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1 use model of familial ALS, since mutant SOD1 is known to accumulate in the IMS of neural tissue and c
4 dividual G-protein-coupled receptors (GPCRs) are known to activate one or more G proteins, the GPCR-G
5 cule associated with cardiovascular disease, is known to activate extracellular signal regulated kina
8 h Set1) family of histone methyltransferases is known to activate transcription of Hox genes in other
9 al reactive oxygen species production, which is known to activate transient receptor potential ankyri
10 ases have flexible surface-exposed loops and are known to adopt higher and lower activity conformatio
12 tissue-specific chemical modifications that are known to affect TF binding (such as DNA methylation)
15 ancer-promoting gene expression.Inflammation is known to affect cancer development, yet the mechanism
16 the nucleosome binding proteins H1 and HMGN is known to affect chromatin dynamics, but the biologica
18 ene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell differentiatio
19 rease in the quantity of available resources is known to affect temporal variability of aggregate com
20 protein post-translational modification that is known to affect the association between histone and D
22 olid tumor progression, and tissue stiffness is known to alter cell behaviors including proliferation
26 thin the aggregation end products of fibrils are known to arise due to microstructural differences am
29 ls, and variations in charged tRNA fractions are known to be a useful parameter in cellular responses
30 ily integrity, family, or social structures, are known to be associated with cardiometabolic outcomes
31 tely altered bodily sensations-both of which are known to be associated with insular functioning.
34 of reading, a crucial ability in which there are known to be considerable individual differences in t
35 response to two immunodominant epitopes that are known to be dependent on Ag cross-presented by DCs,
38 ical and structural properties of these gels are known to be governed by the conditions under which f
45 n and nuclear envelope A-type lamin proteins are known to be key nuclear mechanical components pertur
46 S-mutated colorectal liver metastases (CRLM) are known to be more aggressive than KRAS wild-type tumo
47 ing two tridentate chelates (bis-tridentate) are known to be more robust compared to those with three
51 are not induced, including at enhancers that are known to be repressed by a transcriptional repressor
52 tion factor G and ribosome recycling factor, are known to be required for recycling, but there is con
54 Even though sulfur atoms on the basal plane are known to be stable and inert, we find that they can
55 ubset of never-smokers, and these two probes are known to be strongly associated with maternal smokin
56 methylation levels of neighboring CpG sites are known to be strongly correlated, methods that incorp
57 with changing task-sets and motor responses are known to be strongly interactive: switch costs at th
60 mbination of land subsidence, which has long been known to be present in the region, and rising seas
61 mong patients with acute stroke who had last been known to be well 6 to 24 hours earlier and who had
62 proximal middle cerebral artery who had last been known to be well 6 to 24 hours earlier and who had
69 e is due to the flexural phonons, whose flow is known to be ballistic and distance-independent up to
70 The growth of several biological tissues is known to be controlled in part by local geometrical f
71 epigenetic marks, as tumor mutational burden is known to be coupled to chromatin structure, we examin
74 45, which is crucial for AMPAR recycling and is known to be dephosphorylated in the presence of Abeta
76 mobility of organic semiconducting polymers is known to be enhanced when the energetic disorder of t
78 e TFs regulating NHX1 gene expression, which is known to be highly induced under salt stress, we have
80 ich contains a hydrophobic triad W1L4L8 that is known to be important in the interaction with centrin
81 ng the directionality of other group members is known to be important to maintain cohesion, it is not
91 In the mammalian brain, auditory information is known to be processed along a central ascending pathw
93 lta mutant and bcr1Delta/Delta mutant, which is known to be severely defective in biofilm formation w
97 ign and control of the platinum shell, which is known to be the structural feature responsible for th
99 reased heparan sulfate levels on ASCs, which are known to bind pro-survival cytokines, leading to inc
102 e incubated with rat liver microsomes, which are known to bioactivate APAP to the reactive metabolite
104 0 individuals with breast cancer, of whom 22 were known to carry a germline BRCA1 or BRCA2 mutation,
105 Although a number of Gram-negative bacteria are known to catabolize quinate and shikimate, only limi
107 d superalloy, resulting from heat treatment, is known to cause disastrous failure, but its mechanism
111 phase-relationship to sleep in a manner that is known to cause switches from depression to mania.
122 of the industrially relevant alloy Ti-6Al-4V is known to create a multitude of phases and microstruct
124 Glucocorticoid steroids, like prednisone, are known to delay loss of ambulation in patients with D
125 While the origins of physiological tremor are known to depend on muscle afferentation, it is possi
126 by chemical oxidants in various DNA systems are known to deprotonate, at most, within a few microsec
127 nature of cortical organization, because it is known to develop only through experience (i.e., readi
128 tum and heat transport in rarefied gas flows is known to deviate from the classical laws of Navier an
129 apered junctions of orthopaedic hip implants are known to differ and the debris generated varies in s
130 l gene gagIMPORTANCE HIV disease progression is known to differ between individuals, and defining whi
131 nutritional intake from an energy-dense diet is known to disrupt metabolic homeostasis and contribute
133 ile cholinergic receptor activation has long been known to dramatically enhance the excitability of c
134 ttributes of the extracellular matrix (ECM), are known to drive cell branching and shape change large
135 mediate(s) and solvent (Bronsted-Lowry base) is known to drive the reaction, the gas-phase reaction f
137 OSMOTICALLY RESPONSIVE GENES 1 (HOS1), which is known to either act as E3 ubiquitin ligase or affect
138 1 are mainly ATP-competitors and, therefore, are known to elicit side effects due to lack of specific
140 r the cerebellum in cognition, granule cells are known to encode only sensory and motor context.
