ライフサイエンスコーパス: be known to

1 tures are now readily accessible, only a few are known to accelerate chemical reactions under substoi

2 Neuroinflammation is known to accelerate disease progression and accentuat

3 cies adapted to contrasting environments and is known to acclimate to sustained changes in temperatur

4 The substrate G3P, which is known to accumulate in the later compartments of the

5 the inner hypoxic regions where tumor cells are known to acquire malignant phenotypes.

6 betaarrs are known to act as adaptor proteins binding receptors a

7 Although TLRs are known to activate type I IFN (T1IFN) signaling, the

8 ue to reduced urea synthesis; and as ammonia is known to activate hepatic stellate cells, we hypothes

9 A growing number of environmental pollutants are known to adversely affect the thyroid hormone system

10 Although short-term drying and warming are known to affect forests, it is unknown if such effec

11 tended to specifically target bacteria, most are known to affect host cell physiology.

12 cies on mechanosensitive channel nanopockets are known to affect mechanical gating and may be linked

13 Tubulin PTMs are known to affect microtubule stability, dynamics, and

14 ental parameters, including sunlight levels, are known to affect the survival of many microorganisms

15 Although surface topography is known to affect bacterial colonization, how multiple

16 ill not fully understood, but its activation is known to affect both cell size and cell number.

17 Particularly, alteration of NLGN1 expression is known to affect the dynamic processes of memory conso

18 ogenous neurotransmitter acetylcholine (ACh) is known to affect the excitatory/inhibitory (E/I) balan

19 Roasting is known to affect the protein profile and allergenicity

20 The local lipid environment is known to affect the structure, stability and intercel

21 Relative humidity (RH) is known to affect the survival of some microorganisms i

22 Catecholamines are known to alter GH secretion and neurons expressing T

23 Vector-borne pathogens are known to alter the phenotypes of their primary hosts

24 ion and differentiation, and acetylated KLF5 is known to alter epithelial proliferation.

25 These two actions are known to alternate during tick engorgement.

26 all-molecule compounds, called potentiators, are known to ameliorate the gating defect.

27 mation theory both shallow and deep networks are known to approximate any continuous functions at an

28 genomes and limited metabolic capabilities, are known to associate with other microbes, thereby comp

29 on and interactions with the human host have been known to attribute detrimental and beneficial effec

30 Although mitochondria are known to be a major source of reactive oxygen specie

31 Although many fungi are known to be able to perform bioweathering of rocks a

32 lopmental cortical interneurons (cINs)-which are known to be affected in schizophrenia (SCZ) when mat

33 d alpha-tocopherol, the three compounds that are known to be associated with lizard territoriality an

34 of a junction between two types of epithelia are known to be cancer-prone in many organ systems.

35 Holdase chaperones are known to be central to suppressing aggregation, but

36 other noble-metal-based delafossites, which are known to be challenging due to the difficulty in ini

37 tations, though large heterozygous deletions are known to be compatible with life.

38 dopamine receptors within brain regions that are known to be critical for decision-making processes i

39 Copper levels are known to be elevated in inflamed and malignant tissu

40 Pyrethroid insecticides are known to be highly toxic to most aquatic nontarget o

41 ets and catalytic activities to gain signals are known to be ideal sensing elements; however, AEC-bas

42 f molecules associated with lipid metabolism are known to be implicated in MNDs, there remains a lack

43 teins contain conserved sequence motifs that are known to be important in helix packing.

44 FTD-ALS causing mutations are known to be involved in endosomal trafficking and RN

45 pathogen recognition receptors (PRRs) which are known to be involved in host antiviral defences.

46 While the melanocortin receptors (MCRs) are known to be involved in numerous biological pathways

47 One third of the regulated genes are known to be involved in pain processing, including s

48 Transcriptional and epigenetic changes are known to be involved in the regulation of the vernal

49 others, areas of the mid- and hindbrain that are known to be involved in wake-sleep control in mammal

50 ily conserved from yeast to humans, and they are known to be key factors in clathrin-mediated endocyt

51 Given that IMPAD1 and KDELR2 are known to be localized to the ER-Golgi pathway, we st

52 K2P potassium channels are known to be modulated by volatile anesthetic (VA) dr

53 In prokaryotes, only ribosomal proteins are known to be N-terminally acetylated, and the acetylt

54 nd retain parsimony-informative sites, which are known to be phylogenetically informative.

