ライフサイエンスコーパス: be limited by

1 Existing ASE analysis methods are limited by a dependence on haplotyping from laboriou

2 urfaces or objects, current adhesion systems are limited by a fundamental trade-off between 3D surfac

3 Existing tools are limited by a lack of annotation sources and flexible

4 gnosing latent tuberculosis infection (LTBI) are limited by a poor predictive value for identifying p

5 ST, including mutant BRAF-driven tumors, has been limited by a lack of model systems.

6 , by inference, of functional receptors, has been limited by a lack of reliable immunohistochemical e

7 hanism of action of CARM1 in oncogenesis has been limited by a lack of selective tool compounds, part

8 lication of immunotherapeutic approaches has been limited by a lack of target antigens that discrimin

9 erization of early brain growth in-utero has been limited by a number of challenges in fetal imaging,

10 ics to prevent diabetic kidney disease (DKD) is limited by a lack of animal models exhibiting progres

11 Decision making is limited by a lack of clear prospective evidence, and

12 However, our understanding of this system is limited by a lack of measurements of the forces drivi

13 Despite its promise, PA imaging is limited by a lack of strategies to design selective a

14 alcohol-dependent patients, but its utility is limited by a narrow therapeutic index.

15 disorder (PTSD); however, our understanding is limited by a paucity of prospective, longitudinal stu

16 in ion sieving and desalination technologies is limited by a permeation cutoff of approximately 9 A,

17 in case of the primary TR, surgical options is limited by a relatively high risk of mortality and mo

18 which interferes with sliding when its range is limited by a truncated linking segment, and the chrom

19 The comparability of measurements is limited by a weak correlation between kit results cau

20 ed (n=7), and home-based (n=2) interventions was limited by a paucity of studies and heterogeneity in

21 reby demonstrating an SSF-based process that was limited by a strain's metabolic capabilities and tol

22 Our findings were limited by a lack of generalizability (given that t

23 symptomatic relief of the movement disorders is limited by adverse effects and the scarcity of eviden

24 r (AI) therapy for early-stage breast cancer is limited by AI-associated musculoskeletal symptoms (AI

25 Current setups are limited by an averaged measurement through the solid

26 f the macroevolutionary legacy of polyploidy are limited by an incomplete sampling of these events ac

27 genetic data from the T2D case-control study are limited by analyzing a few number of SNPs at a time

28 rences persisted through 12 months, findings are limited by attrition, and further research is needed

29 urative therapy for SCD, but its application is limited by availability of a suitable HLA-matched don

30 in vitro systems using purified enzymes and were limited by availability of deuterated substrates.

31 omprehensive analysis of oxidized lipids has been limited by available analytical methods.

32 ellular drug delivery from nanomedicine have been limited by biological barriers and to some extent b

33 stem cell-derived cardiomyocytes has largely been limited by biologically undefined factors including

34 nd simulation, we show collective chemotaxis is limited by cell-to-cell variation in signaling.

35 a mechanism by which the HIV-1 reservoir may be limited by chemotherapeutic drugs.

36 tive to tree and legume nut butter in baking is limited by chlorogenic acid induced greening that occ

37 ZVI (PAA-nano-ZVI) to mineral surfaces could be limited by coating such surfaces with sodium (Na) hum

38 BH3 mimetic venetoclax, anti-tumor efficacy is limited by compensatory induction of MCL-1.

39 insertion of non-natural amino acids (nnAAs) is limited by competition with release factor 1 (RF1).

40 ately, the current efficiency of the process is limited by competition with the relatively facile hyd

41 munoassay tests, their practical application is limited by complex protocols, bulky peripherals, and

42 The use of electroconvulsive therapy (ECT) is limited by concerns about its cognitive adverse effec

43 first-in-class medicines for treating cancer is limited by concerns with their toxicity and safety pr

44 nalysis suggests that prior studies may have been limited by confounding variables or the technique o

45 Previous studies have been limited by convenience sampling, short follow-up pe

46 ool for understanding cellular diversity but is limited by cost, throughput and sample preparation.

