ライフサイエンスコーパス: be necessary to

1 tro, inactivation of both phoP and Sant_4061 is necessary to abrogate growth of this bacterium in an

2 ctor-semiconductor devices has been found to be necessary to access topological superconductivity tha

3 A thorough understanding of methane sources is necessary to accomplish methane reduction targets.

4 capture experimental observations: First, it was necessary to account for the fact that secondary CaC

5 tions to existing assays or novel assays may be necessary to accurately detect carbapenemase-producin

6 Further development and improvement are necessary to achieve the ideal of a noninvasive imag

7 The use of RBV may not be necessary to achieve SVR in this patient population.

8 where ketocarotenoid supplementation of feed is necessary to achieve product viability.

9 d that local vaccine delivery to the mucosae is necessary to achieve that aim.

10 <65 years old, a clinically guided protocol was necessary to achieve well-controlled INR.

11 n factors, synergy between multiple pathways is necessary to activate all the transcription factors n

12 However, further efforts are necessary to address the high rate of primary nonfun

13 development of new antimalarial therapeutics is necessary to address the increasing resistance to cur

14 ement and reporting between laboratories, it is necessary to adopt standardized and integrated method

15 ication of early and modifiable risk factors is necessary to advance the screening and intervention e

16 nd able to support a large transplant volume is necessary to advance this approach.

17 induced dissociation of H1 mediated by HMGN2 is necessary to allow full STAT5 recruitment and promote

18 signal transduction at the single-cell level is necessary to answer a host of important biological qu

19 y establishing a timeline for GRN evolution, is necessary to answer questions about the rate at which

20 , our findings evidence that the hippocampus is necessary to anticipate the occurrence of reversals,

21 nder the control of a PBel(CGRP) switch that is necessary to arouse animals from hypercapnia.

22 Further research is necessary to assess the possible role of vitamin D in

23 Understanding the fate and transport of DNAN is necessary to assess the risk it may represent to grou

24 ucts in the presence of microbial activities is necessary to assess their long-term stability.

25 oplankton species and microbial biodiversity is necessary to assess water ecosystem health and the qu

26 found that to predict observed SVR rates it was necessary to assume that ledipasvir, GS-9669 and GS-

27 strong, such that local inhibitory feedback is necessary to avoid epileptiform runaway activity (an

28 adjustment of antihyperglycemic medications are necessary to balance glycemic control with safety.

29 ailing structural controllability theory, it is necessary to balance the number of driver nodes and c

30 Prenatal diagnosis technology development is necessary to be able to predict or diagnose adverse f

31 of literature, large well-controlled studies are necessary to better quantify the prognostic role of

32 models to account for [CO2] x N interactions is necessary to better evaluate management practices und

33 re developing immunomodulatory therapies, it is necessary to better understand the timing and complex

34 Systematic planning is necessary to bridge implementation, scale, and data g

35 ed, and widely shared arrogance and contempt is necessary to capture the complex mixed feelings of pr

36 hese diverse effects on connection types may be necessary to cause network phenotypes such as increas

37 egions mediate word and face recognition, it is necessary to characterize how stimuli are represented

38 usion, secretion kinetics, and cell geometry is necessary to clarify the role of actin in polarized g

39 However, a prospective randomized study is necessary to clarify their efficacy.

40 and alcohols (phytol and alpha-tocopherol), were necessary to classify the juice samples according t

41 Importantly, MEK1 activity was necessary to clear the pluripotency protein Ventx2 a

42 tive CD4(+) and CD8(+) T cell responses that were necessary to clear the virus after cessation of int

43 tandard methods of defining racial subgroups are necessary to compare results across pharmacokinetic

44 arated in time, in which case working memory is necessary to condition their association in "trace co

45 us on the methodological considerations that are necessary to conduct a mobile fNIRS study in a diver

46 Larger animal studies and human studies are necessary to confirm significance.

47 Prospective controlled studies are necessary to confirm the beneficial effects on durat

48 reaction, however two samples of paired sera are necessary to confirm the diagnosis, since using only

49 Further studies are necessary to confirm the strength of the association

50 It is necessary to consider many factors when formulating r

51 sotopic characterization of multiple tracers is necessary to constrain histories and inventories of P

52 of knockdown resistance in An. funestus, it is necessary to continue to monitor the contribution of

53 reduced the risk of heart attack and that it was necessary to continue PA after college.

