ライフサイエンスコーパス: be overcome by

1 As shown here, such difficulties can be overcome by (13)C-(13)C and for the first time (15)N-

2 stance of Saccharomyces cerevisiae to copper is overcome by 2-(6-benzyl-2-pyridyl)quinazoline (BPQ),

3 This ubiquitin binding inhibition can be overcome by a longer chain of linear, but not K63-lin

4 Here, we show that this limitation can be overcome by a method, termed midfield powering, to cr

5 These defects could all be overcome by a mutation of serine to tyrosine at posit

6 proach showed that the barriers that need to be overcome by a species to successfully establish or sp

7 e activation, although this inhibition could be overcome by a stronger stimulus.

8 For lasers, losses need to be overcome by a sufficient amount of gain to reach the

9 This stalling at C:8-oxo-G can be overcome by a switch from pol delta to pols lambda, b

10 Here we show that this limitation can be overcome by a transition of a matrix of densely packe

11 s with presumed antiviral activity, and must be overcome by a virus for successful replication.

12 which was previously the biggest constraint, was overcome by a novel application of convolution and F

13 n increase in RUNX1 expression; the blockade was overcome by a RUNX1 inhibitor.

14 These ERM limitations were overcome by a dedicated proteomic procedure based o

15 tion of BTIC growth by EGFR inhibitors could be overcome by activation of neurotrophin signaling, and

16 of a restriction in P-TEFb levels, which can be overcome by activation of the TCR.

17 xisting inhalational antigen tolerance could be overcome by activation of the transcription factor NF

18 L-21 to establish CD8 TE/TEM and TRM subsets was overcome by acute lymphocytic choriomeningitis virus

19 level of viral entry and that this block can be overcome by adaptation of the virus in tissue-culture

20 These limitations might be overcome by adding multiphase PMCT angiography.

21 alue in CS but has some limitations that may be overcome by adding newer cardiovascular magnetic reso

22 These defects often can be overcome by adding the Epstein-Barr virus (EBV) parti

23 ence defect of the SMU.1147 mutant could not be overcome by addition of sigX-inducing peptide (XIP) i

24 cells conferred resistance to EGFR TKIs that was overcome by addition of a MEK inhibitor.

25 hampered comparability-deficiencies that can be overcome by adopting good trial planning and reportin

26 It is thought that this may be overcome by allowing some 20 ppb of sodium to be alwa

27 time, such assays have limitations that can be overcome by alternative approaches.

28 ellular blocks limiting replication that can be overcome by an avian-like pH of activation for nuclea

29 induction of RpoS and OspC; this repression was overcome by an excess of Zn(2+).

30 This issue was overcome by analysis of beta-catenin signaling in tr

31 Here we show that these limitations may be overcome by angular momentum-biased metamaterials, in

32 CXCR4 signaling in IgD-deficient B cells can be overcome by anti-CD19 antibody stimulation that also

33 prostate tumor resistance to cabazitaxel can be overcome by antiandrogen-mediated EMT-MET cycling in

34 Poor outcome in high-risk patients cannot be overcome by any of the applied treatment strategies.

35 riction conferred by MCPIP1 does not seem to be overcome by any viral protein, it is removed during c

36 Here we show that these limitations can be overcome by applying high-resolution mass spectrometr

37 ng that neutralization resistance of HCV can be overcome by applying recombinant antibodies.

38 Many underlying causes of infertility have been overcome by assisted reproductive technologies such

39 faulty checkpoints for central tolerance can be overcome by autoantigen-specific immunomodulatory the

40 In fact, these deficiencies can be overcome by balancing NCC intrinsic processes of prol

41 cytotoxicity depends on DNA binding, but can be overcome by BCL2 overexpression, suggesting that apop

42 Permanent arrest can be overcome by blocking autophagy, by deleting the vacuo

43 ases in IFN-gamma with TIGIT knockdown could be overcome by blocking CD226 signaling, indicating that

44 trate that this translational repression can be overcome by blocking the actions of miRNAs, resulting

45 ic liabilities of the piperazine oxadiazoles were overcome by blocking predicted sites of metabolism,

46 Here we show that this material obstacle is overcome by bulk crystals of lightly Sn-doped Bi1.1Sb

47 n transmembrane and cytoplasmic domains must be overcome by cellular energy input to stabilize extens