55 O(2)- and O(4)-alkylated thymidine lesions are known to be poorly repaired and persist in mammalian

56 Microtubules (MTs) are known to be post-translationally modified at the neu

57 explosives involve colorimetric tests, which are known to be rapid and portable; however, they often

58 Molecular motors are known to be responsible for cytoskeletal ordering an

59 centuries in various parts of the world and are known to be rich resources of functionally important

60 evels of soluble and oligomeric Abeta, which are known to be the most toxic amyloid species within th

61 Although menaquinone levels are known to be tightly linked to the cellular redox/ene

62 mid-1800s, certain cognitive functions have been known to be lateralized, but the provenance and fle

63 Prolonged ER stress has been known to be one of the major drivers of impaired li

64 ngest path is well defined and in some cases is known to be a better approximation to geodesics than

65 (Ln) gamma2 chain specific for Ln-332, which is known to be a crucial molecule for the proper attachm

66 of CaM kinase II-delta (CaMKIIdelta), which is known to be activated through diabetic metabolism.

67 i is a fundamental cognitive function, which is known to be affected by two biases: choice bias, whic

68 ANKS4B is known to be an essential scaffold within the IMAC, al

69 Quantitative correction of prebleaching is known to be an ill-posed problem, limiting the utilit

70 Periodontal disease (PD) is known to be associated with endothelial dysfunction i

71 cardiac arrhythmia in clinical practice and is known to be associated with significant morbidity and

72 Bisphenol A (BPA) is known to be biologically active in experimental model

73 Tolerance of abiotic stress in woody plants is known to be constrained by biological trade-offs betw

74 Regulation of Zta is known to be controlled through a number of transcript

75 Although accumulation of excess FA in cells is known to be cytotoxic, it is unknown if an increase i

76 The catalytic efficiency of TET enzymes is known to be enhanced by ascorbic acid.

77 modulation of the type I IFN response, which is known to be exploited by L. monocytogenes during infe

78 The glycoprotein CD83 is known to be expressed by different immune cells inclu

79 Secretion of activin A is known to be higher in tissues with a high MD as well

80 The GLP-1 system is known to be impaired in insulin-resistant conditions,

81 Gingival tissue attachment is known to be important for long-term prognosis of impl

82 te, using a time series of case reports that is known to be incomplete due to reporting delays.

83 Although DGK activity is known to be involved in plant development and stress

84 standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no p

85 s (vHPC) and medial prefrontal cortex (mPFC) is known to be necessary for normal avoidance in the EPM

86 fects cell motility is cell mechanics, which is known to be related to substrate stiffness.

87 The gut microbiome is known to be sensitive to changes in the immune system

88 The development of the visual system is known to be shaped by early-life experience.

89 Although the expression of Ralpha2 is known to be subject to modulation, information about

90 Cohesin is known to be ubiquitinated, although the mechanism, re

91 most of the genes with increased expression were known to be regulated by peroxisome proliferator-ac

92 were vaccine-eligible; only 68 (5%) of 1361 were known to be vaccinated.

93 Rbfox proteins have long been known to bind to the RNA sequence GCAUG with high a

94 HCF173, a psbA translational activator that is known to bind psbA mRNA.

95 In addition, nestin, which is known to bind the neuronal cdk5/p35 kinase, affects r

96 late at concentrations of around 500 muM and are known to block the growth of Clostridium difficile(1

97 The glycosyltransferase ST6Gal-I is known to block homeostatic apoptosis through alpha2,6

98 Chlamydia infection is known to block the induction of apoptosis.

99 eed, there are no genetic perturbations that are known to both improve long-term survival and promote

100 of Tc1/mariner transposable elements, which are known to cause DSBs and alter genome integrity [6, 7

101 urgdorferi sensu lato (s.l.) species complex are known to cause human Lyme borreliosis.

