ライフサイエンスコーパス: be necessary and sufficient for

1 MCT1 is necessary and sufficient for 3-BrPA uptake by cancer

2 that the change in the neurons' selectivity was necessary and sufficient for a network of stochastic

3 and targets Boi2 to the site of abscission, is necessary and sufficient for abscission inhibition.

4 This peptide was necessary and sufficient for accelerated chemotaxis.

5 These signals are necessary and sufficient for accumulating phosphatid

6 in within the C-terminal 76 amino acids that is necessary and sufficient for accumulation as a single

7 c effects of Cdk5 and demonstrates that SynI is necessary and sufficient for achieving the effects of

8 to the minimal modular elements of GIV that are necessary and sufficient for activation of Gi downst

9 ising a phosphatase-activating domain (PAD), are necessary and sufficient for activation of this path

10 function models, we show that Wnt2 signaling is necessary and sufficient for activation of a transcri

11 This suggests that CnfR2 is necessary and sufficient for activation of the nifB2

12 hich links the NTD and the catalytic domain, is necessary and sufficient for activation.

13 ound that formation of an internal disulfide was necessary and sufficient for aggregation under physi

14 The viral protein Nef was necessary and sufficient for all HIV-1-mediated effe

15 C-terminal coiled-coil domain of Slik, which is necessary and sufficient for apical localization of t

16 er of the ASCORBATE PEROXIDASE 2 (APX2) gene were necessary and sufficient for APX2 expression in con

17 Although Asap lacked Golgi enrichment, it was necessary and sufficient for Arf1 accumulation at th

18 all three compounds, and that these neurons are necessary and sufficient for attraction behavior in

19 t a matching pair of tgrB1 and tgrC1 alleles is necessary and sufficient for attractive self-recognit

20 Thus, MeCP2 in cholinergic neurons is necessary and sufficient for autonomic cardiac contro

21 functions in SC development whereby the NTF is necessary and sufficient for axon sorting, whereas th

22 se infection, the deamidase activity of TecA is necessary and sufficient for B. cenocepacia-triggered

23 Human pDCs were necessary and sufficient for B cell activation indu

24 of the EGL-4 kinase that promotes adaption, is necessary and sufficient for behavioral adaptation.

25 at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylati

26 t linear EEIWVLRK peptide motif from Caskin1 is necessary and sufficient for binding CASK.

27 vage fragment of the cellular prion protein, is necessary and sufficient for binding early oligomeric

28 of myosin-IXA revealed that the motor domain is necessary and sufficient for binding to actin filamen

29 nt but distinct septin-associating elements, is necessary and sufficient for binding to septin filame

30 The N-terminal domain was necessary and sufficient for binding to the katanin

31 We show that dPARP16 catalytic activity is necessary and sufficient for both amino-acid starvati

32 d that the first alpha-helix (residues 1-19) is necessary and sufficient for both inflammasome and NF

33 CELF1 is necessary and sufficient for both mesenchymal transit

34 lly disordered protein (IDP) domain of LAF-1 is necessary and sufficient for both phase separation an

35 lycan binding, the fusion (F) protein, which is necessary and sufficient for both viral binding to th

36 ts indicated that such changes in microbiota were necessary and sufficient for both low-grade inflamm

37 n of AF10, and this region has been shown to be necessary and sufficient for CALM-AF10-mediated trans

38 nal coactivator Yes-associated protein (Yap) is necessary and sufficient for cardiomyocyte proliferat

39 op in cytosolic K(+) is the common step that is necessary and sufficient for caspase-1 activation.

40 , termed the kinase inhibitory domain (KID), is necessary and sufficient for Cdk inhibition.

41 mutants, we mapped a C-terminal domain that is necessary and sufficient for Cdr1 node localization a

42 ys reveal that Hoxb4 and its paralogue Hoxd4 are necessary and sufficient for cell segregation, and f

43 that high-affinity Teb1 DNA-binding activity is necessary and sufficient for cell cycle-regulated tel

44 hat the conserved carboxy terminus of CENP-A is necessary and sufficient for centromere and kinetocho

45 pore helix, alone provides the trigger that is necessary and sufficient for channel gating.