141 ked excitation in peripheral olfactory cells is known to encode odor information, the molecular mecha
143 ecifically targets cardiac muscle myosin and is known to enhance cardiac muscle performance, yet its
144 ring vertebrate somitogenesis, retinoic acid is known to establish the position of the determination
147 Melanoma cells treated using these agents are known to exhibit increased levels of melanin pigment
149 is noteworthy that glutamatergic LTD, which is known to exist on stratum lucidum interneurons, coexi
150 Mutants of the fusome, an organelle that is known to facilitate intracyst communication, compromi
153 rrect folding and secretion of proteins that are known to form non-native disulfides during their fol
164 scence-accelerated mouse prone 8 mice, which are known to have deregulated reactive oxygen species me
165 reated with radiotherapy and/or chemotherapy are known to have increased risks of heart failure (HF),
166 nd cortical thickness, and that females, who are known to have lower gray matter volume than males, h
172 though tripartite motif-containing (TRIM)-28 is known to have an immunosuppressive role in immune cel
173 , a major player in Alzheimer's disease that is known to have immune and inflammatory components.
176 patients died postdischarge, and 155 (7.0%) were known to have survived to 36-months postinjury but
178 low doping.Two-dimensional Dirac semimetals are known to host fermionic excitations which can mimic
179 ion, the increased use of interventions that are known to improve compliance, and the use of performa
181 such as epinephrine and norepinephrine, that are known to increase virulence in several pathogens, in
184 ivation (MIA) via infection during pregnancy is known to increase risk for autism spectrum disorder (
192 e response evoked by interleukin (IL)-6 that is known to induce both pro inflammatory and anti-inflam
193 gene array analysis showed that ATF6, which is known to induce genes encoding ER proteins that augme
201 myloid precursor protein transthyretin (TTR) is known to inhibit amyloid-beta (Abeta) aggregation in
203 fluorinated analogues of l-carbidopa, which is known to inhibit DOPA decarboxylase (DDC), a key prot
204 death-1 (PD-1) in the tumor microenvironment is known to inhibit effective adaptive antitumor immunit
207 posi's sarcoma-associated herpesvirus (KSHV) are known to interact extensively with the DDR during th
208 d C1q, in particular its head regions, which are known to interact with other activators of the class
210 action of Red1 remains unclear, although it is known to interact with Hop1 and to suppress the spore
215 telet C-type lectin-like receptor 2 (CLEC-2) is known to maintain the physiological state of blood va
218 Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regene
226 This condition, called positive assortment, is known to occur in spatially-structured viscous popula
227 nucleophosmin/nucleoplasmin proteins, which are known to oligomerize into pentamers and decamers.
228 chment protein receptor (SNARE) protein that is known to participate in the regulation of mitochondri
229 well-described activity-dependent mechanisms are known to play a key role in learning and memory.
232 ctive peptides isolated from natural sources are known to play important physiological roles in the h
233 heir final product, prostaglandin E2 (PGE2), are known to play important roles in the modulation of b
234 Myeloid-derived suppressor cells (MDSCs) are known to play important roles in tumour immune evasi
239 modulates the glutaminolysis pathway, which is known to play an important role in cellular energetic
240 e adipose tissue, brown adipose tissue (BAT) is known to play critical roles for both basal and induc
244 Paramecium and Tetrahymena species have long been known to present a wide variety of mating type numb
245 suppression.SIGNIFICANCE STATEMENT Saccades are known to produce a suppression of contrast sensitivi
246 Although proteasome-mediated proteolysis is known to produce antigenic peptides in adaptive immun
247 ic proteins Munc18-1, syntaxin-1, or SNAP-25 is known to produce cell death, but the underlying featu
248 ons strongly exhibit "karstification," which is known to produce particularly strong subsurface heter
250 Homologous recombination and repair factors are known to promote both telomere replication and recom
254 T follicular helper (Tfh) and Th17 cells are known to promote inflammation and autoantibody produ
257 n (ANG), a secreted vertebrate ribonuclease, is known to promote cell proliferation, leading to neova
260 , is a major virulence factor of SBV, and it is known to promote the degradation of Rpb1, a subunit o
261 n of transcription factors, including STATs, is known to promote tumor initiation and progression.
265 pathogenesis of immune-mediated diseases and are known to reach a lasting homeostatic equilibrium fol
269 exin/calreticulin quality control cycle that is known to regenerate the Glc1Man9GlcNAc2 moiety on gly
271 phosphorylated phosphatidylinositol species are known to regulate key aspects of peripheral myelinat
273 iated by store-operated calcium entry (SOCE) are known to regulate neutrophil activation; however, th
274 Protein degradation and phosphorylation are known to regulate protein activity during this proce
278 fects in pigment biosynthesis or translation are known to repress photosynthesis-associated nuclear g
281 stelium discoideum into a multicellular slug is known to result from single-cell chemotaxis towards e
285 Distinct subtypes of inhibitory interneuron are known to shape diverse rhythmic activities in the co
286 rotein-protein interactions networks (PPINs) are known to share a highly conserved structure across a
287 regular porphyrins, the monoheteroporphyrins are known to stabilize metals in unusual oxidation state
288 Although the cross-linked protamine network is known to stabilize the resulting nucleoprotamine stru
292 omega-3 polyunsaturated fatty acids (PUFAs) is known to suppress inflammatory processes, making thes
293 nose tetra fish, Hemigrammus bleheri, which is known to swim in highly cohesive groups, to analyze t
294 ining if individuals with TT had scarring or are known to the health system was critical for meeting
299 nomes, including GC content and genome size, are known to vary widely among different bacteria and ar
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