102 ing all four TSEN subunits, as well as CLP1, are known to cause neurodegenerative disorders, yet the

103 hemical warfare nerve agents and pesticides, are known to cause neurological damage.

104 s, and more than 40 tandem repeat expansions are known to cause neurological disease.

105 trong contact allergen used in hair dye that is known to cause allergic contact dermatitis (ACD).

106 Chronic inflammation is known to cause alterations in vascular homeostasis th

107 ESCRT function in Drosophila imaginal discs is known to cause neoplastic overgrowth fueled by mis-re

108 Excessive tumor necrosis factor (TNF) is known to cause significant pathology.

109 e member of the Flaviviridae family that has been known to circulate for decades causing mild febrile

110 Although LF is known to cleave mitogen-activated protein kinase kina

111 In vitro, MinC and MinD are known to coassemble into linear polymers; therefore,

112 Although several spatial coding mechanisms are known to coexist in the hippocampus, how they are in

113 me primates, in particular lemurs, have long been known to communicate by smell.

114 Specifically, it is known to complex with BAX and BID.

115 Tumours are known to compromise the integrity of the BBB, result

116 Haloanisoles (HAs) are known to compromise wine quality because of their mo

117 Although cnidaria are known to contain complex apoptotic signaling pathway

118 the role of Asc in NPQ in green algae, which are known to contain low amounts of Asc, we searched for

119 These regions are known to contribute to abnormal interhemispheric inf

120 Although these bases are known to contribute to distinct demethylation pathwa

121 Multiple bacterial factors are known to contribute to persistent colonization of th

122 Germline Ras-activating mutations have been known to contribute to cancer predisposition in a g

123 While many signaling pathways are known to control SC self-renewal, less is known abou

124 Upstream open reading frames (uORFs) are known to control the translation of mRNAs.

125 Only one of them is known to control motility, while the function of the

126 Circulating NK cells are known to convert to a type 1 innate lymphoid cell (I

127 tivity in frontal and parietal cortex, which is known to correlate with the decline in behavioral mem

128 unfolded apo subunits and free hemin, which are known to damage the integrity of blood vessel walls.

129 B. bacteriovorus are known to deacetylate the peptidoglycan of the prey b

130 tiation, engraftment, or mobilization, which are known to depend on expression of Grasp55-dependent p

131 Invasive wild pigs (Sus scrofa) are known to depredate nests, and have been expanding th

132 Domestic cats (Felis catus) are known to develop cognitive impairment, and several s

133 m two divergent life-history ecotypes, which are known to differ in immune function in their native h

134 Long-tailed tits are known to discriminate between the calls of close kin

135 of-function of the transcription factor Gli3 is known to disrupt olfactory development, however, if G

136 Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the o

137 The intracellular protein SOCS1 is known to downregulate cytokine signaling by inhibitin

138 Inflammatory processes are known to drive the pathogenesis of several chronic d

139 wth factor receptor (EGFR) signaling cascade is known to drive cell migration and proliferation.

140 ts the brain's fronto-striatal system, which is known to drive motivational behavior.

141 neuropathy (CIPN), agents such as paclitaxel are known to elicit chronic neuropathic pain in cancer p

142 timulation (iES) of the human brain has long been known to elicit a remarkable variety of perceptual,

143 ost galaxy(9-12), and just one of these four is known to emit repeating FRBs(9).

144 Alkoxy radicals have long been known to enable remote C-H functionalization via 1,

145 Phenotypic plasticity is known to enhance population persistence, facilitate a

146 Thermal annealing is known to enhance the BHJ photoactive layer morphology

147 The application of shear stress is known to enhance tight junction formation and hence i

148 While fullerenes are known to entrap metal atoms to form endohedral metal

149 S aureus is known to exacerbate AD, whereas S epidermidis has bee

150 gh conjugation with fatty acid moieties that are known to exhibit high binding affinities to serum al

151 ons and error-prone repair that underlie SHM are known to exhibit intrinsic biases when targeting the

152 ures of chemically interacting colloids that are known to exhibit nonreciprocal effective interaction