46 id protein (p22) or its processed form (p18) is necessary and sufficient for CNC and likely encoded b

47 o delineate the domains of MINT and CSL that are necessary and sufficient for complex formation.

48 , conserved across all group 4 LEA proteins, is necessary and sufficient for conformational transitio

49 expectedly, the extracellular domain of Fn14 is necessary and sufficient for constitutive turnover.

50 five gene products encoded by the asb operon is necessary and sufficient for conversion of endogenous

51 Six proteins are necessary and sufficient for coupled DNA synthesis,

52 that elevation of the tumour suppressor p53 is necessary and sufficient for crowding hypersensitivit

53 rdR boxes function as an operator since they were necessary and sufficient for CT406-mediated repress

54 and found the viral accessory protein Vif to be necessary and sufficient for CUL5-dependent proteasom

55 C establishment, and that Jak-STAT signaling is necessary and sufficient for CySC maintenance shortly

56 ike Stat92E and its targets ZFH1 and Chinmo, is necessary and sufficient for CySC renewal.

57 contractility, a key myofibroblast feature, is necessary and sufficient for deciliation, since const

58 We show that GPI modification is necessary and sufficient for delivering both BG_pap a

59 estricted cells at the CD4(+)8(lo) stage and is necessary and sufficient for development to the CD4 l

60 istinct binding modules within its IDRs that are necessary and sufficient for directing protein inter

61 nsps), three of which, nsp3, nsp4, and nsp6, are necessary and sufficient for DMV formation.

62 The basic regions of bZIPs (bZIP-bRs) are necessary and sufficient for DNA binding and specifi

63 inner photoreceptors R7+R8 of DRA ommatidia are necessary and sufficient for dorsal polarotaxis, whe

64 generation of reactive oxygen intermediates was necessary and sufficient for DRAK2 activation in res

65 ic mutation or heavy chain VDJ recombination are necessary and sufficient for Dsg3 binding.

66 entify a coiled-coil region within PxdA that is necessary and sufficient for early endosome localizat

67 loid-epithelial-reproductive tyrosine kinase was necessary and sufficient for efferocytosis of cardio

68 ) of the Parkin primary substrate human Miro is necessary and sufficient for efficient ubiquitination

69 Consistently, btd is necessary and sufficient for eliciting a type II neur

70 lass III md neurons of the Drosophila larvae is necessary and sufficient for eliciting behavioral tou

71 We test here whether aldosterone is necessary and sufficient for ENaC expression and acti

72 Our findings define what is necessary and sufficient for engineering Hsc70- and S

73 rrow monocytes from B27-Tg rats was found to be necessary and sufficient for enhanced osteoclast form

74 In contrast, the N-terminal domain of G9a was necessary and sufficient for enhancement of ERalpha-

75 We conclude that Sp-Eph signaling is necessary and sufficient for epithelial insertion.

76 the spliced X-box-binding protein-1 (sXBP1) is necessary and sufficient for ER stress-associated miR

77 O binding site functions as an operator that is necessary and sufficient for EUO-mediated repression

78 tain a carboxy-terminal signal sequence that is necessary and sufficient for export, although both tr

79 lacement strategy to identify sequences that are necessary and sufficient for Fab-7 boundary function

80 CarT expression in photoreceptors is necessary and sufficient for fly vision and behavior.

81 tonomous structural and functional unit that is necessary and sufficient for folding and partial acti

82 Ostalpha, demonstrating that the TM segment is necessary and sufficient for formation of a heteromer

83 upancy of CaM Ca2+ binding sites 1, 3, and 4 is necessary and sufficient for full activation.

84 The integrin-binding domain of CD98 was necessary and sufficient for full clonal expansion,

85 on the hinge and the other on the appendage, are necessary and sufficient for functional clathrin eng

86 ivation of viral glycoproteins is thought to be necessary and sufficient for fusion, accumulating evi

87 in vivo demonstrated that both DLX1 and DLX2 are necessary and sufficient for Gad gene expression.

