ライフサイエンスコーパス: be needed for

1 A hospital admission was needed for 34% (148/434) of recurrences.

2 Larger studies are needed for a further validation.

3 target viral replication and CSC properties are needed for a risk-free treatment of advanced stage l

4 d greater process or performance versatility are needed for a variety of optoelectronic applications.

5 ded in a 1 year clinical trial and 184 would be needed for a 2 year trial.

6 es that persistent sterilizing immunity will be needed for a successful vaccine candidate.

7 Significant preparation will be needed for a thorough, synchronized, and full withdra

8 Further adaptation is needed for A(H3N2) CIVs to present a likely threat to

9 ally, at least three MELT repeats per Spc105 are needed for accurate chromosome segregation.

10 These inputs are needed for accurate prediction of feedbacks in water

11 Each GST is needed for accurate molecular diagnosis in different

12 and parametrization of intermolecular forces is needed for accurate predictions of SOA formation.

13 her interventions focusing at the unit-level are needed for achieving high care quality.

14 proteins that are required for cell polarity are needed for actin assembly or activation of core chem

15 High p62 expression is needed for activation of NRF2 and mTORC1, induction o

16 better assess their potency and composition are needed for adequate studies of their safety and effi

17 enterocolitis, international collaborations are needed for adequately powered preventive trials.

18 Still, specific actions for stillbirths are needed for advocacy, policy formulation, monitoring,

19 lthood extracellular matrix remodelling, and are needed for ageing to be delayed by interventions tha

20 significantly lower concentrations of B[j]A were needed for an effect on cell viability compared to

21 ic- and glutamine-derived intermediates that are needed for anabolic metabolism were increased.

22 New, computationally efficient methods are needed for ancestry inference that can effectively u

23 ed, a simple, sensitive, reproducible method is needed for application to large clinical trials.

24 Here we show that neither RbcX nor CcmM35 is needed for assembly of active cyanobacterial Rubisco.

25 s of the health outcomes of preterm children are needed for assessing perinatal care, informing paren

26 Validated objective measures are needed for assessing the health impact of WASH inter

27 ethod that takes into account these features is needed for association analysis in longitudinal micro

28 hes for patients without type 2 inflammation are needed for asthma and allergic disease treatment.

29 generating transplantable HSCs in vitro that are needed for autologous HSC transplantation therapies.

30 wn and overexpression studies show that COBL is needed for BB assembly and sufficient to induce micro

31 ge and to controllably deliver several drugs are needed for better cancer treatments.

32 We conclude that more research is needed for better screening and preventive strategies

33 Temporal baselines are needed for biodiversity, in order for the change in

34 Targeted interventions are needed for black patients and younger women.

35 ng bones not in the perisinusoidal space and are needed for bone development, bone remodeling, and fr

36 iminished surface tension, and a longer time was needed for both water and oil to wet and diffuse.

37 nd raises novel questions what other factors are needed for break of tolerance.

38 rface and prevent IgG oligomerization, which is needed for C1q binding and subsequent CDC activity.

39 viruses, including AAV, carry proteases that are needed for capsid maturation or for capsid modificat

40 healthy tissues, yet high-throughput methods are needed for capturing the unbiased diversity of cells

41 A-binding tristetraprolin, encoded by Zfp36, is needed for CD8(+) T-cell production of IFN-gamma in v

42 ults showed that while TGB1 self-interaction is needed for cell-to-cell movement, importin-alpha-medi

43 LAMP2 is needed for chaperone-mediated autophagy, and its expr

44 imental approaches, computational techniques are needed for characterization of protein-RNA interacti

45 e is suited to the large-scale analyses that are needed for characterizing human populations and defi

46 blood, whereas CD28 signaling, but not TNF, was needed for chemotaxis of inflammatory monocytes into

47 s further supported the conclusion that CypA is needed for chondrogenic differentiation.

48 ntly, there is global loss of H3K9me2, which is needed for chromatin binding of UHRF1.

49 d therapy and is an area in which biomarkers are needed for clinical development.