54 To prevent contamination, it is necessary to control the flow of air or sift flour in

55 a negatively charged residue at position 180 was necessary to convey the CaValpha2delta1-mediated shi

56 cated injection, valving, or voltage changes were necessary to couple the two separation modes.

57 comprehensive study of individual mutations is necessary to create a realistic picture of the evolut

58 s outside of well-resourced laboratories, it is necessary to create robust and cost-effective alterna

59 ultural differences in intestinal microbiota are necessary to define applicability of new strategies

60 Clinical trial eligibility criteria are necessary to define the patient population under stu

61 mechanisms of cooperative ligand binding it is necessary to define at a microscopic level the struct

62 esmoplastic elements and T-cell infiltration is necessary to delineate their roles.

63 bon dioxide levels, but further studies will be necessary to demonstrate benefit with this technology

64 itivity to predict global-change impacts, it is necessary to design new experiments located in region

65 n subfoveal CT or 63.9 mum in average CT may be necessary to detect true clinical change in eyes with

66 Large prospective trials are necessary to determine if these physiologic benefits

67 is important for understanding which factors are necessary to determine pandemic potential.

68 Further studies are necessary to determine the efficacy of the intervent

69 Specific validation studies will be necessary to determine the best combination of imagin

70 Further studies will be necessary to determine which patients may benefit fro

71 Further work is necessary to determine how genome-wide changes in DNA

72 tand the physical properties of materials it is necessary to determine the 3D positions of all atoms.

73 Additional research is necessary to determine the clinical efficacy and safe

74 Longer follow-up is necessary to determine the durability of remission an

75 Further research is necessary to determine whether BMI represents a modif

76 or intensive care unit acquired weakness, it was necessary to determine the mechanism underlying the

77 ients and 83% of drug-resistant patients, it is necessary to develop a better understanding of where

78 Thus, it is necessary to develop a sensitive and accurate miRNA a

79 s between neuronal activity and behavior, it is necessary to develop experimental strategies to induc

80 nal proteins essential for viral replication is necessary to develop improved therapies.

81 ble to the effects of ionizing radiation, it is necessary to develop methods that provide diagnostic-

82 Thus, it is necessary to develop microfluidic methods for improvi

83 Therefore, early binocular input is necessary to develop normal neural substrates for sim

84 However, it is necessary to develop strategies that reduce the forma

85 load monitoring for hepatitis C virus (HCV) is necessary to diagnose infection and monitor response

86 osaicking of video-images (video-mosaicking) is necessary to display large areas of tissue.

87 Hence, it is necessary to do diagnostic screening for high-risk HB

88 ve, angiography with one of these modalities is necessary to document a large-vessel occlusion amenab

89 y activating the cyclin B transcription that is necessary to drive cells into mitosis.

90 We demonstrate that GPR88 expression is necessary to efficiently integrate effort and energy

91 a key node of the brain's reward circuitry, is necessary to elicit social reward.

92 Further studies are necessary to elucidate the causal direction of this

93 Future studies are necessary to elucidate the precise mechanisms underl

94 onal research beyond administrative data may be necessary to elucidate any benefits of early preventi

95 It is necessary to elucidate the effect of structural defec

96 itic properties of CA2 compared with CA1 PNs are necessary to enable the CA2 PNs to generate their ch

97 Although WR is necessary to enable Nanog to confer LIF-independent s

98 ss unmet needs and areas where future effort is necessary to enable nucleic acids analysis to become

99 as carbon sources implying that this ATPase is necessary to energize the Mce4-sterol transport syste

100 vibrational mode of the lower-energy monomer are necessary to enhance the observed quantum-beating si

101 tween Cat-1 and its binding partner paxillin are necessary to ensure sufficient Akt activation so tha

102 Therefore spectroscopic methods are necessary to ensure the plastic nature of isolated p

103 anagement and conservation efforts, and will be necessary to ensure future plans and adaptation strat

104 control of veterinary drug residues in food is necessary to ensure consumer safety.

