ライフサイエンスコーパス: be localized to

1 SEMA3F is localized to 3p21, an early and frequently deleted lo

2 DIAPH1 is localized to 5q31 and encodes one of the formin prote

3 However, adaptation effects cannot be localized to a single, local network.

4 the human genome, sequence reads that cannot be localized to a unique location in the genome are filt

5 rs and that these pairs can be thought of as being localized to a particular region of space.

6 portion for IL-28A, IL-28B, and IL-29 genes is localized to a 1-kb region in their respective promot

7 shows that the microtubule depolymerase Kif2 is localized to a cortical subdomain of endoplasmic reti

8 show that the microtubule depolymerase Kif2 is localized to a cortical subdomain of the ER that is i

9 The principal FVIII binding site is localized to a flexible, positively charged region on

10 VprBP is localized to a large set of tumor suppressor genes an

11 Interestingly, although residue 502 is localized to a region thought to be involved in inter

12 that the interaction between FLIL33 and IPO5 is localized to a specific segment of the FLIL33 protein

13 in gene expression, and Il33 gene expression was localized to a virus-induced subset of airway serous

14 on microscopic analyses, we found that HDAC3 was localized to A-band of sarcomeres and capable of dea

15 ontrol recessive effects (P = 8.81 x 10(-8)) were localized to a 53-kb region near HLA-A, in a segmen

16 s is underscored by the fact that histidines are localized to active sites in approximately 50% of al

17 is unknown whether this preparatory activity is localized to ALM or widely distributed within motor c

18 ining receptor TREM-like transcript-1, which is localized to alpha-granules in resting platelets, bin

19 Protease-activated receptor-1 (PAR-1) was localized to amnion mesenchymal and decidual cells.

20 romatin immunoprecipitation showed that Enok is localized to and acetylates H3K23 at the spir and mae

21 Recently, mitochondria have been localized to astrocytic processes where they shape

22 HS1BP3 is localized to ATG16L1- and ATG9-positive autophagosome

23 In patient cohorts, MMP-13 expression was localized to BM-associated myeloma cells, while elev

24 Prdx6 has been localized to both cytosol and lamellar bodies (LB)

25 XO is localized to both cytoplasmic and mitochondrial compa

26 We find that Psd1 is localized to both mitochondria and the ER.

27 Typically, eIF4E is localized to both the nucleus and cytoplasm, where it

28 that of glutelin during seed maturation and is localized to both the nucleus and cytosol.

29 MAC was localized to Bruch's membrane and the choriocapillar

30 ate canonical TGFbeta Smad signalling, which is localized to bulge stem cells in both normal human an

31 coupled beta2-adrenergic receptor (betaAR), are localized to caveola domains.

32 rmed that the vast majority of Ki-67+ nuclei were localized to CD163+ macrophages in perivascular cuf

33 Indels are localized to CDRs, and secondary mutations within in

34 PAN1, but not PAN2, is localized to cell plates in all classes of dividing c

35 uorescent protein (GFP) revealed that AtWSCP is localized to cell walls/apoplastic spaces.

36 Increased DCK was localized to cells associated with hypoxia, and hypo

37 ctively these findings demonstrate that GRK2 is localized to centrosomes and plays a central role in

38 ACK1 and PAT2 were localized to chloroplasts, while ACK2 and PAT1 were

39 As PMP22 is localized to cholesterol-enriched membrane domains th

40 in ciliated hTERT-RPE1 human cell line, P/rd is localized to cilia.

41 use, airway smooth muscle (SM) and cartilage are localized to complementary domains surrounding the a

42 We show that VANG-1 and SAX-3 are localized to contracting edges and rosette foci and

43 CIPP-induced impacts on cytosine methylation are localized to CpG islands within intergenic regions.

44 Binding sites for PAI-1 within LRP1 have been localized to CR clusters II and IV.

45 RBPMS immunoreactivity is localized to cyan fluorescent protein (CFP)-fluoresce

46 lational fusions, CML38 protein was found to be localized to cytosolic granule structures similar in

47 In mature neurons, it is localized to dendritic spines, but little is known ab

48 a secreted extracellular matrix protein, has been localized to deposits of subepithelial fibrosis in

49 ls can be grouped into distinct subsets that are localized to different organs and exhibit a differen

50 the eigenvectors of the connectivity matrix are localized to different parts of the network.

