ライフサイエンスコーパス: be poised to

1 e; with these interactions, the metal center is poised to abstract the C4'-H of an adjacent nucleotid

2 ly and inexpensive technologies, biochemists are poised to accelerate the annotation of biochemical p

3 the residues associated with Mg(II) binding are poised to accept the metal ion.

4 Policymakers are poised to act and 1 proposal entails reorganizing th

5 the N1 position of G33 and N3 position of A1 are poised to act as a general base and acid, respective

6 Aided by divalent cations, P4 is poised to act as a "screw cap" on preQ1 recognition t

7 or of carbon and nucleotide metabolism, AMPK is poised to activate many of the metabolic pathways ind

8 This constellation of residues is poised to activate the substrate by Schiff base forma

9 ule neurons, indicating that endogenous E2F1 is poised to activate transcription of the endogenous cd

10 ances in the past few years and ongoing work is poised to add even more.

11 otocol for data and specimen collection, and are poised to address this critical research need.

12 Apo-LacI appears to be poised to adopt the conformation of either the DNA- o

13 emaining questions where modeling approaches are poised to advance our understanding of complex immun

14 When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon t

15 t the primary role of Mg2+ is to ensure IMAC is poised to allow regulation by small changes in pH in

16 e neuroscience in recent decades, scientists are poised to answer this question.

17 e laboratory back into the field, where they are poised to appreciate the full richness of this remar

18 We must realize that our clinical colleagues are poised to assume the leadership in imaging research

19 ssociated herpesvirus (KSHV) latent episomes are poised to be activated by the KSHV replication and t

20 , evidently, inhibit basal transcription but are poised to be removed quickly upon command.

21 small footprint and large optical bandwidth are poised to be the enabling devices for on-chip optica

22 Dipeptidyl peptidase-IV (DPP-IV) inhibitors are poised to be the next major drug class for the treat

23 syndromes and sporadic cancers, this pathway is poised to be a major driver of the metabolic conversi

24 The Decade of the Spine is poised to be a phase of advancement in the treatment

25 Cdk4 (within the p27/Cdk4/cyclin D complex) is poised to be activated by extrinsic mitogenic signals

26 n excess of 5% and 100 GPa, respectively, GO is poised to be an extremely useful material for micro/n

27 phosphorus (BP), also known as phosphorene, is poised to be the most attractive graphene analogue ow

28 Aptamers, single-stranded DNA/RNA probes, are poised to become a chemist's antibody and have the p

29 Our results suggest that primitive HSCs are poised to become definitive HSCs and that this trans

30 eae, provide the bulk of human nutrition and are poised to become major sources of renewable energy.

31 These new particles are poised to become the 'atoms' and 'molecules' of tomo

32 Axolotls are poised to become the premiere model system for study

33 ons of endogenous ancient DNA, paleogenomics is poised to become a key technology to better understan

34 imaging modalities, the radiology community is poised to become a major force in preclinical and cli

35 xperimental demonstration provided here, PLM is poised to become a powerful technique for revealing t

36 ormation on >400 reactions and compounds, it is poised to become a resource for prediction of microbi

37 E) is an additional ultrasound modality that is poised to become an integral part of the routine echo

38 morbidity and mortality of prematurity, and are poised to benefit from a paradigm shift in the treat

39 te function would be an effective treatment, are poised to benefit greatly from stem cell biology.

40 Neuroscience in particular is poised to benefit from these approaches in light of i

41 ojections also target the striatum, oxytocin is poised to bias the balance of DA tone through multipl

42 The ferroxidase ligands (except His130) are poised to bind iron with minimal conformational chan

43 ntil a suitable host cell is encountered yet be poised to bind receptor, initiate cell entry, navigat

44 E4(4H) is poised to bind and reduce N2 through reductive elimin

45 surface biomarkers in preclinical models and are poised to bring same-day imaging into clinical devel

46 genetic engineering, and cell manufacturing are poised to broaden T-cell-based therapies and foster

47 inactive oligomers and active monomeric BiP is poised to buffer fluctuations in ER unfolded protein

48 In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoat

49 tial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-C

50 This methodology is poised to change how IGH translocations are identifie

51 discovery in molecular and cellular biology is poised to change.

