ライフサイエンスコーパス: be positioned to

1 y suggest that in normal cell division, FtsZ is positioned to a single nucleation site on the inner m

2 erminal domain, conserved in all "enolases", is positioned to abstract the 1-proS proton.

3 xchange even though E164, the glutamate that is positioned to abstract the alpha-proton, is intact in

4 Second, the conserved residue, D22, is positioned to accept a hydrogen bond from the C2-OH g

5 The pyridyl moiety was positioned to accept a hydrogen bond from Asn297, an

6 Glu-234 and Tyr-294 are positioned to act as a general base and general acid

7 We show that these complementarities are positioned to act as intron identity elements, bring

8 n this conformation, the amphipathic helices are positioned to act as molecular wedges that induce me

9 ive site to increase the residue's basicity) is positioned to act as a general base, abstracting the

10 Tyrosine 126 is positioned to act as the general acid that donates a

11 Lysine 199 is positioned to act as the general base that accepts a

12 alized at the nuclear pore complexes, hGle1p is positioned to act at a terminal step in the export of

13 ed structural data predicted that serine 229 was positioned to act as a proton donor to the developin

14 His278 and Asp280, which are positioned to activate the water nucleophile in the

15 its pre-cleaved state, showing that cytidine is positioned to activate the 2'-OH nucleophile in the p

16 The side chain of Asp-273 is positioned to activate the hydrolytic water molecule

17 MST in which an Asp-His-Ser catalytic triad is positioned to activate the nucleophilic cysteine resi

18 ed through an initiative, and each crop will be positioned to advance with cost-effective parallels,

19 of the mutations that cause motor disorders are positioned to affect enzyme activity directly, the r

20 tergic pathway from layer VI, whereas mGluR5 is positioned to affect retinogeniculate activation of r

21 o-terminal and carboxy-terminal domains that are positioned to allosterically modulate cytoplasmic Ca

22 Both the D297G and I19F substitutions are positioned to alter the substrate specificity so tha

23 which are depleted of TFIID, a +1 nucleosome was positioned to be in competition with the PIC, which

24 technologies, whole-genome sequencing (WGS) is positioned to become an essential tool in the control

25 Furthermore, the ATPase Prp16 is positioned to bind and translocate the intron downstr

26 ydrophobic pocket in the active site chamber is positioned to bind long acyl chains, as suggested by

27 the melted template DNA in the open complex is positioned to bind the +2 NTP.

28 the water molecule in-line with the P-O bond is positioned to bring about the change in bond angle.

29 (Glu-343), located at the subunit interface, is positioned to catalyze a nucleophilic attack on the g

30 pore through the S4-S5 linker helices, which are positioned to constrict or dilate the S6 inner helic

31 amide nitrogen of glutamine in the GGQ motif is positioned to contribute directly to catalysis of pep

32 niversally conserved GGQ motif of the factor is positioned to contribute directly to peptidyl-tRNA hy

33 Q230 of the universally conserved GGQ motif is positioned to contribute directly to the catalysis of

34 ansiently in early postnatal hippocampus and is positioned to contribute to the establishment of hipp

35 ion on cholangiocyte secretion suggest EBP50 is positioned to contribute to the organization and regu

36 roperties and the matrin-3-lamin A interface is positioned to contribute to these defects.

37 The microenvironment of the medullary cords is positioned to control these key processes.

38 This pathway is positioned to control tumor metabolism and promote tu

39 At the same time, these circuits are positioned to convey signals from pathologic events

40 Thus, Barrington's nucleus is positioned to coordinate brain noradrenergic activity

41 These developing axonemes were positioned to coordinate trafficking into the furro

42 different trains of radioactive 192Ir seeds was positioned to cover the treated site, and a dose of

43 ifferent trains of radioactive (192)Ir seeds was positioned to cover the treated site, and a dose of

44 The resident peroxisomal protease LON2 is positioned to degrade obsolete or damaged peroxisomal

45 An active site glutamate (Glubeta(117)) is positioned to deprotonate bound acyl-CoA and initiate

46 We show that these cells are positioned to detect external settlement cues and hy

47 Ser-107 is positioned to donate a hydrogen bond to the leaving g

48 dimer surface; and illustrating that His-98 is positioned to donate a hydrogen bond to the scissile

49 ional structures reveal how C1s polypeptides are positioned to enable activation by C1r and interacti

50 heir entry into the islets so they could not be positioned to engage, kill, and thus remove insulin-p

51 tion of an Asn residue from each strand that is positioned to engage in a buried polar interaction.

52 eurons form synaptic contacts that appear to be positioned to exert inhibitory control near sites of

53 The ventral midline thalamus is positioned to exert significant control over fairly w

54 The large PEG loops are positioned to extend out of the peptide binding site

55 is 212, at the end of the third beta-strand, are positioned to facilitate both syn-dehydration and ke

56 and four low-spin, bis-his coordinated hemes are positioned to facilitate intra- and intermolecular e

57 two tyrosine residues, Tyr-108 and Tyr-503, are positioned to facilitate this deprotonation.

