ライフサイエンスコーパス: be of considerable

1 lity of stable human antibody reagents would be of considerable advantage for research, diagnostic, a

2 interested biologists for over a century and is of considerable agricultural importance.

3 erventions directed at microbiome modulation are of considerable appeal.

4 ve affinities for the five receptor subtypes is of considerable basic and therapeutic interest and ha

5 We believe that this approach will be of considerable benefit across a range of disciplines

6 a complete Bacteroides CTn, and they should be of considerable benefit to further functional and gen

7 these MHC molecules is unknown, but they may be of considerable biological significance.

8 The structure and integrity of DNA is of considerable biological and biomedical importance,

9 g of the interaction between these mediators is of considerable biological importance.

10 Mammalian spermiogenesis is of considerable biological interest especially due to

11 us, understanding their folding and assembly is of considerable biotechnological interest.

12 of sites of bone and bone marrow infarction is of considerable clinical and diagnostic import in the

13 mediating stimulation of salivary secretion is of considerable clinical interest.

14 ineralization of dentin during dental caries is of considerable clinical interest.

15 The phenomenon is of considerable clinical relevance because numerous p

16 Polycyclic aromatic hydrocarbons (PAHs) are of considerable concern due to their well-recognised

17 e neurovirulent poliovirus of vaccine-origin are of considerable concern to the Global Polio Eradicat

18 variate between treatment groups at baseline is of considerable concern if one treatment group is fav

19 o cause a pandemic, and antiviral resistance is of considerable concern.

20 Among red mud contaminants, arsenic (As) is of considerable concern.

21 timing of microbial cure, this low efficacy is of considerable concern.

22 zation between native and introduced species are of considerable conservation concern, while the poss

23 nd ecosystem function, declining populations are of considerable conservation concern.

24 Of these materials, those containing boron are of considerable current interest because of their re

25 Transition-metal oxyhydrides are of considerable current interest due to the unique f

26 tures with highly integrated functionalities are of considerable current interest to drug delivery, m

27 d the nature of the released iron and sulfur are of considerable current interest.

28 oparticle probes in live cells, a topic that is of considerable current interest in developing advanc

29 the design and refinement of such molecules is of considerable current interest.

30 -to-spin currents in non-magnetic materials, is of considerable debate.

31 rning functions or is exploited in transport is of considerable debate.

32 tion state of GTPase-mediated GTP hydrolysis is of considerable dissociative character.

33 extraintestinal pathogenic Escherichia coli, are of considerable epidemiological, phylogenetic, and i

34 It is of considerable evolutionary interest that nature use

35 accumulation of plant biomass in nature and are of considerable fundamental and biotechnological int

36 otential, the study by Trankle et al. should be of considerable general interest.

37 any other class A GPCRs, our findings should be of considerable general interest.

38 among all class A GPCRs, our results should be of considerable general relevance.

39 ll biogenic amine GPCRs, our findings should be of considerable general relevance.

40 f fork arrest and of rescue of stalled forks is of considerable general interest.

41 accumulate during DNA and RNA synthesis, and are of considerable importance as the target for antitum

42 Seedless grapes are of considerable importance for the raisin and table

43 These questions are of considerable importance given the interest in dev

44 Extended defects are of considerable importance in determining the electr

45 with other regulators of PS gene expression are of considerable importance to our understanding of t

46 epithelium and especially Paneth cells that are of considerable importance to the maintenance of hom

47 Our findings are of considerable importance when trying to understand

48 e electrical and electronic equipment (WEEE) are of considerable importance, both from an environment

49 reorganization of modules in these proteins are of considerable importance, but distinguishing alter

50 range of exchange rates within such systems are of considerable importance.

51 ated mutations on the structure and function are of considerable importance.

52 expression of SIRPalpha1 on astrocytomas may be of considerable importance in brain tumor biology, an

53 et B cells and their functions may therefore be of considerable importance in these autoimmune diseas

54 This information will be of considerable importance to our understanding of ho

55 cterized with certain amino acids proving to be of considerable importance.

