ライフサイエンスコーパス: be increasingly recognized as

1 Anti-Mullerian hormone (AMH) levels are increasingly recognized as a biomarker of ovarian re

2 species are abundant in the environment and are increasingly recognized as a cause of severe pneumon

3 Sleep disturbances are increasingly recognized as a common problem for chil

4 urophysiological effects of traumatic stress are increasingly recognized as a critical facet of the h

5 The early years in life are increasingly recognized as a critical period for the

6 t lipid environments, including lipid rafts, are increasingly recognized as a crucial factor affectin

7 c leukoencephalopathies and leukodystrophies are increasingly recognized as a heterogeneous group of

8 ponse and link to the adaptive immune system are increasingly recognized as a key influence on early

9 Mutations in alpha- and beta-tubulins are increasingly recognized as a major cause of malforma

10 stinfluenza Staphylococcus aureus pneumonias are increasingly recognized as a major form of life-thre

11 Airway epithelial cells (AEC) are increasingly recognized as a major signalling centre

12 ntigen (HLA) antibodies (DSA) posttransplant are increasingly recognized as a negative prognostic mar

13 ith sharp optical and spin transitions, they are increasingly recognized as a platform for quantum in

14 Macrophages are increasingly recognized as a potential therapeutic t

15 While these zones are increasingly recognized as a primary site for silici

16 Mentorship in medicine has been increasingly recognized as a core component of trai

17 Medication nonadherence has been increasingly recognized as a major impediment to ac

18 hemostasis and thrombosis, the platelet has been increasingly recognized as a multipurpose cell.

19 s of the upstream transcription factors, has been increasingly recognized as a pervasive evolution me

20 Targeting multiple angiogenic pathways has been increasingly recognized as a viable strategy.

21 Commotio cordis is being increasingly recognized as a cause of acute post-t

22 Sphingolipid metabolism is being increasingly recognized as a key pathway in regula

23 Immunotherapy is being increasingly recognized as a key therapeutic modal

24 luding loss of the PTEN tumor suppressor, is being increasingly recognized as a major player in the d

25 Neuroinflammation is being increasingly recognized as a potential mediator of

26 Ultrasound is being increasingly recognized as a powerful tool in oste

27 Epigenetic changes are being increasingly recognized as a prominent feature of

28 Because AD is increasingly recognized as a "synaptic disease," calc

29 Left main coronary artery (LMCA) compression is increasingly recognized as a cause of angina in pulmo

30 common cause of infant hospitalizations and is increasingly recognized as a cause of considerable mo

31 Posttraumatic stress disorder (PTSD) is increasingly recognized as a cause of substantial dis

32 Translation is increasingly recognized as a central control layer of

33 Improved communication is increasingly recognized as a central element in provi

34 However, Skp is increasingly recognized as a chaperone that also assi

35 Sudden unexpected death in epilepsy (SUDEP) is increasingly recognized as a common and devastating p

36 Aortic insufficiency (AI) is increasingly recognized as a complication of continuo

37 Gastroparesis is increasingly recognized as a complication of end-stag

38 Cancer is increasingly recognized as a complication of HIV infe

39 Pulmonary hypertension is increasingly recognized as a complication of these in

40 Dysregulation of the complement system is increasingly recognized as a contributing factor in a

41 r inappropriate triggering of these pathways is increasingly recognized as a contributor to human dis

42 Cellular metabolism is increasingly recognized as a controller of immune cel

43 emost cause of mortality in cancer patients, is increasingly recognized as a coordinated biological p

44 Altered metabolism in tumor cells is increasingly recognized as a core component of the ne

45 n of mRNA splicing, processing and stability is increasingly recognized as a critical control point i

46 lty, as measured by the Fried Frailty Index, is increasingly recognized as a critical determinant of

47 Brain inflammation is increasingly recognized as a critical factor for seiz

48 lecular, genetic, and physiological features is increasingly recognized as a critical feature of comp