50 Antiviral drugs are needed for clinical practice and public health emerg

51 disease progression and response to therapy are needed for clinical trials in Duchenne muscular dyst

52 More specific HER2-targeted agents will be needed for clinical use.

53 d specific criteria, at the component level, is needed for comparison of analytical data from differe

54 hat Spa47 oligomerization and ATP hydrolysis are needed for complete T3SS apparatus formation, a prop

55 Fewer pills were needed for complete adherence in women allocated no

56 sizes of about 40 per treatment group would be needed for confirmation of beneficial effects on symp

57 found that the transcription factor Pt-Ets4 is needed for cumulus integrity, dorsoventral patterning

58 solution, however fewer diffraction patterns are needed for de novo phasing.

59 vior of motor neurons following this surgery is needed for designing biologically inspired prosthetic

60 Sensitive assays are needed for detection of residual human immunodeficie

61 e the authors show that TGFbetaR1 signalling is needed for development of CD103(+)CD11b(+) intestinal

62 cts and poor bioavailability, a new approach is needed for DHE delivery enabling painless self-admini

63 ary function assessment at regular intervals is needed for diagnosis of the predictable but slowly ev

64 that sensitive noninvasive outcome measures are needed for diagnostic monitoring and early intervent

65 Novel electrodes are needed for direct ethanol fuel cells with improved q

66 high storage moduli and yield stresses that are needed for direct ink writing.

67 Reliable clot diagnostic systems are needed for directing treatment in a broad spectrum o

68 Novel approaches are needed for discovery of targeted therapies for non-s

69 An immediate open surgical procedure is needed for dissection of the ascending aorta, given t

70 Mechanical energy harvesters are needed for diverse applications, including self-powe

71 with improved properties and functionalities are needed for diverse applications.

72 ney tissue that recapitulate human responses are needed for drug screening, disease modeling, and, ul

73 New drugs are needed for each of these diseases.

74 For small T antigens, interaction with PP2A is needed for each of these functions.

75 capable of detecting colorectal cancer (CRC) are needed for early CRC diagnosis.

76 Diagnostic biomarkers for cGVHD are needed for early diagnosis and may guide identificat

77 and independent of laboratory infrastructure is needed for effective point-of-care detection and epid

78 also reveal that no other recognition motif is needed for efficient enzymatic phosphorylation of the

79 portant to allow proper MRX-DNA binding that is needed for end-tethering and DSB repair.

80 ipase D, involved in the biosynthesis of PA, is needed for entry of this defensin in N. crassa, but n

81 Soil information is needed for environmental monitoring to address curren

82 ) exposure estimates at a fine spatial scale are needed for epidemiological studies.

83 ntly, we reported that a host factor, ACBD3, is needed for EV71 replication by interacting with viral

84 We determined that a VP1 mutation (K244E) was needed for EV71 virulence in adult AG129 mice.

85 sessment of the provincial burden of disease is needed for evidence-based priority setting at the loc

86 high signal to noise and good photostability are needed, for example, in point-of-care testing.

87 es to improve specificity for specific foods are needed; for example, by modeling intake using multip

88 supercapacitors having improved performance are needed for existing and emerging wearable applicatio

89 opted in clinical practice, further research is needed for external validation, assessment of accurac

90 a sufficient level of energetic frustration is needed for fast-translating codons to be beneficial f

91 red for post-SCI angiogenesis, which in turn is needed for fibrotic scar formation.

92 iol diacetate and desogestrel in water would be needed for fish to receive a human therapeutic dose f

93 imple, rapid, and specific detection methods are needed for food safety.

94 s a result, no image segmentation processing is needed for further analysis of nodule attenuation, al

95 Therefore, computed tomography (CT) is needed for further examination.

96 It was found that a setting period was needed for gel processing to maximize the effect of

97 Consequently, Filamin is needed for growth of the subsynaptic reticulum.

98 BACKGROUND & AIMS: Effective treatments are needed for hepatic steatosis characterized by accumu

99 Surprisingly, even though qrf is needed for heterochromatic silencing, induction of qr

100 Although an arginine patch on the Sm core is needed for Hfq's RNA chaperone activity, the function

101 Current vaccination or several prior doses were needed for high protection.

102 deoxynucleoside triphosphates (dNTPs), which are needed for HIV-1 reverse transcription.