56 st individuals living in northerly latitudes is of considerable importance because of its relationshi

57 riate fluorometric derivatization procedures is of considerable importance for accurate determination

58 This observation is of considerable importance for studies of social mono

59 ion of certain transposons within the genus, is of considerable importance for understanding the evol

60 nzymes target their wide array of substrates is of considerable importance for understanding the func

61 ing of cellular processes at molecular level is of considerable importance in cell biology as well as

62 galactose 1-phosphate equally as substrates is of considerable importance in determining lithium's m

63 approach to the management of the infection is of considerable importance in determining outcome.

64 um beta-lactamase (ESBL)-mediated resistance is of considerable importance in human medicine.

65 NF-kappaB is of considerable importance in leukocyte function beca

66 tamers recognize biological binding partners is of considerable importance in the development of olig

67 ontrary to Halsted's thesis, the bloodstream is of considerable importance in tumor dissemination.

68 on of prosthetic groups in membrane proteins is of considerable importance in understanding their fun

69 tive description and management of such data is of considerable importance to bioinformatics in the p

70 human medicine, and potential for misuse, it is of considerable importance to elucidate the mechanism

71 ices that can accommodate very small samples is of considerable importance to many areas of science a

72 Olfaction is of considerable importance to many insects in behavio

73 This topic is of considerable importance to mental health professio

74 m to continually produce neuronal precursors is of considerable importance, as manipulation of this p

75 The identification of virulence determinants is of considerable importance, because of the potential

76 ing protein binding sites within genomic DNA is of considerable importance, but remains difficult for

77 sm of activation during myocardial ischaemia is of considerable importance, since it may allow preven

78 The level of polymorphism at the HLA-G locus is of considerable importance, since the paternally inhe

79 1 to that of carcinogenic arylnitrenium ions is of considerable importance.

80 structure in the absence of crystal packing is of considerable importance.

81 ular vertically transmitted parasites (VTPs) is of considerable importance.

82 evidence base for psychosocial intervention is of considerable importance.

83 c basis for carbohydrate-protein recognition is of considerable importance.

84 adipose tissue differentiation and function is of considerable importance.

85 ibacterial antibody in the respiratory tract is of considerable importance.

86 nding root phenes that enhance N acquisition is of considerable importance.

87 ng the processes that affect tau aggregation is of considerable importance.

88 ance of interstellar molecular nitrogen (N2) is of considerable importance: models of steady-state ga

89 Graphene heterostructures are of considerable interest as a new class of electroni

90 inc binding and release among bacterial SBPs are of considerable interest as antibacterial drug targe

91 Broad-spectrum anticonvulsants are of considerable interest as antiepileptic drugs, esp

92 ghtweight and flexible solid supercapacitors are of considerable interest as energy storage devices.

93 Drugs that target TLRs are of considerable interest as potential inflammatory r

94 introns are self-splicing RNA molecules that are of considerable interest as ribozymes, mobile geneti

95 Molecular mimetic Ags are of considerable interest as vaccine candidates.

96 These cocrystals are of considerable interest because of their remarkable

97 esentative of numerous misfolding disorders, are of considerable interest because there are mutations

98 Novel and low-cost batteries are of considerable interest for application in large-sc

99 , but also develop additional functions that are of considerable interest for bioelectrochemical appl

100 ic assays based on gold nanoparticles (GNPs) are of considerable interest for diagnostics because of

101 adest heterologous neutralizing activity and are of considerable interest for HIV-1 vaccine developme

102 Silsesquioxanes (SQs) are of considerable interest for hybrid electronic and p

103 Sulfoximines are of considerable interest for incorporation into medi

104 [reaction: see text] Carbocyclic nucleosides are of considerable interest for the development of new

105 o-dimensional van der Waals heterostructures are of considerable interest for the next generation nan

106 ed in some bacterial quorum-sensing pathways are of considerable interest for their ability to block

107 which gene expression is regulated by oxygen are of considerable interest from basic science and ther

108 The neural mechanisms mediating PPI are of considerable interest given evidence linking PPI

109 iers such as liposomal drug delivery systems are of considerable interest in cancer therapy because o

110 Graphene and other 2D atomic crystals are of considerable interest in catalysis because of the

111 at mediate biomembrane shape transformations are of considerable interest in cell biology.