51 be at least part of the process by which tau is localized to distal axons.

52 We demonstrate that these molecules are localized to distinct subcellular domains and create

53 As in mammalian neurons, DISC1 is localized to diverse subcellular domains of developin

54 TSPAN9 was localized to early endosomes containing internalized

55 e well known to activate TLRs 3 and 7-9 that are localized to endocytic compartments and detect ligan

56 ow by super resolution microscopy that DISC1 is localized to endoplasmic reticulum contact sites and

57 MoVps17 is localized to endosomes depending on the activity of p

58 We demonstrate that IGPR-1 is localized to endothelial adherens junctions and, thro

59 Elevated SAMHD1 was localized to endothelial cells, perivascular dendrit

60 icate that representation of facial identity is localized to face patches, but activity in these patc

61 FMDV structural and nonstructural proteins were localized to follicle-associated epithelium of the

62 of the zebrafish Nodal factor, Squint (Sqt), are localized to future embryonic dorsal.

63 GmWRP1 and some of the GmExo70J proteins are localized to Golgi apparatus through a novel N-termi

64 sphatidylinositol 4-phosphate (PtdIns4P) has been localized to Golgi membranes based on the distribut

65 l as six proteins not previously reported to be localized to GSVs.

66 rmine whether the effect of mPGES-1 and PGE2 was localized to hematopoietic or nonhematopoietic cells

67 We show by proteomic analysis that P450 27C1 is localized to human skin, with two proteins of differe

68 ssue sections confirmed that this metabolite is localized to hypoxic tissue regions.

69 In contrast, during development they are localized to immature myofibrils together with their

70 the same RTK depending on which endosome it is localized to in the cell.

71 ne novel Inc and 3 previously described Incs were localized to inclusion membrane microdomains, as ev

72 Hot spots were localized to inner-city, impoverished neighborhoods

73 PDE3A1, which is localized to intracellular membranes, and PDE3A2, whi

74 patterns of altered histone acetylation that were localized to intragenic regions, enriched for Myc D

75 Two cleavage sites were localized to IR downward arrowTT and NR downward ar

76 ncreatic vasculature while its TrkA receptor is localized to islet beta cells.

77 lled vacuolar soluble proteins (VSPs), which are localized to its acidocalcisomes.

78 A fraction of Stx3 is localized to late endosomes/lysosomes, although how i

79 ysis revealed that this early attention bias was localized to lateral occipitotemporal cortex, reflec

80 We show that Tgl4p and Tgl5p, which are localized to lipid droplets in wild type, are partia

81 LMP1 is localized to lipid raft domains to induce signaling.

82 CD19 is localized to lipid rafts and constitutively activated

83 iFC between the identified proteins and LMP1 was localized to lipid raft domains and was dependent on

84 interaction between LMP1 and these proteins was localized to lipid rafts and dependent on LMP1 signa

85 which is scheduled to enter clinical trials, was localized to lysosomes.

86 AH versus control lungs (n=10), and proteins were localized to macrophages.

87 ortions of a virion-incorporated enzyme that is localized to mature retrovirus cores.

88 The proteins are localized to membranes of intracellular Ca(2+) store

89 to a BBSome that interacts with clathrin and is localized to membranes of the flagellar pocket and ad

90 The dimeric proteins were localized to membranes, ran as intact dimeric prote

91 ence analysis demonstrates that the proteins are localized to mitochondria and/or plastids, implicati

92 IHG-1 must be localized to mitochondria to interact with Mfn1 and M

93 the common W279X mutation, and aprataxin has been localized to mitochondria in neuroblastoma cells, w

94 f K-Ras, the scaffold RASSF1A, and Mst1 that is localized to mitochondria and promotes Mst1 activatio

95 We show that NIK is localized to mitochondria in cancer cell lines, ex vi

96 Here we show that NRD1 is localized to mitochondria, where it recruits mitochon

97 The natural product probe was localized to mitochondria within 20 min of treatment

98 The protein was localized to mitochondria.

99 though an increasing number of proteins have been localized to MRGs, a comprehensive analysis of the

100 alpha(2)delta(3) immunoreactivity was localized to multiple cell types, including ganglion

101 , relative to AD subjects without psychosis, are localized to neocortex rather than medial temporal l

102 3alpha,5alpha-THP is localized to neurons in the VTA, including tyrosine h

103 eurokinin-1 receptor (NK1R) immunoreactivity was localized to neurons in the RVM.

