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1 hibition binding affinity constant, 1.73 nM) was prepared in 1 step in a radiochemical yield of 14% +
2 isoquinoline alkaloid, (18) F-aspergillitine is prepared in 10 % isolated radiochemical yield from th
5 id (-)-hymenosetin and its N-methyl analogue were prepared in 11 and 8 steps, respectively, from (+)-
6 tities of the target drug candidates 1 and 2 were prepared, in 12 linear steps with 25% isolated yiel
9 14-membered macrolide 6-deoxyerythronolide B is prepared in 14 steps (longest linear sequence) and 20
11 us, the all-cis 1,5,9-triene natural product was prepared in 15 steps from commercially available sta
12 co-polyethylene glycol diacrylate) monoliths were prepared in 150 microm i.d. capillaries using novel
13 C17-benzene ansamycins trienomycins A and F were prepared in 16 steps (longest linear sequence, LLS)
14 ring bryostatin analogue, macrodiolide WN-1, was prepared in 17 steps (longest linear sequence) and 3
16 as in 2008, when 1,4-dimethoxypillar[5]arene was prepared in 22% yield, and subsequent improvements i
17 ld over 11 synthetic steps and hapalindole U was prepared in 25% overall yield over 13 synthetic step
19 Triethoxysilyl-substituted 1,3-butadiene has been prepared in 30-g quantities from chloroprene via a
21 Results: The target compound 4-(11)C-MBZA was prepared in 46% +/- 7% radiochemical yields by react
24 sphino)phenyl)morpholine (p-Mor-DalPhos, L2) was prepared in 63% yield and was crystallographically c
25 chiometric amount of template, ExBox(4+) can be prepared in 66% yield (following crystallization) usi
26 (III) siloxide [K(18c6)][U(OSi(O(t)Bu)3)4] 2 was prepared in 69% yield by reduction of [U(OSi(O(t)Bu)
27 he polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantiosele
30 carbons and one oxygen of the final product was prepared in 98.6% ee and 39% yield from cyclohexan-1
31 Spheres-on-sphere (SOS) silica particles are prepared in a one-pot scalable synthesis from mercap
35 , and the iridium-based photocatalyst 1a can be prepared in a 56% overall yield ( approximately 4.4 g
37 etermining the number of dosage units (k) to be prepared in a composite sample of which there may be
39 P*, linear aldehydes with beta-chirality can be prepared in a highly enantioselective fashion with go
42 ass of neutral, monofluoroboronates that can be prepared in a one step, gram-scale fashion from readi
44 finity purified IgG glycoprotein samples can be prepared in a single run with a liquid handling platf
45 and a variety of substituted aryl groups can be prepared in a single step from a simple mixture of am
46 Cyclopropyl malonoyl peroxide (1), which can be prepared in a single step from the commercially avail
47 elevant to neuroscience drug development can be prepared in a stereochemically comprehensive manner.