153 Intermediate and non-classical cells are known to exhibit varying levels of phagocytosis and

154 ysical properties of hybrid nucleosomes that are known to exist in human cancer cells and contain H3

155 Significant intraspecific variation in A is known to exist in various autotrophic organs that rep

156 Endocannabinoids were known to exist only among Animalia but recent repor

157 pression quantitative trait loci (eQTL) that are known to explain important expression variation for

158 growth factor receptor 2 (HER2), are absent is known to express the most aggressive phenotype and in

159 her yield point and lower apparent viscosity are known to facilitate and increased drilling rate of p

160 induced fusion loop epitope antibodies that are known to facilitate antibody-dependent enhancement (

161 unction of CblD has been elusive although it is known to form a complex with CblC under certain condi

162 Candida albicans is known to form polymicrobial biofilms with various Str

163 KRIT1's nuclear roles are unknown, but it is known to function as a scaffolding or adaptor protein

164 restructuring of metal nanoparticle surfaces is known to greatly influence their catalytic, electroni

165 ZV and HCMV in culture and in vivo While VZV is known to grow in skin, it was unknown whether skin co

166 Although endogenous retroviruses (ERVs) are known to harbor cis-regulatory elements, their role

167 As SRRP1 is known to harbor RNA chaperone activity, we postulate

168 The heterotrimeric G proteins are known to have a variety of downstream effectors, but

169 Platelets are known to have immunomodulatory properties.

170 tors (GEFs) that activate Rac and Cdc42, and are known to have numerous functions in various cell typ

171 Nanosized materials are known to have the ability to withstand ultralarge el

172 Spillover is known to have effects at the level of families and ho

173 Non-small cell lung cancer (NSCLC) is known to have poor patient outcomes due to developmen

174 Eighty were known to have developed MS by 30 years.

175 and 25 of 26 with myelodysplastic syndrome) were known to have Shwachman-Diamond syndrome before dev

176 cell survival and proliferation, and viruses are known to hijack this pathway for their replication.

177 ced exposure to glucocorticoids (GCs), which are known to impact neurogenesis.

178 tant critical quality attribute (CQA), as it is known to impact efficacy, stability, half-life, and i

179 Glycation of collagen fibrils is known to impact on cell adhesion and migration in the

180 Psychiatric comorbidity is known to impact upon use of nonpsychiatric health ser

181 Spaceflight is known to impose changes on human physiology with unkn

182 Lip-reading is known to improve auditory speech understanding, espec

183 Urolithin A (UA) is a natural compound that is known to improve muscle function.

184 lectron transport chain (ETC), both of which are known to increase aspartate and GOT1 dependencies.

185 t thinning (ST) and their combination (LRST) are known to increase berry solar exposure affecting ber

186 ymorphisms (SNPs) in Apolipoprotein E (APOE) are known to increase risk for developing Alzheimer's di

187 Pathogenic variants (PVs) in multiple genes are known to increase the risk of early-onset renal canc

188 Obesity is known to increase breast cancer incidence and mortali

189 Inhibiting mitochondrial translation is known to increase lifespan in C. elegans, and is acco

190 The large GTPase Dynamin 2 (Dyn2) is known to increase the invasiveness of pancreatic canc

191 collected from bed bug-exposed papers, which are known to induce aggregation behaviour, by air entrai

192 The paradox is that ovulation is known to induce acute inflammation.

193 PyST is known to induce mitotic arrest followed by extensive

194 Of note, alpha-ADABA is known to induce the MocR/GabR-type repressor EnuR, wh

195 a kinase and GTPase, and PD-linked mutations are known to influence both enzymatic activities.

196 However, several factors that are known to influence N(2) O emissions, such as animal

197 sessed whether inflammatory mechanisms-which are known to influence neural and behavioral motivationa

198 l properties of extracellular vesicles (EVs) are known to influence their biological function, in ter

199 oid hormone effects on the microbiome, which is known to influence mucosal immune responses.