104 MMP-12 expression was localized to neurons, oligodendrocytes and microglia

105 CEACAM6 in the lamina propria was localized to neutrophils predominantly.

106 L31 is expressed with true late kinetics and is localized to nucleolin-containing nuclear domains.

107 In the absence of the vitamin, TTP is localized to perinuclear vesicles that harbor CD71, t

108 nduced in k1 k3 and not wild-type plants and was localized to PGs.

109 nt protein-labeled virulent MTB-strain H37Rv was localized to pimonidazole (an in vivo hypoxia marker

110 In axonal profiles M2R immunogold was localized to plasmalemmal and cytoplasmic regions an

111 ed full-length ATM1 expressed in Arabidopsis was localized to plasmodesmata, plastids, newly formed c

112 The mitosis-specific clusters of Kv2.1 are localized to PM:ER MCS, and M phase clustering of Kv

113 NMUR2 is localized to presynaptic gamma-aminobutyric acidergic

114 It is localized to prospore membranes (PSMs), the structure

115 urth, the deltaproteobacteria expressing FDH were localized to protozoa via hybridization chain react

116 Many mRNAs are localized to protrusions, but it is unclear to what

117 Observed focal uptake in the prostate was localized to PSMA-expressing malignant tissue on his

118 nd was detected by an antiapo(a) antibody to be localized to Rab5-positive early endosomes, the trans

119 ular and peripheral RPE, and sites of damage are localized to regions of the mt genome that may impac

120 Kinase activities were localized to regions including the oral sensory pap

121 These findings indicate that Mcm10 is localized to replication initiation sites by directly

122 EDN2 expression was localized to retinal glia and pathological NV tufts

123 ation were increased and that activated EPOR was localized to retinal vascular endothelial cells (ECs

124 Key attentional processes are localized to right lateral parietal cortex in the te

125 visual as well as in the auditory domain and were localized to sensory-specific regions.

126 More recently, immune response genes have been localized to sex chromosomes themselves or found to

127 s lacking this interaction resulted in Opi1p being localized to sites of lipid droplet formation, coi

128 How Mcm10 is localized to sites of replication initiation is uncle

129 Following dual infection, HIV-infected cells were localized to sites of Mtb-driven inflammation and m

130 with a low-level inflammatory response that was localized to small foci across the left and inferior

131 s confirmed early pain-related volume losses were localized to somatosensory regions.

132 many cell signaling pathways, some of which are localized to spatially restricted microdomains.

133 -) mice are particularly instructive as they are localized to specific areas within both the deep cer

134 nal and post-translational regulatory events are localized to specific neuronal cell types or subcell

135 In eukaryotic cells many mRNAs are localized to specific regions of the cytosol, thereb

136 echanisms associated with mood disorders may be localized to specific hippocampal subfields.

137 Although associative learning has been localized to specific brain areas in many animals,

138 ncreased PP2A-B56alpha activity in TG hearts is localized to specific subcellular sites leading to th

139 l transforming 2 and Aurora kinase B (AurkB) are localized to stress granules in human astrocytoma ce

140 The conserved ARF-like small GTPase ARL-8 is localized to SVPs and directly activates UNC-104/KIF1

141 ), and oligomeric assemblies of each protein are localized to synapses.

142 e the first evidence that SAPAP isoforms may be localized to synapses according to circuit-selective

143 Here, we report that Shrm4 is localized to synapses where it regulates dendritic sp

144 GhHOX3 genes are localized to the 12th homoeologous chromosome set of

145 conserved RNA-binding proteins (RNAbps) that are localized to the Balbiani body: RNA binding protein

146 l cells, both the Na,K-ATPase and E-cadherin are localized to the basolateral domains of the plasma m

147 tely activating genes encoding proteins that are localized to the cell envelope; these include metall

148 Tetraspanins are localized to the cell surface in cancer and particip

149 ed in every subtype and all implicated genes are localized to the chromosomal cytoband 1p36.3.

150 y to the expression of Math1 and Pax6, which are localized to the exterior face of the rhombic lip.