112 Rare earth tantalate materials are of considerable interest in energy and environmental

113 The iron values are of considerable interest in terms of the level of ca

114 thods for the quantification of thiol groups are of considerable interest not only for protein analys

115 ia virus (M-MuLV) long terminal repeat (LTR) are of considerable interest since they are crucial for

116 mmune responses are not well understood, but are of considerable interest to a deeper understanding o

117 eth, bones, shells, carapaces, and spicules, are of considerable interest to chemists and materials s

118 lyunsaturated fatty acids (>/=C20; LC-PUFAs) are of considerable interest, based on clear evidence of

119 tem cells and progenitors in the adult brain are of considerable interest, because these cells hold g

120 sponsible for triggering sigmaS accumulation are of considerable interest, because they help to ensur

121 luctuations in inositol pyrophosphate levels are of considerable interest, because, according to prev

122 and characterize chaos in biological systems are of considerable interest, especially in medical scie

123 actors that affect the neutral mutation rate are of considerable interest.

124 echanisms involved in its natural resolution are of considerable interest.

125 clude partial agonists, although such agents are of considerable interest.

126 , the mechanisms underlying their expression are of considerable interest.

127 ecular mechanisms of JSRV Env transformation are of considerable interest.

128 onse to different classes of antidepressants are of considerable interest.

129 defects and restoration of protein function are of considerable interest.

130 ivation, its effects on rhodopsin activation are of considerable interest.

131 roduction, strategies for its downregulation are of considerable interest.

132 of gankyrin and interrupt these interactions are of considerable interest.

133 ission, and overcome single agent resistance are of considerable interest.

134 t dampen inflammation and enhance resolution are of considerable interest.

135 r preferentially Sr and Ba at high rates may be of considerable interest for designing new remediatio

136 thout raising serum calcium levels, they may be of considerable interest for the systemic treatment o

137 -dipolar cycloadditions to acetylenes should be of considerable interest to a broader field of chemis

138 erous cellular and viral homologues, it will be of considerable interest to determine the pervasivene

139 It will therefore be of considerable interest to test empirically the dist

140 ces in their efficacy and side-effects would be of considerable interest.

141 omal/molecular changes that occur would also be of considerable interest.

142 iate TrkB receptor signaling would therefore be of considerable interest.

143 ated activities during development have long been of considerable interest to biologists.

144 A signaling cascade that has been of considerable interest to both developmental and

145 that hominins (early humans) frequented has been of considerable interest.

146 direct oxidation of methane to methanol has been of considerable interest.

147 repair, recombination, and replication have been of considerable interest.

148 attachment of cells to the tooth surface has been of considerable interest.

149 nterferon response and virus replication has been of considerable interest.

150 tive nitrosylation of ferric (met)hemoglobin is of considerable interest and remains incompletely exp

151 Metabotropic glutamate receptor 5 is of considerable interest as a drug target in the trea

152 into its biologically active form, and FTase is of considerable interest as a potential therapeutic t

153 This pathway is of considerable interest because it has an important

154 ane protein encoded in the HIV-1 genome that is of considerable interest because it plays important r

155 Dibenzo[a,l]pyrene, which is of considerable interest because of its high carcinog

156 ng hormone/choriogonadotropin receptor (LHR) is of considerable interest because of its requirement f

157 ly of large (>5 nm) gold nanoparticles (NPs) is of considerable interest because of the promise of no

158 urally similar to parathyroid hormone (PTH), is of considerable interest because PTH and PTHrP both r

159 S) cone responses has yet to be achieved and is of considerable interest because S-cones are the basi

160 re during organ development and regeneration is of considerable interest for application in restoring

161 The red fluorescent protein mCherry is of considerable interest for fluorescence fluctuation

162 Direct electron transfer (DET) to proteins is of considerable interest for the development of biose

163 ated slow excitation of vestibular afferents is of considerable interest given its ability to elevate

164 of this strategy for sessile marine species is of considerable interest given that these resources a

165 The control of quasi-static magnetic fields is of considerable interest in applications including th

166 al sites, arises in highly evolvable systems is of considerable interest in areas ranging from cell b

167 atial gradients in composition and structure is of considerable interest in disciplines as diverse as

168 standing ancestral angiosperm morphology and is of considerable interest in the context of angiosperm

