ライフサイエンスコーパス: be of critical importance

1 idues at positions 170 and 171 were found to be of critical importance.

2 ssing of the amyloid precursor protein (APP) is of critical importance.

3 nding interaction between PCSK9 and the LDLR is of critical importance.

4 he premise that access to effective services is of critical importance.

5 Continued cardiac follow-up of these women is of critical importance.

6 that hydrophobicity, as represented by log P is of critical importance.

7 erstanding of signal transduction mechanisms is of critical importance.

8 etection of transgenic DNA in crop landraces is of critical importance.

9 utrophils, such as nocardial pneumonia, this is of critical importance.

10 threat, and prompt detection of such strains is of critical importance.

11 the identification of their direct effectors is of critical importance.

12 ctors, sensing from the UV to the NIR region is of critical importance.

13 brightness is one of the key parameters that is of critical importance.

14 effects on bone density in growing children is of critical importance.

15 among unselected patients treated with TAVR is of critical importance.

16 intaining graft-versus-tumor (GVT) responses is of critical importance.

17 vern their specific subcellular localization is of critical importance.

18 tructure as one moves away from 3d materials is of critical importance.

19 ted roles for platelets in malaria infection is of critical importance.

20 sensitivity among metals and metal mixtures is of critical importance.

21 e database by both readers and investigators is of critical importance.

22 ent saccharide motifs in a controlled manner is of critical importance.

23 s to study interactions at the cell membrane is of critical importance.

24 for membrane-protein structure determination are of critical importance.

25 fraction around the time of coronary surgery is of critical importance; a period of pre-operative "tu

26 s that precede its development, our findings are of critical importance and must be considered while

27 be relevant for hsp90 binding is now seen to be of critical importance, and these data argue strongly

28 This is of critical importance as the authors continue to exp

29 Proactive quality control is of critical importance as unanticipated biases, artif

30 neurotoxin (BoNT) from Clostridium botulinum is of critical importance because it causes human illnes

31 Understanding this process is of critical importance because the majority of cancer

32 ructural identification of these metabolites is of critical importance because their characterization

33 ompare strategies to optimize antibiotic use are of critical importance but are limited by competing

34 ndicates that the presence of CD4(+) T cells is of critical importance but mast cells, antibodies, an

35 the outer membrane of Gram-negative bacteria is of critical importance due to the emergence of bacter

36 These elements are of critical importance during the first-strand trans

37 Posttranscriptional regulation is of critical importance during mammalian spermiogenesi

38 Lysine selectivity is of critical importance during polyubiquitin chain for

39 Complete digestion of gluten proteins is of critical importance during quantitative analysis.

40 fusion peptide region (L378S)-were found to be of critical importance, ensuring transmission to rode

41 ly paired neuropils in the insect brain that are of critical importance for associative olfactory lea

42 te vascular smooth muscle cell heterogeneity are of critical importance for future therapeutic advanc

43 s controlling synapse growth and maintenance are of critical importance for learning and memory.

44 ements of core and flanking sequences, which are of critical importance for promoter recognition and

45 ERN motif and residue Asp-142 in the loop 2 are of critical importance for RegIIIbeta function.

46 branes have not been studied in detail, they are of critical importance for T cell recognition.

47 roliferating cells, and tumor doubling times are of critical importance for the dynamics of cancer ce

48 mary production in regions of the ocean that are of critical importance for the global carbon cycle.

49 Genes regulated by androgenic hormones are of critical importance for the normal physiological

50 Genes regulated by androgenic hormones are of critical importance for the normal physiological

51 Genes regulated by androgenic hormones are of critical importance for the normal physiological

52 Nervous system maps are of critical importance for understanding how nervous

53 tibility complex class I molecules appear to be of critical importance for altered target cell suscep

54 d to migrate recombination intermediates may be of critical importance for DNA repair and chromosome

55 ltimerization of vitronectin (Vn) appears to be of critical importance for its functions, but little

56 l cord SG region, and that these actions may be of critical importance for nociception and the clinic

57 ins via an ABP1-dependent pathway appears to be of critical importance for temporal and spatial contr

58 Our findings are believed to be of critical importance for the quantitative analysis

59 c pocket involving residues Gly471-Val474 as being of critical importance for both VWF binding and pr

60 ld and acquire disulfide bonds concurrently, is of critical importance for a wide range of biological

61 Hence, Il6 is of critical importance for acquired immunity against

62 cle microvasculature to insulin and exercise is of critical importance for adequate muscle perfusion

