ライフサイエンスコーパス: be presumed to

1 GITR), a TNFR family member whose engagement was presumed to abrogate regulatory T cell-mediated supp

2 ting proteins (RhoGAP), which have generally been presumed to act as tumor suppressors.

3 nto structural ECM proteins and these forces are presumed to activate integrin "switches." The mechan

4 tegrated viral DNA (UVD) accumulation, which is presumed to activate a cellular DNA damage response.

5 (myeloid/lymphoid or mixed-lineage leukemia) is presumed to activate Hox expression, counteracting po

6 non-coding SNPs associated with disease risk are presumed to affect gene regulation.

7 of the Epichloe symbiont and the host grass is presumed to align the coevolution of the species towa

8 rgo frequent antigenic variation (Av), which is presumed to allow reinfection of high-risk groups.

9 zes the Ca(2+)-induced opening of N-cTnC and is presumed to also destabilize cTnI-actin interactions

10 Proteins secreted by the Dot/Icm T4SS are presumed to alter the host endocytic pathway, allowi

11 They are presumed to amplify by rolling-circle replication (R

12 Within dendritic spines, actin is presumed to anchor receptors in the postsynaptic dens

13 cell compartment, where claudin(low) cancers are presumed to arise.

14 This pattern of flow has been presumed to arise from specific features of the res

15 Cardiac neonatal lupus (NL) is presumed to arise from maternal autoantibody targetin

16 While this variability is presumed to arise from overlapping synaptic input, it

17 beta3 subunits are presumed to assemble only in the accessory subunit p

18 BEST1 is presumed to assemble into a calcium-activated chlorid

19 Canonical nutrient-sensing pathways are presumed to be absent from the causative agent of ma

20 ch as CTCF facilitate DNA loop formation and are presumed to be among the major determinants of eukar

21 logical lesions in newborn piglets, but they are presumed to be antigenically distinct.

22 that express mutant TERT and NLRP3 proteins are presumed to be at increased risk for mutagenesis bec

23 eous cause of this condition, whose symptoms are presumed to be caused by different mechanisms.

24 Physiologic sites for inhaled anesthetics are presumed to be cavities within transmembrane 4-alpha

25 ence for three systems in the rat brain that are presumed to be components of the rat's navigational

26 Housekeeping genes (HKG) are presumed to be constitutively expressed throughout t

27 a classic example in which immune responses are presumed to be costly and therefore come at the expe

28 These changes are presumed to be critically involved in many aspects o

29 lf of the human genome and DNA methylome and are presumed to be densely methylated and inactive.

30 s of DNA lesions such as extrahelical bulges are presumed to be essential for recognition of defects

31 lutamate transporter VGlut2, the projections are presumed to be excitatory.

32 in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases

33 and yet mechanistic features of HCV variants are presumed to be held in common.

34 sory systems, a range of computational rules are presumed to be implemented by neuronal subpopulation

35 ce or in the apical organelles of merozoites are presumed to be important components of naturally acq

36 ne 39, aspartate 44, and arginine 184, which are presumed to be in the vicinity of the damaged base i

37 y depend entirely on glycinergic inputs that are presumed to be inhibitory.

38 ext and enzymological studies; these enzymes are presumed to be involved in peptidoglycan recycling.

39 erebral microinfarcts are small lesions that are presumed to be ischaemic.

40 urface density is very low, these "silanols" are presumed to be isolated.

41 educational formats, other core competencies are presumed to be learned on the job or emphasized in c

42 MLIV patients accumulate large vacuoles that are presumed to be lysosomes, but whose exact nature rem

43 ients can experience rejection episodes that are presumed to be mediated by immune mechanisms similar

44 ients can experience rejection episodes that are presumed to be mediated by immune mechanisms similar

45 identify patients with low-risk disease who are presumed to be most suitable for AS.

46 ors by as yet uncharacterized ligands, which are presumed to be PG fragments (muramyl di- and tripept

47 membrane, while their cognate Eph receptors are presumed to be pre-synaptic.

48 GUD(+) NSF O157:H7 strains are presumed to be precursors of GUD(-) NSF O157:H7 stra

49 ties for small molecule CCR5 inhibitors that are presumed to be present in different proportions on d

50 e antibody titers (> or =1:32) to TSST-1 and are presumed to be protected from mTSS.

