ライフサイエンスコーパス: be less effective

1 50 7A1 expression is reduced these drugs may be less effective.

2 ditional control interventions are likely to be less effective.

3 fied until after age 5 years, when treatment is less effective.

4 Concurrent CAD is less effective.

5 e mRNA translation by cap-dependent scanning is less effective.

6 elated to regeneration, and that G-CSF alone is less effective.

7 peptides when the original Stachel sequence is less effective.

8 After autoimmunity was established, HOT was less effective.

9 ich limits signaling through both receptors, was less effective.

10 ression, whereas ectopic expression of HMGA2 was less effective.

11 aptic stimulation lasting from 15 s to 2 min was less effective.

12 to DC, whereas addition at later time points was less effective.

13 lar treatment with N-acetyl-L-cysteine (NAC) was less effective.

14 ated with CPT-11, whereas either agent alone was less effective.

15 ing to type II receptors, but the short form was less effective.

16 ation with the monomeric alpha-chain of C4BP was less effective.

17 3L) DNA, which expanded both subpopulations, was less effective.

18 -linolenic acids, two popular dietary PUFAs, were less effective.

19 The E-isomers ent-15a, ent-13a, and 15b were less effective.

20 Glutathione and ascorbate were less effective.

21 s p110delta or p110beta/p110delta inhibitors were less effective.

22 d flexible sigmoidoscopy every 5 years alone were less effective.

23 amount, whereas the A146K and G222E mutants were less effective.

24 as antibodies to the midregion or C-terminus were less effective.

25 3 months), whereas other antiepileptic drugs were less effective.

26 weight or albumin-binding gadolinium agents were less effective.

27 by warfarin and dabigatran, meaning that it was less effective (8.44, 8.54, and 8.59 quality-adjuste

28 Treatment is less effective after inflammation begins.

29 ; p<0.0001) but postprandial glucose control was less effective after breakfast and dinner.

30 rapies treat hematopoietic malignancies, but are less effective against solid tumors.

31 Emerging data suggest that vancomycin may be less effective against serious methicillin-resistant

32 the tumor-associated isoforms CA IX and XII, being less effective against the cytosolic CA I and II.

33 d TcCA with KIs in the range of 0.5-12.5 nM, being less effective against the human off-target isofor

34 nanomolar inhibitory action against hCA II, being less effective against the other isoforms.

35 The compound is less effective against the beta-amyloid peptide, indi

36 AE in inhibiting Listeria monocytogenes, but was less effective against Escherichia coli O157:H7 than

37 UVA alone was less effective against the second group of bacteria

38 odies that efficiently inhibit cell-free HIV were less effective against cell-to-cell transmitted vir

39 (50): 0.30 and 0.13 mg/ml, respectively) and were less effective against lipase.

40 osuppressive treatment after transplantation were less effective against the fungus than those from h

41 art failure medications), disease management is less effective among African Americans, yielding high

42 te than in black participants, and treatment was less effective among black participants.

43 However, the intervention was less effective among FSW-IDUs, and had no effect on

44 Current treatments are less effective and have more severe side effects in

45 Doubly modified siRNAs were found to be less effective and lose their efficacy at low nanomol

46 admitted late after injury, tranexamic acid is less effective and could be harmful.

47 FS-DSEK was less effective and more costly compared to both DSAE

48 er monotherapy and triamcinolone monotherapy were less effective and more costly than combination the

49 erred strategy, because RFA-RFA and SBRT-RFA were less effective and more costly.

50 Strategies based on symptom screening alone were less effective and more expensive than MMR-based st

51 While aminoglycosides appear to be less effective antimicrobial agents than other antibi

52 However, evidence suggests that patents are less effective as an incentive to innovate in the fi

53 able carbocyclic versions of these analogues are less effective as the role of the ribose in facilita

54 her hematologic malignancies, bortezomib has been less effective as a single agent.

55 hat L-arginine synthesized from L-citrulline was less effective as a substrate for arginase-mediated

56 n U-251MG cells, rapamycin (10 nM) treatment was less effective as an antiproliferative agent when ce

57 gonists had a shorter duration of action and were less effective as pseudoirreversible antagonists.

