ライフサイエンスコーパス: be repaired by

1 highly lethal DNA double-strand breaks that are repaired by 2 major mechanisms: BRCA-dependent homol

2 ydro-8-oxo-2'-deoxyguanosine (8-oxoG), which is repaired by 8-oxoguanine DNA glycosylase1 (OGG1) duri

3 atson and Crick strands of the double helix, are repaired by a complex, replication-coupled pathway i

4 efore, in high-grade tumours mismatched DSBs are repaired by a highly mutagenic, microhomology-mediat

5 Plasma membrane wounds are repaired by a mechanism involving Ca(2+)-regulated e

6 Genetic variants then result when breaks are repaired by a mutagenic mechanism involving recombin

7 lude that long resected chromosomal DSB ends are repaired by a single-strand DNA oligonucleotide thro

8 ch causes double-stranded breaks that cannot be repaired by a haploid cell if induced before replicat

9 s analysis indicated that the DSBs appear to be repaired by a mechanism similar to nonhomologous end

10 during meiotic prophase become designated to be repaired by a pathway that specifically yields interh

11 ecombining with a template sequence, DNA can be repaired by a recombination-dependent DNA replication

12 The F167Y defect could also be repaired by a second, independent suppressor in the C

13 Traditionally, these defects would have been repaired by a maxillofacial prosthesis but advances

14 n induced site-specific DSB in budding yeast is repaired by a 2-kb donor sequence inserted at differe

15 In humans this lesion is repaired by a mismatch-specific thymine DNA glycosyla

16 Mitochondrial DNA (mtDNA) is repaired by a mtBER pathway.

17 g agents, indicating that a cytotoxic lesion is repaired by a PCNA-dependent DNA repair pathway.

18 It is repaired by a radical SAM (S-adenosylmethionine) enzy

19 In A. aegypti, the midgut epithelium is repaired by a unique actin cone zipper mechanism that

20 Each of the resulting gingival defects was repaired by a distinct plastic surgery procedure, in

21 owed that RE was high because the cross-link was repaired by a pathway involving nucleotide excision

22 Twenty-one median or ulnar nerve lesions were repaired by a collagen nerve conduit or direct sutu

23 alysis established that DSBs occurring in G1 were repaired by a replicative mechanism, producing two

24 sylase acts on lesions previously thought to be repaired by Aag.

25 rves, indicating that the respective isomers are repaired by AlkB with different efficiencies.

26 silonG is the only etheno lesion that cannot be repaired by AlkB, which partially explains its persis

27 This mutation was repaired by allelic replacement, resulting in restor

28 Breaks are repaired by an end-joining reaction that requires DN

29 Previously studied [3Fe-4S] clusters are repaired by an Isc/Suf-independent pathway, so the r

30 ng frame of an out-of-frame DMD deletion can be repaired by antisense oligonucleotide (AO)-mediated e

31 A DNA double-strand break (DSB) can be repaired by any of several alternative and competing

32 Double-strand DNA breaks can be repaired by any of several alternative mechanisms tha

33 AP sites are repaired by AP endonucleases during the process of b

34 cision of damaged bases by DNA glycosylases, are repaired by AP-endonucleases (APEs).

35 nd breaks induced by reactive oxygen species are repaired by AP-endonucleases.

36 , such as uracil and abasic sites, appear to be repaired by at least two base excision repair (BER) s

37 endonuclease-induced double-strand break can be repaired by at least two pathways of nonhomologous en

38 ) are single strand breaks (SSBs) thought to be repaired by base excision repair enzymes.

39 These lesions cannot be repaired by base excision repair, but they are substr

40 te of 5-fluorouracil, causes DNA damage that is repaired by base excision repair (BER).

41 These lesions are repaired by BCR/ABL-stimulated homologous recombinat

42 een the base and sugar moieties, they cannot be repaired by BER.

43 t cytotoxic lesions to eukaryotic genome and are repaired by both homologous recombination-dependent

44 A to form interstrand cross-links, which can be repaired by both nonmutagenic nucleotide excision rep

45 Because oxidized cysteine can be repaired by cellular reductants, the effect was to av

46 Function was "repaired" by charge reversal (E91R/R298E), implying

47 For the extreme case of damage that cannot be repaired by conventional enzymes, there are proteins

48 The break is repaired by copying DNA from an extrachromosomal temp

49 nal or ablation injury to the corneal stroma is repaired by deposition of a fibrotic tissue produced

50 aline-challenged rats were dysfunctional and were repaired by DIZE treatment.

