ライフサイエンスコーパス: be introduced by

1 Human platelet FVIII expression was introduced by 2bF8LV-mediated transduction of human

2 to their relative frequency and new variants are introduced by a process of random mutation.

3 Ig somatic mutations would be introduced by a polymerase (pol) while repairing DNA

4 We first met on a Boston streetcar in 1940, being introduced by a mutual friend.

5 netics of motors at the protrusion tip which is introduced by a boundary condition.

6 For serotonin, a link to the indole core is introduced by a Claisen rearrangement from the allyla

7 Bending is introduced by a strong (i, i + 8) hydrophobic interac

8 ne in 2,2'-positions of the 4,4'-bipyridines was introduced by a copper-catalyzed Finkelstein reactio

9 pment in NOD/Lt mice, a disrupted Casp1 gene was introduced by a speed congenic technique.

10 ed with lines where endogenous PsGA3ox1 (LE) was introduced, by a series of backcrosses, into the sam

11 and assembly of ribosomes, operon variations were introduced by a plasmid into an Escherichia coli st

12 Insertions were introduced by a two-step mutagenesis procedure into

13 attice-spring lattice-Boltzmann model (GLLM) is introduced by adding a three-body force in the tradit

14 A hydrogen bond or hydrophobic interaction was introduced by adding a single functional group to th

15 48 segment of the eventual triene side chain was introduced by addition of a functionalized Grignard

16 Out-of-plane curvature is introduced by adjusting the particular position and p

17 OVA-specific CD8(+) T cells were introduced by adoptive transfer and then activated

18 ve generated much interest since the concept was introduced by Aleksandr Oparin in the 1920s, and the

19 eletion of 727 bp in the 5' end of the gene, was introduced by allelic replacement into S. aureus Rey

20 The first two stereocenters are introduced by an asymmetric allylic alkylation react

21 Immortal time bias is introduced by an "anytime-in-pregnancy" exposure defi

22 Specificity of the immunoassay was introduced by an anti-immune complex (IC) antibody b

23 disease in which the 79A murine prion strain was introduced by an intraperitoneal route into BALB/cJ(

24 The C23 hydroxyl of oridamycin B was introduced by an sp(3) C-H bond oxidation at a late

25 Moreover, the pyro-phototronic effect can be introduced by applying a -0.45% compressive strain to

26 es suggest two acceptors and one donor level were introduced by As doping with activation energies at

27 The absolute stereochemistry was introduced by asymmetric Noyori reduction of furfury

28 naturally occurring hypermodified nucleoside was introduced by automated chemical synthesis.

29 The propionyl-lysine modification is introduced by bacterial Gcn-5-related N-acetyltransfe

30 by fungi; antimicrobials and acaricides that are introduced by beekeepers; and fungicides, herbicides

31 c organic matter on the early Earth may have been introduced by carbonaceous asteroids and comets.

32 Vascular injury was introduced by carotid air-dry endothelium denudation

33 The results are consistent with the disease being introduced by cattle infected with T b rhodesiense

34 mple cell we can detect 3-A-sized steps that are introduced by cell translations at rates of 10 Hz, w

35 Typically, anisotropy has been introduced by changing the shape of the inorganic n

36 The term was introduced by Charles Sherrington in 1897.

37 n, hydrophobic and hydrophilic moieties have been introduced by chemical and mutagenic methods to the

38 These have been introduced by chemical synthesis at central sites w

39 Unnatural amino acids were introduced by chemical synthesis at the N- and C-ca

40 pH-switchable ion-transport selectivity was introduced by chemisorbing L-cysteine to the inside

41 The term "autophagy" was introduced by Christian de Duve in part based on ult

42 etically modified plants when R genes cannot be introduced by classical breeding.

43 s and the reactants for the modification can be introduced by coating them onto the AFM tip.

44 initiate movement only if surface asymmetry is introduced by coating the beads on one hemisphere.