105 This efflux is necessary to ensure Fe(III) solubility and mobility i

106 opose that DROSHA-mediated processing of RNA is necessary to ensure full DNMT1 activity.

107 Successful targeting of CSCs will therefore be necessary to eradicate and cure cancer.

108 gnition and clearance of this reservoir will be necessary to eradicate HIV-1 in infected individuals.

109 Further clinical trials are necessary to establish oncologic efficacy.

110 at support implantation in eutherian mammals are necessary to establish pregnancy.

111 dation in cell culture and mouse models will be necessary to establish causality for these genes.

112 tion and additional randomised evidence will be necessary to establish the supposed superior efficacy

113 Therefore, it is necessary to establish a bioassay correlating with th

114 repression of VRN1 in the fall season, which is necessary to establish a vernalization requirement.

115 It is necessary to establish maximum levels of mycotoxins i

116 he cerebellar lobules in disease populations is necessary to establish the functional significance of

117 e a meaningful biological interpretation, it is necessary to estimate the amount of labelling, and on

118 nding virus transfer between liquid and skin is necessary to estimate transmission during water-relat

119 he patchy landscape of parasites in the skin is necessary to explain infectiousness.

120 h ionic conductances and tissue conductivity was necessary to explain the experimentally observed var

121 Further studies are necessary to explore root causes for this difference

122 , variations in hydrogen bond strength might be necessary to facilitate the TM helix breaking and ben

123 octulosonate (Kdo)-lipid A domain in E. coli was necessary to facilitate chemical structure analysis

124 eir relationships with environmental drivers is necessary to forecast disease outbreaks, and to predi

125 structured monocular and binocular training are necessary to fully recover deficient functions in am

126 input for the chemical kinetic modeling that is necessary to fully extract physics from the observati

127 Our results support the idea that NFAT1 is necessary to fully suppress effector responses during

128 Future prospective studies are necessary to further characterize potential causal l

129 Future studies are necessary to further explore the mechanisms by which

130 However, pharmacodynamic and safety studies are necessary to further investigate the use of these NS

131 drolysis is coupled to calcium transport, it is necessary to gain knowledge about the conformational

132 anistic target of rapamycin (mTOR) signaling is necessary to generate a mechanically induced increase

133 hitecture and function of brain circuits, it is necessary to generate maps of neuronal connectivity a

134 We suggest it is necessary to go further and consider lifelong learnin

135 alium improve reproductive outcomes in women are necessary to guide public health policy for this eme

136 his suggested that binding of MDDEF to MVAPP is necessary to guide ATP into a catalytically favorable

137 m (VPT) or with very low birth weight (VLBW) is necessary to guide clinical management, provide infor

138 dicting biological impacts of climate change is necessary to guide policy.

139 equent interactions with implanted materials is necessary to guide the design of these materials.

140 eterogeneous, international interconnections are necessary to help achieve low-carbon development for

141 the presence of aPLs is low, and new markers are necessary to identify aPL carriers at higher risk an

142 poor maturity measure, longitudinal studies are necessary to identify the growth patterns and identi

143 luation of STING agonist-based therapies may be necessary to identify the possible effects on the T c

144 s of individuals waiting for transplants, it is necessary to identify reasons for this shortage and d

145 Additional efforts are necessary to improve cardiovascular care in the peri

146 ient cultivation and harvesting technologies are necessary to improve economic viability.

147 their surrounding surface topographies, will be necessary to improve the yield of single quantum dot

148 Neurochemical monitoring for long timescales is necessary to improve diagnostic and therapeutic proce

149 Further study is necessary to improve patient care with additional dat

150 y, diagnostic markers, and future treatments is necessary to improve the care of patients with FPIES.