51 The fact that the oxidative damage can be repaired by DTT suggests that a cysteine or methionin

52 ar plasmid with a single defined fluorescein was repaired by efficient extracts from Xenopus oocyte n

53 DSBs are repaired by either error prone non-homologous end-jo

54 DNA double-strand breaks (DSBs) are repaired by either homologous recombination (HR) or

55 uble-strand breaks (DSBs) in mammalian cells are repaired by either homology-directed repair (HDR), u

56 DNA double-strand breaks (DSBs) are repaired by either the non-homologous end joining (N

57 hat arise through DNA replication errors can be repaired by either base excision repair or mismatch r

58 are potentially lethal DNA lesions that can be repaired by either homologous recombination (HR) or n

59 Chromosomal double-strand breaks (DSBs) can be repaired by either homology-dependent or homology-ind

60 Chromosomal double-strand breaks (DSBs) can be repaired by either homology-dependent or homology-ind

61 DNA double strand breaks (DSBs) can be repaired by either recombination-based or direct liga

62 gle-strand annealing and much less likely to be repaired by end joining compared with identical break

63 In Escherichia coli, oxidative pyrimidines are repaired by endonuclease III (EndoIII) and endonucle

64 tudy, it was found that the strand break can be repaired by Escherichia coli DNA polymerase I and E.

65 activates a checkpoint response, the damage is repaired by factors required for inter-sister homolog

66 crystallo isolation, suggested that epsilonA was repaired by formation of an epoxide (epsilonA-ep) th

67 ion does occur at the bulged guanine, but it is repaired by Fpg.

68 A DNA double-strand break (DSB) is repaired by gene conversion (GC) if both ends of the

69 om cell cycle checkpoint arrest when the DSB is repaired by gene conversion is substantially defectiv

70 by TCR whereas the lesions induced by 4-NQO are repaired by global genome repair.

71 ase mispairs, and all substrates tested that were repaired by hMutSbeta.

72 DNA double-strand breaks (DSBs) are repaired by homologous recombination (HR) and nonhom

73 DSBs are repaired by homologous recombination (HR) and nonhom

74 We also find that heterochromatic DSBs are repaired by homologous recombination (HR) but with s

75 Most double-strand breaks in flies are repaired by homologous recombination through the syn

76 s programmed DNA double-strand breaks (DSBs) are repaired by homologous recombination using the siste

77 In the absence of RNAi, stalled forks are repaired by homologous recombination without histone

78 When DSBs are repaired by homologous recombination, DNA ends can u

79 Double-strand breaks are repaired by homologous recombination.

80 lindromic DNA sequence by the SbcCD nuclease are repaired by homologous recombination.

81 ate repair: D10A but not N863A-induced nicks are repaired by homologous recombination.

82 on of DNA double-strand breaks (DSBs), which are repaired by homologous recombination.

83 By contrast, AID-induced non-Igh DSBs are repaired by homologous recombination.

84 site-specific DNA double-strand breaks that are repaired by homologous recombination.

85 apse and chemical or physical damage and may be repaired by homologous recombination (HR) and non-hom

86 DNA DSBs can be repaired by homologous recombination (HR) and nonhomo

87 Double-strand breaks (DSBs) can be repaired by homologous recombination (HR) in mammalia

88 The break can be repaired by homologous recombination, an error-free m

89 to instances of telomere damage that cannot be repaired by homologous recombination.

90 t of the palindrome-induced breaks appear to be repaired by homologous recombination.

91 that is processed to form breaks, which can be repaired by homologous recombination.

92 f DNA cleavage by the SbcCD complex that can be repaired by homologous recombination.

93 A DSB in MATa is repaired by homologous recombination--specifically, b

94 he mutated alleles in the Rag2(-/-) ES cells was repaired by homologous recombination, thereby restor

95 Double strand breaks (DSBs) can be repaired by homology independent nonhomologous end jo

96 DSBs can also be repaired by homology-dependent pathways (HDR), in whi

97 DSBs may also be repaired by homology-directed repair (HDR) using a DN

98 e misprocessed intermediates in ERCC1- cells are repaired by illegitimate recombination.

99 DNA double-strand breaks can be repaired by illegitimate recombination without extend

100 dues produced deleterious effects that could be repaired by increased temperature in combination with

101 ) and observed that a fraction of these DSBs were repaired by insertion of sequences, which we termed

102 The defect could be repaired by intergeneric complementation with E. coli

103 Interstrand DNA cross-links (ICLs) are repaired by mechanisms using translesion DNA synthes

104 forms of methionine residues in proteins can be repaired by methionine-S-sulfoxide reductase (MsrA) a

105 s double-stranded DNA breaks (DSBs) that can be repaired by mitotic recombination with the homolog.

106 s will be converted to strand breaks if they are repaired by MMR.

