ライフサイエンスコーパス: be required for

1 A further course of rituximab was required for 4 patients as a result of FSGS relapse,

2 We demonstrate that Boi1/2 are required for a late step in the fusion of secretory

3 Indeed, agonist ligands are required for a plethora of GPCRs for therapeutic int

4 ll (RGC) differentiation and axonal guidance is required for a functional visual system.

5 ultiple interdependent phosphorylation sites is required for a GC-A conformation capable of transmitt

6 e PLA2G16 as a picornavirus host factor that is required for a previously unknown event in the viral

7 rapping in the pre- or post-hydrolytic state was required for a pronounced conformational shift.

8 showed that the enzymatic activity of JMJD6 was required for a subset of JMJD6-regulated splicing, a

9 Correction for H-D exchange is required for accurate assessment of biological source

10 cells lacking both RTKs indicating that Egfr is required for activation of Axl in this context.

11 expression of 3BP2, an adapter protein that is required for activation of SRC tyrosine kinase and si

12 STRACT: Voltage-gated sodium channel NaV 1.7 is required for acute and inflammatory pain in mice and

13 d unclear whether endogenous KLF4 and Krox20 are required for adipogenesis in culture and in vivo Usi

14 First, we show that receptor internalization is required for agonist-induced phosphorylation of extra

15 rtite contacts with the native core of HspQ, is required for allosteric Lon activation.

16 We argue that the MD may be required for amplifying and sustaining cortical repre

17 r activity, except for kinesin-6 Klp9, which is required for anaphase spindle elongation.

18 BPTF is required for anterior-posterior axis formation of the

19 duces T helper 1 (Th1) immune responses that are required for anti-tumor immunity.

20 of aPC, demonstrating that Nlrp3 suppression is required for aPC-mediated protection from IRI.

21 on of SMARCA2 in response to EZH2 inhibition is required for apoptosis, but not for growth arrest, th

22 demonstrate that ERalpha in kisspeptin cells is required for appropriate differential regulation of t

23 We demonstrate that neuroplastins are required for associative learning in conditioning pa

24 MK) and promotes nuclear actin assembly that is required for ATR recruitment.

25 Here we show that Foxo3 is required for auditory function after noise exposure i

26 e noted that Optn phosphorylation at Ser-177 was required for autophagosome formation but not for Opt

27 y mediated by the common C-type Pcdh isoform is required for axonal tiling and assembly of serotonerg

28 The EZH2 histone methyltransferase is required for B cells to form germinal centers (GC).

29 Larger population-based, prospective studies are required for better estimates of the risk.

30 the five residues in the conserved sequence are required for binding to Nedd8.

31 that one of these adhesins has been shown to be required for binding of multiple glycan receptors.

32 , and rearrangement of the surrounding loops is required for binding to substrate ssDNA.

33 dination between osteoblasts and osteoclasts is required for bone health and homeostasis.

34 Rho-associated protein kinase (ROCK) is required for both high-speed migration and straight m

35 malian SWI/SNF chromatin-remodeling enzymes, is required for both myoblast proliferation and differen

36 ding assay, indicating that GTP-bound LdSar1 is required for budding of Ldgp63-containing COPII vesic

37 Here, we show that PlrS is required for BvgAS to become and remain fully active

38 We show that COX-2 and prostaglandin E2 are required for C1P-mediated increases in P-glycoprotei

39 e have recently shown that both Ras and Rap1 are required for cAMP signaling to ERKs.

40 he 5'-phosphate, and thus three metals could be required for catalysis in analogy to other nucleases.

41 r gene in a T cell receptor (TCR) locus that was required for CD8(+) T cell responses to the Plasmodi

42 Although CDK7 activity was recently shown to be required for CDK4 activation, we proposed that prolin

43 scription factor of the Forkhead family that is required for cell proliferation of normal cells.

