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7 ve intact paranodal axoglial contacts, which is indicated by a complete lack of neurexin/contactin-as
8 he biological significance of this mechanism is indicated by a complete suppression of the ionizing r
9 y in the mutated, but still functional, step is indicated by a greatly reduced sensitivity of its rat
10 ecificity of iron/copper inhibition of NEILs is indicated by a lack of similar inhibition of OGG1, wh
14 tion showed a lower level of toxicity, which is indicated by a steady increase in body weight of mice
15 t is competent for hydride transfer and that is indicated by a strong charge-transfer interaction.
16 leading to their accumulation in the bulges is indicated by a strongly reduced response to mobilizat
17 f a stable N2 nanobubble at the Pt electrode is indicated by a sudden drop in voltammetric current, a
19 ift from IgM to IgG, and affinity maturation was indicated by a change from mostly low affinity IgM a
23 capability of the proposed scoring algorithm was indicated by a receiver operating characteristic cur
29 ents showed positive clinical effects, which were indicated by a reduction in AVH scores (p </= .001)
31 essive effects of MnSOD-overexpressing cells were indicated by: (a) decreased plating efficiency; (b)
32 f adjacent tumor into underlying musculature was indicated by abnormal enhancement within these struc
35 for beta-catenin in basal cell proliferation was indicated by activation of the TOPGal transgene on p
36 Deficiency of apical retinal neuroepithelium is indicated by altered localization of apical junction
39 vidence of excitation-contraction uncoupling is indicated by an elevation in diastolic calcium that i
41 ss in the TLR2(-/-) mice than in the WT mice was indicated by an elevation in auditory-evoked brain s
42 intrinsic problems with the oligodendrocyte was indicated by an impaired ability of oligodendrocytes
43 d to the increase in oxidative stress, which was indicated by an increase in cytosolic 8-iso prostagl
44 ate effect of {Mo(36)} to MB wheel synthesis was indicated by an increase in the yield and rate of pr
46 de Ge-H bonds oriented normal to the surface was indicated by angle-dependent Fourier-transform infra
50 role for Insv in transcriptional repression was indicated by binding of Insv to Su(H), and by strong
51 However, increased polarity of empty capsids was indicated by bis-ANS binding, something not seen for
52 olecules involved in FDC-B-cell interactions are indicated by blocking the ligands and receptors on F
53 de bodies on infusion of activated platelets was indicated by both elevation of plasma VWF levels and
55 tween the small and large ribosomal subunits are indicated by CG interactions with large spring const
58 hormone in the outer region of the membrane is indicated by characteristic changes in the transition
60 The formation of the G-quadruplex structure was indicated by circular dichroism (CD) spectroscopy an
61 domain of endopin 2 with papain and elastase were indicated by cleavage of endopin 2 near the predict
62 equently observed, and genetic heterogeneity is indicated by clinical and morphological variability i
63 teraction of rat TFIIIA with rat TFIIIA-intP was indicated by co-chromatography of the two proteins o
64 Conserved microsynteny of the CpCYC-b region is indicated by colinearity of two to four genes between
67 primary human monocyte rolling and adhesion was indicated by competition studies in which addition o
70 n 6hydroxy-1-indanone and aromatic aldehydes is indicated by cooperative interactions between p-methy
72 Impaired cell adhesion and epithelialization are indicated by decreased E-cadherin and NCAM expressio
73 sistance to parathyroid hormone (PTH), which is indicated by decreased double-labeled surface and ost