200 tatins are HMG-CoA reductase inhibitors that are known to inhibit cellular cholesterol biosynthesis a

201 In the Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and

202 We also show that netrin-1 expression, which is known to inhibit UNC5B apoptotic activity, promotes s

203 Drugs and drug metabolites are known to interact directly and indirectly (through i

204 l Wbl proteins of Mycobacterium tuberculosis are known to interact with its principal sigma factor Si

205 Viral IRFs 1, 3, and 4 are known to interact with ubiquitin-specific protease 7

206 Although LRP6 ectodomain 1 (E1) is known to interact with SOST, several unresolved quest

207 The Epstein-Barr virus (EBV) episome is known to interact with the three-dimensional structur

208 ase of beta oscillations in the motor cortex are known to lead to muscle responses of greater amplitu

209 on of apoptotic signaling in the CECs, which is known to lead to the blood-brain barrier disruption a

210 Cyclin-dependent kinase 2 (CDK2) is known to localize to so-called "late recombination no

211 instability of perovskite solar cells (PSCs) is known to mainly originate from the migration of ionic

212 Molecular chaperones are known to maintain protein homeostasis.

213 s considered to be an immunogenic tumour but is known to mediate immune dysfunction in large part by

214 Many non-ant parasites of ant colonies are known to mimic the morphology of their host species,

215 Micronutrients are known to modulate host immunity, and there is limite

216 M(1) receptors are known to modulate medium spiny neuron responses to c

217 Intestinal bile acids are known to modulate the germination and growth of Clos

218 , the invertebrate analog of norepinephrine, is known to modulate a large variety of behaviors in Dro

219 Predictability is known to modulate semantic processing in language, bu

220 irus (dengue virus and Zika virus) particles are known to near-atomic resolution and show detailed st

221 The s(2)C(32) modification is known to negate wobble codon recognition of the rare

222 Given that rate-limiting steps of metastasis are known to occur while tumor cells enter, travel throu

223 Metabolic reprogramming is known to occur during the epithelial-mesenchymal tran

224 Criticality is known to occur in "hot" Fermi pockets with a high den

225 to generate mitochondrial plastid DNA (MTPT) is known to occur in plants, but its impacts on mitochon

226 Flying insects are known to orient themselves over large distances usin

227 e hydroxylase (TH), a compartment where PPGL is known to originate.

228 They are known to participate in cell cycle and in signaling

229 Viruses are known to perturb host cellular metabolism to enable

230 As both low oxygen and cAMP are known to play a central role in placental function,

231 vironmental factors, and in particular diet, are known to play a key role in the development of Coron

232 (PBRs), which are important biotic factors, are known to play a vital role not only in the developme

233 -beta and Wnt signaling-related genes, which are known to play an important role in regulating cartil

234 MDSCs are known to play important roles in tumor immune evasio

235 Metal ions are known to play various roles in living organisms; the

236 tein ProQ is an RNA-binding protein that has been known to play a role in osmoregulation in proteobac

237 r colliculus (SC), a midbrain structure that is known to play a crucial role in the control of visual

238 -secreted protein of region of difference 1, is known to play a crucial role in virulence and pathoge

239 Although NF-kappaB is known to play a pivotal role in lung cancer, contribu

240 The P4 residue of the 1/2 site is known to play a regulatory role during processing at

241 ly deposited gene in Nile tilapia eggs which is known to play a role in repression of transposon elem

242 The embryonic hypochord is known to play a significant role in the positioning o

243 ein-9 (BMP-9) is a circulating cytokine that is known to play an essential role in the endothelial ho

244 of the immune system and the nervous system is known to play an important role in the development an

245 lfate forms as a stable surface product that is known to poison the catalytic surface.

246 reover, some of the current NMOSD treatments are known to pose risks to the developing fetus and only

247 settings, and triggers such as cold exposure are known to precipitate vaso-occlusive crises by still

248 The thalamus is known to process information from various brain regio

249 ns of the family Baculoviridae, for example, are known to produce a UDP-glycosyltransferase (UGT) tha

250 were compared with Synodontis eupterus that is known to produce both signal types, and representativ

251 kinase C/Mzeta (PKCzeta/PKMzeta) inhibitor, is known to produce the loss of different forms of memor

252 trinsically disordered domain; these domains are known to promote biomolecular condensation.