88 GILZ has been shown to be necessary and sufficient for GC-induced tolerogenic D

89 mitochondrial dysfunction motif (MDM), which is necessary and sufficient for gene expression under va

90 CF ASL had a reduced pH, which was necessary and sufficient for genotype-dependent visc

91 diated by an inflammatory cascade, with IL-6 being necessary and sufficient for GLP-1 induction.

92 The N-terminal ChREBP regulatory region is necessary and sufficient for glucose-responsive ChREB

93 The data demonstrate that the C2GnT1 CT is necessary and sufficient for Golgi localization of C2

94 monstrates that ALDH2-catalyzed NO formation is necessary and sufficient for GTN bioactivation in VSM

95 An intraepidermal Wnt signal is necessary and sufficient for hair follicle initiation

96 tudies show that this down-regulation of p63 is necessary and sufficient for HBC activation.

97 Here we show that p62 is necessary and sufficient for HCC induction in mice an

98 terochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochromatin protein

99 ication for each HHV studied, with caspase-3 being necessary and sufficient for HHV replication.

100 Induced proximity is necessary and sufficient for HOTTIP RNA activation of

101 ghly conserved N-terminal DNA-binding domain is necessary and sufficient for (i) adult viability, (ii

102 ription factors AhR and RORgammat in T cells was necessary and sufficient for IL-22 production.

103 We also found the N-terminal domain to be necessary and sufficient for immune antagonism.

104 of neuromyelitis optica and that aquaporin-4 is necessary and sufficient for immunoglobulin G from ne

105 TATA-binding protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription,

106 drial alanine transaminase GPT2 was found to be necessary and sufficient for increased alanine flux u

107 Downstream of calcium, NFAT activity is necessary and sufficient for inducible IL-33 expressi

108 ngly, although HH-independent FOXA2 activity is necessary and sufficient for inducing MFP-specific ge

109 A G-box sequence in the JAZ2 promoter was necessary and sufficient for induction by MYC5 (as i

110 ally blocking sodium pumps in the cerebellum was necessary and sufficient for induction of dystonia.

111 permissive cells, and that ANTXR1 expression is necessary and sufficient for infection in cell lines

112 ent (ICE)-encoded DNase, which we name IdeA, is necessary and sufficient for inhibiting natural trans

113 ermore, we found that a hexapeptide from F1L is necessary and sufficient for inhibiting the NLRP1 inf

114 ating AAD and show that IVIg-generated pTreg are necessary and sufficient for inhibition of allergen-

115 yses reveal that cFLIPL nuclear localization is necessary and sufficient for inhibitory function.

116 i3 to its repressor, Gli3R, and was shown to be necessary and sufficient for initiating this transiti

117 C-terminal domain (amino acids 852-876) that is necessary and sufficient for INM localization of the

118 A conserved I/L-X-C-X2-D/E motif was necessary and sufficient for iNOS-S100A8/A9-mediated

119 Protein kinase C (PKC) activation was necessary and sufficient for integrin- and Rac1-depe

120 n the flexible N-terminal region of F1L that is necessary and sufficient for interaction with and inh

121 ow that the N-terminal RUN domain of PLEKHM1 is necessary and sufficient for interaction with Arl8b a

122 he carboxy-terminal domain of N protein, N3, is necessary and sufficient for interaction with M prote

123 The Nanog tryptophan repeat region is necessary and sufficient for interaction with Sox2, w

124 ributes to its subcellular distribution, and is necessary and sufficient for interactions with core e

125 g to the receptor tyrosine kinase PVR, which is necessary and sufficient for intestinal ERK responses

126 can-containing linker region of neuropilin-2 are necessary and sufficient for its polysialylation and

127 The End3 C-terminus is necessary and sufficient for its cortical localizatio

128 leotide region of the amphoterin mRNA 3'-UTR is necessary and sufficient for its localization into ax