48 Although major challenges remain, these can be overcome by cementing our resolve, raising advocacy,

49 nd discusses technical barriers that need to be overcome by chemists and other scientists in order fo

50 rganization cannot be detected and which can be overcome by choosing suitable experimental parameters

51 pha-induced hyperexcitability by minocycline was overcome by coadministration of sIL-6R, showing that

52 results in centriole length diminution that is overcome by codepletion of Klp10A to give longer cent

53 elicit a boosted PPS14-specific IgG response was overcome by coimmunization with unencapsulated GBS-I

54 esistance to macrophage-mediated killing can be overcome by combination regimens involving therapeuti

55 nhibitors in SPOP-mutant prostate cancer can be overcome by combination with AKT inhibitors and furth

56 This resistance could be overcome by combined EGFR and MET inhibition.

57 o Braf(V600E) inhibitor PLX4720, which could be overcome by combined treatment of PI3K inhibitor LY29

58 induces senescence and growth arrest, which is overcome by combined CAR activation, resulting in unc

59 GFR-mutant tumor cells, the effects of which were overcome by combined treatment with osimertinib and

60 Here we show that this restriction can be overcome by combining several well-established quantu

61 istance to RAF-MEK-ERK inhibition, which may be overcome by combining signalling- and chromatin-direc

62 istence of an acidifying synaptic force that is overcome by commonly used concentrations (10 mm) of H

63 Mutual gametophytic sterility was overcome by complementation with a genomic construct

64 alpha inhibition; yet such limitations could be overcome by concomitant blockade of one or more of th

65 This catalyst decomposition can be overcome by conducting the reactions with [(R)-BINAP]

66 uggest that the radiative-pressure limit may be overcome by considering more complex, non-spherical i

67 Whereas the thermal motion can be overcome by cooling a mechanical oscillator to its mo

68 in the absence of RNA and that this barrier is overcome by correct placement of appropriately orient

69 Here, we show that this limitation is overcome by correcting the geometric distortion induc

70 signaling pathway gene expression and could be overcome by costimulation through CD28 or innate cyto

71 amuscular transplantation, but that this can be overcome by cotransplantation of an oxygen carrier, t

72 ibitors that may arise in the clinic yet can be overcome by cotreatment with PI3K/AKT inhibitors.

73 This bottleneck was overcome by coupling Raman spectroscopy with chemome

74 estations of patients with WHIM syndrome may be overcome by dampening the gain of CXCR4 function.

75 g hydrophobic character of the dipolarophile is overcome by decreasing water solubility causing chang

76 upport of this, we found that the defect can be overcome by deleting the regulatory gene lcrQ.

77 Limitations that may be overcome by delivery include, but are not limited to,

78 o test whether this natural resistance might be overcome by derivatization, we synthesized analogues

79 These problems have been overcome by developing a novel blend technique wher

80 and microstructure control in complex oxides is overcome by developing a general two-step synthetic a

81 This disadvantage can be overcome by direct measurement of the intact protein

82 triction of infection via apical inoculation was overcome by disruption of intercellular junctions.

83 by the same antigen-presenting cell and may be overcome by distributing these sequences among severa

84 During S-phase, minor DNA damage may be overcome by DNA damage tolerance (DDT) pathways that

85 red resistance to PI3K inhibition that could be overcome by downstream AKT or mTORC1/2 inhibitors.

86 s suggest that resistance to fulvestrant can be overcome by drugs targeting the PI3K pathway.

87 Nonetheless, these defects could be overcome by early or prolonged exposure to IL-2, or b

88 ndicating that limits on diversification can be overcome by ecological or evolutionary change.

89 This block was overcome by either increasing occludin expression, c

90 The defects are overcome by eliminating sensitivity of cells to INK4

91 This red light hypersensitivity can be overcome by eliminating phytochrome B (phyB) and phyD

92 e ions with unique histidine residues, which were overcome by employing ETD fragmentation.

93 This obstacle has been overcome by energy-dispersive Laue diffraction.

94 his study shows that genetic constraints can be overcome by environmental change and that cross-envir

95 ian statistical theory, a priori beliefs can be overcome by experience.