58 Although variant peptide vaccines were less effective as TAA expression increases, data pr

59 prepared from metastatic cells in the liver are less effective at activating CD4(+) T cells, suggest

60 Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Abeta, and LD

61 Large molecules are less effective at crowding than water and ions.

62 kely source of water contamination, but they are less effective at determining the potential risk to

63 R-transgenic effector cells lack Tbx21, they are less effective at entering the pancreas and promotin

64 out the vote message, we estimate that both are less effective at increasing turnout than a much sho

65 sion contact time revealed that PDA coatings are less effective at preventing bioadhesion when the co

66 CB[7].2,6-Ad(NH3)2 and CB[7].2,6-Ad(NMe3)2) are less effective at realizing the potential 1000-fold

67 t analyses have suggested that beta-blockers are less effective at reducing cardiovascular events tha

68 ound some HIV-1-neutralizing patient sera to be less effective at blocking VS-mediated infection than

69 Streptokinase may be less effective at saving lives in patients with heart

70 In clinical trials, cancer vaccines have been less effective at priming T cells and extending sur

71 s that multisite phosphorylation, by itself, is less effective at creating switchlike responses than

72 This is less effective at generating within-group diversity w

73 Previous studies also suggest that REBOV is less effective at inhibiting host innate immune respo

74 Cancer vaccination is less effective at old than at young age, due to T cel

75 use of such a top-down attentional strategy is less effective at preventing errors caused by competi

76 Activated CaMKII is less effective at promoting cholinergic transmission

77 is due to the fact that purifying selection is less effective at removing weakly deleterious Neander

78 The isolated DNA binding domain of Cdc13 is less effective at shielding telomeres.

79 The EPO mutant is less effective at stimulating erythroid cell prolifer

80 dvantages are negated if the fractal's field is less effective at stimulating neurons.

81 In contrast, ICA-27243 was less effective at activating KCNQ4 and KCNQ3/Q5 and

82 reductase (an H-TrxR homologue lacking Sec) was less effective at HOSCN turnover.

83 transfusion of c-kit(+) cells from IRKO mice was less effective at improving endothelial repair.

84 Localized BH(4) alone or combo was less effective at increasing NO-dependent vasodilata

85 In contrast, IGF-1 was less effective at inducing ERK activation than were

86 reas the obligate dimeric mutant MCP-1(T10C) was less effective at inducing leukocyte recruitment in

87 That the partially processive APOBEC3G was less effective at inducing mutagenesis in a model HI

88 gh dose of TN robustly activated the UPR but was less effective at inducing steatosis.

89 ficient potency against the p110beta isoform was less effective at inhibiting the PI3K pathway in PTE

90 hereas the isogenic clone p30 knockout virus was less effective at inhibiting TLR3 and TRL4 signaling

91 Although LAT sRNA2 was less effective at inhibiting virus production, it in

92 r hand, administration of TNP-470 before PDT was less effective at local tumor control.

93 Although percutaneous repair was less effective at reducing mitral regurgitation than

94 Dopamine-modulated transmission was less effective at resetting autonomous activity or g

95 Antagonists were less effective at 2 h, which we demonstrate is like

96 lls lacking the ability to produce IFN-gamma were less effective at controlling pathogen load upon he

97 Strains unable to communicate via QS were less effective at defending against invaders target

98 , the DAT blockers nomifensine and bupropion were less effective at inhibiting dopamine uptake follow

99 Cells grown at high density were less effective at invading an endothelial monolayer

100 did, however, exhibit less fluent output and were less effective at modulating their behavior by pare

101 ated by skin vaccinia virus (VACV) infection were less effective at protecting mice from a lethal pul

102 kin CD8(+) TRM cells that lacked Fabp4/Fabp5 were less effective at protecting mice from cutaneous vi

103 The MDA strategies were less effective at reducing prevalence and intensity

104 Both enalapril and telmisartan were less effective at reducing renal injury in diabetic

105 domestic gardens, which tend to be smaller, were less effective at reducing summer soil surface temp

106 transplanted these mucosal cell preparations were less effective at repair.