49 Inflammation is increasingly recognized as a critical mediator of ang

50 Alternatively, multimodal therapy is increasingly recognized as a critical pain management

51 to as cardiorenal metabolic syndrome (CRMS), is increasingly recognized as a critical pathological en

52 Protein histidine phosphorylation is increasingly recognized as a critical posttranslation

53 Mixing is increasingly recognized as a critical process for und

54 Job satisfaction is increasingly recognized as a crucial factor for high

55 y, which we refer to as "complex infection", is increasingly recognized as a determinant of treatment

56 Enteroaggregative Escherichia coli (EAEC) is increasingly recognized as a diarrhoeal pathogen in d

57 Schizophrenia is increasingly recognized as a disorder of distributed

58 Antibody therapy is increasingly recognized as a favored drug modality du

59 The plant metabolite oxalic acid is increasingly recognized as a food toxin with negative

60 modulation of ion channel activity by lipids is increasingly recognized as a fundamental component of

61 Degradation of white matter microstructure is increasingly recognized as a general mechanism of cog

62 The bacterial Mfd ATPase is increasingly recognized as a general transcription fa

63 Genome condensation is increasingly recognized as a generic stress response

64 ike growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emergin

65 le serious conditions, including cancer, and is increasingly recognized as a growing cause of prevent

66 Neuroinflammation is increasingly recognized as a hallmark of neurodegener

67 Transient ischaemic attack (TIA) is increasingly recognized as a harbinger of stroke and

68 oke and heart failure, this common condition is increasingly recognized as a heritable disorder.

69 ally occurring variation in gene copy number is increasingly recognized as a heritable source of susc

70 Asthma, and severe asthma, in particular, is increasingly recognized as a heterogeneous disease.

71 Microglial dysfunction is increasingly recognized as a key contributor to the p

72 ntent) and quality (structure and function), is increasingly recognized as a key factor in the benefi

73 or that responds to environmental toxicants, is increasingly recognized as a key player in embryogene

74 The genomic organization of chromatin is increasingly recognized as a key regulator of cell be

75 ppressive and anti-cancer drug rapamycin and is increasingly recognized as a key regulator of cell gr

76 soft path" approach toward water management, is increasingly recognized as a key strategy toward ensu

77 Thus, partner availability is increasingly recognized as a key variable structuring

78 for decades, the humoral alloimmune response is increasingly recognized as a leading cause of graft l

79 er farmers with agricultural intensification is increasingly recognized as a leading priority of sust

80 Cardiovascular disease is increasingly recognized as a life-limiting problem in

81 The latter is increasingly recognized as a major cause of late graf

82 s in patients with rheumatoid arthritis (RA) is increasingly recognized as a major comorbidity.

83 Glycogen synthase kinase-3 (GSK-3) is increasingly recognized as a major contributor to sig

84 between the vasculature and retinal neurons is increasingly recognized as a major factor contributin

85 Gender is increasingly recognized as a major factor in the outc

86 ess favoring the G and C over A and T bases, is increasingly recognized as a major factor.

87 Structural polymorphism is increasingly recognized as a major form of human geno

88 The Golgi apparatus is increasingly recognized as a major hub for cellular s

89 transcripts by nonsense-mediated mRNA decay is increasingly recognized as a mechanism for reducing m

90 Nuclear-electronic (vibronic) coupling is increasingly recognized as a mechanism of major impor

91 ranscriptional regulation of gene expression is increasingly recognized as a model for inherited and

92 RNA editing is increasingly recognized as a molecular mechanism regu

93 Additionally, SZ is increasingly recognized as a neurodevelopmental disor

94 Schizophrenia is increasingly recognized as a neurodevelopmental disor

95 dogenous inhibitor of nitric oxide synthase, is increasingly recognized as a novel biomarker in cardi

96 The adenosine A(2A) receptor (A(2A)R) is increasingly recognized as a novel therapeutic target

97 s 3 and 4.IMPORTANCE Hepatitis E virus (HEV) is increasingly recognized as a pathogen that affects bo

98 is a well-known initiator of cell death that is increasingly recognized as a physiological modulator

99 The human gut microbiota is increasingly recognized as a player in colorectal can

100 (LSD1) regulates histone methylation and it is increasingly recognized as a potential therapeutic ta

101 oral routes, in particular through the skin, is increasingly recognized as a potentially important fa

102 Immunotherapy, both active and passive, is increasingly recognized as a powerful approach to a w

103 nd factor (VWF), a key player in hemostasis, is increasingly recognized as a proinflammatory protein.