52 cause of cancer death in the world today and is poised to claim approximately 1 billion lives during

53 These high-resolution approaches are poised to contribute new insights into mechanisms fo

54 The zebrafish is poised to contribute greatly to our understanding of

55 In this area, my lab is poised to contribute significantly toward understandi

56 CCR4 is poised to contribute to central tolerance due to its

57 main link the Piezo repeats to the pore, and are poised to control gating allosterically.

58 h a multitude of substrates, gamma-secretase is poised to control neuronal function through a variety

59 esting that only a minority of S. pneumoniae are poised to cross the BBB.

60 vision that online electrochemical reduction is poised to decrease the complexity of sample handling

61 the respiratory tract, alveolar macrophages are poised to defend against hantavirus infection, but t

62 and all the signs are that genetic research is poised to deliver crucial insights into the nature of

63 Only systems in which Cys70 is poised to deprotonate d-Glu were found to be catalyti

64 With this knowledge, we are poised to design the next generation of complex biol

65 se signals arise from functional groups that are poised to detect changes in the extent of channel cl

66 hannels, located at the tops of stereocilia, are poised to detect tension induced by hair bundle defl

67 ular signature of stressed HCM myocytes that are poised to die.

68 nestin-positive progenitor-like cells, which are poised to differentiate into hepatocellular carcinom

69 le retaining certain B-cell signatures, iPCs are poised to differentiate to end-stage PCs although th

70 pability to differentiate into Th1 cells but were poised to differentiate better into induced nTreg c

71 ediates produced from methanol decomposition are poised to directly undergo hydroformylation upon mig

72 These results demonstrate that CTLs are poised to divide in transit and that their numbers c

73 dramatically changed refractive surgery and is poised to do the same for cataract surgery.

74 es BMP-mediated pSmad1/5/8 signalling, which is poised to downregulate Shh.

75 eing transmitted from host to host, but also is poised to eject efficiently and rapidly its double-st

76 mphomas express high levels of TGFbeta, they are poised to elicit an autocrine program of senescence

77 The immune system recognizes and is poised to eliminate cancer but is held in check by in

78 pproaches with emerging molecular tools will be poised to elucidate the functional importance of endo

79 Genome Atlas initiative proposed by the NIH is poised to elucidate the contribution of somatic mutat

80 s become available for many more species, we are poised to emerge from the bottleneck and once again

81 can be eliminated, then biofabrication will be poised to emerge as the standard for nanoscale constr

82 iven their location, these aromatase neurons are poised to engage nociceptive circuits, whether it is

83 m a DNA recognition-competent structure that is poised to engage double-stranded DNA target sequences

84 f local CaM, as if a "school" of nearby CaMs were poised to enhance the transduction of local Ca2+ en

85 enzymatic configuration of beta-cells, which is poised to ensure glucose oxidation and the generation

86 ancer, a paradigm shift in clinical research is poised to ensure that new molecular insights are rapi

87 These new medicines are poised to enter clinical use in 2002.

88 s plays a pivotal role in modern biology and is poised to enter the field of molecular diagnostics.

89 f specifically targeted antiviral inhibitors is poised to enter the market.

90 nd easy-to-use CRDS-based instrumental setup is poised to evolve into a credible challenge to the hig

91 roliferating applications of this technology are poised to exert heavy influence on the very way biol

92 addition, this degree of extensive CDF would be poised to exert large order-of-magnitude effects on s

93 t of [Na(+)]i and [Ca(2+)]i, neuroscientists are poised to expand the understanding of noncanonical r

94 Developmental systems biology is poised to exploit large-scale data from two approache

95 ing these challenges, neurogenetics research is poised to exponentially increase our understanding of

96 rs exist at a developmental stage where they are poised to express Foxp3 without further TCR engageme

97 Thus, in contrast to mDCs, pDCs are poised to express ICOS-L upon maturation, which lead

98 ncreased numbers of Valpha14i NKT cells that are poised to express IL-17, especially in the thymus an

99 HMGN1 binds to Sox9 chromatin in cells that are poised to express Sox9.

100 ging with positron emission tomography (PET) is poised to fill this unmet need through noninvasive pr

101 hen monomers access rogue conformations that are poised to form amyloid fibrils.