253 ta) and insulin-like growth factor-1 (IGF-1) are known to promote fibrosis; however, myofibroblast sp

254 The PVC command interneurons, which are known to promote forward locomotion during wakefulne

255 SGPs are known to promote PGC survival during embryogenesis a

256 Lifestyle factors that are known to promote the metabolic syndrome generally ca

257 d oligosaccharides with specific chemistries are known to promote tight adhesion between adjacent mem

258 ys key roles during development and has also been known to promote metastasis by inducing invasive ph

259 Fluorine is known to promote ortho-C-H metalation.

260 th several proteins, including HMGI-C, which is known to protect against apoptosis.

261 Under eubiotic conditions commensal microbes are known to provide a competitive barrier against invad

262 omega-dicarboxylic acid (heptanedioic acid), is known to provide seven of the ten biotin carbon atoms

263 ritoneal (i.p.) injection of glucagon, which is known to rapidly deplete hepatic glycogen.

264 using diverse plant and animal species that are known to receive or exchange RNA with their symbiont

265 VEGF also changes expression of genes that are known to regulate barrier function.

266 OLIFERATING CELL FACTOR (TCP) protein family are known to regulate bilateral symmetry in single flowe

267 BMP9 and BMP10 (bone morphogenetic protein) are known to regulate endothelial quiescence after secre

268 Innate lymphoid and adaptive immune cells are known to regulate epithelial responses, including mu

269 tivities of multiple signaling pathways that are known to regulate HF stem cells.

270 f transcription factors cFos and IRF1, which are known to regulate IL-12 family members, including IL

271 nsic mechanisms operating in sensory neurons are known to regulate nerve repair, but whether satellit

272 ely to the interpeduncular nucleus (IPn) and are known to regulate nicotine avoidance behaviors.

273 Circadian oscillator proteins are known to regulate the expression of clock-controlled

274 Although sympathetic nerves are known to regulate the HSC niche(3-6), the contributi

275 Although many genes are known to regulate those processes, the molecular mec

276 Circumferential stretch is known to regulate contractile function in collecting

277 erian hormone (Amh) is a peptide factor that is known to regulate sexual differentiation and gonadal

278 While p44 is known to regulate the helicase activity of XPD during

279 For example, DNA methylation is known to regulate transcription factor binding but al

280 These myeloid cells are known to secrete several proangiogenic factors in tu

281 ex, which includes IcmS, IcmW and LvgA, that are known to selectively assist the export of a subclass

282 suspensions of cellulose nanocrystals (CNCs) are known to self-assemble into a chiral nematic liquid

283 no- and disaccharides that mimic glycolipids are known to self-assemble into glycodendrimersomes, whi

284 he repetitive RNA derived from the C9 repeat is known to sequester hnRNPH, a splicing regulator, into

285 ylation, carbohydrates and their derivatives are known to show several derivatives, since derivatizat

286 interior; this is consistent with the former being known to stimulate T4P retraction needed for commu

287 Reticulospinal connections are known to strengthen following damage to the corticos

288 Although dispersal is known to strongly affect spatial genetic structure du

289 LBBM) occurs in confined spaces and vimentin is known to strongly influence cell-mechanical propertie

290 These currents are known to supply oxygen and nutrients to deep-sea ben

291 features of productive marine ecosystems and are known to support higher trophic levels.

292 A few matrix metalloproteinases (MMPs) are known to support this key process, but its energetic

293 cotinamide nucleotide transhydrogenase (NNT) is known to sustain mitochondrial antioxidant capacity t

294 Typical 2-Cys peroxiredoxins are known to switch between different oligomeric states,

295 hment or positions of HCs since daughter HCs are known to switch positions with each other.

296 ction as chemosensors on the gut epithelium, are known to translate environmental cues into serotonin

297 nic solvents used in conservation treatments are known to trigger multiple physical and chemical degr

298 Although thousands of human proteins are known to undergo S-palmitoylation, how this modifica

299 id salts, the cyclic ether, dioxolane (DOL), is known to undergo ring-opening polymerization inside e

300 While microglia are known to use extracellular vesicles to communicate w