104 serum metabolite alpha-hydroxybutyrate (AHB) is increasingly recognized as a reliable IGT and diabete

105 endent pathways in pathological angiogenesis is increasingly recognized as a result of the emerging d

106 Although adiposity is increasingly recognized as a risk factor for atrial f

107 Traumatic brain injury (TBI) is increasingly recognized as a risk factor for deleteri

108 Bariatric surgery is increasingly recognized as a safe and effective inter

109 Although Mycoplasma genitalium is increasingly recognized as a sexually transmitted pat

110 Respiratory syncytial virus (RSV) is increasingly recognized as a significant cause of adu

111 Pulmonary hypertension is increasingly recognized as a significant source of mo

112 Variation in gene copy number is increasingly recognized as a source of inter-individu

113 Functional tricuspid regurgitation (TR) is increasingly recognized as a source of morbidity.

114 lternative splicing (AS) of mRNA transcripts is increasingly recognized as a source of transcriptome

115 Pluripotency is increasingly recognized as a spectrum of cell states

116 malin-fixed paraffin-embedded tissues (FFPE) is increasingly recognized as a strategy for the discove

117 Vascular targeting for cancer is increasingly recognized as a therapeutic strategy alt

118 he prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imagin

119 Glial cells are increasingly recognized as active players that profo

120 k factor for neurodegenerative diseases, age is increasingly recognized as adversely influencing rege

121 normalities in the coronary microcirculation are increasingly recognized as an elementary component o

122 Enteroaggregative Escherichia coli (EAEC) are increasingly recognized as an important agent of inf

123 ndromes of frontotemporal lobar degeneration are increasingly recognized as an important cause of ear

124 ella Typhi, invasive nontyphoidal Salmonella are increasingly recognized as an important cause of feb

125 Mutations in bestrophin-1 are increasingly recognized as an important cause of inh

126 r interstitial fibroblasts (lipofibroblasts) are increasingly recognized as an important component of

127 (AT) generated by alternative splicing (AS) are increasingly recognized as an important mechanism en

128 Executive function (EF) abilities are increasingly recognized as an important protective f

129 Epigenetic effects are increasingly recognized as an important source of va

130 Copy number variations (CNVs) are increasingly recognized as an substantial source of

131 y information relay center, the thalamus has been increasingly recognized as an essential node in var

132 Among the latter, behavioral stress has been increasingly recognized as an important factor in t

133 Hydrogen sulfide (H2S) has been increasingly recognized as an important signaling m

134 olonizes a wide spectrum of organisms and is being increasingly recognized as an opportunistic human

135 , the disordered matrix in the diseased lung is increasingly recognized as an active and important co

136 Vertebral compression fracture (VCF) is increasingly recognized as an adverse event after spi

137 olved in social and reproductive activities, is increasingly recognized as an antinociceptive and anx

138 Acquired neuromyotonia is increasingly recognized as an autoimmune disorder, fr

139 'Citizen science' is increasingly recognized as an effective tool to monit

140 Rothia mucilaginosa is increasingly recognized as an emerging opportunistic

141 Cellular NADH conformation is increasingly recognized as an endogenous optical biom

142 mC), the sixth base of the mammalian genome, is increasingly recognized as an epigenetic mark with im

143 Inflammation is increasingly recognized as an essential component of

144 Propionibacterium acnes is increasingly recognized as an important agent of pros

145 dynamics in allosteric signaling of proteins is increasingly recognized as an important and subtle as

146 Mixotrophy is increasingly recognized as an important and widesprea

147 e transthyretin cardiac amyloidosis (ATTRwt) is increasingly recognized as an important cause of hear