75 s accompanied by synaptic dysfunction, which is indicated by decreased fluorodeoxyglucose uptake on P
76 hepatic immune activation by IFNalpha, which is indicated by decreased levels of CXCL10 and CXCL11 an
78 istic role of miR-155 in TNFalpha regulation was indicated by decreased TNFalpha levels in alcohol-tr
80 This inhibition of cell cycle progression was indicated by delayed progression into nocodazole-ind
83 rity in the pharmacokinetics of rhEndostatin was indicated by dose-proportionate increases in the are
84 ads to marked oxidative stress in cells that is indicated by elevated intracellular reactive oxygen s
86 ive response and not an adverse toxic effect was indicated by enhanced survival of ribosome mutants a
89 st in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, com
90 UX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities
93 etween SMN and Gemin2 within single granules was indicated by fluorescence resonance energy transfer
95 l functional organization in the human brain is indicated by gaze-adaptation experiments, in which sy
97 etabolism or increased secretion in PNS rats was indicated by greater plasma testosterone and progest
99 steine thiolate coordination in Co(2+)-MT2-A was indicated by high absorptivity in the 300-400 nm cha
101 yet a greater abundance of thin, dense walls was indicated by high-resolution x-ray tomography of ste
104 s may have a macrophage origin, despite what is indicated by immunostaining for macrophage-related ma
106 ional significance of the structural changes was indicated by improved oxygenation and lung complianc
107 ct role for OX40L in regulating inflammation was indicated by improved survival, decreased cytokine p
109 At the cellular level, impaired neurogenesis is indicated by increased early-born retinal neurons tha
111 reased treatment intensity in the EGDT group was indicated by increased use of intravenous fluids, va
112 veillance intervals (unless shorter interval is indicated by individual findings), and a CF-specific
113 independent functions of the receptor, which are indicated by its only known physiological ligand, po
114 S-1/Rab4-mediated mitochondrial accumulation is indicated by its abrogation by dominant-negative HRES
115 The d orbital aromaticity of Cu(4)Li(2) also is indicated by its atomization energy, 243.2 kcal/mol,
117 urn-on probe in longer-term cellular studies is indicated by its lack of influence on cell viability
120 A critical concentration of 0.4-1.0 microM was indicated by light scattering experiments and extrap
125 -sheet structures in the majority of fibrils are indicated by measurements of intermolecular distance
127 r cells could be due to promoter methylation was indicated by methylation-specific PCR analysis.
128 perspective of TRADD's role in TNF signaling was indicated by microarray gene expression analysis, wh
130 es within this regulatory fragment that have been indicated by mutational studies to influence prion
131 han anticipated role of NF-kappaB signalling was indicated by mutations in 11 members of the NF-kappa
132 is and its intracellular accumulation, which was indicated by neuron-specific transcript analysis.
136 The significance of this gene signature is indicated by our demonstration of cadmium chloride- o
137 trolling the bull sperm chromatin morphology is indicated by our observation that DNA condensates for
139 o release ETH in betaftz-f1 silenced animals is indicated by persistent ETH immunoreactivity in Inka
142 /-) mice were also found to be hypotonic, as was indicated by poor performance on the wire hanging ta
143 structural ordering of the carbon materials is indicated by powder XRD patterns with at least two we
144 e outermost layers of the B. anthracis spore is indicated by previous proteomic analyses of the exosp
146 ose effects at least three years longer than was indicated by previous, data-limited evaluations.