107 form long single-stranded overhangs that can be repaired by mutagenic pathways.

108 base excision repair, we found that cyclo-dA is repaired by NER and not by base excision repair.

109 noglobulin class switch recombination (CSR), are repaired by non-homologous end joining (NHEJ).

110 DSBs are repaired by non-homologous end-joining or homology d

111 tion is prevented, most double-strand breaks are repaired by non-homologous end-joinings similar to t

112 DNA double strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homo

113 karyotic cells, DNA double-strand breaks can be repaired by non-homologous end-joining, a process dep

114 tabilize the PCC, allowing coding and SEs to be repaired by non-standard pathways, including alternat

115 asion steps, DSBs either are not repaired or are repaired by nonconservative single-strand annealing

116 DNA double-strand breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or homo

117 mologous template, as expected, Ac excisions are repaired by nonhomologous end joining (NHEJ) that ca

118 cleavage generates four broken DNA ends that are repaired by nonhomologous end joining forming coding

119 DNA strand breaks are repaired by nonhomologous end joining in mammalian c

120 aks (DSBs) activate checkpoint signaling and are repaired by nonhomologous end-joining (NHEJ) and hom

121 DNA double strand breaks (DSB) are repaired by nonhomologous end-joining (NHEJ) or homo

122 by initiating DNA double strand breaks that are repaired by nonhomologous end-joining pathways.

123 n the remaining observed repair events, DSBs are repaired by nonhomologous processes.

124 crosslink and the acetylaminofluorene lesion were repaired by normal cell extracts approximately 15-2

125 There is evidence that these lesions are repaired by nucleotide excision repair (NER).

126 erally block replicative DNA polymerases and are repaired by nucleotide excision repair or bypassed b

127 produces cyclobutane pyrimidine dimers that are repaired by nucleotide excision repair, whereas DMS

128 8,5'-cyclopurine-2'-deoxynucleosides in DNA are repaired by nucleotide-excision repair, and act as s

129 The lesions can only be repaired by nucleotide excision repair with a low eff

130 hylcytosine and a neighboring guanine, which is repaired by nucleotide excision repair.

131 cts induced by tobacco-specific nitrosamines are repaired by O(6)-alkylguanine DNA alkyltransferase (

132 and mutagenic O6-alkylguanine adducts in DNA are repaired by O6-alkylguanine-DNA alkyltransferases (M

133 This lesion is repaired by O6-methylguanine-DNA methyltransferase (M

134 damage sustained by the OM of one population was repaired by OME with a healthy population.

135 They can be repaired by one of two pathways, homologous recombina

136 Repair of shorter deletions, however, are repaired by other mechanisms.

137 The remaining DSBs must be repaired by other mechanisms to restore genomic integ

138 ed that RAG-generated chromosomal breaks can be repaired by pathways other than NHEJ in mouse embryon

139 This damage is repaired by photolyase and the nucleotide excision re

140 These cellular defects can be repaired by physiologic activation, transfection, or

141 henotype of pos5 and its arginine auxotrophy were repaired by plasmid-borne POS5 but not UTR1 or ADH1

142 tors or after exposure to ionizing radiation are repaired by proteins important for nonhomologous end

143 Ku: in lower eukaryotes such as yeast, DSBs are repaired by Rad52-dependent homologous recombination

144 emonstrated that a DSB in one chromosome can be repaired by recombination with a homologous sequence

145 some forms of spontaneous S-phase damage can be repaired by recombination without activating checkpoi

146 In yeast, broken chromosomes can be repaired by recombination, resulting in nonreciprocal

147 Replication forks frequently break and must be repaired by recombination.

148 S-phase damage in checkpoint mutants, which is repaired by recombination without activating checkpoi

149 Once the fork is repaired by recombination, PriA is important for rest

150 response to severing, a finite gap forms and is repaired by recruitment of new material in an actin p

151 Damaged DNA can be repaired by removal and re-synthesis of up to 30 nucl

152 The demyelination can be repaired by remyelination in both humans and rodents,

153 This structural incompatibility was "repaired" by replacing the specific beta 2 TMD sequ

154 rks lacking Mrc1 create DNA damage that must be repaired by Rrm3.

155 ated mutagenic adducts epsilonA and epsilonC are repaired by separate gene products; and (iii) APNG d

156 Broken chromosomes can be repaired by several homologous recombination mechanis

157 DNA double-stranded breaks (DSBs) can be repaired by several mechanisms, including classical N

158 ismatches during T. brucei recombination may be repaired by short-patch mismatch repair.

159 endonuclease-induced double-strand break can be repaired by single-strand annealing (SSA) between fla

160 A total of 112 (56%) patients were repaired by specialist hepatobiliary surgeons [timi

161 s in DNA, e.g., unpaired/bulged nucleotides, are repaired by specific repair enzymes.