58 nclude that E106 residues in wild-type ORAI1 are positioned to form a Ca(2+) binding site in the chan

59 , the two cysteine residues in the extension are positioned to form an interdomain disulfide cross-li

60 sor protein, the side chains of H74 and D278 are positioned to form an ion pair between monomers that

61 buted by both subunits of the dimeric enzyme are positioned to form hydrogen bonds with the 2'- and 3

62 Within the active site of Fms1, His67 is positioned to form hydrogen bonds with the polyamine

63 ne inhibitors, and the terminal 5'-phosphate is positioned to form medium-range Coulombic interaction

64 ng specificity is provided by Asp-196, which is positioned to form two hydrogen bonds to the guanine

65 The FAPY formyl group was positioned to form a hydrogen bond with A6 N6Ha.

66 determined here indicates that Arg93 in NucA is positioned to fulfill this role.

67 Lys(133) and Lys(235) are positioned to function as acid/base catalysts in the

68 Pro-1 is positioned to function as a catalytic base.

69 Glu370 is positioned to function as the catalytic base, and pre

70 These data indicate that TGF alpha and EGF-R are positioned to have a role in the genesis, differenti

71 es may coexist in common axon terminals that are positioned to have an impact on the LC.

72 Although the human population was positioned to have strong effects, arrival and prese

73 cent to the target base, and a conserved Arg is positioned to help flip the target base out of the st

74 His-143 is positioned to help polarize the carbonyl group of the

75 Each gene pair was positioned to homeologous regions of the genome usin

76 Active site residue Asn(297) is positioned to hydrogen bond with an adventitious liga

77 88 imidazole still stacked with the heme and was positioned to hydrogen bond with the heme thiolate.

78 Mechanistically, 5-HT2CRs are positioned to influence both homeostatic feeding cir

79 es of cortical pyramidal neurons, where they are positioned to influence both synaptic and dendritic

80 We propose that cortical nNOS neurons are positioned to influence neuronal activity across wid

81 CRF-enriched CEA-DA projections are positioned to influence outputs to the 'limbic-assoc

82 inputs to the midbrain dopamine (DA) system are positioned to influence striatal functions through m

83 y contact the substrate during catalysis but are positioned to influence the packing of substrate bin

84 )-5 and IL-13, group 2 innate lymphoid cells are positioned to initiate and maintain homeostatic type

85 Arg 147 at the end of the second beta-strand are positioned to initiate the reaction by abstraction o

86 have been identified in which His159-ImH(+) is positioned to initiate a general acid-catalyzed addit

87 e formation of macromolecular scaffolds that are positioned to integrate biochemical processes in cel

88 in the pathophysiology of schizophrenia, and is positioned to integrate information from limbic and c

89 of basic residues lining the nuclease groove are positioned to interact with DNA in the tensed state

90 r surface of the plasma membrane, where they are positioned to interact with membrane-spanning recept

91 Second-sphere active-site residues that are positioned to interact with the HPCA and/or bound O2

92 rim of the channel entrance that appears to be positioned to interact with the distal primary amine

93 The re face of E4P can be positioned to interact with the si face of PEP with o

94 Lys-39 which is positioned to interact electrostatically with the alp

95 a-hairpin structure when the phosphate group is positioned to interact with a tryptophan residue on t

96 The 50-20K loop is positioned to interact with actin, while the 25-50K l

97 ndothelial and smooth muscle cells, where it is positioned to interact with adiponectin.

98 l prediction that the carboxyl-leaving group is positioned to interact with Phe-397.

99 The 'ratchet helix' is positioned to interact with RNA substrates as they mo

100 hereas the carboxylate side chain of Glu 211 is positioned to interact with the 3-OH of 2-PGA.

101 Tyr212 is positioned to interact with the aldehyde group of the

102 NMR analysis reveals that Asn64 in Ht Q64N is positioned to interact with the axial Met61, whereas

103 urface of helix E within the helicase domain is positioned to interact with the primase domain and th

104 loop (BG3) and Asp-500 in the EF loop (EF1) are positioned to interfere with the binding of the P+3

105 The N-terminal helix of OTUB1 is positioned to interfere with UEV1A binding to UBC13,

106 Catheters were positioned to intracardiac targets by use of an MRI

107 The camera was positioned to look down into a 10-cm-deep water bath

108 ealth information providers, and parents may be positioned to make the largest impact.