151 Both AP-3 and AP-1 are localized to the Golgi but occupy adjacent domains.

152 ferase, we found that RDN1 and RDN2 proteins are localized to the Golgi, as was shown previously for

153 d long-term memory (LTM) retrieval processes are localized to the left lateral parietal cortex in the

154 Atg8 proteins are localized to the membrane in an ubiquitin-like conju

155 unogold-electron microscopy, these filaments are localized to the non-compacted adaxonal myelin compa

156 Almost all risk variants are localized to the noncoding region of the genome; the

157 opic organelles called nuage granules, which are localized to the outer face of the nuclear envelope.

158 a model in which the Bam lipoproteins, which are localized to the outer membrane by the BAM-independe

159 chial biopsies revealed that KCa3.1 channels are localized to the plasma membrane and nucleus of ASM

160 Heterotrimeric G proteins are localized to the plasma membrane where they transduc

161 ction with a systemic pathogen, most T cells are localized to the pulmonary vasculature.

162 on the size of the nanocubes, and that they are localized to the surfaces of the nanocube.

163 myocytes, the calcineurin sensors appear to be localized to the cardiac z-lines, and respond to cumu

164 experiments strongly suggest this enzyme to be localized to the cytosol.

165 pothesized that type IV collagen should also be localized to the DEJ in mature human teeth.

166 acental alkaline phosphatase (ALPP) mRNA can be localized to the ER membrane independently of transla

167 o the outer bulge, whereas Dkk3 continues to be localized to the inner bulge during the hair cycle gr

168 our results suggest that Eut proteins might be localized to the Pdu MCP in vivo.

169 show that RPS5 activation requires that PBS1 be localized to the plasma membrane and that plasma memb

170 Previously, betaCA4 was reported to be localized to the plasma membrane, but here, we show t

171 Engrafted cells could be localized to the stroma surrounding acini and ducts.

172 Septins have been localized to the cell cortex at the base of cilia,

173 ins of cortical interneurons in rodents have been localized to the embryonic subcortical telencephalo

174 Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pi

175 As translocation in A. thaliana, with PvACR3 being localized to the plasma membrane.

176 AAD1) and AAD3 We found that AAD3 expression is localized to the aleurone where mutants show an appro

177 The Kir7.1 channel is localized to the apical aspects of retinal pigment ep

178 we show that the Legionella export apparatus is localized to the bacterial poles, as is consistent wi

179 We propose that Cobl is localized to the basal region of microvilli both to p

180 SLC4A11 is localized to the basolateral membrane in BCEC.

181 Chp2 is localized to the cell envelope fraction, consistent w

182 the bacterial nucleoid, slow diffusing tRNA is localized to the cell periphery (showing a 30% enrich

183 We show that C2cd3 is localized to the centriolar satellites in a microtubu

184 kinase distantly related to the MAPK family is localized to the centrosome, where it restricts core

185 SCO4 is localized to the chloroplasts, which suggests the exi

186 Live imaging of roots indicates that SCM:GFP is localized to the cytoplasm in a non cell type depende

187 umophila is a bona fide F-box protein, which is localized to the cytosolic side of the Legionella-con

188 fied that reduces sEH hydrolase activity and is localized to the dimerization interface of the protei

189 Tjp1b is localized to the electrical synapse, where it is requ

190 By contrast, AAD1 is localized to the embryo where mutants show a small re

191 of heparanase 2 and showed that the protein is localized to the embryonic ventrolateral neural tube

192 Overexpressed ZmARGOS1 is localized to the endoplasmic reticulum and Golgi memb

193 Mechanistically, NRROS is localized to the endoplasmic reticulum, where it dire

194 and we show that in the absence of E2, Rint1 is localized to the ER and associates with ZW10.

195 dicted Src-homology 3 (SH3) domain and DHHC6 is localized to the ER membrane.