51 e biogenesis and protein quality control but are presumed to be proteolytically inactive.

52 per cent exhibit strong surface fields that are presumed to be residuals from the star formation pro

53 eloma are unknown, treatment-related factors are presumed to be responsible.

54 CAM interventions are presumed to be safe, yet they may not be, particular

55 unknown molecular mechanisms, although they are presumed to be secondary to immune activation.

56 Immature osteoblasts are presumed to be the cell type harboring translocation

57 Although NMDA receptors are presumed to be the most sensitive targets of ethanol

58 rulent drainage, beta-hemolytic streptococci are presumed to be the predominant pathogens.

59 he absence of ligand, and downstream signals are presumed to be the same as the ligand-induced signal

60 nic light chain-associated (AL) amyloidosis, are presumed to be the source of light chains that depos

61 Both enantiomers of HNE are presumed to be toxic, and GSTA4-4 has negligible ste

62 These proteins are presumed to be trimmed proteolytically and undergo p

63 tibodies have targeted antigens that are, or are presumed to be, extracellular.

64 onments without light-sensing organs may not be presumed to be light insensitive.

65 ivity of axon terminals to GABA, these could be presumed to be nascent, excitatory synapses.

66 ontained in the CAS database, while they can be presumed to be products generated during the producti

67 Untested chemicals should not be presumed to be safe to brain development, and chemica

68 Myelodysplastic syndrome (MDS) has long been presumed to be a stem cell disorder, but rigorous f

69 Previously, SLC30A10 had been presumed to be a zinc transporter.

70 ons for bacterial NOSs are unknown, but have been presumed to be analogous to their role in mammals.

71 Nodule formation has long been presumed to be central for adjuvant activity by pro

72 Increased PAI-1 levels have been presumed to be consequent to obesity.

73 by tyrosinase-expressing cells, and this has been presumed to be due to quantitative glycosylation of

74 to be uniquely sensitive to heat, which has been presumed to be due to the existence of an unidentif

75 troscopic studies, the four hemes sites have been presumed to be equivalent.

76 t and most massive asteroid, has in contrast been presumed to be homogeneous, in part because of its

77 nd the actions of B1 agonists have therefore been presumed to be indirect.

78 ssociated cardiomyopathy is unknown, but has been presumed to be mediated indirectly, owing to the ab

79 T-helper type 2 responses have been presumed to be pathogenic in this disease, and a hi

80 14S particles have long been presumed to be pentamers.

81 TCR-based therapies have been presumed to be restricted to one HLA subtype.

82 st (SCT) at the maternal-fetal interface has been presumed to be the primary driver of placental meta

83 with great specificity and stability and has been presumed to be the replicative ssDNA binding protei

84 inglet carbene cyclopropenylidene (C3H2) has been presumed to be too unstable to isolate in the labor

85 Decreased collagen synthesis is (presumed to be) the result.

86 The CASK CaM-kinase domain is presumed to be a catalytically inactive pseudokinase

87 ension, diabetes, dyslipidemia, and obesity, is presumed to be a close associate of AF.

88 f creatine via increased energy availability is presumed to be a contributing factor of the restorati

89 The reduced activity is presumed to be a function of the nascent DNA-template

90 ed to result in a truncated CLN3 protein and is presumed to be a null mutation.

91 Anemia is often observed in AML but is presumed to be a secondary consequence of leukemic cl

92 -2beta is highly expressed in thymocytes and is presumed to be a transcriptional repressor because of

93 Whereas excess adiposity is presumed to be advantageous for the skeleton, studies

94 * Carnivory in plants is presumed to be an adaptation to a low-nutrient enviro

95 Photoferrotrophy is presumed to be an ancient type of photosynthetic meta

96 Cancer development is presumed to be an evolutionary process that is influe

97 The RPE/BM angulation is presumed to be caused by elevated pressure in the sub

98 e is associated with pain on movement, which is presumed to be caused by noxious stimulation.

99 Congenital heart block (CHB) is presumed to be caused by transplacental passage of ma

100 or chronic obstructive pulmonary disease and is presumed to be central to the altered responsiveness

101 uman urine in significant concentrations and is presumed to be derived from COX activity.