102 mplex are formed on the end-blocked DNA that are poised to form the holoenzyme with the polymerase.

103 s-collectively referred to as soft photonics-are poised to form the platform for tunable optical devi

104 om the ground state into a conformation that is poised to form the transition state geometry required

105 cation site, generating a beta radical which is poised to fragment the peptide backbone.

106 ther than cross-sectional studies, the field is poised to fulfill its ultimate role of linking defect

107 This complex appears to be poised to function in heterochromatin assembly later

108 the last species in the five-step mechanism is poised to function as a helicase at the unwinding jun

109 , and absolute myocardial perfusion imaging, are poised to further advance our knowledge.

110 from a structurally unique hinge domain that is poised to further contribute to CjFur's regulatory fu

111 The field is poised to further delineate this paradigm, with the g

112 hat a neuron containing 0.1-0.3 micro M cAMP is poised to give the largest possible depolarization in

113 It is poised to grow in many different ways, including mirr

114 obank represents a new branch on a tree that is poised to grow rapidly and offer new kinds of insight

115 omated technologies and linkage analysis, we are poised to harvest a wealth of information about our

116 s, these sequence-indexed mutant collections are poised to have a larger impact on our understanding

117 linical studies, these emerging technologies are poised to have a major impact on adoptive T-cell the

118 tem cell engineering and mechanotransduction are poised to have substantial implications for stem cel

119 n important generalization of the HMM, which is poised to have a deep impact across the field of biop

120 and other ligands, this family of receptors is poised to have a significant role in complex biologic

121 at which these discoveries are taking place is poised to have significant impact for patient stratif

122 This strategy is poised to help elucidate the role of variants at the

123 y addressing these challenges, iGxE research is poised to help identify the neural mechanisms underly

124 Cardiac pacing is poised to help millions of patients worldwide to live

125 Programmable protein phosphorylation is poised to help reveal the structural and functional i

126 I data on an unfolded cortical surface atlas are poised to improve the integration of information acr

127 The field of congenital heart surgery is poised to incorporate new innovations such as bioengi

128 Future rates depend on many factors and are poised to increase.

129 peratures go up, the use of air conditioning is poised to increase dramatically.

130 fitness remains challenging, clinal genomics is poised to increase our understanding of local adaptat

131 e conformation of the 4-carboxamide of AICAR is poised to increase the nucleophilicity of the C5 amin

132 ulation into a heterogeneous population that is poised to infect the mammalian host.

133 ode ongoing synaptic competition and, hence, are poised to influence its outcome.

134 These properties suggest that mast cells are poised to influence neural systems underlying behavi

135 er to regulate sphingolipid biosynthesis and is poised to influence cell fate.

136 that the timing of the victorin-induced MPT is poised to influence the cell death response.

137 e regulators of the cell cycle and therefore is poised to influence the fate of a cell at the crossro

138 Thus, O-GlcNAcylation is poised to influence trans-generational epigenetic inh

139 We find that multiple UbiB-specific features are poised to inhibit protein kinase activity, including

140 Prior to S phase, multiple origins are poised to initiate replication by recruitment of the

141 , colitogenic memory CD4+ T cell subset that is poised to initiate inflammation when there is loss of

142 The insights presented herein are poised to inspire the design of other catalyst-contr

143 Golgi cells are poised to integrate multimodal influences by partici

144 With these tools, we are poised to integrate structural information gathered

145 e pocket of thrombin, but all other residues are poised to interact with thrombomodulin (TM).

146 and it suggests that the ATP lid of CheA may be poised to interact with receptors and coupling protei

147 The complex is poised to interact with H(+) from E126 (and H124) in

148 igand heavy atom rms deviation = 0.90 A) and is poised to interact with NADPH.

149 bacterial interaction with fibronectin, RevA is poised to interact with the extracellular matrix of t

150 um of PLN conformers toward a structure that is poised to interact with the regulatory target.