107 Column experiments showed that iron minerals were less effective at retarding Tc release under flow-t

108 reduced levels of MHC class II and CD86 and were less effective at stimulating CD4(+) T cell prolife

109 Other homologues, such as Z-d-Phe, are less effective but may act through the same mechanis

110 en, whereas single-monoclonal HEL antibodies were less effective despite the use of saturating doses.

111 cute myocardial infarction, whereas morphine is less effective due to signaling events that adversely

112 56.6%, depending on their concentration, but were less effective, especially at lower concentrations,

113 otics, which are standard initial treatment, are less effective for treating refractory or recurrent

114 ed ties and a high degree of separation will be less effective for behavioral diffusion than networks

115 dence is scarce and such interventions might be less effective for smokers with low socioeconomic sta

116 The dose deposited by (64)Cu is less effective for cell killing than gamma-rays.

117 tastatic HER2-positive breast cancer, but it is less effective for controlling metastases in the CNS,

118 pneumococcal polysaccharide vaccine (PPV23) is less effective for older adults than for young adults

119 pulations, there is evidence that vancomycin is less effective for prevention and treatment of methic

120 tive for terminating slower tachycardias but is less effective for treating AF.

121 Furthermore, the antiviral drug oseltamivir is less effective for treating influenza B virus infecti

122 TIW therapy was less effective for MAC-PD patients with cavitary dis

123 Prophylaxis was less effective for nonfirst (odds ratio [OR] = 0.78;

124 The system was less effective for PM2.5 (55+/-22%) but successfully

125 e for MyoD transcriptional targets, although was less effective for Rb1 targets.

126 ication of HCV genotype 1b Con1 replicon but was less effective for the 2a/JFH1 replicon and infectio

127 edges of CDR3, whereas other polar mutations are less effective (glutamine and serine) or ineffective

128 same motor rehabilitation intervention could be less effective if administered in the presence of pai

129 PH oxidases and prevent postoperative AF but are less effective in AF secondary prevention; the mecha

130 Despite successes, oral rotavirus vaccines are less effective in developing countries.

131 Nonmyeloablative allogeneic transplants are less effective in heavily diseased burdened patients

132 ssic therapeutics for ischemic heart disease are less effective in individuals with the metabolic syn

133 These results imply that mutator phenotypes are less effective in larger asexual populations.

134 relapsed chronic myeloid leukemia (CML), but are less effective in non-CML diseases.

135 hy, in people with asthma, deep inspirations are less effective in reversing bronchoconstriction.

136 However, CAR T cell treatments are less effective in solid tumors for several reasons.

137 water eutrophication, while solid phosphates are less effective in supplying the nutrient P.

138 re at a high risk of infection, but vaccines are less effective in this age group; tailored adjuvants

139 dden cardiac death (SCD) concluded that ICDs are less effective in women and the elderly.

140 Colorectal cancer screening might be less effective in black individuals, if there are rac

141 However, ID331 is likely to be less effective in inducing CD because of its inabilit

142 ted secondary olfactory fibers caused DiI to be less effective in labeling secondary olfactory projec

143 a brush made of mutant nsp1 that is known to be less effective in NPC-selective transport, finding th

144 restricted by age and race; the systems may be less effective in other samples.

145 ion (HCV(+) ) has historically been shown to be less effective in patients with a heavy drinking hist

146 uggest that some chemotherapeutic agents may be less effective in patients with ER-positive (ER+) tum

147 suboptimal (low) systemic exposure that can be less effective in patients with higher rates of drug

148 heory suggests that natural selection should be less effective in regions of low recombination, poten

149 catheter aortic valve replacement (TAVR) may be less effective in small surgical valves because of pa

150 itors of IAPP amyloid formation are shown to be less effective in the presence of GAGs.

151 ed largely by purifying selection, which has been less effective in primates than in rodents, presuma

152 tivity in hematological malignancies, it has been less effective in prostate cancer and other solid t

153 tivity in hematological malignancies, it has been less effective in solid tumors, including EOC.

154 mals to deliver gene editing constructs have been less effective in songbirds, likely due to immune s

155 n to remove weakly deleterious mutations has been less effective in the history of non-Africans.