129 eplication and transcription activator (RTA) is necessary and sufficient for KSHV reactivation from l

130 Although Hedgehog (HH) signaling is necessary and sufficient for LFP specification, it is

131 ich is expressed in an opposing gradient and is necessary and sufficient for limiting Bcd-dependent a

132 The conserved CAP domain of Pry1 is necessary and sufficient for lipid export and sterol

133 e actin-related protein 2/3 (Arp2/3) complex is necessary and sufficient for Listeria actin tail asse

134 r-specific genes, indicating that Med1 alone is necessary and sufficient for liver cell proliferation

135 Although InlA-E-cadherin interaction is necessary and sufficient for Lm crossing of the intes

136 This domain is necessary and sufficient for localization and morphol

137 PtdIns4P was necessary and sufficient for localization of P4M, wh

138 ere we found that the V3 domain of PKC-theta was necessary and sufficient for localization to the imm

139 opulation encodes locomotor state and speed, is necessary and sufficient for locomotion, and is selec

140 sory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance.

141 hat the endoplasmic reticulum-resident STIM1 is necessary and sufficient for LRC channel activation b

142 Our work suggests that neutrophils are necessary and sufficient for mAb-induced therapy of

143 ubstrate whose phosphorylation at serine 109 is necessary and sufficient for maintaining Xenopus oocy

144 f fruitless in about 2000 neurons appears to be necessary and sufficient for many aspects of male cou

145 show that a highly conserved domain of Rtf1 is necessary and sufficient for mediating a physical int

146 Post-AAI rAMs were necessary and sufficient for mediating these proinf

147 discover that only one phosphorylation event is necessary and sufficient for MEK1 activity.

148 sed of basic and hydrophobic residues, which is necessary and sufficient for membrane localization, b

149 g ETV4-mediated upregulation of MMP24, which is necessary and sufficient for metastasis.

150 mical analyses, we show that BMP attenuation is necessary and sufficient for MHP formation.

151 ver, Dpp ligand and Tkv receptor interaction is necessary and sufficient for microtubule-based nanotu

152 Tailor is necessary and sufficient for mirtron hairpin uridylat

153 Vms1 contains a highly conserved region that is necessary and sufficient for mitochondrial targeting

154 recipitation analysis to show that the M46RE was necessary and sufficient for MYB46-responsive transc

155 ine 739 in the NCX1 large intracellular loop is necessary and sufficient for NCX1 palmitoylation.

156 These assemblies are necessary and sufficient for neurotoxicity in a C. e

157 show that the cytoplasmic amphipathic helix is necessary and sufficient for NGC generation.

158 show that an early and transient BMP signal is necessary and sufficient for NMJ growth as well as fo

159 l conditioning, and cAMP signaling molecules are necessary and sufficient for normal memory in intrin

160 As E cell and gDN1 activity is necessary and sufficient for normal evening locomotor

161 These data suggest that H3K4 di-methylation is necessary and sufficient for normal origin function.

162 Yorkie is necessary and sufficient for NSC reactivation, growth

163 We show that Yap/Taz-Tead activity is necessary and sufficient for optic vesicle progenitor

164 t that degradation of the peptidoglycan (PG) was necessary and sufficient for osmotic bursting of the

165 e, we report that a short N-terminal peptide is necessary and sufficient for packaging enzymes into t

166 egative regulator of the Yap oncoprotein and is necessary and sufficient for pancreatic cancer suppre

167 show experimentally that a single parS site is necessary and sufficient for ParB-DNA complex formati

168 of one receptor and its compatible pheromone is necessary and sufficient for perithecial development

169 ain within the nonstructural gene NS1/2 that is necessary and sufficient for persistence.

170 ed mutants, suggesting that raft association is necessary and sufficient for PM sorting of LAT.

171 encoding a Spm/Spd N-acetyltransferase that is necessary and sufficient for polyamine resistance.

172 neurotrophic factor (BDNF) has been shown to be necessary and sufficient for post-stroke recovery in

173 X. nematophila cells showed that rhabduscin was necessary and sufficient for potent inhibition (low

174 for the identified transcription factors and are necessary and sufficient for PRE activity.