44 n in multiple prostate cancer model systems, was required for cell proliferation, enhanced AR's trans

45 Results demonstrate that GM-CSF is required for cholesterol clearance in macrophages, id

46 PRC2 is required for chromatin reprogramming in the germline,

47 CDK6, in neutrophils, is required for clearance of the fungal pathogen Candida

48 hout eliminating clock function, whether vri is required for clock function and/or output is not know

49 PICK1-AP2 interactions are required for clustering AMPARs at endocytic zones in

50 mmetric divisions resulting from CE polarity are required for commitment to differentiated somatic ce

51 er than the thermodynamic enthalpy threshold is required for complete conversion from the initial mon

52 t lineages arise as organogenesis begins and are required for construction of all major organ systems

53 nzyme suggested that the full-length protein was required for correct lipid substrate binding and cat

54 Mechanistically, BRD4 is required for cyclin-dependent kinase 9 (CDK9) recruit

55 ank identified PLA2G16 as a host factor that is required for cytotoxicity by rhinoviruses, which caus

56 hat reorganisation of the actin cytoskeleton is required for dark-induced stomatal closure.

57 t the DAT carboxy-terminal PDZ-binding motif was required for DAT recycling and exit from retromer.

58 read primary islet cells on glass coverslips is required for detailed imaging studies by super-resolu

59 ick brain slice from adult mice, and 14 days were required for detecting antibody-labeled markers in

60 Only six days were required for detecting transgene-labeled markers in

61 e that structurally integrated primary cilia are required for detection of electrical field signals i

62 metabolites by HIMECs required MFSD2A, which is required for DHA retention and metabolism in the gut

63 Means to target these repetitive RNAs are required for diagnostic and therapeutic purposes.

64 viral genome replication and, interestingly, are required for different early steps of lytic gene exp

65 While previous studies show that autophagy is required for differentiation of other blood cell line

66 In contrast, Tcf1 long isoforms were required for differentiation of T follicular helper

67 of DLL4 transcription and that this pathway is required for DLL4 expression.

68 romotes facilitated diffusion, whereas Mre11 is required for DNA end recognition and nuclease activit

69 ATR-dependent DNA damage response (DDR) and is required for DSB repair by homologous recombination (

70 Yra1 and Def1 were required for DSB repair per se, while Sit4 was requ

71 This indicated that 2 copies of Zeb2 are required for EDN3 to prevent neuronal differentiatio

72 arily weak binding of tropomyosin to F-actin is required for effective thin filament function.

73 in vivo, thus inhibition of both AR and PARP is required for effective treatment of high risk prostat

74 tent lung inflammation, a multidrug approach is required for efficacious CF therapy.

75 nd we now show that these metabolic pathways are required for efficient lytic replication, providing

76 Additionally, acidic residues in Csm5 are required for efficient maturation, but recombinant C

77 -III components (but not ESCRT-I components) are required for efficient nuclear egress of progeny nuc

78 al host, where the AddAB system was found to be required for efficient C. jejuni colonization of the

79 Here we show that H375 is required for efficient CRF01_AE Env binding to CD4.

80 for H3-H4 tetrasome deposition in vitro, it is required for efficient DNA synthesis-coupled nucleoso

81 f RHD3 has a membrane anchoring ability that is required for efficient ER membrane fusion mediated by

82 Mechanistically, we demonstrate that Nedd4-1 is required for efficient internalization of major growt

83 ere, we provide the first evidence that TRBP is required for efficient neurosphere formation and for

84 Together, these data demonstrate that H2A.Z is required for efficient pre-mRNA splicing and indicate

85 ntification of a bacterial gene, yqiC, which is required for efficient UQ biosynthesis, and which we

86 Furthermore, these proteins were required for efficient virus replication and the ab

87 Surface-associated HA was required for eIF4E's oncogenic activities suggesting

88 Hydroxyacyl-coA dehydratases are required for elongation of very long chain fatty aci

89 nonical TISs and argues that further studies are required for elucidation of functional implications

90 These results demonstrate that UTF1 is required for embryonic development and regulates male

91 ted in endothelial microparticles (EMPs) and is required for EMP biogenesis.