63 beta (ratio of plasma to magnetic pressures) is of critical importance for an economic magnetic fusio

64 bility of human embryonic stem cells (hESCs) is of critical importance for both experimental and clin

65 e early signs of malfunctioning mitochondria is of critical importance for cellular welfare and survi

66 a region of the alpha cytosolic domain that is of critical importance for defining receptor specific

67 The regulation of TSP I expression is of critical importance for designing new approaches i

68 aints on the carbon equation of state, which is of critical importance for devising models of Neptune

69 SUMOylation (SUMO modification) is of critical importance for maintaining neuronal funct

70 ng clinical trials, overcoming such barriers is of critical importance for maintenance of core oncolo

71 undaries at both the 5' and 3' ends of genes is of critical importance for microbial genome annotatio

72 Protein lifetime is of critical importance for most biological processes

73 nd their potential for lineage reprogramming is of critical importance for moving Treg therapy into t

74 Protein traffic is of critical importance for normal cellular physiology

75 We conclude that CAR-1 is of critical importance for oogenesis, that the associ

76 nesthesiologists as perioperative physicians is of critical importance for optimizing surgical outcom

77 ute and water movement across cell membranes is of critical importance for osmotic balance.

78 is regulated by light and phytohormones and is of critical importance for plant growth.

79 Electrochemical energy storage technology is of critical importance for portable electronics, tran

80 This information is of critical importance for potential interventions ai

81 chloroplasts, the control of mRNA stability is of critical importance for proper regulation of gene

82 ng the factors responsible for this behavior is of critical importance for protein engineering and de

83 mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and

84 Sensitive, real-time detection of biomarkers is of critical importance for rapid and accurate diagnos

85 Physiological regulation of iron stores is of critical importance for RBC production and antimic

86 ogical inactivation of ML to test whether ML is of critical importance for real-world face detection.

87 Receptor tyrosine kinase (RTK) recycling is of critical importance for RTK signaling and cancer,

88 growth and suggesting that electron donation is of critical importance for selective deposition.

89 omparative genomic hybridization (aCGH) data is of critical importance for the accurate detection of

90 lts demonstrate that the Hin dimer interface is of critical importance for the activation of catalysi

91 vascular smooth muscle cell (SMC) migration is of critical importance for the development of atheros

92 recognition of the origin of cardiomyocytes is of critical importance for the development of strateg

93 This issue is of critical importance for the mechanism of platelet

94 The availability of coherent laser sources is of critical importance for the realization of such op

95 sulting product trans-4-hydroxyproline (Hyp) is of critical importance for the stability and thus fun

96 invasive identification of colorants in situ is of critical importance for the understanding of histo

97 ation of plant biomass to fermentable sugars is of critical importance for the use of plant materials

98 muD gene products are highly flexible, which is of critical importance for their many protein interac

99 w the IFT subunits interact with their cargo is of critical importance for understanding how the uniq

100 ical properties of these ganglion cell types is of critical importance for understanding the function

101 s of GPCRs that mediate receptor association is of critical importance for understanding the function

102 of the calcium spark amplitude distribution is of critical importance for understanding the nature o

103 The answer is of critical importance for understanding the neurobio

104 eriments indicate that ORF47 kinase activity is of critical importance for VZV infection and cell-cel

105 titin regulation in cardiac muscle function is of critical importance given recent compelling eviden

106 samples and indicate that primer specificity is of critical importance if the ITS region is used as a

107 t both duration and magnitude of BDNF dosing are of critical importance in achieving functional outco

108 ation of abnormalities within the breast and are of critical importance in breast cancer diagnosis.

109 n of drug delivery to the tumor interstitium are of critical importance in cancer chemotherapy.

110 cific cytotoxic T lymphocyte (CTL) responses are of critical importance in controlling virus replicat

111 psychiatric sequelae such as traumatic grief are of critical importance in determining which bereaved

112 siologist, as a key perioperative physician, are of critical importance in developing a successful fa

113 between centromeres and spindle microtubules are of critical importance in ensuring accurate segregat

114 anding why this occurs and how to prevent it are of critical importance in improving pain therapies.

115 Phospholipids are of critical importance in mammalian cell biology, bo

116 polysaccharides in the plant cell wall, and are of critical importance in plant development.