151 With more and more genomes available, it is necessary to improve the scalability and robustness o

152 Thus, developing new therapeutics is necessary to improve the treatment of these invasive

153 mpounds in aqueous slurries of rice proteins is necessary to improve their overall flavor characteris

154 data with a consistent set of parameters, it was necessary to incorporate intramonomer Coulombic effe

155 ective means to preserve/restore ventilation are necessary to increase the quality and duration of li

156 hreshold of socioenvironmental adversity may be necessary to increase incidence.

157 y and indicates that silencing of both genes is necessary to increase the efficacy of immune interven

158 i-tumor activity from loss of self-tolerance is necessary to increase the therapeutic efficacy of che

159 monstrate that activation of the SHH pathway is necessary to induce LHX3(+)/LHX4(+) RP identity in mo

160 V protons, a fluence of 10(16) protons/cm(2) was necessary to induce a significant charge transfer fr

161 n the murine decidua in vivo A high inoculum was necessary to infect both human and mouse deciduas, a

162 This more complete understanding is necessary to inform climate adaptation actions, manag

163 of HIV among men who have sex with men (MSM) is necessary to inform HIV prevention and care strategie

164 ere we demonstrate that the N terminus of E3 is necessary to inhibit an IFN-primed virus-induced necr

165 ugation system and the IFN-inducible GTPases were necessary to inhibit MNV replication in mice and hu

166 Smarcb1 loss in early neural crest was necessary to initiate tumorigenesis in the cranial n

167 but that crosstalk with the hippocampus may be necessary to integrate new trialwise outcomes in both

168 derstanding of human health and diseases, it is necessary to integrate multiple data sources.

169 tational models of optogenetic perturbations are necessary to interpret the results of experimental p

170 tients with gastrointestinal carriage of CPO is necessary to interrupt their spread within health car

171 Thus, it is necessary to investigate the link between the in vivo

172 Still, further research is necessary to investigate whether hen's egg allergen i

173 a, alliances between proposers and acceptors are necessary to isolate defectors when proposers do not

174 In worms, a histone-modifying enzyme is necessary to keep small RNA-guided transgenerational

175 cure or the eradication of HIV infection, it is necessary to know the sizes of the reservoirs from wh

176 Finally, PAR-6 is necessary to localize polarity proteins such as DLG-1

177 rthermore, we determine that HDAC1 and HDAC7 are necessary to maintain CSCs, and that over-expression

178 ndeed, low levels of extracellular glutamate are necessary to maintain epithelial homoeostasis, and p

179 ore frequent, lower-dose supplementation may be necessary to maintain steady VA concentrations in rap

180 ion diversity as farm sizes increase seem to be necessary to maintain the production of diverse nutri

181 Degradation of excess cyanuric acid is necessary to maintain chlorine disinfection in the wa

182 Rapid clearance of acid loads is necessary to maintain control of neurotransmission, b

183 tabeta-Cell adaptation to insulin resistance is necessary to maintain glucose homeostasis in obesity.

184 NOX4 is necessary to maintain parenchymal structures, increas

185 and polar environments, particularly when it is necessary to maintain the full functionality of biolo

186 ion of both affinity and stability mutations is necessary to maintain thermodynamic stability during

187 addition to its role in cell adhesion, PKP2 is necessary to maintain transcription of genes that con

188 Increased mitochondrial metabolism was necessary to maintain cell survival under drug stres

189 ivating NK cell receptors and actin dynamics were necessary to maintain a stable contact in an energy

190 Both activities were necessary to maintain nuclear position in uncentrif

191 Additional evidence is necessary to make a definitive recommendation for or

192 stical association, so functional validation is necessary to make strong claims about gene function.

193 ever, heat combined with enzymatic digestion was necessary to markedly lower IgE binding to cashew al

194 itations, and lay out the approach they feel is necessary to maximise the potential of organoid techn

195 Early treatment may be necessary to maximize the benefit of the drug.

196 Significant discounts are necessary to meet conventional cost-effectiveness st

197 Transformative land-use solutions are necessary to mitigate climate change and restore cri

198 rowth of NAFLD cases and therapeutic options are necessary to mitigate disease burden.