148 of endopin 2C with cathepsin L and elastase were indicated by protease cleavage of the RSL region be
149 uch tasks, to a version in which the choices were indicated by reaching movements, which affords exec
151 cient serotonin neurotransmission in suicide is indicated by reduced brainstem serotonin (5-HT) and 5
154 Deficits in central neurosteroid production were indicated by reduced 5alpha-reductase mRNA levels i
155 airwise additivity of the hydrophobic effect is indicated by reliable experimental Henry's constants
157 nthesis of VirF and its downstream effectors was indicated by restoration of invasion when a mutation
159 cade is relevant to asthmatic hypersecretion was indicated by results showing that mucin induction by
160 Pathophysiological significance of VEGF-Ax is indicated by robust expression in multiple human tiss
162 nectivity in the ventral and dorsal striatum was indicated by seed-based analyses on resting-state da
163 tional importance of bidirectional promoters is indicated by selective pressure to maintain the arran
168 ia-mediated apoptosis induced by survivin-2B was indicated by Smac release from mitochondria, activat
169 ctions between cells and the mineral surface were indicated by sorption and pH-induced desorption res
170 likely being mediators in electron transfer, was indicated by specific inhibition of their activity t
171 ng complexes at saturating levels of 2 and 4 is indicated by splitting of the backbone NH resonances
174 Convergence of the calculated free energies was indicated by substantial declines in standard deviat
175 al significance of scale-free brain activity is indicated by task performance modulation and regional
176 expression between zebrafish and mouse teeth are indicated by the apparent lack of fgf8 and pax9 expr
177 dazole, two separate pathways of heme access are indicated by the distinct kinetics at low and high c
178 n and compensatory insertion/deletion events are indicated by the failure of mutations to affect seco
179 requirement of Wg signaling for the process are indicated by the finding that mislocated RP2 neurons
181 the gene is unclear; horizontal transfer may be indicated by the similarity of the tRNA domain to tha
182 athways related to the SLE pathogenesis have been indicated by the identified genetic risk factors, i
183 A developmental role for the Ahr locus has been indicated by the observation that mice harboring a
186 ding protein (C/EBP) family in myeloid cells is indicated by the ability of C/EBPbeta to replace C/EB
189 educes the baseline inflammatory status that is indicated by the CRP concentration in healthy adult b
190 een confined to the last 4 million years, as is indicated by the dating of intact retroelements.
191 e relevance of these studies to human cancer is indicated by the demonstration that: (a) activation o
193 meostasis of the adult cardiovascular system is indicated by the development of aortic ossification a
194 lowed cooling responsible for CM enhancement is indicated by the development of shell-related emissio
195 ctive site, and is the site of the mutation, is indicated by the disappearance in the F50A mutant of
197 for Runx function in the senescence program is indicated by the effects of Runx2 disruption, which r
198 acids; instead, it is related to flux, which is indicated by the enzymatic capacity to use these cent
199 ortance of this relatively small pool of TAG is indicated by the fact that cardiac mechanical functio
200 al role for the apical localization of ErbB2 is indicated by the fact that ErbB2 phosphorylated at ty
202 ional significance of CD40 ligand clustering is indicated by the finding that clustering of CD40 on B
203 nvolvement of this lysine in proton transfer is indicated by the finding that its substitution with a
205 ation of COX-2 expression in the vasculature is indicated by the findings that the expression of COX-
206 EMT processes induced by EtDO-P4 or TGF-beta is indicated by the following findings: (i) The enhanced
207 angement of the bases in Rh2(DTolF)2{d(ApA)} is indicated by the H8/H8 NOE cross-peaks in the 2D ROES
210 sponse in the development of atherosclerosis is indicated by the increased expression of adhesion mol
212 dissociation at the transition state of TadA is indicated by the large [6-(15)N] KIE of 1.022 and cor
213 e ribose 2'-OH and alpha-P in enzyme binding is indicated by the loss of productive binding seen with
219 pecific ketonization of an enol(ate) species is indicated by the observation that COMC-6 (chirally la
221 upport for a more significant role for GNA-3 is indicated by the observation that expression of a GTP
222 The clinical significance of these findings is indicated by the observation that the BRCA2/APRIN int
223 nism through which SP may promote plasticity is indicated by the observations that STIM-1, the sensor
225 nic potential of many Gram-negative bacteria is indicated by the possession of a specialized type III