156 The latter result may be related to miR-H2 being less effective in inhibiting ICP0 expression in tr

157 However, this technique is less effective in accurately identifying transcript i

158 ined by the advent of endocrine therapy that is less effective in African American women because of t

159 Influenza vaccination is less effective in elderly as compared to young indivi

160 atment of chronic myeloid leukemia (CML) but is less effective in eliminating CML stem cells.

161 ffect on the POPC bilayer, although ceramide is less effective in inducing order in the bilayer compa

162 no measurable effect on cationic current and is less effective in influencing intercellular Ca(2+) co

163 ay of treatment for cerebral malaria, but it is less effective in later stages of disease when the ho

164 3, with an efficacy that depends on TMEM173, is less effective in mHAQ mice than in wild type mice.

165 ns are predicted to result in a product that is less effective in neutralizing negatively charged lin

166 O2 as found for other hemoproteins, but H2O2 is less effective in oxidizing the peptide, and further

167 For that purpose, CTA is less effective in patients with calcium score >/=600

168 py trials suggested that cytotoxic treatment is less effective in patients with estrogen receptor (ER

169 ll death in actively proliferating cells, it is less effective in quiescent cells.

170 Lightweighting EVs is less effective in reducing greenhouse gas emissions t

171 nd mortality risk, but the influenza vaccine is less effective in the elderly.

172 us (HIV) natural course, and HBV vaccination is less effective in the HIV infected.

173 e early phase of Parkinson's disease, but it is less effective in the long term.

174 durance athletes, which may explain why HIIT is less effective in this group.

175 We discovered that RNAi is less effective in zebrafish at least partly because A

176 filaments from forced depolymerization, but was less effective in both assays than full-length dystr

177 Treatment for PAH was less effective in CTD-PAH compared with IPAH in term

178 eroxide level in the aorta in all groups but was less effective in epineurial arterioles.

179 r cells caused a marked cytolytic effect and was less effective in HBV control.

180 to induce protective immunity, although this was less effective in heterologous challenge situations,

181 However, LY294002 was less effective in inhibiting Munc18-3 phosphorylatio

182 By contrast, recombinant human alpha-Gal A was less effective in normalizing the cholesterol conten

183 wo groups, whereas in historical data, G-CSF was less effective in patients with diabetes.

184 ncentrations of 4-OHT and tamoxifen, but DES was less effective in PGC1alpha displacement.

185 01, ifenprodil, a selective NR2B antagonist, was less effective in protecting older than younger neur

186 In comparison with RTL201, RTL200 was less effective in protecting the eye from AU.

187 NAC treatment was less effective in recovering ATP and mitochondrial G

188 In netrin-1(+/-) mice, resolvin D1 (RvD1) was less effective in reducing neutrophil influx promoti

189 hazard ratio, 1.00 [CI, 0.84 to 1.20]), but was less effective in reducing stroke, combined CVD even

190 Treatment was less effective in reducing the occurrence of clinica

191 st completely rescued HttQP103 toxicity, but was less effective in rescuing HttQ103 toxicity.

192 R: 0.15, 95% CI: 0.06-0.41, p = 0.0002), but was less effective in reversing the methylation that occ

193 Nevertheless, in general, ellagic acid was less effective in scavenging ROS (IC(50) from 1.7 to

194 Microstimulation was less effective in shifting perceptual choices toward

195 tervention after grade 1 damage had occurred was less effective in suppressing proinflammatory genes

196 We then confirmed that BMP4 was less effective in suppressing the tumor growth of TS

197 The AC was less effective in the field than in the laboratory,

198 that in vivo FLT3 inhibition by lestaurtinib was less effective in the relapsed patients compared wit

199 In behaving mice, cholinergic stimulation was less effective in the theta (4-10 Hz) band yet it al

200 ment with pegylated interferon and ribavirin was less effective in this population than is implied by

201 ration by S. aureus and S. pyogenes; NeoForm was less effective in withstanding these organisms.

202 ed, fibroblasts isolated from Pn(-/-) hearts were less effective in adherence to cardiac myocytes and

203 roblast cells, the less helical p27 variants were less effective in causing cell cycle arrest relativ

204 ast, soluble AGE-BSA, fresh Abeta, and S100B were less effective in increasing VEGF secretion.