48 lactones obtained from marine sources, have been prepared in a concise and stereocontrolled manner f
49 es of anilines of industrial importance have been prepared in a continuous regime using this protocol
50 le alkaloids, 1, 2, and 3 respectively, have been prepared in a convergent manner by two related rout
51 enclosed by 24 high-index {720} facets, have been prepared in a monodisperse fashion by a modified se
52 y substituted pyrazolo[3,4-b]pyridines 4 has been prepared in a regioselective manner by the microwav
53 ne-substituted gamma- and delta-lactams have been prepared in a single step with high diastereoselect
57 re, we describe a method in which the sample is prepared in a buffer at a lower concentration than th
58 compound is soluble in nonaqueous solvents, is prepared in a single synthetic step, has a low equiva
63 ',4'-difluoroarabinouridine (2,'4'-diF-araU) was prepared in a stereoselective way in six steps from
66 ric 2,5-diazabicyclo[2.2.2]octanes 14 and 15 were prepared in a chiral-pool synthesis starting from (
68 -Azabicyclo[3.1.0]hex-2-en-1-yl phosphonates were prepared in a five-step reaction route from beta-ke
69 ith a fragment of the bacterial 30S ribosome were prepared in a fully automated fashion and binding r
73 methylsilyl)dicyclopenta[de,mn]tetracene (4) were prepared in a one-pot, palladium-catalyzed cross-co
77 nds with a quaternary center (at C-2 or C-5) were prepared in a stereoselective fashion by engineered
80 cid (3-MPA) capped lead sulfide quantum dots were prepared in a variety of organic solvents stabilize
84 lternative for cellular therapy, as they can be prepared in advance, screened for pathogens and activ
90 ly tunable chiral Clickphine P,N-ligands has been prepared in an enantioselective fashion by Cu(I)-ca
92 mples of various natural colouring solutions were prepared in aqueous model matrices at a range of pH
99 4-benzenedicarboxylic acid (bdc) linkers can be prepared in both interpenetrated and noninterpenetrat
100 ndrical cavities (4-mm diameter, 2-mm depth) were prepared in bovine incisors and restored using Bond
104 tetrasubstituted N-confused porphyrins (1-3) were prepared in ca. 3-5% yields using a [2 + 2] synthes
105 icative components from four unique species, were prepared in ca. 70% isolated yields and fully chara
106 ate-co-ethylene dimethacrylate) columns have been prepared in capillaries ranging in inner diameter f
107 ese interactions, a set of model DNA hybrids was prepared in conformations that ranged from end-tethe
108 of 1alpha,25-dihydroxy-19-norvitamin D have been prepared in convergent syntheses using the Wittig-H
109 eactions involving multiple reactants cannot be prepared in current microfluidic mixer designs, nor i
110 , unlike past methods, allows the protein to be prepared in defined conditions, free of excess deterg
111 (4-dihydroxymethylsilyl)butyl side chain has been prepared in enantiomerically pure form as a potenti
113 zabicyclo[2.2.1]heptane-2-carboxylic acid 11 was prepared in enantiopure form, and its catalytic pote
114 s dramatically expand the materials that can be prepared in epitaxial heterostructures with precise i
115 f zeolite nanosheets (3 nm thick MFI layers) were prepared in ethanol following acid treatment, which
118 ated ynamides, a new type of building block, were prepared in excellent yields for the first time.
120 the gamma-secretase inhibitor LY411575, can be prepared in five steps from 2-bromophenylboronic acid
121 e, pentafluoroferrocene [Fe(C5F5)(C5H5)] can be prepared in five steps via a one-pot lithiation-elect
123 unds 12a-g and the (S)-prolinate analogue 13 were prepared in five steps from 2-nitrobenzoic acid (7)
124 H-imidazo[4,5-b]quinoline-9-carbonitriles 15 are prepared in four steps from N'-arylbenzamidines 11 a
128 this case, an electron-rich aryl bromide 18 was prepared in four steps and subjected to palladium-ca
129 on of enantiopure 4-piperidone (-)-11, which was prepared in four steps from alpha-amino nitrile 6 th
133 The synthetically versatile Michael adducts are prepared in good yields, with high levels of diaster
134 structurally diverse N-aryl heterocycles can be prepared in good to excellent yields under conditions
138 eries of 2-iminoimidazolin-4-ones could also be prepared in good yields from the reaction of aryl iso
140 ylic, aryl, and heteroaryl substituents have been prepared in good to excellent yields (up to 99%).