175 n as a muscle-derived retrograde signal that is necessary and sufficient for presynaptic differentiat

176 shown that nuclear translocation of PKCdelta is necessary and sufficient for pro-apoptotic signaling.

177 tric and colorectal cancer cell lines, CCK2R was necessary and sufficient for progastrin binding and

178 A signal causes high cytosolic Ca(2+), which is necessary and sufficient for progenitor maintenance.

179 y, we show that signaling through stromal PR is necessary and sufficient for progesterone antitumor e

180 redicted N-terminal helical region of PstB2p was necessary and sufficient for promoting the interacti

181 egion of negatively charged amino acids that is necessary and sufficient for proper chromosome segreg

182 ; however, deletion of CTLA-4 on T reg cells was necessary and sufficient for protection from EAE.

183 between Hp and Sp in the nanos2 3'UTR which is necessary and sufficient for protein enrichment in th

184 n of Psk1 appears to be direct, in that Snf1 is necessary and sufficient for Psk1 activation by alter

185 +) innate lymphocytes and gammadelta T cells are necessary and sufficient for psoriatic plaque format

186 in TGD4, amino acids 1-80 and 110-145, which are necessary and sufficient for PtdOH binding.

187 The C-terminal arm of the GLEBS hairpin is necessary and sufficient for Rae1 binding, and we ide

188 This phosphorylation is necessary and sufficient for RAIDD binding and caspas

189 zation, but not inner membrane localization, was necessary and sufficient for rapid and efficient het

190 Presynaptic expression of CCKLR was necessary and sufficient for regulating NMJ growth.

191 evidence demonstrates that IkappaK activity is necessary and sufficient for regulation of neuronal f

192 The Bvg(+) phase is necessary and sufficient for respiratory infection wh

193 Molecular oscillators in GRNs are necessary and sufficient for rhythms in gustatory re

194 ROOT HAIR DEFECTIVE SIX-LIKE4 (RSL4) is necessary and sufficient for root hair elongation in

195 n factor root hair defective 6-like 4 (RSL4) is necessary and sufficient for root hair growth(2).

196 ivates core stem cell transcription factors, is necessary and sufficient for self-renewal, and is sup

197 Finally, we show that brain neurons are necessary and sufficient for sensing all main dietar

198 hermore, we find that Cep4l and Cdc42 itself are necessary and sufficient for sensory neurogenesis in

199 ing HPF1 to in vitro PARP-1/PARP-2 reactions is necessary and sufficient for serine-specific ADPr of

200 Expression of MHCII on CD11c(+) cells was necessary and sufficient for SFB-induced Th17 cell d

201 iew results demonstrating that S-locus genes are necessary and sufficient for SI signaling and for re

202 hat dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction.

203 1alpha- and ERRalpha-dependent pathways that are necessary and sufficient for signaling by oncogenic

204 enitor maintenance, and that Notch signaling is necessary and sufficient for Six2 downregulation.

205 in skeletal muscle Gadd45a expression, which is necessary and sufficient for skeletal muscle fiber at

206 icase DNA-binding protein 1 (Chd1) remodeler are necessary and sufficient for sliding nucleosomes.

207 In human breast cancer cells, alphavbeta3 was necessary and sufficient for Slug activation, tumors

208 strate that the ~100-nucleotide T-box stem I is necessary and sufficient for specific, high-affinity

209 d by loop 1 and helix 2 of the histone fold, is necessary and sufficient for specifying centromere fu

210 Our findings reveal that the GEF Mon1-Ccz1 is necessary and sufficient for stabilizing prenylated Y

211 coded by the small, centrally located exon 6 are necessary and sufficient for stable membrane associa

212 Finally, leucine deprivation is shown to be necessary and sufficient for starvation-induced, IKK-

213 demonstrate that mTORC1-regulated autophagy is necessary and sufficient for starvation-induced LD bi

214 b meristem (RM) of the shoot apical meristem is necessary and sufficient for stem cell regulation.