45 ontaining BR96 V region sequences, mutations were introduced by codon-based mutagenesis at single pos

46 rectly investigate the consequences of virus being introduced by DCs or T cells, we reinjected ex viv

47 egments, increased junctional diversity that was introduced by differential TdT activities, and somat

48 sMMO hydroxylase into which product alcohols were introduced by diffusion represent the structures in

49 We speculate that the tandem mutations are introduced by direct sequential misinsertions and th

50 ion, and the halogens in the aromatic ring A were introduced by direct halogenation of protected comp

51 +/- 0.4 mug of MC and 1.0 +/- 0.5 mug of DC were introduced by downstream sample preparation (drying

52 were observed in both LTRs, which could have been introduced by either RT or RNA pol II, whereas the

53 Those hydrazide groups are introduced by electrografting of diazonium salts or

54 DNA substrates generated by recombinant PCR are introduced by electroporation into strains containin

55 re linked to a luciferase reporter gene have been introduced by electroporation into the retinoblasto

56 The best inhibitor of the Shc domain was introduced by electroporation into Rat1 fibroblasts

57 ry system, nanoparticles and protein species are introduced by electrospray injection from the fluid

58 ently, dual viral transneuronal labeling has been introduced by employing recombinant strains of PRV-

59 complementarity determining regions that had been introduced by engineering these segments next to hu

60 Mutations can be introduced by error-prone polymerases such as polymer

61 the intended substitutions, novel mutations were introduced by errors that occurred during PCR.

62 A design rule is introduced by establishing and proving the theoretica

63 Phe37 might be introduced by evolution generating a catalytic advant

64 rved between mismatched cytosine base pairs, was introduced by first incorporating a cross-linked pho

65 ions 71-72, which is shared with KIR3DL2 and was introduced by gene conversion before separation of t

66 In this model, depigmentation was introduced by gene gun vaccination with eukaryotic e

67 ion of the GATA-1 locus in which GATA-3 cDNA was introduced by gene targeting.

68 The 8-phenyl group was introduced by Grignard addition to ketone 6 or nucle

69 d (CAG)(76) and (CAG)(84) repeat motifs have been introduced by homologous recombination.

70 first step, a loxP recombination target site is introduced by homologous recombination into a predete

71 gene encoding the C-terminal McpG-GFP fusion was introduced by homologous recombination into the chro

72 arginine (R454)) within the catalytic domain was introduced by homologous recombination.

73 The problem was introduced by Hubbell et al.

74 itoes transmit pathogens which have recently been introduced by humans and the larvae of the fly suck

75 the overlap complexity of a pattern set that was introduced by Ilie and Ilie is closely related to th

76 inhibited when the RNA replication template was introduced by in vivo transcription from DNA or by t

77 nesis." Meta-substituted analogs of Tyr(274) were introduced by in vitro translation in the presence

78 Instead, competition can be introduced by including a separate mechanism that sca

79 The salt bridges were introduced by incorporating arginine and glutamic a

80 Second, response interference was introduced by infrequently changing the location of

81 tified a single "hotspot" at which variation is introduced by insertion of peptide segments.

82 An antibody to mouse GM-CSF was introduced by intracerebroventricular (ICV) injectio

83 ntical to those of animals in which leukemia was introduced by intravenous transplantation of the sam

84 to an explicit theoretical concept that had been introduced by Janet-as the basis for classification

85 a vibrant area of research since this field was introduced by Joseph Barcroft, a century ago.

86 new version of the motif search problem has been introduced by Kuksa and Pavlovic.

87 X-independent decondensation when DNA damage is introduced by laser microirradiation.

88 Allergen immunotherapy was introduced by Leonard Noon 100 years ago and is the

89 acterial genomes, large proportions of genes are introduced by LGT, as indicated by their composition

90 or biotinylated (-S-PEG-biotin) ligands had been introduced by ligand exchange.

91 ient used in the analysis of microarray data was introduced by M. B. Eisen, P. T. Spellman, P. O. Bro

92 array (SGA) method, wherein a query mutation is introduced by mating to mutant arrays, selection of d

93 , a transgene encoding the BCL2 gene product was introduced by mating into the mutant background, and

94 The 13C8 atom is introduced by means of a ring closure of the exocycli

95 Asymmetry is introduced by means of an enantioselective conjugate

96 The protecting group is introduced by means of the readily prepared benzyl br

97 Pay for performance programs being introduced by Medicare and other insurers will lin

98 For 1 and 2, the (18)O atom was found not to be introduced by moisture or by singlet oxygen [(18)((1)

99 copper-coordinating thiolate sulfur of Cys92 is introduced by movement of the amide nitrogens of Phe9

100 more likely from global properties that can be introduced by multiple somatic mutations.