117 Primary data analysis methods are of critical importance in second generation DNA sequ

118 Histone lysine demethylases (KDMs) are of critical importance in the epigenetic regulation

119 for target detection: these characteristics are of critical importance in the screening of mutations

120 ental cell-matrix and cell-cell interactions are of critical importance in tissue engineering and reg

121 ges of a next-generation sequencing pipeline are of critical importance in translational biomedical s

122 cellular redox state and radical metabolism are of critical importance in tumor biology and treatmen

123 oproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metasta

124 esult in amino acid residue changes (nsSNPs) are of critical importance in variation between individu

125 stsynaptic receptor clustering is thought to be of critical importance in central neurotransmission.

126 perty of functional avidity is recognized to be of critical importance in determining pathogen cleara

127 that the precise level of Cx43 function may be of critical importance in downstream events involving

128 ents and asymptomatic mutation carriers will be of critical importance in future trials of experiment

129 ctor in chromatin disruption and that it may be of critical importance in gene regulation.

130 urrently in use in vaccine trials, which may be of critical importance in immunogen design and testin

131 Regulation of this protein may be of critical importance in modulating the role of Ang

132 s (NFAT) signaling pathway has been shown to be of critical importance in regulating the growth respo

133 by NO( small middle dot)-derived ONOO(-) may be of critical importance in regulating the process of i

134 idation of low density lipoprotein (LDL) may be of critical importance in the pathogenesis of atheros

135 idation of low density lipoprotein (LDL) may be of critical importance in triggering the pathological

136 in biological materials, which may prove to be of critical importance in understanding the disease m

137 This key innovation may have been of critical importance in the radiation and ecologi

138 Proper PVC methodology is of critical importance in accurate quantitative asses

139 sets for self assembling rectilinear shapes is of critical importance in algorithmic self assembly.

140 servation of random, nonrepetitive phenomena is of critical importance in astronomy, spectroscopy, bi

141 deregulates the mammalian cell cycle, which is of critical importance in B-cell transformation.

142 The detection of viral pathogens is of critical importance in biology, medicine, and agri

143 r protein signaling and biochemical networks is of critical importance in biology.

144 of fresh, hot magma and an ensuing eruption is of critical importance in both understanding the trig

145 n their concentration inside living systems, is of critical importance in deciphering their exact bio

146 nd molecules from a heterogeneous population is of critical importance in diagnosis of common lethal

147 ow CMV induces and circumvents host immunity is of critical importance in efforts to design effective

148 Therefore, targeting Fas resistance is of critical importance in Fas-based cancer therapy an

149 hology of micrometre-size particulate matter is of critical importance in fields ranging from toxicol

150 Identification of unknown compounds is of critical importance in GC/MS applications (metabol

151 The regulation of its expression is of critical importance in hematopoietic cells.

152 ion of cell-mediated immunity to C. albicans is of critical importance in host defense and the prime

153 he induction of cell-mediated immunity to Hc is of critical importance in host defense, we sought to

154 duction of cell-mediated immunity to Candida is of critical importance in host defense, we sought to

155 Osteoporosis imaging is of critical importance in identifying individuals at

156 ar signals that initiate cardiac hypertrophy is of critical importance in identifying the pathways th

157 burst of polymorphonuclear leukocytes (PMNs) is of critical importance in inflammatory disease.

158 patients undergoing angiographic procedures is of critical importance in limiting the risk of CI-AKI

159 The CD4(+) T cell response is of critical importance in maintaining long-term prote

160 RNA localization is of critical importance in many fundamental cell biolo

161 burst firing in awake conditions, I(Twindow) is of critical importance in neuronal population dynamic

162 t development at the time of transplantation is of critical importance in recipient repertoire "remod

163 communication in cardiac neural crest cells is of critical importance in right ventricular outflow t

164 eptides to T cells by MHC class II molecules is of critical importance in specific recognition by the

165 This latter point is of critical importance in the ability to apply these

166 Obesity is of critical importance in the development of metaboli

167 y microbial cell wall components such as LPS is of critical importance in the development of sepsis a

168 ion of (12)CO2 and (13)CO2 in exhaled breath is of critical importance in the field of breath analysi

169 hing pathogenic mutations from rare variants is of critical importance in the interpretation of genet

170 oxic impurities (GIs) such as hydrazine (HZ) is of critical importance in the pharmaceutical industry

171 chromatin remodeling complex, whose function is of critical importance in transcriptional regulation,

172 isions and bonding interactions in solutions is of critical importance in understanding and predictin

173 ory lesions are spatially restricted in vivo is of critical importance in understanding skin disease.