141 of new (E) and (Z)-benzoyl-homoquinones have been prepared in good yield by the parent quinone-electr
142 ings threaded by a two-binding-site axis has been prepared in good yield from relatively simple organ
144 ad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF3 CO2 K
145 aborated tetracyclic core of rhodexin A, 23, was prepared in good yield and excellent selectivity usi
147 opure C,N-palladacycles (PIN-acac complexes) were prepared in good overall yield in three steps from
148 The desired 3-amino-1,2,4-triazoles (1) were prepared in good overall yield via two convergent r
150 amino acids bearing hydrophobic side chains were prepared in good to excellent yield by treating N-a
151 henoxazin-3-one substrates 23c, 23d, and 23e were prepared in good to high overall yield and were sel
154 An array of C-aryl and C-vinyl furanosides were prepared in good yields and diastereoselectivities
155 alyst epoxypyrrolo[1,2-a]azepine derivatives were prepared in good yields and excellent diastereosele
156 N-alkyl sulfinamides with diverse structure were prepared in good yields and excellent enantioselect
157 variety of aryl-substituted pyrroloindolines were prepared in good yields and with high levels of ena
158 ))(n)CH(2)(R)OH, n = 1, 2, 3, R = H, Me, Ph) were prepared in good yields by selenative demetalation
159 Potassium trifluoroboratoketohomoenolates were prepared in good yields from either the correspondi
162 ,4E,6E)- and (2Z,4E,6Z)-trienoic esters have been prepared in >/= 98% selectivity by a newly devised
163 oisomers (7-10) of ethyl undeca-2,4-dienoate were prepared in >/= 98% isomeric purity by Pd-catalyzed
164 ,5]imidazo[1,2-c]quinazoline-6-carbonitriles are prepared in high yields via three new routes: (1) a
165 tituted vinylaluminum reagents, which cannot be prepared in high efficiency through direct reaction w
167 -dihydro-2-vinyl-2H-1,4-benzoxazines (3) can be prepared in high yields (90-98%) and excellent enanti
171 dazo[1,2-a]pyridine (alpidem derivative) has been prepared in high chemical yield through a unique pr
172 Diporphyrinbenzyloxy-BODIPY derivatives have been prepared in high yields, and the photophysical prop
173 romolecular chain transfer agent (macro-CTA) is prepared in high yield (>95%) with 97% dithiobenzoate
174 B, and C as well as its synthetic analogues was prepared in high chemical yield, from 27 to 91%, usi
176 lkylated metallic nitride cluster fullerenes was prepared in high-temperature reactions and character
177 A series of alpha-quaternary arylglycines were prepared in high optical purity (up to 98% ee) by a
179 tricyclic and tetracyclic tetralin analogues were prepared in high yield and up to 20/1 diasteroselec
183 oles with desired N and O coordination atoms were prepared in high yield via click chemistry for pote
186 ne, and [(18)F]fluoroethyl-phenethyl-orvinol were prepared in high yields and quality from their 6-O-
188 oil droplets after intravitreal bevacizumab was prepared in insulin syringes by a compounding pharma
190 er designs, but is far more accessible as it is prepared in just five steps and 23% overall yield.
191 ived from the abundant amino acid valine and are prepared in large quantities in four steps with inex
197 ,2,3-dithiazol-5-ylidene}methanes, these can be prepared in moderate yields via classical cycloadditi
199 inolines, furopyridines, and thienopyridines is prepared in moderate to excellent yields (up to 86%).
200 3-spiro[3-azabicyclo[3.1.0]hexane]oxindoles were prepared in moderate to high yields via one-pot thr
201 sly unknown, enantiopure, beta-amino ketones were prepared in modest yield by addition of lithium rea
202 ved from a robust heterocyclic salt that can be prepared in multigram quantities from inexpensive sta
203 and three [2,2']-paracyclophanes (pCps) has been prepared in multistep synthetic procedures involvin
204 nd 2-bromo-4-silacyclohexan-1-ones 5a and 5b were prepared in multistep syntheses, starting from trim
206 controlled length with low polydispersities were prepared in N,N-dimethylformamide using small seed
207 ew binary compound, Zn(8)Sb(7), has recently been prepared in nanoparticulate form via solution synth
208 s, a variety of functionalized anilines have been prepared in nearly quantitative yields within 2-8 m
210 Versatile trichloromethyl carbinols can be prepared in one pot from primary alcohols by treatmen
211 pports with a hierarchical cross section can be prepared in one step by hollow fiber spinning, double
213 y valuable substrate for drug discovery, can be prepared in one step from propargyl alcohol in a fair
214 zyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a p