47 tcomes, and culture-independent studies have been limited by cross-sectional design and small cohort

48 ries, respectively.Although causal inference is limited by cross-sectional survey data, results sugge

49 to measure seasonality in human movement has been limited by data availability.

50 The range of most M1s is limited by depolarization block, which is generally c

51 iaturization of antennas beyond a wavelength is limited by designs which rely on electromagnetic reso

52 Meanwhile, the RT efficacies are limited by different mechanisms, among which the tum

53 The study is limited by different mammography systems and its cros

54 uces a higher signal but the signal increase is limited by diffusion of the MNPs.

55 ounds (VOCs) from a source toward a building is limited by diffusion through the soil gas.

56 iscrete crust, indicating that CV electrodes were limited by diffusion.

57 The upper bound of entropy change (Smax) is limited by distinct correlation volumes (V cr ) and t

58 d, their application to FGF19-driven HCC may be limited by dose-limiting toxicities mediated by FGFR1

59 ut their efficacy in BRCA-deficient patients is limited by drug resistance.

60 for cancer treatment, but its effectiveness is limited by drug resistance.

61 ee survival than did placebo; these findings are limited by early trial termination.

62 Therapies are limited by efficacy, safety concerns, and multiple d

63 We postulate that the ductility of nacre can be limited by eliminating tablet interactions during cra

64 e length, quality and cost of gene synthesis are limited by errors produced during oligo synthesis an

65 l treatment for type 1 diabetes, but success is limited by extensive beta-cell death in the immediate

66 mediated cytotoxicity and barrier disruption was limited by extent of CPE-binding.

67 However, the production of TAG can be limited by flux through the enzymatic reactions that

68 Urinary polyphenol excretion is limited by genetic variance, metabolism, and bioavail

69 Studies in sepsis are limited by heterogeneity regarding what constitutes

70 ssessing earlier or more intensive screening were limited by high attrition.

71 chronic kidney disease (CKD), but their use is limited by hyperkalemia, especially when associated w

72 their results shows that the histamine model is limited by inadequate frequency and duration of scrat

73 However, current protocols are limited by incomplete CpG coverage and hence methods

74 eic hematopoietic cell transplantation (HCT) are limited by incomplete understanding of their epidemi

75 of precision oncology for these patients has been limited by incomplete understanding of the molecula

76 ween 22q11DS and nondeleted (ND) individuals are limited by inconsistency and small samples.

77 rs into groups on the basis of violence risk are limited by inconsistency, variable accuracy, and uns

78 Furthermore, cross-species translation is limited by inconsistent findings between rodent fear

79 Nucleic acid therapeutics are limited by inefficient delivery to target tissues an

80 of pediatric echocardiographic measurements are limited by insufficient sample size to assess the ef

81 Access to dialysis for ESKD is limited by insufficient infrastructure and catastroph

82 on growth fueled by nitrate (new production) is limited by iron.

83 multiple classes of cancer chemotherapeutics is limited by irreversible, dose-dependent, and sometime

84 in a substantial proportion of patients and is limited by ischemic adverse events.

85 nding of the electrodeposition mechanism has been limited by its complexity and is often gained only

86 research studies, but its clinical role has been limited by its lack of reproducibility, its lack of

87 However, afterglow imaging has been limited by its reliance on inorganic nanoparticles

88 ological processes, but its clinical utility is limited by its hypercalcemic effect.

89 with potent in vitro anti-cancer properties, is limited by its inability to specifically reach tumors

90 the development of Ang II as an antimalarial is limited by its potent induction of vasoconstriction a

91 anagement of schizophrenia; however, its use is limited by its potential to induce agranulocytosis.

92 The model is limited by its reliance on all-cause mortality data,

93 This study is limited by its sample size, precluding more detailed

94 iociguat in other cardiovascular indications is limited by its short half-life, necessitating a three

95 The validity of this study is limited by its small size and uncontrolled design.

96 RM(FSA) in those without airflow obstruction was limited by its low burden.

97 Existing treatment methods are limited by lack of specificity, systemic toxicity, t

98 essments of the model's prediction precision are limited by lack of sufficient ground truth data.