101 We found that phenotypic diversity can be introduced by mutagenesis of the principal sigma fact

102 In this study, carboxylate residues were introduced by mutagenesis into highly oxidizing rea

103 Single Cys residues were introduced by mutation in several consecutive posit

104 The (3)H label is introduced by NaB(3)H(4) reduction and the resulting

105 s that a steric hindrance at the active site was introduced by Nbs but removed by cyanide.

106 However, pathological mutations can also be introduced by nonreciprocal recombination events betw

107 f lymph nodes in healthy mice has previously been introduced by our group.

108 and nonconservative amino acid substitutions were introduced by overlap extension PCR.

109 stimulating factor (GM-CSF) or globin mRNAs were introduced by particle-mediated gene transfer into

110 the MICU during the study period, four (18%) were introduced by patients admitted directly from the c

111 ed directly from the community and ten (45%) were introduced by patients admitted from other hospital

112 sample preparation thus no biases and errors are introduced by PCR reaction.

113 The L2 sequence was introduced by PCR (by replacing 13 codons) into sequ

114 uced by anesthetics, and the extrinsic input is introduced by periodic stimulation of vibrissae.

115 All subsequent modifications of that gene are introduced by phiC31-mediated integration of plasmid

116 dgap in a graphene layer where the asymmetry was introduced by placing a graphene layer on a hexagona

117 er, the large deletions were absent when cre was introduced by pollination.

118 mers are inherently limited by stresses that are introduced by post-gelation volume changes during po

119 These atypical amino acids are introduced by post-translational modification of a r

120 f neuronal activity and anticorrelations can be introduced by preprocessing steps, such as global sig

121 A small amount of the substance of interest was introduced by pressure injection and transport to th

122 Alternate donor substrates were introduced by priming apo AT(4)E with synthetically

123 ure-sensitive) and non-ts (host range), that were introduced by prolonged passage in cell culture or

124 cal, the pair of hydroxyl groups in 37 could be introduced by proper recourse to the oxidation of 36

125 -phenyl-2-(phenylsulfanyl)ethyl moiety could be introduced by reaction of a sugar alcohol with acetic

126 The (13)C labels were introduced by reaction of KS(13)CN with allyl bromi

127 Subsequently, these were introduced by recombination into the C. glabrata ge

128 tion of linearly independent restraints, can be introduced by reducing the negative charge of DNA nan

129 Two mutations were introduced by replacing the essential Arg in each c

130 When a functional alphaGT gene was introduced by retroviral gene transfer into bone mar

131 Retinal vascular occlusion was introduced by rose Bengal and laser photocoagulation

132 eplacement (AVR) with homograft aortic valve was introduced by Ross in 1962 and Barratt-Boyes in 1964

133 present in a single LTR and could only have been introduced by RT.

134 olutions in use today.The intravenous "drip" was introduced by Rudolph Matas in 1924.

135 zing multisignal sedimentation velocity data was introduced by Schuck and coworkers.

136 Tracer fluorescent dyes were introduced by scrape-loading or by microinjection,

137 omyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a transg

138 The benzophenone moiety was introduced by selective hydroboration of the double

139 act number called half-sphere exposure (HSE) was introduced by separating the contacts within upper a

140 For this report, selective deletions in V3 were introduced by shortening of the stem of the V3 loop

141 2 method of comparing haplotype frequencies, is introduced by simply adding the chi2 test statistics

142 Furthermore, specific amino acids can be introduced by site-directed mutagenesis within the la

143 itutions with deleterious effects on fitness was introduced by site-directed mutagenesis into the bac

144 Mutations in PAX6 and PAX6(5a) were introduced by site-directed mutagenesis and tested

145 Mutations in the prpB gene were introduced by site-directed mutagenesis based on th

146 The 151L and 151K mutations were introduced by site-directed mutagenesis in RTs from

147 Mutations were introduced by site-directed mutagenesis of amino ac

148 h, respectively, mild and severe OI variants were introduced by site-directed mutagenesis.