196 tes, we show that the OR coreceptor, AgOrco, is localized to the flagella of A. gambiae spermatozoa w

197 fluorescent protein (YFP) fusion of BdCSLF6 is localized to the Golgi apparatus and that the Golgi l

198 stent with findings in S. cerevisiae, MoGlo3 is localized to the Golgi, and that the localization is

199 rexpression of a phospholipase TgLCAT, which is localized to the IVN, results in a decrease in the nu

200 eptide is conserved between human and mouse, is localized to the late endosome/lysosome and interacts

201 The AnkB-Paris effector is localized to the LCV membrane most likely through the

202 Moreover, we find that CACNA1A is localized to the lysosomes and that loss of lysosomal

203 CNR13/NOD is localized to the membrane and is enriched in dividing

204 IRT3) is a class III lysine deacetylase that is localized to the mitochondria and regulates mitochond

205 t mammalian TAZ, like its yeast counterpart, is localized to the mitochondrion where it adopts an ext

206 We demonstrated that the SLO3-GFP is localized to the mitochondrion.

207 -3-3sigma expression, which in normal breast is localized to the myoepithelial cells, tracks with mal

208 is normally spatially restricted, because it is localized to the nuclear periphery via interactions w

209 TaR1 is localized to the nucleus and binds to wheat Histone 3

210 It is localized to the nucleus and induced specifically in

211 PTEN is localized to the nucleus in NSCs, binds to the PAX7 p

212 Here, we report that MS is localized to the nucleus of Pichia pastoris and Candi

213 Furthermore, Miz1 is localized to the nucleus upon Hh activation in a Smo-

214 een examined, it is not clear why or how Arc is localized to the nucleus.

215 ::Gfp or MybA::3xHa protein showed that MybA is localized to the nucleus.

216 xpressed at the meristematic regions and NFL is localized to the nucleus.

217 scopy and PAGE analysis, we show that Kdo-N3 is localized to the outer membrane and specifically inco

218 In humans, a well-developed serotonin system is localized to the pancreatic islets while being absent

219 Analysis of the mutants confirmed that qH is localized to the peripheral antenna (LHCII) of photos

220 GT in cis via DNA endonuclease activity that is localized to the periplasm.

221 LAMB1 is localized to the pial basement membrane, suggesting t

222 We demonstrate that AtRLPH2 is localized to the plant cell cytosol, is resistant to

223 ein capable of rescuing the sunn-4 phenotype is localized to the plasma membrane and is associated wi

224 In this report, we confirm that Siglec-15 is localized to the plasma membrane where it can be targ

225 SWELL1 is localized to the plasma membrane, and its knockdown d

226 Normally, GhoT is localized to the pole and does not cause cell lysis u

227 The depletion of several key miRNA is localized to the proliferative crypt region of the gu

228 Swe1 is localized to the septin cytoskeleton at the bud neck

229 in the amount of ACT, and >/=90% of this ACT is localized to the supernatant, unlike growth without F

230 by the cytochrome P450 monooxygenase CYP81F2 is localized to the surface of the endoplasmic reticulum

231 the Cullin 3 (Cul3) substrate adaptor KLHL20 is localized to the trans-Golgi network (TGN) and is imp

232 he choline transporter-like 1 (CTL1) protein is localized to the trans-Golgi network (TGN), prevacuol

233 Water outgassing was localized to the "neck" region of the comet.

234 region on MBP responsible for this activity was localized to the 64 N-terminal amino acids (MBP1-64)

235 This Stx binding was localized to the A1 and A2 domain of VWF monomeric s

236 IL-22 receptor was localized to the airway epithelium in naive mice but

237 TSLP expression was localized to the airway epithelium, whereas IL-33 wa

238 curred, and the majority of ridge width loss was localized to the buccal aspect.

239 Gadolinium deposition in the contrast group was localized to the capillary endothelium and neuronal

240 Immunoreactive APOBEC2 was localized to the cell nucleus of developing myocardi

241 ssues, including vascular tissues, and PRX17 was localized to the cell wall.

242 is with contrast redemonstrated disease that was localized to the chest with mild compression of the

243 ADCY1 was localized to the cytoplasm of supporting cells and h

244 The N-terminal FLD was localized to the cytoplasmic side of the inner membr

245 FAM190A was localized to the gamma-tubulin ring complex of early

246 ZIP8 expression was localized to the hepatocyte canalicular membrane, an

247 that the main source of arrhythmic activity was localized to the higher-order thalamic relays of the

248 This arrhythmic activity was localized to the higher-order thalamic relays of the

249 distributed throughout the fruiting body, it was localized to the hymenophore region in Shiitake.

250 In control mice REEP6 was localized to the inner segment and outer plexiform l

251 hereas the low-density lipoprotein component was localized to the lysosomal compartment.