99 cell biology, and other investigations, has been limited by lack of a robust gene knockout or knock-

100 , which accumulates when tRNA aminoacylation is limited by lack of substrates or inhibition of synthe

101 Our analysis was limited by lack of a gold standard for viral pneumon

102 f single-junction solar cells; however, they are limited by large nonideal photovoltage loss (V oc,lo

103 area oxide supported metal nanoparticles has been limited by less than atomic resolution typically ac

104 However, this approach is limited by local retention of cell-effluxed radiotrac

105 Study interpretation is limited by loss to follow-up.

106 ent whole-genome amplification (WGA) methods are limited by low accuracy of copy-number variation (CN

107 igns, and the deposition of carbon fractions are limited by low nitrogen input.

108 jugating preformed polymers to cell surfaces are limited by low polymer grafting efficiency.

109 that use conventional separation techniques are limited by low sample throughput and complicated dat

110 hods for long-term measurement of C. elegans are limited by low throughput and the difficulty of perf

111 alination or industrial wastewater reuse may be limited by low rejection of volatile and semivolatile

112 ions, but the yields of these reactions have been limited by low chemoselectivity for the amination o

113 rs using antibody-targeted radionuclides has been limited by low therapeutic indices (TIs).

114 ns with high E-selectivity (>99% E) but have been limited by low to moderate yields.

115 rs in this environment, where photosynthesis is limited by low concentrations of dissolved iron and l

116 However, this approach is limited by low current density and the need for recti

117 uggest that Dengue virus (DENV) transmission is limited by low winter temperatures in the mainland Un

118 but the use of sex pheromones as attractants is limited by male multiple mating and immigration of ma

119 nce-based single-molecule analysis, however, is limited by matrix interference and can only probe a v

120 Moreover, previous studies were limited by measurement error from dietary self-repo

121 e than a single molecular contrast agent has been limited by MRI's ability to only dynamically measur

122 radication of systemic tuberculosis (TB) has been limited by neglected populations and the HIV pandem

123 he leaves, indicating that urease activation is limited by nickel accessibility in vivo Our data unco

124 The application of base editing is limited by off-target activity and reliance on intrac

125 hole tooth regeneration approaches currently are limited by our inability to bioengineer full-sized,

126 ure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in lon

127 se sample types, but in the clinical setting are limited by overwhelming host material and ultra-low

128 and track individual molecules in live cells is limited by packing of multiple copies of labeled mole

129 onography for the evaluation of calf DVT may be limited by patient characteristics such as obesity, e

130 worsened ejection fraction in CB2(-/-) mice were limited by pericardial AT removal.

131 heir low fidelity and loose active site, but are limited by poor processivity and activity.

132 mbinant MOMP protein for vaccine development are limited by poor solubility, low yield, and protein m

133 Current immunotherapeutic approaches have been limited by poor clearance of a core AD lesion, cere

134 This strategy is limited by poor signal-to-noise ratio and only offers

135 e 7 low- and middle-income countries studied is limited by poor specificity and by poor sensitivity a

136 organic dyes, but their in vivo application is limited by potential toxicity from systemic administr

137 promise signal quality, while throughput can be limited by processing time.

138 in patients with acute myeloid leukaemia has been limited by rapid generation of resistance mutations

139 m transient increases in cell signaling that are limited by receptor tachyphylaxis.

140 for opposite reasons: Ag85B-specific T cells were limited by reduced antigen expression during persis

141 equence-intrinsic activity of promoters have been limited by relatively low throughput and the length

142 owever, reproducibility of current protocols is limited by reliance on poorly controlled processes (e

143 of late-onset ADHD, but these investigations are limited by relying on screening instruments to asses

144 es of opiate painkillers, like morphine, can be limited by respiratory depression.

145 ninvasively imaging tumor perfusion with PET are limited by restricted accessibility and short half-l

146 tudy (especially those on FIT screening) may be limited by restricted evidence available for patients

147 in patients with ischemic heart disease have been limited by sample size and design.