215 ion experiments, we show that FGF signalling is necessary and sufficient for stratification but not i

216 s in circulating ghrelin, a peptide hormone, are necessary and sufficient for stress-associated vulne

217 increased tonic activity of the LC-NE system is necessary and sufficient for stress-induced anxiety a

218 increased the specific activity of AMPK, and was necessary and sufficient for stress-dependent activa

219 ST PACAP, and BNST PACAP receptor activation was necessary and sufficient for stress-induced reinstat

220 Domains I and II are necessary and sufficient for substantial RRE functio

221 riptional level and that FtsA overproduction is necessary and sufficient for suppression of Deltapbp2

222 nc886 alone is necessary and sufficient for suppression of PKR via d

223 n of the transcription repressor ATF3, which is necessary and sufficient for suppression of type I IF

224 hat DksA expression from a multicopy plasmid is necessary and sufficient for suppression, that overex

225 ment, and in legume crops, this phytohormone is necessary and sufficient for symbiotic nodule organog

226 ility complex (MHC) class I molecule H2-D(b) is necessary and sufficient for synapse elimination in t

227 66-nt element in the 5' UTR of sensorin that is necessary and sufficient for synaptic mRNA localizati

228 otif is the core of a functional module that is necessary and sufficient for targeting of the transcr

229 ine a minimum recognition sequence (RS) that is necessary and sufficient for TclM activity.

230 tment (SC(-)HPC(+)), we report that HPC TLR4 is necessary and sufficient for Th1 sensitization to OVA

231 s of postmitotic COUP-TFI (Nr2f1) expression are necessary and sufficient for the development of sens

232 bacteria, just two subunits, BcsA and BcsB, are necessary and sufficient for the formation of the po

233 Thus, neuro-adipose junctions are necessary and sufficient for the induction of lipoly

234 ction manipulations to identify neurons that are necessary and sufficient for the initiation of reori

235 These data show that c-kit(pos) eCSCs are necessary and sufficient for the regeneration and re

236 ition to its known targets, Vpu was found to be necessary and sufficient for the downregulation of th

237 ocated in the spinal cord have been shown to be necessary and sufficient for the generation and contr

238 m of protein kinase C, has been suggested to be necessary and sufficient for the maintenance of long-

239 cific product of the doublesex gene (dsx(M)) is necessary and sufficient for the acquisition of the p

240 study demonstrates that interaction with p50 is necessary and sufficient for the anti-inflammatory pr

241 lthough the C-terminal domain of the protein is necessary and sufficient for the assembly of a minima

242 nd pluripotent stem cells, we show that DKK3 is necessary and sufficient for the correct differentiat

243 We report that exon 11 is necessary and sufficient for the damage-specific alte

244 synaptic rhythmic activity of the heart tube is necessary and sufficient for the development and matu

245 Disease (AD) is whether the neuritic plaque is necessary and sufficient for the development of tau p

246 ng through endogenous 5-HT(1A) autoreceptors is necessary and sufficient for the establishment of nor

247 on of Rgt1 from Ssn6-Tup1, but not from DNA, is necessary and sufficient for the expression of its ta

248 wn that direct presentation of antigen by LC is necessary and sufficient for the generation of antige

249 The ETS transcription factor Etv2 is necessary and sufficient for the generation of hemato

250 addition, our results indicate that miR-125b is necessary and sufficient for the induction of fibrobl

251 We have also found that the HPR motif is necessary and sufficient for the intracellular target

252 (Tac2) pathway in the central amygdala (CeA) is necessary and sufficient for the modulation of fear m

253 ence of propionaldehyde dehydrogenase (PduP) is necessary and sufficient for the packaging of enzymes

254 regulator of morphogenesis in Cryptococcus, is necessary and sufficient for the production of this s

255 otosynthesis-derived sugar into the root tip is necessary and sufficient for the regulation of root e