109 AFF4 is positioned to make unexpected direct contacts with HI

110 The large V1/V2 loops, previously unmapped, are positioned to mask the coreceptor binding site in an

111 lls are a syncytium in which the many nuclei are positioned to maximize the distance between adjacent

112 .6 demonstrated that FKBP12.6-tagged sensors are positioned to measure local [Ca(2+)]Cleft in adult r

113 gh each endotracheal tube such that it could be positioned to measure pressures proximal and distal t

114 periosteum through the calvarial sutures may be positioned to mediate migraine headache triggered by

115 hibit appetite in response to metabolic cues is positioned to mediate the suppression of food intake

116 n contrast, delta-opioid receptors appear to be positioned to modulate the activity of GABAergic neur

117 racrine factors secreted into the cyst would be positioned to modulate the rate of hepatic cyst growt

118 These findings suggest that presynaptic TrkB is positioned to modulate estradiol-mediated and BDNF-de

119 N-lobe of cardiac troponin C (cTnC) and thus is positioned to modulate myofilament Ca2+-sensitivity.

120 wild-type and CaBP4(-/-) mice and therefore is positioned to modulate native Ca(v)1.3 channels.

121 ATP-driven domain motion is positioned to move double-stranded DNA through the he

122 y 3.1 A away from the heme iron, where Phe14 is positioned to occlude binding of NO as a 6th (distal)

123 e radioactive gas-filled balloon (3.5/45 mm) was positioned to overlap the injured segment with margi

124 nt adhesion site (MIDAS) in the betaA domain is positioned to participate in a ligand-binding interfa

125 mmalian wounds, stromal stem cells appear to be positioned to perform functions similar to those of b

126 His287 is not a Type 2 ligand but is positioned to perturb an axial water or a nitrite of

127 m origins of glutamatergic input to PVH that are positioned to play a role in transducing a diverse r

128 eriod for cortical plasticity, and that they are positioned to play an important role in experience-d

129 o the transcriptional landscape of cells and are positioned to play significant roles in cellular dif

130 These results also suggest that Ucn III is positioned to play a role in mediating physiological

131 Cytoplasmic MCD is positioned to play a role in the regulation of cytopl

132 The guanidinium of the invariant Arg-170 is positioned to potentially interact with a bound acylp

133 CDR1beta D30, CDR2beta N51, and CDR3beta Q97 were positioned to potentially participate in hydrogen b

134 Thus, chandelier cells are positioned to powerfully regulate the excitatory out

135 lucidate whether cannabinoid (CB1) receptors are positioned to presynaptically modulate norepinephrin

136 findings indicate that the GABA(B) receptor is positioned to presynaptically modulate afferent trans

137 These late-binding AFs are positioned to prevent each step in the translation i

138 ch case, the 3' OH created on the cut strand is positioned to prime DNA synthesis towards the intron,

139 tes that the residues of the catalytic triad are positioned to promote each step of both the forward

140 on possibly serving as metal ligands, Lys-39 is positioned to promote departure of the NMP leaving gr

141 Retail clinics are positioned to provide immunizations and care for sim

142 The side chains of Lys 269 and Arg 119 are positioned to provide leaving-group activation in th

143 ucts since the nucleophile (Asp333-CO(2)(-)) is positioned to react with either carbon center in the

144 Therefore, these neurons were positioned to receive both visual and auditory info

145 he catalytic triad, another arginine residue is positioned to recognize the substrate beta-sulfate gr

146 these results show that lamina I pacemakers are positioned to regulate both the level of activity in

147 Neural circuits that are positioned to regulate rat distal colon function wer

148 onjecture that penetrating arterioles, which are positioned to regulate the delivery of blood, are lo

149 ablishes a local negative feedback loop that is positioned to regulate inner hair cell excitability a

150 c factor (BDNF) in the CNS, yet whether BDNF is positioned to regulate the excitatory and/or inhibito

151 These cells are positioned to relay ejaculation-related signals from

152 I, that changes conformation on GTP binding, are positioned to relay the receptor-initiated signal ac

153 t to the LGN and pulvinar nucleus appears to be positioned to selectively influence the response of t

154 The epsilon-amino group of Lys 345 is positioned to serve as the base in the forward reacti

155 A fourth cysteine was positioned to serve as the bridging ligand between t

156 TOP2B is positioned to solve topological problems at diverse c

157 The third metal is positioned to stabilise the negative charge of the 5'

158 omplex with manganese suggests how the metal is positioned to stabilise the transition state.

159 across the beta- and gammaherpesviruses and is positioned to stabilize a putative syntaxin-like bund

160 The finding that APE1 residues are positioned to substitute for Nfo metal ions is suppo

161 binuclear metal center, and the indole ring is positioned to suggest that it could provide a hydroph

162 cy, the laboratory, and information services are positioned to support the complexities of ICU care.

163 minant in the preoptic area-hypothalamus and is positioned to support maternal behavior since this fo

164 Such 'wet programming' is positioned to transform a wide and diverse swathe of

165 proteins in the developing olfactory system are positioned to underlie the formation of the odorant

166 searchers-there are important audiences that are positioned to use neuroscience findings to affect po