

103 fects on function, although channel function was inactivated by G2586P and F2592D mutations.

104 In more than 50% of tumors p53 is inactivated by gene mutations.

105 and fibroblast models in which class I PI3Ks were inactivated by genetic and pharmacological approach

106 lucose; however, it is derepressed when Mth1 is inactivated by glucose.

107 The results suggest that GA can be inactivated by glycosylation of C-17-position and rea

108 cts HBV production at intracellular MVBs but is inactivated by HBV through a novel mechanism requirin

109 LVS was inactivated by heat, paraformaldehyde treatment, or

110 membrane (STM) chemoattractant receptors can be inactivated by heterologous desensitization.

111 is YAP1, a transcriptional coactivator that is inactivated by Hippo kinase activity.

112 Isolated cathepsin G was inactivated by HOCl but not by hydrogen peroxide in

113 used murine cells in which the WT1 gene has been inactivated by homologous recombination.

114 erated mice in which the gene encoding GlyT1 was inactivated by homologous recombination through inse

115 uires both the N- and C-terminal domains and is inactivated by human IPEX (immunodysregulation, polye

116 ther metals, and only this metalloform could be inactivated by hydrogen peroxide or superoxide.

117 f cancer-associated genes have been shown to be inactivated by hypermethylation of CpG islands during

118 RASSF1A is a tumor suppressor gene that is inactivated by hypermethylation of its promoter regio

119 ite pyrosequencing demonstrated that miR-34A was inactivated by hypermethylation across many histolog

120 proliferative and survival advantage when Rb is inactivated by hyperphosphorylation.

121 GSK-3 is inactivated by hypertrophic stimuli through phosphory

122 ages suggested that both ECs and macrophages were inactivated by I3C.

123 Nine of these genes were inactivated by in-frame deletions, and their roles

124 TRPV6 channels have been shown to be inactivated by increased cytoplasmic Ca(2+) concentra

125 The tumor-suppressing function of E-cad was inactivated by increased microenvironmental rigidity

126 ity when assayed in the presence of EDTA but is inactivated by incubation with 1,10-phenanthroline in

127 alleles were cultured and the HNF4alpha gene was inactivated by infection with an adenovirus containi

128 , the LXR transrepression pathway can itself be inactivated by inflammatory signals that induce calci

129 ner in MO59K extracts in which accurate NHEJ was inactivated by inhibition of Ku70 or DNA-PK(cs).

130 focal adhesion molecules, and that integrins are inactivated by inhibitory molecules in the CNS.

131 major spore proteins (mspA, mspB, and mspC) were inactivated by insertion mutagenesis, and the devel

132 ted to nucleotide sequence analysis and then was inactivated by insertional mutagenesis.

133 Glycogen synthase kinase 3 (GSK3) is inactivated by insulin and lithium and, like insulin,

134 The tyrosine kinase c-Abl is inactivated by interactions made by its SH3 and SH2 d

135 hrR protein, these mutants (G120C and Q124C) are inactivated by intermolecular disulfide bond formati

136 This neuroactive steroid can be inactivated by its 3alpha-oxidation to yield 5alpha-D

137 When the RTG pathway is on, Mks1p is inactivated by its association with Rtg2p; and when t

138 Both clusters were inactivated by lambda-RED-mediated PCR-targeting mu

139 xidation of NAD(P)H, is upregulated when p16 is inactivated by looking at gene expression profiling s

140 When the reductant is omitted, RNR is inactivated by loss of the essential tyrosyl radical

141 KLF6 was inactivated by loss and/or mutation in most sporadic

142 ation of pre-existing ROMK channels that had been inactivated by low external K.

143 HSV is inactivated by low-pH preexposure, and gB, a class II

144 Tumor-suppressor proteins are inactivated by many different mechanisms, including

145 BACKGROUND & AIMS: Tumor-suppressor proteins are inactivated by many different mechanisms, including

146 gen-activated protein kinases (MAPKs), which are inactivated by MAPK phosphatases (MKPs), represent a

147 The human NTPDase 2 activity is inactivated by membrane perturbation that disrupts in

148 show that none of the MHC class I promoters are inactivated by methylation.

149 FXS), the boundary is lost, and the promoter is inactivated by methylation spreading.

150 TRPA1 currents could be inactivated by Mg(2+), Ba(2+), and Ca(2+) but potenti

151 oles in anaphase when the spindle checkpoint was inactivated by microinjection with Mad2 antibodies.