103 ontrolled and more effective waste treatment is needed for hospital wastewaters.

104 Iron-based interventions are needed for IDA and IDA+AI, and monitoring of iron bi

105 ransplantation, but more screening campaigns are needed for identification of infected people in high

106 genous IL-33 treatment revealed that miR-155 is needed for IL-33-induced ILC2 expansion and eosinophi

107 suggest that this infiltrating sIL-6R, which is needed for IL-6 trans-signaling, is involved in the c

108 Solutions are needed for immediate personal protection (for exampl

109 survival of people with type 1 diabetes and is needed for improved management of diabetes for some p

110 t of diseases; however, targeted integration is needed for improved safety.

111 psid assembly and genome packaging mechanism is needed for improved vector production.

112 ribution in realistic microvascular networks is needed for improving our understanding of neurovascul

113 l, neurological, and substance use disorders are needed for India and China but the large population

114 tivated microglia, consistent with K(+) loss being needed for inflammasome assembly.

115 ing access to high quality data, new methods are needed for informing transportation emissions assess

116 ding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required f

117 f ELNs induction, preclinical models of ELNs are needed for interrogation of these chemokines.

118 strate recognition domain within ZRANB3 that is needed for it to recognize forked DNA structures, hyd

119 Additional studies are needed for its further optimization and validation a

120 tional ensembles of disordered proteins that are needed for linking structure and dynamics to functio

121 types of complex interventions or approaches are needed for long-term gains in maternal and child wel

122 e nucleus of the hypothalamus, these changes are needed for lordosis behavior.

123 eta1, alphaMbeta2, and alphaXbeta2 integrins are needed for lumican-induced fibrocyte differentiation

124 gests that combining AKT and WEE1 inhibitors is needed for maximal efficacy.

125 or forensic applications, although more work is needed for method validation.

126 igh transition temperature in nanostructures is needed for miniaturizing ferroelectric devices.

127 These interactions might be needed for molecular assembly of a high-order nucleop

128 immunotherapies and combinations likely will be needed for most subtypes.

129 the data indicate that the beta-catenin MCC is needed for mucosal repair and carcinogenesis.

130 r samples that have limited availability but are needed for multiple analyses, especially for the cor

131 Therapies with novel mechanisms of action are needed for multiple myeloma (MM).

132 rovide the clearest evidence to date that B1 is needed for multiple critical junctures in the poxvira

133 h primed and naive adaptation, and that RecB is needed for naive adaptation.

134 think that a minimum CO2 mixing ratio might be needed for natural N2 fixation and only used the time

135 e find that self-association of the Nek9-CTD is needed for Nek7 activation.

136 ive and neuroprotective treatment strategies are needed for neuroinflammatory and neurodegenerative d

137 , but it is unclear whether all interactions are needed for neutralization.

138 e mechanistic details of inhibition pathways are needed for new inhibitor development.

139 linear at equilibrium, mass transfer models are needed for nonequilibrium conditions.

140 ss the auxiliary subunit alpha2delta2, which is needed for normal hearing thresholds.

141 This region is needed for normal SNARE complex assembly.

142 Although mitochondrial ROS is needed for NOX-independent NETosis, it is not importa

143 Our data further show that PLK-1 is needed for nuclear envelope breakdown during early em

144 Treatment is needed for obstructive sleep apnea (OSA) because untr

145 uggesting that consecutive rewarded episodes are needed for OFC computations that integrate reward hi

146 la clade, suggesting that taxonomic revision is needed for one or both genera.

147 re, we show that serum response factor (Srf) is needed for optimal SC-mediated hypertrophic growth.

148 region spanning +35 to +50 of the zorO mRNA is needed for optimal translation of zorO.

149 al lysine 56 of SLP-76 where the interaction was needed for optimal RanGAP1-NPC localization and GAP

150 f the permittivity in a given spectral range is needed for optimizing the spectral performance.