92 oreover, AMPK-directed SIRT1 phosphorylation is required for energy starvation-induced PABP1-SIRT1 as

93 apical plasma membrane of epithelial cells, is required for epithelial polarity.

94 sults altogether suggest that MSRB8 function is required for ETI and containment of stress-induced ce

95 chnique is useful when a large field-of-view is required, for example, in the case of weakly interact

96 r collimated or polarised incident light, as is required for existing methods.

97 amygdala to orbitofrontal cortex projections are required for expectations of specific available rewa

98 reviously determined that beta2AR activation is required for expression of the asthma phenotype in mi

99 f the SWI/SNF chromatin-remodelling complex, is required for expression of Wilms' tumour 1 (Wt1), fet

100 We found that BRG1 was required for expression of Dct, Tyrp1 and Tyr, genes

101 or protein products of the gene miranda that is required for fate determination with GFP.

102 es with long polyunsaturated fatty acids and is required for ferroptosis.

103 Thus, mTORC1 activation is required for fueling B cells prior to DZ proliferatio

104 tion via plasma is inhibited by tetherin and is required for full MoMLV pathogenesis.IMPORTANCE Retro

105 Instead, we demonstrate that SET1A/COMPASS is required for full transcriptional activation of multi

106 sponsive transcription factors Pho4 and Pho2 are required for gene induction and survival during phos

107 t controlled but not constitutive activation is required for gonococcal infection in mice.

108 se data indicate that an intact MisRS system is required for gonococcal infection of mice.

109 in E3 ligase, murine double minute-2 (Mdm2), is required for Gp1 mGluR-induced translation and neural

110 we have identified S. aureus components that are required for growth in human blood.

111 d that ClpXP activity controls cell size and is required for growth at low temperature.

112 1 protein, a classical GAS virulence factor, was required for high-level histone resistance.

113 ding the HIV co-receptors CD4 and CCR5, that are required for HIV infection yet are dispensable for c

114 lenium (Se), an essential trace element that is required for humans.

115 Gene silencing revealed that STAT4 was required for IL-6 transcription.

116 hrough Ska complex recruitment and that this is required for improved load-bearing capacity and silen

117 Novel therapeutics are required for improving the management of chronic inf

118 DED-induced IL-12 and IL-23 are required for in vivo transition of pathogenic Th17 c

119 for homeostatic Th17 cell development, JunB is required for induction and maintenance of Th17 effect

120 eIF2alphaP and demonstrated that eIF2alphaP is required for induction of ATF4 protein synthesis in v

121 Because mTOR signaling is required for initiation of messenger RNA translation,

122 , and Mac-1 engagement of platelet GPIbalpha is required for injury responses in diverse disease mode

123 rminal domain of heme binding protein (PhuS) is required for interaction with the iron-regulated heme

124 trikingly, we find that Shelterin components are required for interactions between Taz1-associated ch

125 wn to remain at the base of mature cilia and is required for intraflagellar transport trafficking.

126 We also found that moesin is required for iTreg conversion in the tumor microenvir

127 a lipid binding property of VapA, which may be required for its function during intracellular infect

128 binds very-long-chain acyl-CoA esters, which is required for its ability to stimulate CerS activity.

129 results suggest that phosphorylation of EMS1 is required for its function in anther development.

130 Consequently, Arl8b binding to PLEKHM1 is required for its function in delivery and, therefore,

131 factor implicated in sprouting angiogenesis) is required for its VEGF-mediated induction.

132 wn that multiple cellular metabolic pathways are required for latency, and we now show that these met

133 and cellular modifications in PV+ cells that are required for learning and memory.