151 nformations indicated that MMP-1 in solution was poised to interact with collagen and then could read

152 ntred on a hypothesis that these crabs might be poised to invade the Antarctic shelf if the recent wa

153 these features, the cyclopropenone ligation is poised to join the ranks of chemistries with utility

154 w technologies, the adult neurogenesis field is poised to leap forward in the next decade.

155 ting that the RNA-maturation protein complex is poised to leave the capsid as the first step of the i

156 The National Institutes of Health (NIH) is poised to lift its funding moratorium on research inv

157 bile nucleic acid restriction mechanism that is poised to limit internal as well as external assaults

158 nded RNA and suggests that this conformation is poised to load onto mRNA.

159 cells reside in tissues where they appear to be poised to locally regulate tissue function.

160 SPR biosensors are poised to make a significant impact in basic researc

161 materials developed and studied in this area are poised to make a substantial impact in real-world ap

162 3 (Asp(25)-Glu(334)-Lys(326)-Lys(328)) that are poised to make electrostatic interactions with the r

163 ve unusual profiles of transcribed genes and are poised to make rapid changes in those profiles upon

164 Synthetic biology and nanotechnology are poised to make revolutionary contributions to the 21

165 es are essential, the attributes of FTICR-MS are poised to make significant contributions.

166 nd theoretical resources currently available are poised to make the dream of reaction control a reali

167 from the pharmaceutical industry, the field is poised to make a breakthrough.

168 Integrated whole-cell modeling is poised to make a dramatic impact on molecular and sys

169 As the genome resources develop, the cat is poised to make a major contribution to many areas in

170 ce as a valuable tool in drug discovery, and is poised to make a major impact on the design of enzyme

171 tactic to study bacterial epigenetics, which is poised to make novel and far-reaching discoveries tha

172 figuration of the loop suggests that 7SK-SL4 is poised to make ternary contacts with P-TEFb and HEXIM

173 ustrative of the unique contribution SiMPull is poised to make to in planta protein interaction studi

174 nance and recall of T-cell memory, the field is poised to make tremendous progress.

175 Even though the brain is poised to mediate the effects of GLP1 analogs, it rem

176 cs analysis reveals that B. phytofirmans PRF is poised to metabolize thiosulfate to sulfite in a sulf

177 elp explain how a strong pOFC pathway, which is poised to moderate activity of CeM, through IM, can b

178 These findings indicate that kappaORs are poised to modulate LC activity by their localization

179 tonic arrangements and synaptic connectivity are poised to modulate olfactory processing in humans.

180 are positioned at the apical pole where they are poised to monitor the sensitive balance of the lumen

181 the macrophages of the islets of Langerhans are poised to mount an immune response even at steady st

182 a site of intense immune cell activity that is poised to mount an effective response against a patho

183 ent of high-throughput platforms, genotyping is poised to move into the mainstream, revolutionizing t

184 ychology, animal learning, and ethology, and is poised to move toward greater understanding of animal

185 ng of chemical bonds in polyatomic molecules is poised to open new pathways for the laser-driven synt

186 organic crystalline surfaces - research that is poised to open this new frontier in understanding and

187 Computational models are poised to play a key role in addressing these challe

188 Inclusion body refolding processes are poised to play a major role in the production of rec

189 Thus, mGluRs are poised to play a pivotal role in providing a direct

190 The ubiquitin-proteasomal pathway (UPP) is poised to play a central role in the processing of da

191 x metalloproteinase (MMP) 13 (collagenase 3) is poised to play a crucial role in bone formation and r

192 cross a broad range of scientific fields and is poised to play a pivotal role in the latest therapeut

193 levels of MHC class II, suggesting that they are poised to present self-antigens efficiently.

194 ether, these results indicate that kappa-ORs are poised to presynaptically inhibit diverse afferent s

195 nonlinear and hyper-resolution microscopies are poised to profoundly transform many fields of biolog

196 of synaptic modulation and show that Munc13 is poised to profoundly impact information transfer at n

197 ust shape changes, but if they go awry, they are poised to promote disease states such as cancer cell

198 eliminate pathogens, and memory cells, which are poised to protect against reinfection.