205 rains not expressing major virulence factors were less effective in inducing IL-1 and IL-23 release b

206 tivators xanthenone and diminazine aceturate were less effective in inducing the migration in cells f

207 urine myeloid precursors, and tumor exosomes were less effective in inhibiting differentiation of BM

208 although exhibited antioxidant activity, but were less effective in maintaining the muscle quality du

209 Furthermore, tocopherols were less effective in protecting the oils in the presen

210 ese subsets persisted for several months but were less effective in recall than memory precursor effe

211 herapeutics such as paclitaxel and cisplatin were less effective in targeting CSC than bulk tumor cel

212 ated peptide receptor inhibitor, olcegepant, were less effective in this model.

213 line coating, whereas the amorphous coatings were less effective in this respect.

214 Immature dendritic cells were less effective in transferring surface molecules on

215 rthermore, gemcitabine and radiation therapy were less effective in tumor cells treated with HPSC-CM.

216 However, ERK2-T183A/Y185F was less effective, indicating the requirement of TEY si

217 to disrupt the secondary structure of VQDLL were less-effective inhibitors of P. gingivalis adherenc

218 re found to loosen eudicot cell walls but to be less effective on grass cell walls, whereas the rever

219 of CCR4(+) activated CD4 cell migration but was less effective on memory cells where alpha(4)beta(1)

220 lts indicate that antiamyloid therapies will be less effective once p-tau pathology is developed.

221 n reducing CV risk in the general population are less effective or ineffective in favorably modifying

222 It is generally accepted that CA is less effective or even inactive at frequencies > appr

223 ibited PIV3, whereas IFIT2, IFIT3, and IFIT5 were less effective or not at all.

224 However, when compared with CABG, PCI was less effective (OR, 1.36; 95% CI, 1.18-1.58; P<0.001

225 nu)beta(3)-targeted fumagillin nanoparticles were less effective (P>0.05).

226 tial infusions, and additional RTX infusions were less effective, presumably due to epitope loss.

227 fferent animal species, but fictive outcomes are less effective than actual outcomes in the increment

228 onclude that poorly hydrolyzable nucleotides are less effective than ATP at opening CFTR channels eve

229 Macrophages are less effective than DC at priming naive CD4(+) T cel

230 blood pressure alone and that beta blockers are less effective than expected.

231 Conventional broadband UVB lamps are less effective than narrowband UVB lamps, which have

232 Pre-post designs are less effective than randomized, controlled trials on

233 3) the determination that short light pulses are less effective than sustained light if the goal is t

234 derived dendritic cells (DC) from aged miced are less effective than their young counterparts in indu

235 The combination was shown to be less effective than (177)Lu-DOTATATE alone.

236 occupancy, a rapidly dissociating ligand can be less effective than a more slowly dissociating analog

237 psychiatric side effects, are also likely to be less effective than brain-permeable CB(1) antagonists

238 icts that once a week dosing of GM-CSF would be less effective than daily, twice a week, or three tim

239 of natriuresis showed bendroflumethiazide to be less effective than either spironolactone or amilorid

240 Why zinc seems to be less effective than expected at all ages, and ineffec

241 eatments designed to target such sources may be less effective than global interventions.

242 as been suggested that acellular vaccine may be less effective than previously believed.

243 r influenza, but have recently been shown to be less effective than previously thought.

244 percutaneous coronary intervention (PCI) may be less effective than transferring only high-risk STEMI

245 To understand why the program has been less effective than expected, the paper then turns

246 Dronedarone is less effective than amiodarone for the maintenance of

247 Moreover, apoE4 is less effective than apoE2 in promoting Abeta transpor

248 acking one of the two actin-binding domains, is less effective than dystrophin in regulating actin dy

249 ficantly better inhibitor, but in humans, it is less effective than GPRPam, indicating that in the la

250 r results show that increasing the viscosity is less effective than increasing the energy density in

251 rrhythmic drug treatment after cardioversion is less effective than is long-term treatment, but can p

252 JA-Ile to 12OH-JA-Ile, and that 12OH-JA-Ile is less effective than JA-Ile in promoting the formation

253 and-treat with a highly sensitive diagnostic is less effective than mass drug administration owing to

254 an induce tumor killing deep within body, it is less effective than NIR-PIT, possibly related to the

255 rgin of -15%, the null hypothesis that cSEMS is less effective than plastic stents was rejected.