148 otherapeutic agent, but its use to treat GBM is limited by severe systemic toxicity and inefficient p

149 ogical therapies for cardiovascular diseases are limited by short-term pharmacokinetics and extra-car

150 Existing clinical trials have been limited by short duration, low doses of vitamin D,

151 are potent analgesics but their clinical use is limited by side effects including analgesic tolerance

152 and oxime has been traditionally regarded as being limited by slow rates, developments in the past 5

153 alve replacement (TAVR) in diabetic patients are limited by small sample size and contradictory resul

154 ns of brain development, but frequently have been limited by small samples and analytics that do not

155 ssociation with cardiovascular disease (CVD) were limited by small numbers of patients or a narrow ra

156 dicates that reaction rates in ionic liquids are limited by some factor not properly accounted for in

157 We show that fragment formwation is limited by stalk expansion, a key intermediate of the

158 ate-directed synthesis of nucleic acids have been limited by 'strand inhibition', whereby transferrin

159 sk assessment among adults without known CVD are limited by suboptimal performance and a narrow focus

160 ising investigational therapy, its potential is limited by substantial adverse events (AEs), which ar

161 liable quantification of the latter estimate is limited by substantial measurement noise.

162 s, including probing depth measurements, but is limited by systematic and random errors.

163 capable of uniquely specific targeting, but are limited by technical challenges such as low potency

164 ultaneous detection of multiple gene fusions are limited by tedious and prolonged experimental protoc

165 However, the accuracy of these models is limited by that of the force fields used to generate

166 Our findings are limited by the absence of a control group in the stu

167 In summary, CTG*CAG expansions are limited by the abundance of MutSbeta and rely heavil

168 ing (MRI) applications, but these techniques are limited by the biotoxicity of bulk-manganese.

169 ity, but the efficiencies of the solar cells are limited by the confinement of excitons.

170 ality, but the accessible layer combinations are limited by the crystal chemistries of the available

171 on the two-dimensional (2D) cell culture and are limited by the difficulty of simulating three-dimens

172 need to be replicated in larger samples and are limited by the fact that only peripheral methylation

173 However, MB and HIFU are limited by the half-life of the contrast agent and c

174 r, studies of these phenomena in mango fruit are limited by the lack of genome-scale data.

175 However, applications to plasma are limited by the need for complex preanalytical sample

176 measurements of macromolecular dynamics, but are limited by the number of degrees of freedom that can

177 Although the findings are limited by the observational study design and the sm

178 its use for different applications, but all are limited by the properties available to natural nucle

179 rtunately, current hyphenated 2D separations are limited by the speed of the second dimension separat

180 Commercialized PCRAM products are limited by the tens of nanoseconds writing speed, or

181 s in phenotyping techniques are exciting, we are limited by the tools to analyze fully the massive ph

182 tigations and utilizations of the QAH effect are limited by the ultralow temperatures needed to reach

183 Although these results are limited by the uncertainty associated with the small

184 l structure of taxonomic classifications and are limited by the use of color for categories.

185 Although our results are limited by the usual biases related to the observati

186 Since engineering trimers can be limited by the difficulty of rationally predicting be

187 ddressing this issue, preclinical models may be limited by the inability to accurately replicate path

188 r stem cell therapy but success is likely to be limited by the inflammatory response.

189 The accuracy of the model may be limited by the small number of AFP cases in some dist

190 the pathophysiology of these conditions has been limited by the availability of animal and human mod

191 s implementation in nanophotonics has so far been limited by the coarse resolution of conventional in

192 h temperatures, but liquid-metal pumping has been limited by the corrosion of metal infrastructures.