169 This form of plasticity is of considerable interest in the context of neurologic

170 se of "anchor-fixed" altered peptide ligands is of considerable interest in the development of therap

171 Manipulation of the interaction is of considerable interest in the immunotherapy of canc

172 The European badger (Meles meles) is of considerable interest in the UK as it is both a pr

173 /=10(8), measurement accuracy and precision, is of considerable interest in various fields of applica

174 r clusters in a real-world, networked system is of considerable interest in various fields such as so

175 Thus, mTOR is of considerable interest in view of its potential as

176 Pore size is of considerable interest in voltage-gated Ca(2+) chan

177 bacteria as delivery vehicles for biologics is of considerable interest scientifically and has attra

178 Therefore, it is of considerable interest that individuals with autism

179 It is of considerable interest that the association of comm

180 It is of considerable interest that, although the binding a

181 It is of considerable interest to design or discover new ol

182 cans is an important biological process that is of considerable interest to environmentally relevant

183 For the latter, it is of considerable interest to explore ways to influence

184 For many species, it is of considerable interest to quantify the contribution

185 Consequently, it is of considerable interest to quantify the energetic fa

186 It is of considerable interest to understand how the low ab

187 It is of considerable interest to understand how these agen

188 Therefore, it is of considerable interest to understand the regulation

189 Since NS5A is a phosphoprotein, it is of considerable interest to understand the role of ph

190 apamycin pathway in hematologic malignancies is of considerable interest with major clinical/translat

191 crobicides for either topical or ex vivo use is of considerable interest, mainly due to the difficult

192 ts role in the progression of ocular disease is of considerable interest, yet few details are known a

193 ys and rates associated with this phenomenon is of considerable interest.

194 ronal activation that is specific to reading is of considerable interest.

195 hich case, the response of V. fischeri to NO is of considerable interest.

196 miRNAs in BMP2-mediated biological processes is of considerable interest.

197 , of which some are seemingly contradictory, is of considerable interest.

198 cts of these stimuli on endothelial function is of considerable interest.

199 cts of these stimuli on endothelial function is of considerable interest.

200 on in cerebellar cortex might lead to ataxia is of considerable interest.

201 umors with an estrogen-independent phenotype is of considerable interest.

202 nto the polyketide backbone, its specificity is of considerable interest.

203 ther, the impact of one process on the other is of considerable interest.

204 ture and function of these biological motors is of considerable interest.

205 hese materials to humans and the environment is of considerable interest.

206 How this regulation is exerted is of considerable interest: promoter-based control and

207 presence of PGP 9.5 in cells at a wound site was of considerable interest.

208 Cholangiocytes are of considerable intrinsic biologic interest, particu

209 of interaction of RTP with the terminus DNA is of considerable mechanistic significance because the

210 These protists are of considerable medical and veterinary importance wo

211 iology of progenitor activation in the liver is of considerable medical and scientific interest.

212 on determines the final nephron count, which is of considerable medical importance.

213 Since this epitope may be of considerable pathophysiologic importance and since

214 This mechanism is of considerable pharmaceutical interest, since it is

215 el in some tissues, and (c) DII is likely to be of considerable physiologic importance in thyroid hor

216 research indicates that these enzymes might be of considerable physiological importance for human he

217 on in that tissue, such an interaction could be of considerable physiological significance.

218 f end-of-life care among developed countries are of considerable policy interest.

219 ons on the vessel wall, and as such, PDT may be of considerable potential therapeutic value to inhibi

220 proach for the therapy of malignant melanoma is of considerable potential.

221 These issues are of considerable practical importance for cardiovascu

222 cal-grade reagents and pharmaceuticals would be of considerable practical utility to T-cell cancer ge

223 o liquid methanol and other oxygenates would be of considerable practical value.

224 ormation that is now available on both genes is of considerable prognostic value with the prospects f

225 its from reduction in overweight and obesity are of considerable public health importance.

226 Infections with Strongyloides stercoralis are of considerable public health relevance.

227 If such a risk does exist, the matter would be of considerable public health importance, given the r

228 d to infected persons reduces infectiousness is of considerable public health importance, but the que

229 arsenic can adversely affect birth outcomes is of considerable public health importance.