102 mtDNA cytosine methylation, from which 5hmC is presumed to be derived, and its expression is control

103 ments, this 13-residue segment of the enzyme is presumed to be disordered in the unliganded enzyme.

104 the impermeable shell-wall under irradiation is presumed to be due to an increase in internal pressur

105 n chronic HCV, the mechanism of liver injury is presumed to be due to HCV-specific T cell destruction

106 ermore, the bipartite nature of the ribosome is presumed to be essential for biogenesis, since dedica

107 lastid interdependence within the plant cell is presumed to be essential, but measurable demonstratio

108 lack of pathogenicity in a non-human protein is presumed to be explained in most cases by the presenc

109 ugh reduced grey matter volumes, this region is presumed to be healthy in our sample and its grey mat

110 rved in other drug-induced liver injury that is presumed to be immune mediated.

111 specific mechanisms are unclear, clustering is presumed to be important for common stringent transcr

112 The stiffness of this supportive layer is presumed to be important to the degree to which compr

113 of IL-7 when the cytokine is limited, as it is presumed to be in vivo.

114 n exolytic mechanism, and Gro3P substitution is presumed to be inhibitory for GDPDLd17 activity.

115 of primary sequence conservation, the linker is presumed to be intrinsically disordered.

116 Phenotypic plasticity is presumed to be involved in adaptive change toward spe

117 ion of oskar mRNA; this biochemical activity is presumed to be involved in other functions of arrest.

118 an enzyme mechanism where only a single step is presumed to be isotopically sensitive can be written

119 accumulation of surfactant in the lungs that is presumed to be mediated by disruption of granulocyte/

120 lly shortened telomeres in higher eucaryotes is presumed to be mediated by nonhomologous end-joining

121 other high-latitude regions, glacial erosion is presumed to be minimal, where a mantle of cold ice ef

122 This drug is presumed to be mutagenic because of error-prone trans

123 ld thrombosis (VLScT) occurs when resorption is presumed to be nearly complete.

124 Drd3 is presumed to be palmitoylated, based on sequence homol

125 atency persists for the life of the host and is presumed to be parasitic, as it leaves the individual

126 yclic carbene that has high-affinity for and is presumed to be subsequently captured by the heme iron

127 Improvement in protein function is presumed to be the driving force behind the evolution

128 easurements, because morphology of the brain is presumed to be the neurocranium's main shaping force

129 ns-Columbia River (SCR) flood basalts, which is presumed to be the onset of Yellowstone volcanism, ha

130 The gastrointestinal tract is presumed to be the primary site of infection and path

131 ever, the general transcription factor TFIIB is presumed to be universally required for RNAP2 transcr

132 ource of this virus is currently unknown but is presumed to be zoonotic.

133 sensitive to mitomycin C, and the mechanism was presumed to be a defect in the repair of interstrand

134 HPV16 was presumed to be causative in 14 of 31 biopsy specimen

135 The acquisition of both functions was presumed to be developmentally linked, but this link

136 lation was patients with cardiac arrest that was presumed to be of cardiac origin and that had occurr

137 abilities intact, damage to the hippocampus was presumed to be the critical factor.

138 lar activation from right ventricular pacing was presumed to be the likely cause for these maladaptiv

139 Until recently, transport of tRNA was presumed to be unidirectional, from the nucleus to t

140 f 84 germline DNA-repair gene mutations that were presumed to be deleterious were identified in 82 me

141 in NR2E3, and 2 additional sibling patients were presumed to be homozygous for a missense change bas

142 r bed ("tumoral pseudoblush") at MR imaging, were presumed to be related to tumoral microvascularity.

143 Until recently, human breast tissue and milk were presumed to be sterile.

144 I within Descemet's membrane, a process that is presumed to begin during fetal development.

145 lies to which the conserved T3SS enzymes had been presumed to belong.

146 esistance has been focused on compounds that are presumed to bind the Q(o) site (one of two potential

147 Both MMOB and MMOD are presumed to bind to the same region of the MMOH alph

148 rminal, the C2 domain of synaptotagmin (C2A) is presumed to bind Ca2+ and the membrane in a stepwise

149 idue (Val96) to which the amino group in ATP is presumed to bind.