193 ionally, the utility of methyl NMR has often been limited by the difficulty in assigning the methyl r

194 MBLs are currently unavailable as design has been limited by the incomplete knowledge of their mechan

195 l study of cotranscriptional RNA folding has been limited by the lack of easily approachable methods

196 The study of Tspan5 has been limited by the lack of good antibodies.

197 as targets for therapeutic intervention has been limited by the lack of tool compounds that can spec

198 intrahost evolution in AIDS pathogenesis has been limited by the need for longitudinally sampled vira

199 lication of this technology in catalysis has been limited by the relatively poor chemical reactivity

200 Quantifying that response has, however, been limited by the typically coarse temporal resolution

201 study culture and society, but its power has been limited by the use of data from books and simple an

202 ude liquid cells without the time resolution being limited by the response of the detector.

203 The development of therapies for TBI is limited by the absence of diagnostic and prognostic b

204 ing single-cell RNA-sequencing (RNA-seq) but is limited by the assumptions of current analytic method

205 to treat these diseases, but this procedure is limited by the availability of a suitable donor.

206 rowth in many environments where growth rate is limited by the availability of nutrients.

207 diseases has become a clinical standard but is limited by the availability of suitable matched donor

208 ly engineered microbes for secreted products is limited by the available assay throughput.

209 Their synthesis, however, is limited by the behaviour of common boron starting mat

210 perceptual resilience to accelerated speech is limited by the brain's ability to parse speech into s

211 It is limited by the calibration uncertainties in strain am

212 te that the formation of a relational memory is limited by the capability of temporal binding, which

213 by the structural changes, whereas the decay is limited by the charge recombination step.

214 is rare, and duration of treatment response is limited by the development of drug resistance.

215 of natural methane bubble size distributions is limited by the difficulty in measuring bubble sizes o

216 r SCA and sudden cardiac death in particular is limited by the diversity of the study population base

217 We show that the templated reaction turnover is limited by the duplex dissociation kinetics beyond pr

218 AAV-mediated gene replacement in the cochlea is limited by the extensive remodeling of the organ of C

219 ering genetic variation through resequencing is limited by the fact that only sequences with similari

220 usefulness of diastolic function assessment is limited by the heterogeneity in the existing definiti

221 aceutical products, however, their potential is limited by the high cost of development and manufactu

222 l and pathological functions of brain lipids is limited by the inability to analyze these molecules a

223 This study is limited by the inability to determine the timing of a

224 The rate of progress in human neurosciences is limited by the inability to easily apply a wide range

225 matching metabolites; however, this approach is limited by the incomplete coverage of these libraries

226 However, this immunotherapy is limited by the increase in alloreactive CD4(+) T lymp

227 This study is limited by the information provided in published data

228 ve view of the evolution of gene repertoires is limited by the intrinsic limitations of common sequen

229 ment of therapies that prevent disease onset is limited by the lack of adjuvant-free experimental ani

230 racellular cholesterol; however, its utility is limited by the lack of an efficient temporal control

231 owledge about the properties of ECC couplons is limited by the lack of appropriate experimental and a

232 ds (CE-MS) for glycomics and glycoproteomics is limited by the lack of convenient interfaces for coup

233 This retrospective study is limited by the lack of information to assess reasons

234 o accurately predict As surface complexation is limited by the lack of molecular-level understanding

235 detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease s

236 This approach, however, is limited by the lack of residential histories typicall

237 However, their development is limited by the lack of solid electrolyte materials th

238 tion of antibody-based immunotherapy in cats is limited by the lack of species-specific complete sequ

239 r understanding of their mechanism of action is limited by the lack of structural information on acti

240 However, broad application of 2 A peptides is limited by the lack of systematic comparison of diffe

241 charge mobility of molecular semiconductors is limited by the large fluctuation of intermolecular tr

242 e-stored lithium, the overall energy density is limited by the low-capacity lithium metal oxide catho

243 e nozzle's diameter, and the printed pattern is limited by the motion paths.