151 ocaine intake, indicating that CeA circuitry is needed for ordinary cocaine motivation.

152 Fine tuning of conditions will be needed for other amino acid/carbohydrate combinations

153 Further data maturation is needed for overall survival analyses and evaluation o

154 xpected recovery based on statistical models are needed for patient management during the early years

155 Guidelines are needed for patient selection to list for and receipt

156 lzheimer disease (AD) in its prodromal state is needed for patient stratification in clinical trials

157 Background Effective and safe treatments are needed for patients who have irritable bowel syndrom

158 Effective treatment options are needed for patients with genotype 1 or 3 hepatitis C

159 New treatment options are needed for patients with multiple myeloma that is re

160 in's lymphoma (HL), novel therapeutic agents are needed for patients with refractory or relapsed dise

161 Novel therapies are needed for patients with relapsed or refractory mult

162 and illustrates that precision medicine may be needed for patients with PBC at various stages of the

163 Further evidence is needed for patients with ASPECTS 0-4, for whom treatm

164 reatments, especially non-chemotherapeutics, is needed for patients with Waldenstrom's macroglobulina

165 rug costs to $4536 per patient or less would be needed for PCSK9 inhibitors to be cost-effective at l

166 ction (HFpEF), feasible surrogate end points are needed for phase II trials.

167 n Actinomyces oris, disulfide bond formation is needed for pilus assembly, coaggregation, and biofilm

168 educed ARSB activity, since molecular oxygen is needed for post-translational modification of ARSB.

169 rent-source density (CSD)-estimation methods are needed for precise assessment of the underlying spat

170 Further refinements are needed for prediction of ARDS.

171 st tube exposure, and that better strategies are needed for preventing this complication.

172 While etiological understanding is needed for prevention, epidemiological studies indica

173 -to-perform human papillomavirus (HPV) tests are needed for primary cervical cancer screening in lowe

174 Firm guidance is needed for primary care on the use of liver blood tes

175 mation at all time points, and Gal4 and Rfx2 are needed for proper biofilm formation at intermediate

176 ut determining when and where such precision is needed for proper embryogenesis has been a long-stand

177 on, suggesting that V1 IN-derived inhibition is needed for proper extension movements of the limb.

178 WT) controls, implying that some MC mediator is needed for proper healing.

179 olarization or junction assembly, but rather is needed for proper junctional actin regulation during

180 licit a large number of CD8 T cells that may be needed for protection.

181 A minimum of 100 MscL (or MscS) channels is needed for protection when a single type of channel i

182 and effective vaccine, urgent consideration is needed for public health interventions in the Netherl

183 train PA14, suggesting no additional factors are needed for PumA function.

184 racterization of cardiomyocyte beat patterns is needed for quality control of cells intended for surg

185 that came before, there are parameters that are needed for quantitative interpretation of data but t

186 ke complex and both this complex and TBC1D14 are needed for RAB1 activation.

187 In somatic cells, BRCA2 is needed for RAD51-mediated homologous recombination.

188 e is high, and objective risk stratification is needed for rational use of advanced therapies such as

189 usable energy, so energy-harvesting circuits are needed for real world applications.

190 These shuttles are needed for reducing equivalents generated by metabol

191 in to address causation, an effective system is needed for refining this catalogue of differentially

192 detected and at least 21% of the population was needed for reliable results.

193 Further research is needed for replication and to assess longer-term outc

194 Clear guidelines are needed for retesting alongside improved diagnostic t

195 vealed a class of quasi-essential genes that are needed for robust growth, explaining the failure of

196 tylcholine (ACh) arousal system in the brain is needed for robust attention and working memory functi

197 or stable binding to short ssDNA regions and are needed for RPA melting of partially duplex DNA struc

198 1295, STM1297, STM3612, STM3615, and STM3734 are needed for Salmonella to colonize and persist in chi

199 D, the smaller area of ion-exchange membrane was needed for salt separation.

200 Sensitive and fast optical imaging is needed for scientific instruments, machine vision, an

201 The results showed that (i) hydroxyl ions are needed for scission to occur, (ii) hydroxide-induced

202 geting aberrant molecular pathways of cancer is needed for sensitive detection, accurate diagnosis, a

203 in patients with symptoms, so new approaches are needed for short-term prevention of SCA.