152 Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the follo

153 Lnp is inactivated by mitotic phosphorylation, which contrib

154 The eCB ligand 2-arachidonoylglycerol (2-AG) is inactivated by monoacylglycerol lipase (MAGL).

155 preparation is water-soluble, monomeric, and is inactivated by monothiol- and especially dithiol-modi

156 f a dominant-acting 4E-BP1 variant unable to be inactivated by mTORC1.

157 However, BRCA1 can be inactivated by multiple mechanisms and determining it

158 Rac1 can be inactivated by multiple mechanisms; however, negative

159 The tumor suppressor p53 is inactivated by multiple mechanisms that include mutat

160 We found that, in cHL cell lines, FOXO1 is inactivated by multiple mechanisms, including constit

161 The latter gene, coding for BLIMP1, was inactivated by multiple mechanisms, more frequently,

162 However, when SI was inactivated by muscimol infusion, whisker twitching

163 s in which either of the two helicase motors is inactivated by mutagenesis.

164 In turn, each catalytic site was inactivated by mutagenesis to form dimeric enzymes i

165 V-1 replication was reduced by 95% when ESSV was inactivated by mutagenesis.

166 Although many of these elements have been inactivated by mutation, several active retroelemen

167 The NsrR target is inactivated by mutation at the Salmonella enterica se

168 The tumor suppressor protein p53 is inactivated by mutation in about half of all human ca

169 C/EBPalpha is inactivated by mutation in acute myeloid leukemia (AM

170 matous polyposis coli (APC) tumor suppressor is inactivated by mutation in most colorectal tumors.

171 pothesis: the TGF-beta type II receptor gene is inactivated by mutation in nearly all colorectal carc

172 LKB1 is a serine/threonine kinase which is inactivated by mutation in the Peutz-Jeghers polyposi

173 bonuclease activity in vitro, and the enzyme is inactivated by mutation of two highly conserved amino

174 DNA unwinding when either of these subunits is inactivated by mutation.

175 showed the expected pH-rate profile, and it was inactivated by mutation of its active site Glu to Gl

176 iants in which the late domains of one virus were inactivated by mutation showed a strong bias agains

177 riptionally active locus to one in which HS2 was inactivated by mutations in the core NF-E2 sites.

178 id, a key frontline antitubercular drug that is inactivated by mycobacterial and human arylamine N-ac

179 arginine (ADMA), which inhibits NO synthase, is inactivated by N(G),N(G)-dimethylarginine dimethylami

180 MAO A is inactivated by N-ethylmaleimide (NEM) much faster (ta

181 XIAP, an inhibitor of apoptosis, was inactivated by NO-Cbl.

182 ent at the wild-type (wt) allele when the tg is inactivated by nonproductive VH replacement.

183 we show that Cdc25A, a protein phosphatase, was inactivated by novel arylating K vitamin analogues.

184 herichia coli is a dimeric Fe-S protein that is inactivated by O(2) through disruption of its [4Fe-4S

185 These enzymes were inactivated by O(2)(-) both in vitro and in vivo.

186 AChE is inactivated by organophosphates as they pass through

187 e absence of ClO2 pressure but that they can be inactivated by other common disinfectants.

188 p53 is deleted or mutated, but in others p53 is inactivated by overexpression or amplification of its

189 These data demonstrate that ER-iPLA(2) is inactivated by oxidants, that the mechanism of inacti

190 sin (IDE) and neprilysin (NEP) were found to be inactivated by oxidation with hydrogen peroxide, an i

191 nsensitive to redox changes, while the other was inactivated by oxidation.

192 ing kinases for cyclin D-CDK4 complexes that are inactivated by p21-mediated stabilization.

193 erred by its transactivation activity, which is inactivated by p53 mutations in approximately 50% of

194 These lipid mediators are inactivated by PAF-acetylhydrolase (PAF-AH).

195 thase, as well as glucosylceramide synthase, was inactivated by PDT in both cell lines in a dose-depe

196 ) has been expressed in E. coli and shown to be inactivated by pentalenolactone.

197 cine hearts, we also showed that the Ca pump is inactivated by peroxynitrite exposure, and inactivati

198 ioxidative enzyme glutathione reductase (GR) is inactivated by peroxynitrite, with GR from the malari

199 osynthesis of the neurotransmitter dopamine, is inactivated by peroxynitrite.

200 ild-type levels of TH catalytic activity and were inactivated by peroxynitrite while showing reduced

201 -7 cells overexpressing hACVI even when G(i) was inactivated by pertussis toxin.