244 tically ill patients suffering from delirium is limited by the need for a valid/reliable translation

245 Targeting of multiple genomic loci with Cas9 is limited by the need for multiple or large expression

246 for new reactivity, reactions and molecules is limited by the need for separate work-up-separation s

247 unction of genes implicated in tumorigenesis is limited by the need to generate and cross germline mu

248 tion for precursor ion since this resolution is limited by the number of evolution interval steps to

249 However, its utility is limited by the number of experimental CCS values curr

250 Causal interpretation is limited by the observational and ecological nature of

251 Remarkably, dispersion along c is limited by the orthogonal Vdpi-H1s-Vdpi arrangement d

252 dence base for the care of transgender women is limited by the paucity of high-quality research, and

253 enesis (in melanomas and other tumour types) is limited by the paucity of mouse models for live imagi

254 cific function to regions of DNA methylation is limited by the poor correlation between global patter

255 sion patterns of genes between plant species is limited by the quality of the genomic and transcripto

256 However, for exogenous siRNAs it is limited by the rapid removal of the 5- phosphate of t

257 n replicators can be altered selectively, it is limited by the reaction environment employed.

258 omic markers in microbial ecological studies is limited by the scarcity of comparative data on the me

259 rate detection of pathological STR expansion is limited by the sequence read length during whole-geno

260 However, progress is limited by the sheer diversity and complexity of thes

261 However, progress is limited by the small family of suitable materials, an

262 on goes beyond the sensor coherence time and is limited by the stability of a classical clock.

263 edge of brain correlates of postural control is limited by the technical difficulties in performing c

264 of the complex hierarchical microstructures is limited by the traditional fabrication techniques.

265 , accurate estimation of BC's climate effect is limited by the uncertainties of its spatiotemporal di

266 environmental biodegradability of pollutants is limited by the use of low throughput systems.

267 This study is limited by the use of municipal-aggregate data, which

268 Photodynamic therapy (PDT) efficacy is limited by the very short half-life and limited diffu

269 Here, we provide evidence that rod length is limited by the width of the periplasmic space between

270 roduction of both C3 and C4 crop progenitors was limited by the atmospheric conditions of the last gl

271 Our analysis was limited by the availability and quality of data in t

272 nterpretation and generalization of the data was limited by the heterogeneity of study populations, m

273 Analysis of consumption was limited by the small effect size in relation to high

274 This study was limited by the small sample size, which was a result

275 Progress in the ensuing years was limited by the tools available for both organometall

276 in commonly used nanodiscs of 10-nm diameter were limited by the high molecular weight of these parti

277 first-line therapy for Dravet syndrome, they are limited by their ability to only modulate synaptic r

278 However, cell targeted therapeutics are limited by their complexity, heterogeneity, and diff

279 They are limited by their intermittent and user-dependent nat

280 Current biomarkers for sepsis are limited by their non-specificity, short half-life, a

281 gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high

282 ous studies of emergency department sedation are limited by their single-center design and are underp

283 olled studies of these therapies, which have been limited by their small sample sizes; most studies h

284 tch dystrophic muscles and because their use is limited by their adverse effects on bone and cardiac

285 developed for in vivo studies in Drosophila is limited by their incompatibility with existing GAL4 l

286 chnospiraceae bacterium ND2006 Cpf1 (LbCpf1) is limited by their requirement of a TTTV protospacer ad

287 peutic use of single-chain antibodies (VHHs) is limited by their short half-life in the circulation.

288 ing transcriptional diversity in tumors, but is limited by throughput, cost and the ability to proces

289 croRNA expression in human kidneys, however, were limited by tissue heterogeneity or the inclusion of

290 Both are limited by today's technology.

291 ysical biopsy and conventional pathology can be limited by tumor heterogeneity.

292 e find that the performance of these devices is limited by tunneling through the Schottky barrier at

293 the quality gap in ICU-based palliative care is limited by uncertainty about acceptable models of col

294 However, its effectiveness is limited by underuse, particularly among racial/ethnic

295 Balloon angioplasty was limited by unpredictable procedural outcomes due to

296 Its utility in the abdomen is limited by uptake in normal structures.

297 etic valve endocarditis, but its specificity is limited by uptake on noninfected valves.

298 Various marketed antiarrhythmic drugs are limited by ventricular adverse effects and efficacy

299 t challenge; topical therapy, in particular, is limited by very poor transport of active agents acros

300 However, frequency tuning is also thought to be limited by viscous loss in subtectorial fluid.