148 Chronic pain is increasingly recognized as an important comorbidity o

149 ntibody formation and allograft dysfunction, is increasingly recognized as an important complication

150 dition known as cerebral amyloid angiopathy, is increasingly recognized as an important component lea

151 deposition and associated neuroinflammation is increasingly recognized as an important component lea

152 Epidemiology is increasingly recognized as an important component of

153 Inflammation is increasingly recognized as an important component of

154 Bs, metabolic sulfation to form PCB sulfates is increasingly recognized as an important component of

155 Copy number variation (CNV) is increasingly recognized as an important contributor t

156 Inflammation is increasingly recognized as an important contributor t

157 Structural chromosomal variation is increasingly recognized as an important contributor t

158 The endosome is increasingly recognized as an important crossroad for

159 between different parts of the renal tubule is increasingly recognized as an important determinant o

160 kidney stiffens after injury, a process that is increasingly recognized as an important driver of fib

161 The poly(Pro)II (P(II)) conformation is increasingly recognized as an important element in pe

162 imarily affects the arteries, venous disease is increasingly recognized as an important entity.

163 Lymphatic vasculature is increasingly recognized as an important factor both i

164 Genetic predisposition is increasingly recognized as an important factor.

165 genetic material between non-mating species, is increasingly recognized as an important force in the

166 Osteoporosis in men is increasingly recognized as an important health proble

167 Like the internal gut microbiome, which is increasingly recognized as an important instructor of

168 Sleep is increasingly recognized as an important lifestyle con

169 ted defense against natural enemies of hosts is increasingly recognized as an important mechanism by

170 Sumoylation is increasingly recognized as an important mechanism con

171 sarcoplasmic reticulum calcium (Ca) cycling is increasingly recognized as an important mechanism for

172 Nuclear compartmentalization is increasingly recognized as an important mechanism for

173 Acetylation is increasingly recognized as an important metabolic reg

174 Allostery through DNA is increasingly recognized as an important modulator of

175 Transient disulfide bond formation is increasingly recognized as an important molecular reg

176 ut CDI among pediatric patients, C difficile is increasingly recognized as an important pathogen amon

177 Respiratory syncytial virus (RSV) is increasingly recognized as an important pathogen in a

178 rrhea among adults in Western countries, and is increasingly recognized as an important pathogen in c

179 Synovial inflammation is increasingly recognized as an important pathophysiolo

180 The galactoside-binding protein galectin-3 is increasingly recognized as an important player in can

181 Intracellular pH (pHi) dynamics is increasingly recognized as an important regulator of

182 Nicotinamide adenine dinucleotide (NAD) is increasingly recognized as an important signaling mol

183 ulation of hepatoviral or misfolded proteins is increasingly recognized as an important step in the p

184 he prostate-specific membrane antigen (PSMA) is increasingly recognized as an important target for im

185 tent and elevated distress following a loss, is increasingly recognized as an independent form of psy

186 in the development of atherosclerosis, which is increasingly recognized as an inflammatory condition.

187 Cardiac rehabilitation is increasingly recognized as an integral component of t

188 ix-producing fibroblasts and myofibroblasts, is increasingly recognized as an integral part of tissue

189 Strong social capital is increasingly recognized as an organizational advantag

190 Genetic defects in DNA repair are increasingly recognized as being able to cause degen

191 Children are increasingly recognized as being at risk for C. diff

192 The role of intercellular communication is increasingly recognized as being critical to tumoral

193 Extraction of higher value from lignin is increasingly recognized as being crucial to the econo

194 Inflammation is increasingly recognized as being of both physiologica

195 is a feature of intestinal barrier function, is increasingly recognized as being of relevance for hea

196 Cholangiocytes are increasingly recognized as biologically important be

197 Cholangiocytes are increasingly recognized as biologically important be

198 Cholangiocytes are increasingly recognized as biologically important ep

199 Cholangiocytes are increasingly recognized as biologically important ep

200 les of intercellular communication, exosomes are increasingly recognized as biomarkers and prognostic

201 mbly of peptides into ordered nanostructures is increasingly recognized as both a bioengineering tool

202 oth inherited and acquired defects, and they are increasingly recognized as causes of human diseases.