174 This conformational transition is of critical importance in understanding the molecular

175 l near-resonance interactions between states is of critical importance in understanding the origin of

176 e modulators are released onto their targets is of critical importance in understanding the outcomes

177 ication of virulence determinants of viruses is of critical importance in virology.

178 their cognate nucleoside diphosphates (NDPs) is of critical importance in virtually every aspect of c

179 The AA dinucleotide at nt 2 and 3 is of critical importance since point mutations and dele

180 ntribute to the kinetic behavior of myosin V is of critical importance, since it is unclear which lig

181 c gene dosage of TOAD2 in an rpk1 background is of critical importance, suggesting that signaling med

182 It is of critical importance that we know how much person-t

183 The C(3)-substituent in morphinan opioids is of critical importance; the 3-OH group is usually ass

184 Interventions to prevent future illnesses are of critical importance to childhood cancer survivors

185 Such materials are of critical importance to many applications involvin

186 pping molecular composition at the nanoscale are of critical importance to materials research, biolog

187 is and precise control of protein expression are of critical importance to synthetic biology and biot

188 ituents at the 4-position on this extra ring are of critical importance to the biological activity.

189 trocatalysts for methanol oxidation reaction are of critical importance to the commercial viability o

190 Animal models are of critical importance to this effort and bone marro

191 Decreasing such "irrelevant cleavage" would be of critical importance to the ability of the antisens

192 inked enzyme effector system in HCC that may be of critical importance to the formation and progressi

193 Mitigating these costs is of critical importance to a growing bioenergy industr

194 operties of random packings of solid objects is of critical importance to a wide variety of fundament

195 se classes of pesticides and this adaptation is of critical importance to agriculture.

196 hes in diagnostic microbiology means that it is of critical importance to assess potential biases.

197 ying the genes most likely to be of interest is of critical importance to avoid wasting resources.

198 For food applications, it is of critical importance to better understand the hydro

199 Hence, regulation of these channels is of critical importance to cellular function.

200 Viral pathogen discovery is of critical importance to clinical microbiology, infe

201 r surface plasmon polariton (SPP) waveguides is of critical importance to construct the frequency-agi

202 examples demonstrate that spatial computing is of critical importance to design computing methods to

203 evelopmental history of each cell population is of critical importance to determine the ultimate outc

204 ct with the tripeptide Asn-Pro-Phe (NPF), it is of critical importance to elucidate the molecular mec

205 ts by which Ang II induces ECM dysregulation is of critical importance to further define its contribu

206 ne monophosphate (cGMP) by guanylate cyclase is of critical importance to gastrointestinal physiology

207 indicate that PKC-dependent phosphorylation is of critical importance to homologous regulation of hI

208 Chemical sensing is of critical importance to human health, safety, and s

209 The fungal genus Aspergillus is of critical importance to humankind.

210 Wood is of critical importance to humans as a primary feedsto

211 ven the technological complexity of ICDs, it is of critical importance to identify and control possib

212 It is of critical importance to improve toughness, strength

213 tegies to reverse the loss of lean body mass is of critical importance to increase survival in men wi

214 etic competition among its many targets, and is of critical importance to infection outcomes.

215 thermodynamic characterization are feasible is of critical importance to our understanding of the am

216 tion of water while excluding protons, which is of critical importance to preserving the electrochemi

217 VIII (FVIII) and von Willebrand factor (VWF) is of critical importance to protect FVIII from rapid in

218 anding the molecular underpinnings of cancer is of critical importance to the development of targeted

219 o generate and obtain full-length (FL) cDNAs is of critical importance to the field of genomics.

220 d blood oxygen level-dependent (BOLD) signal is of critical importance to the interpretation of fMRI.

221 esponse of marine plankton to climate change is of critical importance to the oceanic food web and fi

222 us, the hemodynamic role of PC during sepsis is of critical importance to the outcome of the disease.

223 eads for G-protein-coupled receptors (GPCRs) is of critical importance to the pharmaceutical and biot

224 e a feature of meningococcal bacteria, which is of critical importance to the progression of the infe

225 porosity of metal-organic frameworks (MOFs) is of critical importance to their materials function.

226 Thus, it is of critical importance to understand the pathology an

227 e binding energy in DNA-protein interactions is of critical importance to understand transcriptional

228 of branched alpha-alkylidene or acyl chains was of critical importance to reach low nanomolar bindin

229 t, but subtle, risk factors, and replication is of critical importance where results can inform subst

230 he mechanisms underlying this immune control is of critical importance, yet they remain unclear.