96 Here we show that this block can be overcome by exposure to cell-associated virus.

97 ections, but their virus-blocking activities were overcome by expressing excess TEM-associated protea

98 mitochondrial pyrimidine nucleotide carrier, were overcome by expressing SLC25A33 or SLC25A36 in thes

99 ate limiting step is reduced uptake that can be overcome by expression of C. albicans Dur proteins in

100 opmental defects in imp-beta11 mutants could be overcome by expression of Fz2-C fused to a nuclear lo

101 The negative effect on HGF-mediated growth was overcome by expression of CD44v4-10, but not by CD44

102 The adf3-conferred susceptibility to GPA was overcome by expression of the ADF3 coding sequence f

103 ng quartz fork, the reactor size limit could be overcome by extending the substrate area to a continu

104 by reducing equivalents supply, which could be overcome by externally supplying hydroxylamine (NH(2)

105 in protein aggregation and loss of activity, were overcome by formulating the drug as a dry-powder th

106 ral defenses reliant on type III IFNs, which are overcome by FV3 pathogens.

107 predominated by IFN-lambda responses, which are overcome by FV3.

108 This defect was overcome by gavage with B. fragilis, by immunization

109 The GC-MS component co-elution was overcome by GCxGC-qMS.

110 ion of IFNgamma production by Th17 cells can be overcome by genetic ablation of CD73 or by using IL1b

111 f bacteriophage T7 to synthesize primers can be overcome by genetic alterations that decrease the exp

112 Resistance is overcome by genetic or pharmacological inhibition of

113 This limitation is being overcome by genome-editing technologies, which mar

114 nicotine resulting in reduced yields of DHT was overcome by glutathione.

115 ions are not fundamental and that they might be overcome by growth processes that mimic polymerizatio

116 Interestingly, the lethality can be overcome by growth under elevated temperatures due to

117 lassification is a significant issue but can be overcome by harmonizing SULs using a proprietary soft

118 roquine resistance is dose dependent and can be overcome by higher, still well-tolerated doses.

119 C3G, a potent HIV-1 host restriction factor, is overcome by HIV-1 viral infectivity factor (Vif), whi

120 Replication fork inactivation can be overcome by homologous recombination, but this can ca

121 ating that the IFN-alpha-induced barrier can be overcome by HSIV-vif chimeras in PTM CD4(+) T cells.

122 This limitation may be overcome by hybrid imaging through the individual int

123 ast data processing and communication, might be overcome by hybridization with their organic counterp

124 recoveries of Au-NPs in DOM model solutions were overcome by hydrogen peroxide pretreatment up to a

125 evidence indicates that GSK3 inhibition can be overcome by hyperactivation of the canonical Wnt sign

126 This problem can be overcome by hyperpolarization techniques dramatically

127 This challenge can be overcome by (i) sampling the large sequence space of

128 Treg-/Foxp3-independent, requires IL-10 and is overcome by IL-1beta.

129 posed by interference effects cannot simply be overcome by improved sampling frequencies or sizes.

130 n obtained from DWI data that is unlikely to be overcome by improvements in data acquisition and anal

131 re limits to their precision, which may only be overcome by improving our knowledge of the fossil rec

132 perfect stereochemical complementarity could be overcome by incorporating an appropriate P1 side chai

133 many protein targets, these bottlenecks can be overcome by incorporating electrophiles into small mo

134 prognostic factors in MM, but the latter may be overcome by incorporating novel agents in the HDT/ASC

135 Remarkably, both of these challenges were overcome by incorporation of a single carboxylate m

136 undamental to the mapping process and cannot be overcome by increasing coverage.

137 This suggests that drug resistance could be overcome by increasing hydrogen bond interactions bet

138 n the magnitude of the T cell response could be overcome by increasing the vaccine dose, which was al

139 ssion and in cleavage of tethered substrates was overcome by increasing the stalk length of the NA pr

140 excitotoxicity on the GluN2 CTD subtype can be overcome by inducing high levels of NMDAR activity.

141 d in complex phenotypes and could ultimately be overcome by infection at high multiplicities.

142 We conclude that this resistance can be overcome by inhibiting eIF4E phosphorylation with Mnk

143 ce and suggest that cisplatin resistance can be overcome by inhibition of autophagy in ovarian cancer

144 r failure after extended hepatectomy and can be overcome by inhibition of p21.

145 emotherapeutic treatment of cancer and might be overcome by inhibition of the transporter.