202 thesis that horseradish peroxidase (HRP) can be inactivated by phenoxyl radicals upon reaction with H

203 specific sites at their activation loop and are inactivated by phosphatases.

204 In Saccharomyces cerevisiae, Orm1 and Orm2 are inactivated by phosphorylation in response to compro

205 SFKs are inactivated by phosphorylation of their C-terminal t

206 6A/R588A/R591A, which retains the ability to be inactivated by phosphorylation, resulted in lower gly

207 Cofilin is inactivated by phosphorylation at Ser-3 by LIM kinase

208 Although Rb is inactivated by phosphorylation by cyclins D and E and

209 Conversely, eEF2 is inactivated by phosphorylation in response to stimuli

210 n phosphatase (MP) that dephosphorylates MLC is inactivated by phosphorylation of the myosin binding

211 in interphase, whereas in G(2)/M phase, NIPA is inactivated by phosphorylation to allow for cyclin B1

212 Rb is inactivated by phosphorylation upon growth factor sti

213 , a proapoptotic member of the Bcl-2 family, is inactivated by phosphorylation, and this loss of acti

214 Cofilin, an F-actin severing protein that is inactivated by phosphorylation, is a downstream targe

215 function, i.e., inhibition of proliferation, is inactivated by phosphorylation, whereas RB tumor prom

216 , as well as other tumour types in which PRH is inactivated by phosphorylation.

217 a, we show that Atonal outlives its mRNA but is inactivated by phosphorylation.

218 When the tetrapyrrole is inactivated by phototransforming it with ultraviolet

219 These results demonstrate that METTL1 is inactivated by PKB and RSK in cells, and the potentia

220 Of 18 genes, 8 are functional and 10 were inactivated by point mutation.

221 It is known that PAO1 QS molecules are inactivated by PON-2.

222 MGMT is inactivated by promoter hypermethylation in many huma

223 on, apoptosis, and microtubule stability and is inactivated by promoter methylation in approximately

224 ith which the novel tumor suppressor RASSF1A is inactivated by promoter methylation suggests that it

225 resented by intact cells, and unlike DDM, it was inactivated by proteases and augmented by protease i

226 ecule upstream of the Hippo pathway and that is inactivated by protein kinase C-alpha isoform, was ac

227 he data support the scenario that iNOS(P420) is inactivated by protonation of the native proximal thi

228 rapy of S. aureus bloodstream infections but is inactivated by pulmonary surfactant, making it of no

229 bited by cytosolic stathmin, which, in turn, is inactivated by Rac1.

230 ssed in human squamous cell carcinoma (SCC), is inactivated by rap1GAP.

231 When TORC1 was inactivated by rapamycin, FBPase degradation was inh

232 AGT is inactivated by reacting stoichiometrically with O(6)-

233 IDE was inactivated by reaction with 4-hydroxy-2-nonenal (HN

234 g region of another, several genes that have been inactivated by rearrangements in the region, and ge

235 e residue by a disulfide-clasped loop, which is inactivated by reduction.

236 ree anti-rat HARE monoclonal antibodies, and is inactivated by reduction.

237 itical for mitotic chromosome structure that is inactivated by Repo-Man-PP1 during anaphase.

238 rthermore, McTNs were suppressed and cofilin was inactivated by restoration of PTEN in the PTEN(-/-)

239 These proteins are inactivated by Rho-selective GTPase-activating prote

240 pes caused when each of a large set of genes is inactivated by RNA interference.

241 ed the activities of GST and GPx, after each was inactivated by S-thiolation with cystine in vitro.

242 phorylates the S6 peptide, and this activity is inactivated by S386A mutation, but RSK2-(aa1-389) doe

243 growth factor-1 receptor were also found to be inactivated by Sb.

244 Complex II was inactivated by SDHa silencing, which led to aerobic

245 D2 is inactivated by selective conjugation to ubiquitin, a

246 P-TEFb is inactivated by sequestration in a complex with the He

247 Thus, TNF is inactivated by sequestration.

248 ame, in which the terminal packaging signals were inactivated by serial synonymous mutations, was fla

249 resembles a nuclear export signal, and could be inactivated by site-directed mutagenesis.