199 to harvesting stormwater, adequate treatment is necessary to mitigate risks derived from such harmful

200 physico-chemical composition; therefore, it is necessary to monitor contamination by toxic metals su

201 a key role in T lymphocyte migration, which is necessary to mount a local immune response, and is al

202 m adolescents of the different types of LARC is necessary to normalize offering LARC as a contracepti

203 establish that complete structural integrity is necessary to observe single-molecule fluorescence of

204 st in both the excited and the ground states is necessary to obtain a photocontrolled system rather t

205 in amount of disorder introduced by Fe atoms is necessary to obtain high oxygen evolution reaction (O

206 Overall, 35% believed it was necessary to obtain consent each time such research

207 However, in many cases it is necessary to optimise beliefs about sequences of stat

208 his nanoscopic heterogeneity of cAMP signals is necessary to optimize cardiac contractility upon adre

209 to novel bacterial drug targets and vaccines are necessary to overcome tuberculosis.

210 y, it is possible that actin-based transport is necessary to overcome vesicle transport limitations t

211 on of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues.

212 In addition, it was necessary to pool primary and secondary outcomes.INT

213 TR) interacted directly and this interaction was necessary to position PTEN at the membrane.

214 y processes and microbial community dynamics is necessary to predict microbial response to perturbati

215 inning in childhood and into early adulthood is necessary to preempt the development of prehypertensi

216 factors that influence CVD risk factors may be necessary to prevent CVD in LMICs.

217 ge of potential drug-drug interactions (DDI) is necessary to prevent ADR, the rapid pace of drug disc

218 immediate, proper surgical intervention and is necessary to prevent complications and preserve futur

219 the diagnostic workup, and prompt diagnosis is necessary to prevent complications.

220 ection or sterilization of medical equipment is necessary to prevent future fomite-associated outbrea

221 pression of effector CD4(+) T cell functions is necessary to prevent immune cell-mediated damage to h

222 in modulating a rapid component of NPQ that is necessary to prevent photoinhibition in excess light.

223 to remove cellular debris completely, which is necessary to prevent prion transmission.

224 Immune tolerance is necessary to prevent the immune system from reacting

225 onas aeruginosa and Acinetobacter baumannii, is necessary to prevent their dissemination within healt

226 shows that continuous exposure to vismodegib is necessary to prevent tumor recurrence, suggesting the

227 al processing of the spikes and nucleocapsid is necessary to produce infectious virus.

228 the first time that both eIF2alphaP and ATF4 are necessary to promote erythroid differentiation and t

229 induced obesity and uncover that hepatic SHP is necessary to promote fatty liver disease.

230 ice and that sustained p16(INK4a) expression is necessary to protect against tumorigenesis.

231 Vaccination against all serotypes is necessary to protect susceptible animals and to preve

232 ting of these materials above 2000 degrees C is necessary to prove their capabilities at anticipated

233 ndidate pathogen actually causes disease, it is necessary to provide additional evidence of causality

234 nol uptake in developing liver and intestine is necessary to provide sufficient substrate for ocular

235 tween subunit rotation and translocation, it is necessary to rationalize these conflicting descriptio

236 els do not include adverse consequences that are necessary to reach a diagnosis of addiction in human

237 the unique features of algal metabolism may be necessary to realize the full potential of algae as f

238 ut the findings of this case suggest that it is necessary to recognize them as a causative allergen o

239 Hence, it is necessary to record from neuronal dendrites, which ca

240 GAP1, and that GPCR-triggered Ras activation is necessary to recruit C2GAP1 from the cytosol and reta

241 , more frequent virological monitoring might be necessary to reduce the risk of virological failure.

242 An elevated electrical field is necessary to reduce clustering of primary hydronium (

243 Early diagnosis is necessary to reduce the mortality and morbidity assoc

244 , and a higher concentration of human plasma was necessary to reduce the cytotoxicity of an ILY-high-

245 identify HSCs from in vitro sources, it will be necessary to refine markers of HSCs matured ex vivo.