162 tablished that the kidney tubular epithelium is repaired by surviving epithelial cells.

163 cyclobutane pyrimidine dimers, are known to be repaired by TCR whereas the lesions induced by 4-NQO

164 ther I-AniI or the CRISPR/Cas9(D10A) nickase are repaired by the alternative HDR pathway with little

165 Most of these small base modifications are repaired by the base excision repair (BER) pathway.

166 lesions such as oxidized or alkylated bases are repaired by the base excision repair (BER) pathway.

167 Although these lesions are repaired by the base excision repair pathway, they h

168 It has been inferred that these gaps are repaired by the cellular DNA repair machinery.

169 oduced in the G1 phase of the cell cycle and are repaired by the classical NHEJ machinery.

170 In Escherichia coli, Fapy lesions are repaired by the Fapy-DNA glycosylase (Fpg) protein.

171 idatively generated DNA lesions, cdG and cdA are repaired by the human nucleotide excision repair (NE

172 igned structures that escape the exonuclease are repaired by the methyl-directed mismatch repair, alb

173 e DNA resulting from insertions or deletions are repaired by the mismatch repair (MMR) machinery.

174 In wild-type strains, these mismatches are repaired by the mismatch repair (MMR) system, produc

175 erase epsilon; that most of these mismatches are repaired by the MMR system; and that MMR repairs abo

176 In human cells, NMPs are repaired by the multi-step base excision repair path

177 ggest that some DSBs in mre-11(iow1) mutants are repaired by the nonhomologous end joining (NHEJ) pat

178 ation induces DNA double-strand breaks which are repaired by the nonhomologous end joining (NHEJ) pat

179 man cell nuclear extracts the HNE-dG adducts are repaired by the nucleotide excision repair (NER) pat

180 CPDs are repaired by the nucleotide excision repair pathway.

181 cleotide runs, most frameshift intermediates are repaired by the postreplicative mismatch repair (MMR

182 Intestinal mucosal defects are repaired by the process of intestinal restitution, d

183 Intestinal mucosal defects are repaired by the process of intestinal restitution, d

184 ces cerevisiae), and mammals, these hydrates are repaired by the tandem action of an ADP- or ATP-depe

185 generate a DNA double strand break that can be repaired by the DNA damage response machinery.

186 ICLs can be repaired by the Fanconi anemia (FA) pathway and throu

187 upt the brain microvasculature, which cannot be repaired by the hemostasis system because of its proc

188 mpression of the fate map does not appear to be repaired by the induction of new cell divisions.

189 Damage to peripheral nerves often cannot be repaired by the juxtaposition of the severed nerve en

190 ithin retroviral double-strand DNA could not be repaired by the mismatch-deficient cells.

191 an cells DNA double strand breaks (DSBs) can be repaired by the non-homologous end-joining (NHEJ) pat

192 lesions are highly toxic and are believed to be repaired by the sequential activity of nucleotide exc

193 sed to determine whether the injured RPE was being repaired by the donor bone marrow.

194 8-oxoG is repaired by the 8-oxoguanine glycosylase 1 (OGG1)-ini

195 tive oxygen species (ROS)-induced DNA damage is repaired by the base excision repair pathway.

196 udies demonstrate that, although base damage is repaired by the BER pathway, incomplete BER intermedi

197 f several endogenously produced DNA adducts, is repaired by the nucleotide excision repair pathway.

198 pproximately 25% of the 8-oxoguanine lesions were repaired by the long patch repair pathway.

199 -RO) and methionine S-sulfoxide (Met-SO) can be repaired by thioredoxin-dependent enzymes MsrB and Ms

200 DNA ends generated at a double strand break being repaired by this pathway.

201 ations suggest that psoralen cross-links can be repaired by three pathways: an error-free recombinati

202 oduce targeted chromosomal breaks, which can be repaired by transformation with a homologous DNA frag

203 DNA replication-associated mutations are repaired by two components: polymerase proofreading

204 DNA double-strand breaks are repaired by two main pathways: nonhomologous end joi

205 Most DNA double-strand-breaks (DSBs) are repaired by two major mechanisms, homologous-recombi

206 In humans, DNA double-strand breaks (DSBs) are repaired by two mutually-exclusive mechanisms, homol

207 DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous

208 s presented here show that these defects can be repaired by unpairing short (3 or 5 bp) DNA segments

209 s in most eukaryotic cells (including axons) are repaired by vesicles, at least some of which arise b

210 cal assay, we confirmed that tandem mispairs were repaired by wild-type cells but not by Pms2(-/-) hu