146 27 macro-re-entrant (perimitral) AT that can be overcome by injecting atrioventricular node blockers

147 anol yields during high-solids fermentations are overcome by integrating newly developed cosolvent-en

148 nt in advanced tumors, which are unlikely to be overcome by intervention at a single signaling checkp

149 This can be overcome by introducing a minuscule amount of long fl

150 w that the processing bottleneck of LCEs can be overcome by introducing exchangeable links in place o

151 stability in any binary AuHn at P < 300 GPa was overcome by introducing alkali atoms as reductants.

152 Pol II stalling can be overcome by irradiation involving the epigenetic regu

153 counters many impediments, some of which can be overcome by lesion bypass or replication restart path

154 raints exist, and, even if they do, they may be overcome by long-term natural selection.

155 ersion to baseline is not obligatory and can be overcome by manipulating feedback.

156 cific CD8 T cells in progressors that cannot be overcome by manipulation of inhibitory cell-signaling

157 These problems can be overcome by measurement of FRET in single molecules,

158 on, serving as a mechanical barrier that can be overcome by mechanical force as well as disruption of

159 B signal transduction pathway, and that can be overcome by miR-7 overexpression.

160 centrally located dense permeability barrier is overcome by multivalent interactions, which provide t

161 addition, restriction of PB2 627E polymerase was overcome by mutations specific to the viral RNA temp

162 These effects were overcome by mutations in a C-rich region of the mRN

163 f HCD on the estradiol-induced GnRH/LH surge were overcome by neuron-specific SOCS3 knock-out.

164 are formed the effects of the substitutions are overcome by new quaternary interactions between subu

165 Treg suppression of SFZ70 T(conv) cells can be overcome by nonspecific activation of APCs.

166 This requirement can be overcome by oncogene activation.

167 ioma invasion and that its inhibition cannot be overcome by other motility mechanisms.

168 These shortcomings were overcome by our therapeutic Ad, thus representing a

169 This requirement for MCL-1 can be overcome by overexpression of other antiapoptotic mol

170 ent for SYD and BRM in flower patterning can be overcome by partial loss of polycomb activity in curl

171 ween memory strength and memory lifetime can be overcome by partitioning the memory system into multi

172 d acrosome reaction and that this inhibition is overcome by pharmacological hyperpolarization.

173 that constraints to domain movement in ERK2 are overcome by phosphorylation at pTyr, which increases

174 This may be overcome by placing a gas-permeable membrane over the

175 human leukocyte antigen antibodies (DSA) can be overcome by plasmapheresis-based strategies with some

176 Such social dilemmas can be overcome by positive or negative incentives.

177 Such resistance can be overcome by potent BIM induction and concurrent BCL-X

178 ecific aggregation of AuNPs in urine samples was overcome by pre-treatment of samples with the polyca

179 grown in hypoxic conditions, an effect that is overcome by preinduction of HIF-1alpha.

180 in samples with high salt concentrations can be overcome by preparing samples in this way.

181 uminal cells for virus attachment, which can be overcome by pretreating cells--or virus--with neurami

182 This impairment could be overcome by pretreatment of AMPK-deficient MEFs with

183 re we demonstrate that these limitations can be overcome by protecting the sample with a chemically i

184 caused by the presence of galacturonic acid were overcome by protecting the acid with a group inert

185 This condition-specific inactivation of Pufs is overcome by Puf overexpression, and Puf4p/Puf5p overe

186 on reaction rates and product isolation can be overcome by purging CO(2) from the system.

187 However, this challenge can be overcome by quantum computers.

188 These problems were overcome by reacting protected iodofulvenes with ma

189 t microscopy ( approximately 200-300 nm) has been overcome by recent superresolution (SR) methods inc

190 These limits can be overcome by reconstructing ancient proteins, experime

191 ereas smc6 sensitivity to chronic stress can be overcome by reducing recombination intermediates.

192 This reaction impedance can be overcome by reducing the magnitude of the barrier thr

193 This can be overcome by reducing the particle dimensions.

194 transport CQ suggests that resistance could be overcome by reoptimizing the CQ dosage.

195 reversible growth arrest is induced that can be overcome by reoxygenation.