250 Each of these initiation codons was inactivated by site-directed mutagenesis.

251 when the proteolytic activity of the protein was inactivated by site-specific mutagenesis or inhibite

252 Additionally, MmaK is inactivated by slightly acidic pH only from the cytop

253 Additionally, MthK is inactivated by slightly acidic pH only from the cytop

254 We show that PTEN is inactivated by small deletions affecting a few exons

255 The gene CDKN1B is inactivated by small insertions/deletions in 8% of pa

256 sites, but highly glycosylated seasonal IAV are inactivated by soluble lectins of the innate immune

257 However, the JSRV vector was inactivated by standard disinfectants, indicating th

258 The synaptic complex is inactivated by strand transfer inhibitors (STI) with

259 We report here that the BLIMP1 gene is inactivated by structural alterations in 24% (8 out o

260 t CDC37's client stabilising function cannot be inactivated by substantially reducing its direct inte

261 e obtained when the catalytic dyad of PNPLA3 was inactivated by substituting the catalytic serine wit

262 the development of pediatric de novo AML or are inactivated by such means as methylation and point m

263 0/11 provide compelling evidence that SnRK1s are inactivated by sugars and share central roles with t

264 ated by nitric oxide (NO), which is known to be inactivated by superoxide produced by NADPH oxidase.

265 WT littermates (Uro-SV40T-AR(+/y)), and p53 was inactivated by SV40T in both genotypes.

266 f Chinese Spring show that the D genome gene is inactivated by tandem premature stop codons.

267 f each of the three isoforms, the VDAC3 gene was inactivated by targeted disruption in embryonic stem

268 thylated set was enriched for genes known to be inactivated by the polycomb repressive complex 2, whe

269 tively engaged in asparagine synthesis could be inactivated by the sulfoximine; free enzyme was unaff

270 pecificity for pre-existing tumor cells will be inactivated by the tumor antigens in the host.

271 sigma(EcfG) is inactivated by the anti-sigma factor NepR, which is i

272 ng licensing in metazoans and, like cyclins, is inactivated by the APC/C.

273 that the HIV-1 envelope glycoprotein trimer is inactivated by the binding of a single antibody molec

274 s known to contribute to cancer progression, is inactivated by the catabolic enzyme, 15-hydroxyprosta

275 te that when the Rb tumor suppressor pathway is inactivated by the E7 protein, E6 repression activate

276 identify a haematopoietic enhancer hub that is inactivated by the EBV repressors EBNA3A and EBNA3C t

277 e of the two X chromosomes in female mammals is inactivated by the noncoding Xist RNA.

278 Instead, AbrB is inactivated by the product of a uncharacterized gene,

279 the presence of organic hydroperoxides, OhrR is inactivated by the reversible oxidation of a single c

280 known "erythroid regulator." The BMP pathway is inactivated by the serine protease TMPRSS6 that cleav

281 Serotonin is inactivated by the serotonin reuptake transporter (SE

282 o be degraded in the prometaphase when APC/C is inactivated by the spindle assembly checkpoint (SAC).

283 The FabI isoform was inactivated by the FabI selective inhibitor AFN-1252

284 CPS was inactivated by the glutamine analog, acivicin.

285 Bovine heart cytochrome c oxidase (CcO) was inactivated by the lipid peroxidation product 4-hydr

286 NagA from E. coli was inactivated by the removal of the zinc bound to the

287 cation, SFGHs behave as cysteine hydrolases, being inactivated by thiol alkylating agents, while bein

288 Purified GGT was inactivated by TLCK (Nalpha-p-tosyl-L-lysine chlorom

289 se as isolated contains Zn2+, and the enzyme is inactivated by treatment with EDTA.

290 Further, rLEKTI inhibitory activity was inactivated by treatment with 20 mM DTT, suggesting

291 AdoMetDC was inactivated by treatment with the imine reductant Na

292 an apparent molecular mass of 55-150 kDa and is inactivated by trypsin or chymotrypsin.

293 ticola responsible for glutathione breakdown was inactivated by trypsin or proteinase K, by heating (

294 S I is conserved in alphaCP1, whereas NLS II is inactivated by two amino acid substitutions.

295 id hormone-activating type 2 deiodinase (D2) is inactivated by ubiquitination via the hedgehog-induci

296 n cancers are rare, suggesting that Chk2 may be inactivated by unknown alternative mechanisms.

297 e 5-HT that is involved in mucosal signaling is inactivated by uptake into mucosal epithelial cells,

298 cific retroviral restriction factor that can be inactivated by viral protein Vpx from HIV-2 and certa

299 ession occur in primary human tumors; and it is inactivated by viral gene products.

300 can induce autophagy in 293T cells where p53 is inactivated by viral proteins, and, notably, expressi