256 arting iron treatment after the onset of IDA is less effective than prevention.

257 ions, screening of TRAM flap reconstructions is less effective than screening asymptomatic women in t

258 analysis indicates that screening such women is less effective than screening asymptomatic women in t

259 aser settings, PRP performed with the PASCAL is less effective than that performed with traditional a

260 ts that co-administration of both treatments is less effective than the most effective single treatme

261 ts onset of effects is slower and overall it is less effective than tumor necrosis factor blockers.

262 suppresses release, and mutant PNKD protein is less effective than wild-type at inhibiting exocytosi

263 ater) in combination with voluntary exercise was less effective than administration of the low dose o

264 ong patients with AAV, mycophenolate mofetil was less effective than azathioprine for maintaining dis

265 ol groups, and there is no evidence that IPT was less effective than CBT.

266 Preformed ferric hydroxide was less effective than freshly dosed ferric chloride in

267 artially relieved cell growth inhibition but was less effective than inhibition of AMPK.

268 oncentration intranasal naloxone (2 mg/5 mL) was less effective than intramuscular naloxone but was a

269 AR-13324 0.02% was less effective than latanoprost by approximately 1 m

270 so reduced diabetic nephropathy, although it was less effective than MK-801.

271 nd multivariate Cox regression analysis, KLH was less effective than MM regarding RFS (all P < .001).

272 Although memantine was less effective than NGP1-01 (p<0.05), it still signi

273 However, rXlIFN-lambda was less effective than rXlIFN in preventing FV3 replica

274 Chlorproguanil-dapsone was less effective than sulfadoxine-pyrimethamine (adjus

275 reatment with either dox or AAV1-mIL-6 alone was less effective than the combination.

276 y in H3255 (L858R EGFR) xenograft growth but was less effective than the EGFR TKI gefitinib.

277 vity, the novel combination of PA-824 and MZ was less effective than the standard first-line regimen

278 Pioglitazone was less effective than troglitazone on all parameters t

279 in combination (EDTA and vitamin E acetate) was less effective than using them individually.

280 UVA alone was less effective than UVA+B2 (MD = 25.31) and UVA+B2'

281 Seasonal supplementation was less effective than was daily supplementation (P < 0

282 that dual PI3K/mTOR inhibition by apitolisib was less effective than was everolimus in mRCC, likely b

283 This mutant was less effective than wild-type human nectin-4 at prom

284 s inhibited by IFN-gamma in HEL-30 cells and was less effective than wild-type virus in induction of

285 4E9 and 1H5 were less effective than HF5 and CD6, as indicated by th

286 iabetic mice demonstrated that diabetic EPCs were less effective than normal EPCs at accelerating wou

287 i BCAA auxotrophic cells, but SlBCAT1 and -2 were less effective than SlBCAT3 and -4 in growth restor

288 lower doses of pegylated interferon alfa-2b were less effective than standard doses (2 to 4 fair-qua

289 e report that pharmacologic NOTCH inhibitors were less effective than targeting RBPJ in suppressing t

290 with a single N-glycan at nonconserved sites were less effective than those with one at a highly cons

291 fer experiments showed that Spi6(-/-) nTregs were less effective than wild type nTregs in suppressing

292 ed that both factor B- and C3-deficient mice were less effective than wild-type mice in clearing orga

293 that existing methods for gene set analysis are less effective when sample heterogeneity exists.

294 d at early stages of tumor vessel growth but is less effective when administered later.

295 Filtering is less effective when there is low redundancy between h

296 e or at the same time as virus infection and was less effective when added 24 h after EBOV infection.

297 Epilepsy surgery was less effective when there were extratemporal lesions

298 eft-handed), these cognitive representations are less effective, which leads to decreased batting ave

299 prevent other types of caries are likely to be less effective with HAS-ECC because the structural in

300 tment with epinephrine after PAF stimulation was less effective with time after PAF stimulation.