196 e we show that many of these limitations can be overcome by replacing interferometric optics with a t

197 shown that these physiological barriers may be overcome by, respectively, opening the BBB with MR im

198 tatistical rigor, they can to a large extent be overcome by restricting the analysis to moderate ion

199 , we show that this diffusion limitation can be overcome by reversibly creating and destroying confin

200 periment due to short plasma stability; this was overcome by reversing the amide bond and changing th

201 ion produces behavioral suppression that can be overcome by salient environmental response elicitors,

202 sion produce behavioral impairments that can be overcome by salient response-eliciting environmental

203 The latter was overcome by selection of BCL-2 overexpressing cells

204 This weakness can be overcome by separating the CO(2)-captured product to

205 tions intrinsic to this approach that cannot be overcome by sequencing more species.

206 of studying a rare disease such as JDM have been overcome by several collaborative studies and have

207 m, we conclude that capacity limitations can be overcome by short-term training.

208 This tradeoff could be overcome by simultaneous introduction of separate mut

209 ired lung surfactant mechanics, effects that were overcome by siRNA to beta-TrCP and GSK-3beta or LPC

210 251 to examine how the mucosal immune system is overcome by SIV during acute infection.

211 estriction factor for poxviruses, but it can be overcome by some poxvirus host-range proteins that sh

212 rbic acid but had slight interference, which was overcome by specific ion selective electrode.

213 iciencies in HDR-mediated DNA DSB repair can be overcome by stabilizing RAD51 filament formation in c

214 e redundant; blockade of any one pathway can be overcome by stimulation of another.

215 res of anxiety or motor impairment and could be overcome by strong motivational drive.

216 and not an activation energy issue that can be overcome by stronger reductants/catalysts.

217 acilitating response to imatinib that cannot be overcome by subsequent intensification of therapy.

218 suggests that this is a rare event that can be overcome by subtle structural modifications of an AMP

219 ata demonstrate that this adverse effect can be overcome by supplementing its substrate, GSNO, or by

220 with viral proteolytic priming in ways that are overcome by surplus proteases.

221 Saturation was overcome by switching from ESI to APCI, and our expe

222 lso unclamped release, but this effect could be overcome by synaptotagmin overexpression, arguing aga

223 However, this defect was overcome by T-cell receptor engagement.

224 that some age-associated immune defects may be overcome by targeted activation of APCs by TLR ligand

225 Moreover, this resistance could be overcome by targeting the secondary oncogene in conju

226 These obstacles were overcome by Teoc protection of the beta-amino group

227 effects of primase and rNTPs on processivity are overcome by the extra grip on DNA provided by the la

228 ating a negative iron balance that could not be overcome by the adaptive increase in duodenal iron ab

229 han wild-type plants, and this reduction can be overcome by the application of the synthetic SL GR24.

230 nce to the ERBB1/2 inhibitor lapatinib could be overcome by the B cell CLL/lymphoma-2 (BCL-2) family

231 iated with matrix and processing effects may be overcome by the choice of extraction buffer and detec

232 ndings suggest that cisplatin resistance can be overcome by the combination of cisplatin and the prot

233 ghts into how obstacles to transcription may be overcome by the concerted actions of multiple accesso

234 SypE of SypG-induced biofilm formation could be overcome by the expression of a non-phosphorylatable

235 eceptor without involvement of SMO and could be overcome by the HH-blocking Ab 5E1 or a combination o

236 helix of the POTRA 1 domain (DeltaR44), can be overcome by the insertion of alanine 2 residues upstr

237 Importantly, this could be overcome by the introduction of long-acting injectabl

238 stic hypotheses about how each problem might be overcome by the macromolecules involved.

239 nactivated by CSPGs, and this inhibition can be overcome by the presence of a beta1-binding integrin

240 This problem can be overcome by the present postcalorimetric ICcE procedu

241 )O males have spermatogonial arrest that can be overcome by the re-addition of Eif2s3y from the delet

242 The effort to simplify diagnosis could be overcome by the risk of undiagnosed HBP.

243 IBG imaging has several limitations that can be overcome by the use of a PET agent.

244 pression of plasma estrogen levels and might be overcome by the use of an increased dose of anastrozo

245 itative workflows, (ii) ratio distortion can be overcome by the use of an SPS-MS3 scan, (iii) interfe

246 This issue could be overcome by the use of less basic amino derivatives l

247 These biosafety hurdles could be overcome by the use of recombinant single-cycle infec

248 This limitation has been overcome by the development of sensitive enzyme-lin

249 This dilemma has been overcome by the introduction of unprecedented chemi

250 This is overcome by the acquisition of multiple spacers that

251 eficiency viruses (SIVs), SAMHD1 restriction is overcome by the action of viral accessory protein x (

252 opolymers, where unfavorable Shannon entropy is overcome by the catalytic activities of selected gene

253 This activity is overcome by the induction of expression of Wnt3 by th

254 ion state occurs when this activation strain is overcome by the stabilizing interaction energy.