204 indicating the LHY and CCA1 splice variants are needed for sic-3 circadian clock phenotypes.

205 2O2 reveal that a minimum potential of 1.5 V is needed for significant deposition of 4 nm diameter Au

206 ane curvature, PI(4,5)P2, and PI(3)P signals are needed for SNX9 assembly via its PX-BAR domain, wher

207 glutamatergic synapse organizer Cbln1, which is needed for sociability in mice.

208 More randomised controlled trials are needed for some mental health disorders such as obse

209 p14 is bifunctional; together with Bud23, it is needed for stable interaction of Dhr1 with the prerib

210 ring the past ten years, but additional work is needed for standardization, development of extraction

211 ar), accurate and updated maps of paddy rice are needed for studies of food security and environmenta

212 Characterized animal models are needed for studying the pathogenesis of and evaluati

213 Large sample sizes are needed for sublingual immunotherapy (SLIT) trials be

214 Therefore, a responsive DMN might not be needed for successful cognitive performance.

215 The large-area synthesis of Mo2 C film is needed for such applications.

216 he induction of multiple regulatory networks is needed for survival within the host.

217 lower bacterial inoculum concentrations than were needed for survival and colonization in its absence

218 Developing O2-tolerant enzymes is needed for sustainable H2 production technologies, bu

219 ceptors CXCR3 and CCR5, but neither receptor was needed for T cell recruitment to the salivary gland

220 lts suggest that immune cells harboring EOPs are needed for the antihyperalgesic effects of sigma-1 a

221 ions of the gut, but other bacterial factors are needed for the bacteria to adhere and colonize the i

222 They are needed for the correct formation of centrosomes, the

223 ut validated assay-specific reference ranges are needed for the determination of iodine sufficiency i

224 ditional genetic or epigenetic abnormalities are needed for the development of these nerve sheath mal

225 Further studies are needed for the effects on clinical symptoms.

226 ecently showed that only two genetic changes are needed for the L-form transition in Bacillus subtili

227 acromolecular complexes with calnexin, which are needed for the proper maturation, processing, and fu

228 New approaches are needed for the protection of biological cells from U

229 wever, it is not known whether these factors are needed for the regulatory T cell (Treg) arm of MHC c

230 Further investigations are needed for the result that the flow of sand through

231 bcellular localization of bacterial proteins are needed for the study of prokaryotic cell biology.

232 Effective antiinflammatory therapies are needed for the treatment of asthma, but preferably w

233 New therapies are needed for the treatment of toxoplasmosis, which is

234 f innovative technologies and processes that are needed for the water resource recovery facility of t

235 endotype and biomarker efforts will probably be needed for the success of these trials, because the p

236 only a small amount of ovary sample (<50 mg) is needed for the approach established in the current wo

237 action (oligomerization) of p33 and p92 that is needed for the assembly of the viral replicase.

238 Amplification of input sound signals, which is needed for the auditory sense organ to detect sounds

239 nly a unique standard with a known AgNP size is needed for the calibration.

240 Moreover, a photosynthetic signal is needed for the CPuORF action, since plants with uncou

241 ael acceptors under physiological conditions is needed for the design and use of these compounds as b

242 ultiorganisational stakeholder collaboration is needed for the development of functional, sustainable

243 of human iPSC and their cellular derivatives is needed for the development of safe and effective cell

244 lying pathways of this heterogeneous disease is needed for the development of targeted treatments.

245 To promote efficiency, a minimum set is needed for the diagnosis of malnutrition in the acute

246 Additionally, we found that Thpok is needed for the differentiation of thymic Treg precurs

247 Insulin signalling is needed for the efficient assembly of an actomyosin ca

248 at can affect influenza A virus reassortment is needed for the establishment of disease intervention

249 of tinnitus research and treatment and what is needed for the field to achieve success.