230 In addition, they are of considerable relevance for accounts of sleep-depe

231 egulate the repair of bronchiolar epithelium are of considerable relevance for understanding the path

232 r the E3 ubiquitin ligase HAKAI is likely to be of considerable relevance beyond the plant sciences.

233 These findings should be of considerable relevance for the development of rece

234 nd FLT3 (protein) in multipotent progenitors is of considerable relevance for mouse models in which p

235 ong different microenvironments in a bilayer is of considerable relevance to characterization of comp

236 This property is of considerable relevance to solid oxide fuel cells i

237 This question is of considerable relevance, insofar as the basolateral

238 Such susceptibility genes are of considerable scientific interest, but do not conf

239 al populations using whole-genome sequencing is of considerable scientific and clinical interest.

240 dict an outcome based on previous experience is of considerable selective advantage.

241 like the one that distinguishes Tyk2 alleles are of considerable significance given the potential rol

242 ated strain fields and segregated impurities are of considerable significance in many areas of materi

243 of all these features, this versatile yeast is of considerable significance in food-related applicat

244 ng of cereal crops due to high wind and rain is of considerable significance in many parts of the wor

245 ly relevant approach to conducting materials is of considerable significance.

246 beverages in ancient Chinese culture, which were of considerable social, religious, and medical sign

247 Martensitic transformations are of considerable technological importance, a particul

248 polarization on the applied electric field, are of considerable technological importance.

249 Complex insulating perovskite alloys are of considerable technological interest because of th

250 the factors that limit their miniaturization are of considerable theoretical interest to general biol

251 It is of considerable theoretical and practical importance

252 n chemical and physical properties therefore is of considerable theoretical and practical interest.

253 nt of new subtype-specific antagonists would be of considerable therapeutic interest.

254 nzymes, leading to stabilization of HIF, may be of considerable therapeutic potential in treating con

255 e interactions between these common CTSs may be of considerable therapeutic relevance.

256 Glucocorticoid receptor (GR) antagonism may be of considerable therapeutic value in stress-related p

257 ructure and function, this effect of statins is of considerable therapeutic importance.

258 This restricted expression pattern is of considerable therapeutic interest because small no

259 IL-2 is of considerable therapeutic interest, but harnessing

260 e active antipsoriatic component of coal tar is of considerable therapeutic interest.

261 r (mAChR) subtype(s) mediating this activity is of considerable therapeutic interest.

262 We expect this method to be of considerable use in the analysis of ligand binding

263 We conclude that surface EMG recordings can be of considerable use in the assessment of population s

264 Responses to these epitopes should be of considerable utility for immune monitoring, as the

265 in focal cerebral ischemia; this method will be of considerable utility in assessing the BBB-protecti

266 The cap structures have the potential to be of considerable utility in examining the effect that

267 concentrated macromolecular solutions would be of considerable utility in studies of a wide range of

268 t hobo and related transposable elements may be of considerable utility in the germline transformatio

269 hemical assays on the nanoliter scale, which is of considerable utility for RNA-protein binding react

270 This model is of considerable utility for studying viral entry in t

271 hibitors targeted against C-raf-1 kinase may be of considerable value as antineoplastic agents that d

272 rature, the findings described herein should be of considerable value for improving the comprehensive

273 tional recombinant UDP-GlcA 4-epimerase will be of considerable value for the facile generation of UD

274 The approaches described will be of considerable value in associating particular pathw

275 nsic properties of primary charge pairs will be of considerable value in guiding new material develop

276 This observation could be of considerable value in many diverse areas of chemis

277 directly cytotoxic HIV-specific T cells may be of considerable value in the assessment of disease pr

278 elivered to target sites in the skin and may be of considerable value in the treatment of psoriasis a

279 First-photon imaging may be of considerable value to both microscopy and remote s

280 RCAx families into recognizable groups could be of considerable value to further genetic analysis.

281 dentify activators of these receptors should be of considerable value.

282 y future disease progression would therefore be of considerable value.

283 expression of different genes in vivo would be of considerable value.

284 osome or chromosome band-specific ESTs would be of considerable value.

285 This model of electroactivity is of considerable value for the rational design of cond

286 Its determination is of considerable value, particularly in the clinical d

287 Although Capnocytophaga spp. are of considerable zoonotic importance, their clinical