150 e generates the powerful oxidant HOCl, which was presumed to carry out the chlorination reaction.

151 us end-joining (NHEJ) pathways of DNA repair are presumed to catalyze their formation.

152 which indiscriminately modifies proteins and is presumed to cause pain through broadly acting mechani

153 n of beta-hexosaminidases A and B substrates is presumed to cause this fatal condition.

154 ns of RsbRA project from the stressosome and are presumed to channel sensory input to the C-terminal

155 3 to form a protein complex (terminase) that is presumed to cleave concatemeric DNA into genome lengt

156 The remaining approximately 70% are presumed to compete for metals from buffered metal p

157 quences bound by a transcription factor (TF) are presumed to contain sequence elements that reflect i

158 merase ribonucleoprotein in Candida albicans is presumed to contain at least three Est proteins: CaEs

159 lants, electrophysiological reactions (elRs) are presumed to contribute to long-distance intercellula

160 ronal recruitment in an adult animal's brain is presumed to contribute to brain plasticity and increa

161 Although inflammation is presumed to contribute to colonic neoplasia in ulcera

162 Although complement activation is presumed to contribute to organ damage and constituti

163 al injury is a common finding after TBI, and is presumed to contribute to outcomes, but may not alway

164 se I is a secreted enzyme whose function has been presumed to control "waste management" in the human

165 r EBNA proteins, in particular EBNA-2, which is presumed to coregulate transcription with EBNA-3C.

166 tation of one of the stems by around 80A and are presumed to correspond to the active and inactive st

167 These processes are presumed to correspond to the formal potentials for

168 Here, an EF-hand motif substitution that had been presumed to destroy EF-hand function, that of gluta

169 Thus, a subset of T4BSS effectors are presumed to direct PV biogenesis.

170 belonging to the DN and DC subdomains, which are presumed to dock with TolC, in complex stability and

171 During cytokinesis, regulatory signals are presumed to emanate from the mitotic spindle.

172 mucolipin subfamily (TRPML1-3 and MCOLN1-3) are presumed to encode ion channel proteins of intracell

173 cy signals, whereas kainate receptors (KARs) are presumed to encode lower temporal frequencies.

174 e, intracellular replication, and virulence, was presumed to encode a T6SS-like apparatus.

175 Turnover is presumed to encompass a reversible oxidation at the a

176 Merlin mutants, which are presumed to exert a dominant-negative effect, enable

177 des multiple immunosubversive functions that are presumed to facilitate the establishment and persist

178 ome a prominent cancer model system, as they are presumed to faithfully represent the genomic feature

179 Waziristan due to recent military operations was presumed to favor the widespread poliovirus infectio

180 2, and Med13 can associate with Mediator and are presumed to form a stable "CDK8 subcomplex" in cells

181 bulb mitral and tufted (M/T) cells, where it is presumed to form the odor percept.

182 DH(2) and O(2) in the halogenase active site was presumed to form the typical FAD(C4a)-OOH intermedia

183 t also involves Pms1 and other proteins that are presumed to function downstream of mismatch recognit

184 shown to function in insulin exocytosis and are presumed to function in actin remodeling and insulin

185 ersections between pro-octamer dimers, which are presumed to function in allosteric regulation.

186 IL-36 signaling has been presumed to function analogously to IL-1 signaling.

187 AdV protein IVa2 is presumed to function as a DNA packaging ATPase.

188 One of these proteins (SvsR) is presumed to function in protein biosynthesis, because

189 e (PAPS) in the follicle cells in which Pipe is presumed to function.

190 pigenetic alterations, called driver events, are presumed to have a functional role in CRC.

191 are, that have multiple affected members who are presumed to have a similar inherited cause to their

192 and staphylococci are paralogues of SecA and are presumed to have an analogous role in protein transp

193 tions explored previously, while nucleobases are presumed to have been available from hydrogen cyanid

194 In the DSM, phosphorylated carbohydrates are presumed to have been available via reactions explor

195 lity policies, and governmental regulations, are presumed to have major influences on employment, but

196 Nucleoside-based cofactors are presumed to have preceded proteins.

197 Human pluripotent stem cells (PSCs) are presumed to have robust DNA repair pathways to ensur

198 (aP) and whole-cell (wP) pertussis vaccines are presumed to have similar short-term (<3 years after

199 Jehol is presumed to have been a predominantly closed forested

200 Observational learning is presumed to have occurred when an organism copies an

201 Consumption of lignan rich food is presumed to have positive effects on human health.

202 ears to be mediated by low copy repeats, and is presumed to have taken place prior to translocation w

203 s in several copies in the X chromosome, and is presumed to have undergone several duplications to fo

204 der climatic condition of the Little Ice Age were presumed to have caused the abandonment of the colo

205 All patients were presumed to have coronary artery disease (CAD) and

206 larial cause of death and those without, who were presumed to have died of cerebral malaria.