255 high mortality at the seedling stage, which was overcome by the addition of an exogenous carbon sour

256 th transplant failure of whole grafts, which was overcome by the increased regenerative requirements

257 The metabolic instability of 5 was overcome by the replacement of the 6-dimethylisoxazo

258 Of interest, this loss of priming was overcome by the type II anti-CD20 antibody obinutuzu

259 In the present paper, this problem was overcome by the use of effective energy approximatio

260 Barriers at the ends of each segment were overcome by the build-up of pressure in the dyke en

261 rastuzumab resistance in breast cancer might be overcome by therapeutic strategies that jointly targe

262 , we show that Allee effects can potentially be overcome by transient hybridization with a resident s

263 We show that these limitations cannot be overcome by transplantation into the microenvironment

264 This limitation can be overcome by treating cells with TGF-alpha because TGF

265 This effect can be overcome by treating cells with the clinically approv

266 However, this resistance could be overcome by treatment of Kit(V558;T669I/+) mice with

267 In most cases, this defect can be overcome by treatment with all-trans-retinoic acid (A

268 in gH/gL/UL128-131 but low in gH/gL/gO could be overcome by treatment with the chemical fusogen polye

269 of pluripotency-associated factors that can be overcome by two inhibitors (2i) of the MEK and GSK3 p

270 They can be overcome by understanding the causes and finding the

271 scorbic acid and challenges of chiral purity are overcome by using chiral selective conductive polyme

272 d-effect transistor in which these obstacles are overcome by using two quantum point contacts as spin

273 This limitation can be overcome by using a synthetic system in which Spo0A a

274 These complications can be overcome by using an electrically driven on-demand so

275 A limit in the number of available tags can be overcome by using binary encoding so that a total of

276 Here we show that this problem can be overcome by using buffer gas cooling to produce conti

277 We suggest that this failure can be overcome by using chemically and geometrically accura

278 The lognormal problem can be overcome by using cocktails of 2 or more agents, tail

279 This limitation can be overcome by using cold-ion spectroscopy.

280 erials used, but that these difficulties can be overcome by using different additives.

281 otein expression in live bacterial cells can be overcome by using fluorescent sensors based on Spinac

282 tudy demonstrates that this limitation could be overcome by using Fourier self-deconvolution of infra

283 This can be overcome by using inducible promoters with extremely

284 This problem may be overcome by using oocytes containing healthy mtDNA, t

285 These limitations can be overcome by using optical communications based on chi

286 This problem can be overcome by using Order statistics theory, which, in

287 energy gain presented by laser depletion can be overcome by using staged acceleration, suggesting a w

288 e demonstrate that this speed limitation can be overcome by using the faster actomyosin motor system.

289 Here we show that these limitations can be overcome by using yeast-displayed antigens known to b

290 weak individual protein-carbohydrate binding is overcome by using multivalent interactions.

291 This weakness is overcome by using simple linear models, which give ve

292 In this work, the challenge is overcome by using time-resolved photoemission spectro

293 ydrogenation of the acetylated disaccharides was overcome by using a microfluidic continuous flow rea

294 eta-diketones to act as nucleophilic species was overcome by using their enol form to provide the nec

295 e repressive effect of FOF2 in flowering can be overcome by vernalization.

296 has technical limitations, some of which can be overcome by virtual reality applications.

297 targets the HIV-1 envelope protein Env, but is overcome by Vpr and its interaction with DCAF1.

298 This suppression could be overcome by weak synaptic stimulation in the presence

299 ll function stemming from various etiologies are overcome by Wnt ligands, this mechanism is a potenti

300 sents an effective species barrier that must be overcome by zoonotic viruses.