199 including array-based expression profiling, are poised to provide additional insights into this grou

200 oduced by common microfabrication techniques are poised to provide integration of power sources onto

201 Such large-scale gene-finding exercises are poised to provide many useful leads for discovering

202 eatine kinase is bound to PAR-1 where it may be poised to provide bursts of site-specific high-energy

203 tography-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules under

204 y advances in electron optics and detectors--is poised to radically transform our understanding of th

205 Immune memory cells are poised to rapidly expand and elaborate effector func

206 , whereas for alpha-synuclein, the oligomers are poised to rapidly form fibers.

207 hat a greater fraction of cross-bridges will be poised to rapidly produce a force-generating transiti

208 that exposes its ligand-binding site, but it is poised to rapidly assemble into intracellular signal-

209 this study suggests that the reuptake system is poised to rapidly increase its function during dopami

210 us effector lineage after antigen clearance, being poised to reacquire their lineage-specific effecto

211 of development, physiological cardiac models are poised to realise the promise of translational resea

212 , ensuring that the core apoptotic machinery is poised to receive input from a wide range of cellular

213 t counteract numerous cellular defenses that are poised to recognize viruses as nonself and to activa

214 d with dendrites of calbindin neurons, which are poised to reduce noise and enhance signal.

215 A new generation of technologies is poised to reduce DNA sequencing costs by several orde

216 embly of a type of mRNP within P-bodies that is poised to reenter translation.

217 Thus, PI3K activity is poised to regulate both ACA activation and adaptation

218 se studies demonstrate that mossy fiber BDNF is poised to regulate both direct excitatory and indirec

219 mation or nerve injury, neuropeptide Y (NPY) is poised to regulate the transmission of sensory signal

220 These data indicate that Merkel cells are poised to release glutamate and neuropeptides.

221 ed droplet microfluidic screening processors are poised to replace robotic automation by miniaturizin

222 Overall, the new oral anticoagulants are poised to replace vitamin K antagonists for many pat

223 gatran, rivaroxaban, apixaban, and edoxaban, are poised to replace warfarin for treatment of the majo

224 re also addressed, as technological advances are poised to reshape resident education.

225 croscopy techniques, such as PALM and STORM, are poised to resolve, with unprecedented clarity, the o

226 The United Network for Organ Sharing is poised to resolve geographic disparity in liver trans

227 broadly evaluate whether non-native species are poised to respond more positively than native specie

228 lls circulate through lymph nodes where they are poised to respond rapidly upon re-exposure to a path

229 atio motors operating at intermediate speeds are poised to respond sharply to changes in mechanical c

230 We find that animal cells are poised to respond to both increases and decreases in

231 ythroid progenitors, resident in the spleen, are poised to respond to changes in the microenvironment

232 loci may be arranged in nuclear domains that are poised to respond to diverse signals in general and

233 totoxic, and regulatory T cell subsets, that are poised to respond to environmental antigens.

234 s (ILC), a diverse class of lymphocytes that are poised to respond to environmental insults including

235 sults indicate that prospective neural cells are poised to respond to Smad2 and Smad1 signals to adop

236 s with unperturbed forks, implying that they are poised to respond to stalling and collapse.

237 These polymerases are poised to respond to the positive transcription elon

238 In summary, hepatic ILC2s are poised to respond to the release of IL-33 upon liver

239 sures a larger signal change (more molecules are poised to respond), it also reduces affinity (bindin

240 esting that specific groups of organisms may be poised to respond to the wet-up event, in that they p

241 This indicates that the cell is poised to respond maximally to changes in resting pot

242 We demonstrate that the MHB region is poised to respond to calcium transients that occur in

243 must include a T-lymphocyte population that is poised to respond to foreign antigenic peptides prese

244 d negatively and suggest that the RPP5 locus is poised to respond to pathogens that disturb RNA silen

245 ical structures below the diffraction limit--are poised to reveal in quantitative detail the stoichio

246 ISPR/Cas9 is a game-changing technology that is poised to revolutionise basic research and plant bree

247 hnologies for rapid microbial identification are poised to revolutionize clinical microbiology and en

248 the tremendous advances in cardiac modelling are poised to revolutionize medical treatment and preven