256 Mesp-b is necessary and sufficient for the specification of a s

257 These results show that Shh is necessary and sufficient for the specification of adu

258 eplication and transcription activator (RTA) is necessary and sufficient for the switch from KSHV lat

259 eplication and transcription activator (RTA) is necessary and sufficient for the switch from KSHV lat

260 tellite cells), we show that mTORC1 activity is necessary and sufficient for the transition of satell

261 -relevant way, we showed that this sprouting was necessary and sufficient for the acute compensation

262 ants demonstrated that S1916 phosphorylation was necessary and sufficient for the capture and assembl

263 that spatially confined expression of CCRL1 was necessary and sufficient for the creation of functio

264 pression analysis both demonstrated that NS1 was necessary and sufficient for the enrichment of cells

265 TLR4 expression was necessary and sufficient for the protective effect o

266 Induction of repulsive Ca(2+) signals was necessary and sufficient for the stimulated rapid en

267 nt but IL-10 deficient, iTreg-produced IL-10 was necessary and sufficient for the treatment of diseas

268 enes encoding LiaF and a GdpD-family protein were necessary and sufficient for the development of res

269 sis Mediator, while their N-terminal domains are necessary and sufficient for their incorporation int

270 ssor B-cell lymphoma 6 (Bcl6), a factor that is necessary and sufficient for their development in viv

271 sent in the nucleus and nuclear localization was necessary and sufficient for their toxicity.

272 enome editing demonstrated that TAZ mutation is necessary and sufficient for these phenotypes.

273 Furthermore, glucose was necessary and sufficient for these effects.

274 human HOPS complex and that residues 642-736 are necessary and sufficient for this interaction, and w

275 tative changes to the activity of metabolism are necessary and sufficient for this phenotype.

276 d3 participate in neural crest induction and are necessary and sufficient for this process to proceed

277 mation and, furthermore, that p53 inhibition is necessary and sufficient for this activity.

278 The GAR-3 N-terminal extracellular domain is necessary and sufficient for this asymmetric distribu

279 th IN, and the C-terminal domain (CTD) of IN is necessary and sufficient for this binding.

280 )-mediated, glucose-induced TXNIP expression is necessary and sufficient for this effect, and electro

281 n at Ser(608)/Ser(612) and Thr(356)/Thr(373) is necessary and sufficient for this effect.

282 amming, and the disintegrin domain of ADAM29 is necessary and sufficient for this function.

283 terminal catalytic domain of ACT (AC domain) is necessary and sufficient for this inhibitory effect.

284 within the cleaved CLCA1 N-terminal fragment is necessary and sufficient for this interaction.

285 Melanopsin is necessary and sufficient for this nonvisual photorece

286 nt-specific transcription factor LEAFY (LFY) is necessary and sufficient for this transition.

287 ow that the mechanosensor protein, vinculin, is necessary and sufficient for this viscous response, d

288 tation on major histocompatibility complex I was necessary and sufficient for this immunoediting proc

289 FcgammaRIII and TLR4 dependent, and T cells were necessary and sufficient for this process to occur,

290 Moreover, p38gamma activity was shown to be necessary and sufficient for Topo IIalpha expression,

291 e that the N-terminal domain of CdiA-CT(536) is necessary and sufficient for toxin import.

292 STAT3-binding site on the GIV promoter that was necessary and sufficient for transcriptional activat

293 ese data demonstrate that GRP-GRPR signaling is necessary and sufficient for transmitting contagious

294 We also show that [pH]cyt acidification is necessary and sufficient for triggering several key h

295 tion, tumor-released Hsp70/90-expressing EVs are necessary and sufficient for tumor-induced muscle wa

296 CS chain attachment to Ser(507) and Ser(525) is necessary and sufficient for versican proteolysis by

297 at the oxidized sterol, ergosterol peroxide, is necessary and sufficient for Vms1 localization to mit

298 ding studies confirm that this region of VP3 is necessary and sufficient for VP1 binding, while bioch

299 omposed of a putative loop-helix domain that is necessary and sufficient for WDR62 dimerization and i

300 between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-