226 depletion of the proton motive force, which is indicated by the potential-sensitive dye bis-(1,3-dib
227 S, an increase in alpha-helical conformation is indicated by the predominant Raman amide I marker ban
228 wastewater sludge retention pond in Magnolia is indicated by the presence of congeners that had not b
229 Kidney damage is frequently asymptomatic but is indicated by the presence of proteinuria, hematuria,
230 s, but their existence in sexual populations is indicated by the presence of sperm in the reproductiv
231 RI, active inflammation of sacroiliac joints is indicated by the presence of subchondral bone marrow
232 proton between the 2AP and cytosine residues is indicated by the rapid exchange of the cytosine amino
233 gene expression while a core function of EWG is indicated by the regulation of metabolic genes by bot
234 nd impaired basal ganglia-dependent behavior is indicated by the reversal of behavioral deficits thro
235 o the regulation of cellular DNA replication is indicated by the transient translocation in heated ce
236 ction in rsw4 at the restrictive temperature is indicated by the widespread failure of replicated chr
237 nt hypoventilation during the fentanyl trial was indicated by the 9% lower V(E)/V(CO(2)), causing a 5
238 e importance of the VEGF receptor neuropilin was indicated by the ability of a neuropilin-binding VEG
239 contribution of COX-2 to human tumor growth was indicated by the ability of celecoxib, an agent that
240 hway in GM-CSF-stimulated delay of apoptosis was indicated by the ability of LY294002 to attenuate ap
241 role for p53 in TRAIL-R2-mediated apoptosis was indicated by the ability of p53 siRNA to significant
242 bacterial genomic DNA, and high specificity was indicated by the absence of reactivity against close
244 oordination of Pro and redox metabolism also was indicated by the altered expression of chloroplast a
245 able benefit when the location of the target was indicated by the appearance of a brief peripheral pr
246 shown to involve a radical mechanism, which was indicated by the appearance of an induction period w
249 sosomal clearance of alpha-synuclein in vivo was indicated by the detection of alpha-synuclein in the
251 tion-competent HIV-1 in thy/liv-SCID-hu mice was indicated by the emergence of HIV-1 infection in mic
252 ective pressure for increased tmRNA activity was indicated by the emergence of mutant strains with el
253 oxidase in LT-induced microbicidal activity was indicated by the fact that bacterial killing was abr
254 ved in the control of cAMP levels in oocytes was indicated by the finding that expression of the mRNA
255 emporal role for cAMP in biofilm development was indicated by the finding that glucose addition after
258 electrochemical oxidation of adenine, which was indicated by the improvement of anodic peak current
260 for these immune cells in tumor suppression was indicated by the inability of rIL-7/HGFbeta to inhib
261 e outcome of EMT, was abolished by TSA; this was indicated by the inhibition of type I collagen depos
263 eliability between the proxy and self-report was indicated by the kappa statistic and the intraclass
269 ted a higher acyl chain packing order, which was indicated by the lower acyl chain packing free volum
270 ficance of Bim in this GrB apoptotic cascade was indicated by the marked protection against GrB-media
271 n could be relevant to postharvest infection was indicated by the observation that C. gloeosporioides
275 mia virus (MuLV) Env protein in viral fusion was indicated by the potent inhibition of MuLV-induced f
278 n in the species, and population structuring was indicated by the presence of unique alleles and a th
279 CCR2 in upregulating costimulatory molecules was indicated by the reduced expression of CD80, CD86, a
281 lation in enhancing the fitness of R. rubrum was indicated by the relationship between PHA content an
285 he three dominant forms of the fibrils which were indicated by the presence of three distinct, self-c
287 y motor phenotypes observed in these mutants is indicated by their altered sensitivity to the dopamin
288 matory state of patients with hyperlipidemia is indicated by their increased erythrocyte sedimentatio
290 ficity of these antagonists for MC receptors was indicated by their lack of effect on l-Glu responses
291 cond, specific activation of dendritic cells was indicated by their marked up-regulation in expressio
293 ubscale, c) the need for the fifth construct is indicated by this study's results, and d) including t
295 function phenotype for deterin of cell death was indicated by transfections with either a dominant ne
298 or a potential structural variant at a locus is indicated by variation in the counts of short-reads t
299 or activities, but functional specialization was indicated by YqjG and SpoIIIJ showing respectively g
300 organization in response to interneuron loss was indicated by zinc transporter-3 (ZnT3)-- and beta-sy
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