207 107 (36%) of 294 children with ESKD died or were presumed to have died.

208 ildren who could not access dialysis died or were presumed to have died.

209 fissures and previous water flooding events were presumed to have evaporated and sublimed away.

210 admitted to the surgical and cardiac ICU who were presumed to have heparin-induced thrombocytopenia a

211 In approaches 2 and 3, patients were presumed to have sporadic CRC if the tumor lacked M

212 ms, but they do not secrete autoantibody and were presumed to ignore self-Ag.

213 The acidic vaginal milieu is presumed to inactivate pathogens but is neutralized b

214 -yl (NBD) group on the sn-2 C6 position, and were presumed to include phosphatidylcholine and phospha

215 Although cholinergic deficiency is presumed to increase delirium risk and use of medicat

216 Receptor binding is presumed to induce conformational changes in G that s

217 t, whereas activity of indirect-pathway SPNs is presumed to inhibit movement.

218 granule cells and periglomerular cells that are presumed to integrate into the synaptic circuits of

219 se TRX functions remain largely unknown, but are presumed to involve its histone H3K4 methyltransfera

220 al LPFC unexpectedly impaired processes that are presumed to involve rostral LPFC.

221 plane specification in animal cells has long been presumed to involve direct contact between microtub

222 ic pathway of myxoxanthophyll is unknown but is presumed to involve a number of enzymes, including a

223 e human nasopharynx by Moraxella catarrhalis is presumed to involve attachment of this bacterium to t

224 ul recognition of partially occluded objects is presumed to involve dynamic interactions between brai

225 The copper(I) chloride catalyzed reaction is presumed to involve the formation of highly active ar

226 This intake is presumed to maintain a minimally acceptable liver con

227 ro-L-galactose residues, the latter of which are presumed to make the polymer recalcitrant to degrada

228 primary neuromuscular transmitter, has long been presumed to mediate this activity-dependent process

229 sp-, and Met-Asn-starting protein N termini, is presumed to Nt-acetylate 15% of all yeast and 18% of

230 Although polyubiquitination had been presumed to occur by transferring ubiquitin molecul

231 So pre-mRNA splicing has been presumed to occur exclusively in the cell nucleus.

232 This is presumed to occur predominantly by coughing but may a

233 This is presumed to occur through direct interactions of one

234 y correlated with facile (1)O(2) production, was presumed to occur via S(1)-->T(1) intersystem crossi

235 species under the US Endangered Species Act is presumed to offer a defense against extinction and a

236 Defective myosin-IIA complexes are presumed to perturb megakaryocyte (MK) differentiati

237 asts and animals, the GTPases Cdc42 and Rac1 are presumed to play a central role in organizing the mo

238 These regulatory cues are presumed to play a key role in tumorigenesis through

239 may modulate the callosal interactions that are presumed to play a role in coordinating bilateral wh

240 Although these proteins are presumed to play a role in the process of biomineral

241 Although CTTs are presumed to play important roles in MT networks, the

242 ecifically exosomes and microvesicles (MVs), are presumed to play key roles in cell-cell communicatio

243 with a wide variety of cellular proteins and is presumed to play a fundamental role in dynein assembl

244 Each is presumed to possess a near-neutral pK(a), and both li

245 Adiponectin is presumed to possess antiatherogenic and cardioprotect

246 Thus, biophysical constraints should not be presumed to preclude a protein's ability to evolve.

247 NOS reaction has been well-characterized and is presumed to proceed through a compound I heme species

248 biosynthesis, conversion of PCA to pyocyanin is presumed to proceed through the intermediate 5-methyl

249 his novel nucleophilic aromatic substitution is presumed to proceed via a precoordination of the orga

250 ts with TWIST1 directly and this interaction is presumed to protect TWIST1 from degradation.