203 Congenital myasthenic syndromes (CMSs) are increasingly recognized as causes of muscle fatigue

204 Synaptic plasticity deficits are increasingly recognized as causing the memory impair

205 typically thought of as a movement disorder, is increasingly recognized as causing cognitive impairme

206 ically associated with disease in childhood, is increasingly recognized as causing problems in adults

207 The importance of phytohormone balance is increasingly recognized as central to the outcome of

208 roles in maintaining tissue homeostasis and are increasingly recognized as components of stem cell n

209 Although it is increasingly recognized as consisting of numerous het

210 Bacteria biofilms are increasingly recognized as contributing to bacterial

211 hildhood exposure to environmental toxicants is increasingly recognized as contributing to the growin

212 Inflammation is increasingly recognized as contributing to the pathog

213 The ROCKs are increasingly recognized as critical coordinators of

214 Inland waters are increasingly recognized as critical sites of methane

215 d the ECM in the tumor microenvironment have been increasingly recognized as critical modulators of t

216 Clinical practice guidelines are being increasingly recognized as critically important to

217 These diseases are increasingly recognized as disorders of immune dysre

218 st, obesity-related cardiometabolic diseases are increasingly recognized as disorders of metabolic in

219 Signals from the microenvironment are increasingly recognized as drivers of disease progre

220 RNA binding proteins (RBPs) are increasingly recognized as essential factors in tiss

221 Long QT syndrome without symptoms is increasingly recognized as family members are screene

222 e homeostasis and repair of many tissues and are increasingly recognized as functionally heterogeneou

223 Heterogenous transmission is increasingly recognized as fundamental to epidemiolog

224 Children with neurofibromatosis type 1 (NF1) are increasingly recognized as having a high prevalence

225 Marine reserves are increasingly recognized as having linked social and

226 Antibiotics are increasingly recognized as having other, important p

227 As people with intellectual disabilities are increasingly recognized as having severe and endurin

228 Receptor tyrosine kinases (RTKs) are increasingly recognized as having the capacity to si

229 d age and comorbidity, and tumor anatomy are being increasingly recognized as having significant prog

230 As such, they are increasingly recognized as impacting all aspects of

231 y evolved in several eukaryotic lineages and are increasingly recognized as important and emerging pa

232 Although autosomal genes are increasingly recognized as important causes of intel

233 Finally, innate lymphoid cells are increasingly recognized as important cellular source

234 esistance, dyslipidaemia and body mass index are increasingly recognized as important components of n

235 Bacterial biofilms are increasingly recognized as important contributors to

236 Coinfections are increasingly recognized as important drivers of dise

237 Furthermore, viruses such as Influenza are increasingly recognized as important etiologic agent

238 lular processes resulting in this deposition are increasingly recognized as important factors amplify

239 Synaptic changes in the auditory periphery are increasingly recognized as important factors in hear

240 at higher rates than unattached bacteria and are increasingly recognized as important Hg methylation

241 Bacterial virulence factors are increasingly recognized as important in the understa

242 euronal hyperexcitability and excitotoxicity are increasingly recognized as important mechanisms for

243 A(2B) adenosine receptors are increasingly recognized as important orchestrators o

244 ce Ag-specific adaptive immune responses and are increasingly recognized as important players in inna

245 However, MC are increasingly recognized as important regulators of a

246 high-affinity extrasynaptic GABAA receptors, are increasingly recognized as important regulators of c

247 Extracellular nucleotides are increasingly recognized as important regulators of g

248 vascular ectasia (GAVE) and angiodysplasia, are increasingly recognized as important sources of gast

249 he epithelial cells that line the bile ducts-are increasingly recognized as important transporting ep

250 le of genetic heterogeneity within neoplasms is increasingly recognized as important for understandin

251 The complement system is increasingly recognized as important in the pathogene

252 ng cell types in the immune microenvironment is increasingly recognized as important to tumor cell re

253 al carriers of insoluble lipid molecules and are increasingly recognized as innate immune effectors.