149 involved in VEGF165 binding, point mutations were introduced by site-directed mutagenesis.

150 In the greenhouse, a stressor was introduced by soil infestation with western corn roo

151 These are introduced by somatic mutation and are tumor specifi

152 complementarity between QMC partners, which is introduced by specific modifications of the quadruple

153 i in the presence of linkage disequilibrium, was introduced by Spielman et al.

154 Constructions carrying the mutant enhancer were introduced by stable transformation into an avian e

155 ion at 2 K because a dominant 2-fold barrier is introduced by strong Fe(3d)--> H2(sigma*) pi-backbond

156 ithin the context of a synthetic RNA hairpin was introduced by structural remodeling using a magnesiu

157 supplemental alcohol dehydrogenase activity was introduced by substituting the adhB ORF from Zymomon

158 The aromatic side chains were introduced by Suzuki-Miyaura cross-coupling or clic

159 experiment demonstrating that artifacts can be introduced by synchronization methods.

160 which differentiates natural HIV-1 isolates, was introduced by synonymous substitutions into a gene s

161 mice in which a premature stop codon (Y245X) was introduced by targeted mutagenesis in the murine Tfr

162 egions of the lipid bilayer of the particles are introduced by the addition of sphingomyelin.

163 lymerase I suggest that single-stranded gaps are introduced by the hyperactive variants.

164 stem-loop structures in the Snake amplicons are introduced by the unique design of one of the PCR pr

165 concern regarding the possible skew that can be introduced by the inherent bias in the available data

166 ditions, while the endocylic double bond has been introduced by the allylic rearrangement.

167 that a specific interaction for aniline has been introduced by the mutation.

168 The dominant selectable gene, Ecogpt, has been introduced, by the calcium phosphate precipitation

169 ic unsaturated fatty acid (UFA) biosynthesis is introduced by the FabA dehydratase/isomerase of the b

170 of the excitation; rather, angular momentum is introduced by the particle's interaction with the ani

171 Each makes use of filtering that is introduced by the spatial distribution of inputs on d

172 e competencies in graduate medical education was introduced by the Accreditation Council for Graduate

173 Precautionary allergen labelling (PAL) was introduced by the food industry to help manage and c

174 with Op-iap3 dsRNA, the Op-IAP3 protein that was introduced by the inoculum virus decreased to almost

175 or quaternary structure of the chemoreceptor was introduced by the mutations.

176 The triene system was introduced by the Pd-catalyzed tandem cyclization-Su

177 A reporting domain was introduced by the specific substitution of a single

178 A blockage in the turning gate passageway was introduced by the triple mutant C232V/A251V/A314V.

179 or the molecular quantification of HIV-1 RNA was introduced by the United Kingdom National External Q

180 and the cytoplasmic tail of human VPAC1 and were introduced by transfection into HEK-293 cells expre

181 Nestin is introduced by transient transfection and is positivel

182 Plasmids expressing either Hsp53 or Map53 were introduced by transient transfection into the p53-n

183 a variety of contexts, including genes that were introduced by transient transfection, carried on ep

184 were done with an axially chiral borane that was introduced by us a few years ago, and the refined me

185 The approach is introduced by use of myoglobin from four meats: beef,

186 s been developed to minimize errors that can be introduced by using starting concentrations far from

187 Chemical complexity is introduced by using a precipitating agent, SCN(-), wh

188 The coupling is introduced by using Hills classical semi-spherical vo

189 yl)ethyl)-4-(phenylsulfonyl)piperidine (12), was introduced by using stability toward rat liver micro

190 7-Substitutions were introduced by using 7-substituted-7-deaza heterocyc

191 reomers of C-nucleoside analogues of Fapy.dA were introduced by using the respective phosphoramidites

192 ect in a novel tetragonal magnetic structure is introduced by vacancies in Mn3 Ga0.95 N0.94 , due to

193 onstraining the coordination sphere geometry was introduced by Vallee and Williams with the concept o

194 Electrostatic energy differences were introduced by varying the distribution of charged o

195 possible in hearts exceeding a critical size was introduced by W.

196 ciple of piezotronics and piezo-phototronics were introduced by Wang in 2007 and 2010, respectively.

197 The original Daisyworld was introduced by Watson & Lovelock to demonstrate how t