251 Although cryogenic storage is presumed to provide nearly infinite longevity to cell

252 We tested this variant since it is presumed to provide nutritional advantage in specific

253 ubset of microbial product-driven responses, is presumed to provide protection from pathological hype

254 In general, TLR-2s are presumed to recognize lipoteichoic acid of Gram-posi

255 oteins (IAP) baculoviral IAP repeat-3 domain are presumed to reduce the threshold for apoptotic cell

256 hin the 5' noncoding region of genomic RNAs, were presumed to reduce translation in certain target or

257 Such instances are presumed to reflect the presence of conserved suites

258 using the linear extrapolation method (LEM) are presumed to reflect the stability differences betwee

259 n vivo marker of aging, disease, and insult, is presumed to reflect atrophy of surrounding brain regi

260 hibit dominant ferromagnetic coupling, which is presumed to reflect intrastack interactions.

261 This buildup is presumed to reflect the final stages of planning and

262 Although the variation was presumed to reflect genotypic differences among the

263 cision of skilled forelimb movement has long been presumed to rely on rapid feedback corrections trig

264 is complex to specific regions of the genome is presumed to rely on interactions involving one or mor

265 Hence, inactive Mcm complexes are presumed to remain stably bound from early G1 throug

266 DNA methylation at the promoter of a gene is presumed to render it silent, yet a sizable fraction

267 levance to muscle architecture, such targets are presumed to represent myofibrillar proteins, but whe

268 These findings are presumed to represent normal bone remodeling.

269 th prominent hair cell ciliary bundles, that are presumed to represent saccular and lagenar maculae.

270 my is surprising because autonomy would have been presumed to represent the final, irreversible, leuk

271 Duplication of the central focus is presumed to represent active partition of plasmid cop

272 ctable homologs only in other eukaryotes and is presumed to represent proteins that emerged specifica

273 CaV1.2, however, are incompletely known, but are presumed to require phosphorylation of residues in a

274 All of these activities are presumed to require translocation of the protein on

275 tions at positions 120 and 121 in PIB, which are presumed to reside in loop 3 that forms the pore con

276 kemia (CML) and acute myeloid leukemia (AML) are presumed to reside in specific niches in the bone ma

277 most of which are unique to each family and are presumed to result in loss of function.

278 This effect has been presumed to result from higher brain inputs activat

279 ion in terms of receptor activation and have been presumed to result in increased levels of FGF/FGFR

280 This relation is presumed to result from the cooperative binding of th

281 ymptom of subarachnoid hemorrhage (SAH) that is presumed to result from transient intracranial circul

282 In retinal capillaries, pausing is presumed to result from vasomotion-which has been pos

283 Glaucoma is presumed to result in the selective loss of retinal g

284 Pyrrolysyl-tRNA(Pyl) formation was presumed to result from subsequent modification of l

285 y targeted at rapidly cycling cells and have been presumed to retain labels such as the thymidine ana

286 2 bp downstream in all eukaryotes, so Pol II is presumed to "scan" further downstream before starting

287 cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via

288 f mammalian non-REM sleep, during which they are presumed to shape activity-dependent plasticity in n

289 A unique multilayer structure of nanosheets is presumed to significantly reduce energy consumption d

290 ng required for uptake of the colicin and it was presumed to somehow serve as both receptor and trans

291 Like most microRNAs, which are presumed to suppress translation of target mRNAs, we

292 that is embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-m

293 ce of radiocarbon dates, bat extinctions had been presumed to take place during the last glacial-inte

294 Although T4 and its analogs are presumed to target the parasite's lipid metabolism,

295 ylated 3' untranslated region (UTR) that has been presumed to undergo translation in a cap-dependent

296 though experience-dependent cortical changes are presumed to underlie learning differences in these d

297 Dietary effects are presumed to underlie many of the large international

298 archical relationship (CMP-GMP-MDP-monocyte) is presumed to underlie monocyte differentiation.

299 tein-coupled receptor kinases and arrestins, is presumed to underlie these effects, but such a mechan

300 rAAV is presumed to use a pathway of DNA double-strand break