254 Inflammation and thrombosis are increasingly recognized as interrelated biologic pro

255 Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as key chromatin regulators,

256 Podocytes are increasingly recognized as key players in the pathog

257 Gap junctions are increasingly recognized as key regulators of embryon

258 Cardiovascular diseases are increasingly recognized as late effects of Hodgkin l

259 Common ocular pathogens, such as HSV-1, are increasingly recognized as major contributors to vis

260 -AG are receiving renewed attention, as they are increasingly recognized as major determinants of how

261 experimental pulmonary hypertension (PH) and are increasingly recognized as major pathogenic componen

262 Brain glycogen and its metabolism are increasingly recognized as major players in brain fu

263 rapid effects of defensive symbionts, which are increasingly recognized as major players in the ecol

264 Although protein S-nitrosylation is increasingly recognized as mediating nitric oxide (NO

265 Glutamatergic systems have been increasingly recognized as mediators of methampheta

266 which involve patient-derived tumor samples, are increasingly recognized as more representative model

267 Because endocannabinoids are increasingly recognized as neuroendocrine regulators

268 of such circulating ncRNAs, these molecules are increasingly recognized as noninvasive and readily a

269 Patient-reported outcomes (PROs) are increasingly recognized as of substantial importance

270 mmon post-translational modification and has been increasingly recognized as one of the most prominen

271 Microvascular endothelial cells (ECs) are increasingly recognized as organ-specific gatekeeper

272 to be only inert energy storage depots, LDs are increasingly recognized as organelles that have impo

273 Actinomycetes are increasingly recognized as pathogenic in the immunoc

274 Conformational equilibria are increasingly recognized as pivotal for biological fu

275 Halogens in the troposphere are increasingly recognized as playing an important role

276 ion, 2 components of mitochondrial dynamism, are increasingly recognized as playing central roles as

277 lation and capsular polysaccharide formation are increasingly recognized as playing central roles in

278 Respiratory epithelium has been increasingly recognized as playing an important rol

279 egrade misfolded and aggregated proteins are being increasingly recognized as playing a pivotal role

280 Mitochondrial dysfunction is increasingly recognized as playing a causative role i

281 Conditioning involving interoceptive stimuli is increasingly recognized as playing a role in many dis

282 The surrounding cancer stroma is increasingly recognized as playing an important role

283 erefore, these astrocyte-neuron interactions are increasingly recognized as potential contributors to

284 Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as potential key regulators

285 rative disorders, multifunctional drugs have been increasingly recognized as potential treatments.

286 Soil biodiversity is increasingly recognized as providing benefits to huma

287 Exposure to and connection with nature is increasingly recognized as providing significant well

288 mediated by cytoplasmic tyrosine motifs and are increasingly recognized as receptors for pathogens t

289 Bats are increasingly recognized as reservoir species for a v

290 Respiratory viruses are increasingly recognized as serious causes of morbidi

291 its associated small regulatory RNAs (sRNAs) are increasingly recognized as the players of a large ne

292 However, major bleeding is increasingly recognized as the Achilles' heel of the

293 ingae is an emerging bacterial pathogen that is increasingly recognized as the causative agent of a v

294 Mild-to-moderate neutropenia is increasingly recognized as the hepatitis C population

295 Nonalcoholic steatohepatitis (NASH) is increasingly recognized as the most common chronic li

296 ation prior to surgery (neoadjuvant therapy) is increasingly recognized as the preferred strategy for

297 Precision medicine (PM) is increasingly recognized as the way forward for optimi

298 mining from electronic health records, which are increasingly recognized as valuable sources of pheno

299 Long noncoding RNAs (lncRNAs) are increasingly recognized as vital components of gene

300 Although heritable microorganisms are increasingly recognized as widespread in insects, no