246 As more RGENs become available, it will be necessary to refine their activity before they can be

247 These genes are necessary to regulate the steady-state expression, t

248 To achieve this goal it is necessary to reliably predict the temporal evolution

249 Cdc14 is necessary to relocalize Cdc5 from the nuclear SPB pla

250 Priming of human NK cells with IL-2 is necessary to render them functionally competent upon

251 Key components of FMT interventions, which are necessary to replicate and understand study findings

252 ls to reveal that mechanosensitive adhesions are necessary to reproduce the spatiotemporal adhesion p

253 resent results indicate that the hippocampus is necessary to respond in an appropriately flexible man

254 Precipitation is necessary to restore degraded alpine grasslands, but

255 As such, it is necessary to rethink public health messaging and cons

256 These findings suggest that it is necessary to rethink the dogma involving GAS pathogen

257 ividuals infected with diverse HIV-1 strains is necessary to reveal the novel targets for regional pr

258 From this we discovered that 20% DMC is necessary to reverse the sickle phenotype.

259 mbrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2.

260 er of circulating effector cells, thought to be necessary to scan, locate, and kill infected hepatocy

261 ein fragments, but multiple ligations, which are necessary to segmentally label proteins of more than

262 The nucleic acid sensor RIG-I is necessary to sense foreign circRNA, and RIG-I and for

263 rgetable alterations in advanced cancers, it is necessary to sequence recurrent and metastatic tumors

264 Larger studies are necessary to show whether this technique is widely a

265 y represents the object being remembered, it is necessary to show that the signal contains fine-grain

266 nservation efforts to protect intact forests are necessary to slow deforestation rates and to avert a

267 HSPGs are necessary to stabilize microtubules in newly formed

268 Further, ROCK1, but not ROCK2, was necessary to stabilize GTP-RhoA at the ZA, thereby s

269 home with minimal or no instrumentation, it is necessary to streamline unit operations and store rea

270 Further exploration of mAgrin modification is necessary to strengthen its binding to other membrane

271 its invasiveness and economic importance, it is necessary to study how climate change and host availa

272 on, to discover the intrinsic size effect it is necessary to study metallic glass nanowires fabricate

273 Slow cooling rates are necessary to sufficiently separate mixtures with hig

274 B-1 B cells, B cell-specific ATM expression was necessary to support viral reactivation from periton

275 Accurate and high-throughput methods are necessary to systematically analyze epithelial organ

276 eters on ionic conductivity, we find that it is necessary to tailor the lattice stiffness of material

277 DNA methylation is necessary to temporally reorganize circadian phasing

278 PRETATION: Degeneration of serotonin neurons is necessary to trigger spasticity through the 5-HT2B/C

279 ing of SCFA metabolism by the gut microbiota is necessary to underpin effective strategies to optimiz

280 available population-based estimates, which are necessary to understand the impact of this disabling

281 Longer trials are necessary to understand the long-term effects of val

282 Baseline data are necessary to understand the variation between indivi

283 applied to plant domestication processes may be necessary to understand these transformations across

284 esses contribute to the disease, and it will be necessary to understand this heterogeneity to find ef

285 Further research is necessary to understand hospice referral and palliati

286 the upper hand in combating this disease, it is necessary to understand how this virus replicates and

287 e measurement of mRNA levels in single cells is necessary to understand phenotypic variability within

288 sm of intracellular dynamics of IAV assembly is necessary to understand reassortment.

289 utilize the CAST mouse for such purposes, it is necessary to understand the basis for virus susceptib

290 While further research is necessary to understand the causes and costs of HAIs

291 unction due to the continued absence of FMRP is necessary to understand the different roles of FMRP a

292 ng and characterizing these molecular traces is necessary to understand the environmental impact on h

293 Further research is necessary to understand the mechanism of absorption a

294 t for future memory storage applications, it is necessary to understand the origin of the room temper

295 Thus, it is necessary to understand the plant-microbe interaction

296 at characterization of these dynamic changes is necessary to unlock the full potential of bimetallic

297 Further animal and clinical studies are necessary to unveil the multifaceted roles of Lcn2 i

298 replication and functional characterization are necessary to validate our findings.

299 letion mutants by electron tomography, which is necessary to validate membrane continuity, in additio

300 -throughput automated image analysis methods are necessary to work on par with the speed of data bein