252 The M373T mutation was localized to the macroglobulin domain 4 of C3, which

253 otein of Cep55 and GFP identified that Cep55 was localized to the meiotic spindle, especially to the

254 The AceI protein was localized to the membrane after overexpression in E.

255 the fusion protein was degraded only when it was localized to the nucleus, confirming that SAMHD1 is

256 RSD protein was localized to the nucleus, consistent with a role of

257 ene and protein expression in the brain that was localized to the paraventricular nucleus of the hypo

258 nd sushi domains of FXIII-B, and its epitope was localized to the peptide spanning positions 96 to 10

259 otein fused to red fluorescent protein (RFP) was localized to the plasma membrane and specifically as

260 ferentiated epithelial CRC cell lines, KCNQ1 was localized to the plasma membrane in a complex with b

261 SUSD3 was localized to the plasma membrane of breast cancer ce

262 The MtMATE67 protein was localized to the plasma membrane of nodule cells and

263 d in insect cells, but only a small fraction was localized to the plasma membrane.

264 aintaining epithelial homeostasis in the gut was localized to the proliferative crypt region of the i

265 d CBF only was observed after MDMA, and this was localized to the right medial temporal lobe (MTL), t

266 Binding function was localized to the serine-rich and acidic Hinge domain

267 Under basal Cu(2+) conditions, ATP7B was localized to the trans-Golgi network (TGN) and the p

268 profile in which the majority of the signal was localized to the upstream edge of the detection regi

269 hCD39 transgene expression was localized to the vascular endothelium at baseline an

270 NRG1 was localized to the wound epithelium prior to blastema

271 The infarctions were localized to the anterolateral LV wall.

272 Some of these enzymes were localized to the cytoplasm or mitochondrion, but mo

273 The N2 effects across the two tasks were localized to the dorsolateral prefrontal cortex, wh

274 Both PfACT and PfUGT were localized to the endoplasmic reticulum by fluoresce

275 revealed that the majority of cases (77.3%) were localized to the eye; none of the patients develope

276 igh levels of mitochondrial activity and ROS were localized to the growing germ tube and appressorium

277 These 10 mutations were localized to the heptad repeat B (HRB) region of th

278 However, only 11% of critical sites were localized to the latest isochrone (87.5%-100%) of v

279 h annular atrial tachycardia, 4 tachycardias were localized to the mitral annulus and 37 to the tricu

280 0 live tachyzoites; 64.5-95.2% (mean =79.6%) were localized to the nerve fiber layer, but some were d

281 RPS6 and AtHD2B were localized to the nucleolus.

282 ated in the skin, but not in the liver; they were localized to the nucleus and led to elevated lipid

283 s indicated that whilst all isoforms of PARP were localized to the nucleus they are also present in n

284 ly abnormal disulfide-linked complexes which were localized to the outer segment (OS) where they impa

285 rs rose bengal (RB) and acridine orange (AO) were localized to the plasmalemma and vacuole, respectiv

286 tagging demonstrated that two of the TpSAPs were localized to the silicalemma and that the intralume

287 sustained annular ventricular tachycardia, 3 were localized to the tricuspid annulus, and 6 to the mi

288 t lymphocyte and PMN cell infiltrates, which were localized to the vaginal mucosal surface.

289 e) and Sse1 (the major yeast form of Hsp110) were localized to this surface shell of [PSI+] deposits

290 2 (PRC2) is a histone methyltransferase that is localized to thousands of mammalian genes.

291 Nonprocessive motors have also been localized to trafficking cargos, but their roles ar

292 Moreover, the shedding was localized to transmigrating pseudopods within the su

293 In the mouse kidney, ILDR1 is localized to tricellular tight junctions of the dista

294 low nanomolar affinity to CCK2R in vitro and was localized to tumor tissues in athymic nu/nu mice imp

295 Importantly, MMAE radiosensitization can be localized to tumors by targeted activatable cell-pene

296 WRI1 phosphorylation was localized to two variants of the canonical KIN10 rec

297 orebrain-mediated increases in response gain are localized to V1 and are not propagated to LM and est

298 In neurons, receptors are localized to vesicles in the soma and dendrites.

299 lusively expressed in the nervous system and is localized to vesicular structures.

300 he adhesive rings of podosomes, whereas ARF1 was localized to vesicular structures transiently contac