250 The 4.8-kb genomic RNA is needed for the formation of spherules 66 nm in diamet

251 Clear guidance is needed for the investigational pathway for TBM, inclu

252 The microtubule crosslinker NuMA is needed for the local load-bearing observed, whereas E

253 riasis remains uncharacterized, and a method is needed for the noninvasive monitoring of the developm

254 tient; however, a unified, specific approach is needed for the practicing clinician.

255 RDE-8 can cleave RNA in vitro and is needed for the production of 3' uridylated fragments

256 Such predictive understanding is needed for the rational design of intervention strate

257 e and suggest a conformational rearrangement is needed for the simultaneous binding of a monoglucosyl

258 Minimum sample preparation was needed for the analysis of liquid and solid food sam

259 A statistical study was needed for the validation of the method, where the p

260 translating mRNPs, and recapping is all that is needed for their return to the translating pool.

261 s, it is unclear whether common host factors are needed for them to reach the cytoplasm.

262 Enzymes create the strong electrophiles that are needed for these highly energetic reactions by using

263 tablish causality and evaluate interventions is needed for these and other indoor exposures.

264 Neur, which is needed for these processes, was shown to be able to a

265 Thus, a new therapeutic approach is needed for these tumors.

266 es that no external in-plane magnetic fields are needed for this aim.

267 ion of methodologies and prospective studies are needed for this emerging technology to have a signif

268 AGA and the activity of histone deacetylases are needed for this extensive gene recruitment to the nu

269 prognostic biomarkers and localized therapy are needed for this large patient group.

270 een reported to be poor, specific strategies are needed for this patient population.

271 have a dismal prognosis, and new approaches are needed for this very-high-risk group.

272 Greater research into treatment is needed for this common and persistent post-ICU morbid

273 activates the Arp2/3 complex, whose activity is needed for this migration, whereas members of the WAS

274 ysis reveals that a combination of mutations is needed for this phenotype.

275 Our data indicate that Prg4 is needed for TMJ disc integrity and function and that i

276 Benchmarking is needed for tool assessment and improvement but is com

277 As with MEC-6, POML-1 is needed for touch sensitivity, the neurodegeneration c

278 ge shifts is limited, and standardized study is needed for traits to be valid indicators of vulnerabi

279 tential health risk from smoke exposure that is needed for translation of better mitigation policies,

280 Therefore, novel therapeutic approaches are needed for treating DBA.

281 Novel therapies are needed for treating the increasing prevalence of hep

282 and well-tolerated, interferon-free regimens are needed for treatment of patients with chronic hepati

283 ive outcome measures for disease progression are needed for treatment trials of Stargardt disease.

284 tflow, suggesting instead that about 30 eyes are needed for true mastery.

285 Novel drug regimens are needed for tuberculosis (TB) treatment.

286 dies, genes whose wild-type coding sequences are needed for tumor growth are also of key interest.

287 Altered metabolism is needed for tumour cells to survive in this environmen

288 elaborate optics, and phase-locked detectors are needed for ultrasensitive measurements.

289 e mechanical properties of coronary arteries are needed for understanding arterial mechanics in healt

290 ng from the ecosystem to the molecular level are needed for understanding the complicated process of

291 polycations disrupt and cross cell membranes is needed for understanding and controlling polycation-m

292 man cytomegalovirus drugs from novel targets are needed for use instead of, or in combination with, c

293 Although considerable improvements will be needed for viable bacterial production of FAMEs and F

294 UL21 also appears to be needed for viral membrane activities.

295 ar vaccinia virus-related kinases (VRKs) and is needed for viral DNA replication and likely other sta

296 ical threshold of E1B 19/20K expression that is needed for viral replication and infection transmissi

297 er-lying lowest-unoccupied-molecular-orbital is needed for WBG perovskite solar cells, while its ener

298 lysis (MFA), and machine-learning approaches are needed for weighting, standardizing, and predicting

299 ge of highly effective contraceptive methods is needed for women, particularly in sub-Saharan Africa.

300 in obtaining periodic crystal lattices which are needed for X-ray crystal analysis has hindered the d