215 weakly coordinating borate moiety (WCA-NHC) was prepared in one step from free N-heterocyclic carben
216 ide sheet with carboxyl-long-chains (GO-CLC) was prepared in one step from primitive graphite via Fri
217 n new 7'-homo-anhydrovinblastine derivatives were prepared in one or two steps from vinorelbine by me
219 cyclic fused and spiro-4-aminopyridines that are prepared in only three steps from commercially avail
223 planar chiral paracyclophane scaffolds have been prepared in optically pure form starting from 1,8-d
224 diluted" system with a 9:1 Co/Os metal ratio were prepared in order to further probe the nature of th
225 gs were radiolabeled and potent radioligands were prepared in order to image the beta-adrenergic and
226 structurally equivalent positions in FIV PR were prepared in order to study the molecular basis of P
229 ic acid, an analogue of diaminopimelic acid, was prepared in racemic form and the structure establish
230 hexahydropyrazolo[1,5-a]pyridin-8-ium-1-ide, were prepared in seven steps from the respective commerc
234 he reactivity of these silyltriflates, which are prepared in situ, is exemplified by dipolar cycloadd
237 il that yielded poly(HEMA-co-AEMA) foam that was prepared in-situ by UV crosslinking and by sequentia
238 P) natural product (+)-gliocladine C (6) has been prepared in six steps and 29% yield from the di-(te
239 analogue containing a diazirine moiety that was prepared in six steps and incorporated into an a-fac
240 e synthesis, the key building block 2, which was prepared in six steps from thiophene, was arylated r
244 le and easy to use, provided the input files are prepared in the GraphML format, typically using the
247 methacrylate) diblock copolymer vesicles can be prepared in the form of concentrated aqueous dispersi
248 5-epi-7-epi-crassalactone D (15), also have been prepared in the course of the synthesis of (+)-cras
252 r sulfamethizole (SMZ) selective recognition was prepared in the form of a homogeneous thin film on t
254 size of the biocompatible PPy coating, which was prepared in the presence of cetyltrimethylammonium b
255 f FAs in the activity, a mixture of four FAs was prepared in the ratios measured in the dust samples
264 The key dehydrositagliptin intermediate 9 is prepared in three steps in one pot and directly isola
267 g the 1, 2, and 3 positions methyl-protected was prepared in three steps from a commercially availabl
271 be commercially available from Aldrich, can be prepared in two steps using an abundant plant feedsto
273 of perchlorate in water with dihydrogen have been prepared in two ways: (1) by impregnating 5 wt % Pd
275 culate formulations of clopidogrel bisulfate were prepared in two crystal forms (Form I and Form II).
282 uoromethylated oxygenated heterocycles could be prepared in very good yields through a single synthet
284 The shuttle plasmid carrying CCH1-GFP, which was prepared in vitro and propagated in yeast, was succe
285 ree conformationally distinct amyloid states were prepared in vitro using Syrian hamster recombinant
286 ore recently, a small range of complexes has been prepared in which alternative NHC isomers, namely i
287 rming photoinitiated substrate turnover have been prepared in which four different fluorotyrosines (F
289 , a copper-based metal-organic framework has been prepared in which the starting linker (benzene-1,3,
290 Combinatorial scanning mutagenesis libraries were prepared in which CDR residues on the D5 light chai
291 R[N(SiMe3)2]3 R = -CH3, -C identical withCPh were prepared in which coordination of the hydrocarbyl g
292 tRNA synthetase pair, two PPARalpha variants were prepared in which Leu-258 or Phe-273 were site-spec
293 Perylene dyes with N-tert-alkyl substituents were prepared in which noncovalent interactions of the c
294 triphenylphosphine-gold(I) allenyl complexes were prepared in which the alpha carbon coordinates to t
295 To explore this possibility, BLM analogues were prepared in which the disaccharide moiety was attac
296 nucleophile assisting leaving groups (NALGs) were prepared in which the metal chelating unit is attac
297 importance of the thiophenyl moiety, analogs were prepared in which this moiety was replaced by an an
298 ns of geminal methyl and phenyl substituents were prepared in yields of 24-49% via dipyrromethane + d
299 ctionalized with the 5'-siloxyl ether linker were prepared in yields of 75-83% and incorporated last
300 oids pseudopalmatine and pseudoepiberberine, were prepared in yields up to 86% according to this stra
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