249 They are poised to revolutionize optics by enabling complex l

250 tial, induced pluripotent stem cells (iPSCs) are poised to revolutionize stem cell biology and regene

251 assessing global transcript levels, RNA-seq is poised to revolutionize our understanding of transcri

252 field of Functional Genomics and Proteomics is poised to revolutionize the way scientists identify a

253 to the exploitation of conventional oil and are poised to rise in significance along with the exploi

254 This suggests that many cells are poised to secrete IL-10 and will do so if they recei

255 ls that express CD80 in their resting state, are poised to secrete particularly large amounts of clas

256 They are also shown to be poised to secrete high levels of immunoglobulins in r

257 mation, revealing that tissue-resident cells are poised to sense and respond to alterations in microb

258 bbs-1 acts in 15 ciliated neurons that are poised to sense external and internal nutrient level

259 Astrocytes are poised to sense glutamatergic synaptic activity over

260 is characteristic of a motile filament that is poised to sense and respond to the environment.

261 nveil a transcriptional response system that is poised to sense dietary cues and metabolic imbalances

262 The resulting bifunctional molecules are poised to serve as modular building blocks for more

263 N termini of helices for enhancing function) are poised to serve roles in substrate recognition, MIO

264 These studies suggest that Cdc45p is poised to serve as a key regulatory target for both t

265 This property is poised to serve in diagnostic and therapeutic applica

266 The VA is poised to share and extend best practices to other he

267 Three independent lines of research are poised to shed light on the molecular basis of this

268 vere droughts associated with climate change are poised to significantly alter flow intermittence pat

269 enhancement strategies, transdermal delivery is poised to significantly increase its impact on medici

270 ve placed the field in the position where it is poised to significantly reduce the burden of nervous

271 te that catecholaminergic neurons in the NTS are poised to simultaneously coordinate activities in li

272 ne, at the H4B site indicates that this site is poised to stabilize a positively charged pterin ring

273 This structure shows that Mn1 is poised to stabilize the pentavalent transition state

274 n normal), indicating that the Schwann cells are poised to start myelination.

275 he field of experimental genetics in rodents is poised to study discrete epilepsy mutations on a dive

276 Single-cell microfluidic devices are poised to substantially impact the hematology field

277 Use of the technology is poised to substantially advance integrated control of

278 eneral and a molecular machine in particular are poised to support protein-based heredity in the bact

279 cular recognition of polyamides with DNA, we are poised to systematically edit the structure of JH-37

280 nge in biology that computational approaches are poised to tackle.

281 ts and maternal-child health researchers who were poised to tackle this new public health challenge;

282 studies in the animal kingdom, plant studies are poised to take a lead role in this area because of t

283 function and indicate that the intermediates are poised to traffic to sites of inflammation and targe

284 This subpopulation is poised to transcribe plasticity markers, OCT3/4, SOX2

285 udying bacteria and other microorganisms and are poised to transform microbiology.

286 )-Cas9 (CRISPR-associated nuclease 9) system is poised to transform developmental biology by providin

287 Microbial whole-genome sequencing (WGS) is poised to transform many of the currently used approa

288 , and the emergence of personalized medicine is poised to transform pharmaceutical development and cl

289 Nanotechnology is poised to transform research, prevention, and treatme

290 tational analysis provided by these examples is poised to translate the rapidly growing structural da

291 drogen bond donor catalyzed cascade reaction are poised to undergo a McMurry coupling to form previou

292 ot CD40, CD80, or CD86, suggesting that they are poised to undergo deletion rather than activation up

293 uted unsaturated morpholine derivatives that are poised to undergo further functionalization for the

294 dition to hydrolysis, the hydrazone products are poised to undergo numerous different known synthetic

295 s TIPCARM, leads to a spiropyrrolidine which is poised to undergo a second retro-Mannich fragmentatio

296 ant) that is free of inhibitor or ligand and is poised to undergo autoproteolysis.

297 erminal carboxylate of the protein, where it is poised to undergo the required deprotonation to an am

298 h these structures in hand, researchers will be poised to use cryo-electron tomography to view protei

299 f polymeric capsules, the developed strategy is poised to usher the development of the next generatio

300 Such studies are poised to yield a detailed picture of the coupling o