134 between language-relevant brain areas, which is required for linguistic processing, may depend on the

135 eplacement of colonized water reservoirs may be required for long-term clearance.

136 genome and produces no infectious particles, is required for long-term virus persistence.

137 ynaptic properties and that NL1 specifically is required for LTP induced by postsynaptic Ca(2+)-eleva

138 a PKCiota-Ect2-Rac1-NPM signaling axis that is required for lung tumorigenesis.

139 8s that regulated VE-cadherin expression and were required for lymphocyte transmigration.

140 STAT3 is required for maintaining autocrine Schwann cell survi

141 PMCA1 is required for maintaining cellular Ca(2+) homeostasis

142 increase; this led to the concept that glia are required for maintenance of the gastrointestinal epi

143 tor (NHERF) family scaffolding proteins that are required for many aspects of NHE3 regulation.

144 ch encodes the transcription factor FXR that is required for maximal urinary concentration.

145 Finally, TSLP was required for maximal ILC2 gene expression in respons

146 Mechanistically, CD2AP is required for mechanosensitive ICAM-1 downstream signa

147 to (phago)lysosome membranes, whereas PI(3)P is required for membrane association of HOPS only.

148 development, while maternally deposited gdf3 is required for mesendoderm formation and dorsal-ventral

149 Neutrophil necrosis was required for Mtb growth after uptake of infected neu

150 he lysosomal transmembrane protein, SLC38A9, is required for mTORC1 activation by cholesterol through

151 ly inhibited by Deltex2 and whose expression is required for MyoD expression in vivo and in vitro.

152 that the cargo-selective sorting nexin Snx3 is required for Neo1 trafficking and identified an Snx3

153 We found that 85% of these genes are required for nephrocyte functions, suggesting that a

154 d the Grx1-mediated deglutathionylation that is required for NET formation on the other.

155 Here we demonstrate that Prdm16 is required for neural stem cell maintenance and neuroge

156 microarray analyses we found that (1) MYT1L is required for neuronal differentiation and identified

157 t can chelate intracellular labile iron that is required for neutrophil oxidative responses.

158 that condensin II function at the centromere is required for new CENP-A deposition in human cells.

159 HSPGs are required for Nogo-A-Delta20-induced inhibition of ad

160 s between both the epithelium and mesenchyme are required for normal morphogenesis.

161 upstream of the SNARE heptad-repeat domain, is required for normal fusion activity with HOPS.

162 One such nuclear receptor is DAF-12, which is required for normal nematode development, including t

163 data suggested that protein O-mannosylation is required for normal sensory feedback to control coord

164 The DMIA moiety is required for NOS efficacy and is synthesized from l-t

165 ans Repression of nhl-2 by the mir-35 family is required for not only proper sex determination but al

166 we found that ST8Sia-IV autopolysialylation is required for NRP-2 polysialylation and that ST8Sia-II

167 In vitro, Polo directly binds and is required for Nuf phosphorylation at Ser-225 and Thr-2

168 Moreover, we show that SIRT1 levels are required for OGT-mediated regulation of invasion and

169 tead imply that nuclease activities of MRE11 are required for oncogenesis.

170 that the INO80 chromatin remodeling complex is required for oncogenic transcription and tumor growth

171 It is required for opening DNA hairpins generated during an

172 talk via physical interaction, and may also be required for optimal, reciprocal indirect regulation

173 , whereas an acidic region at the N-terminus is required for optimal SWR function.

174 he data suggest that ITAM sequence diversity is required for optimal TCR signal transduction and subs

175 osin I protein in fission yeast, Myo1, which is required for organization of sterol-rich domains in t

176 th PDZ-binding motif (TAZ) expression, which is required for osteoblast proliferation and differentia

177 bone development and homeostasis, but which is required for osteoclast-mediated inflammatory bone lo

178 us VCP negatively regulates Mitofusin, which is required for outer mitochondrial membrane fusion.

179 sion of TSLP receptor (TSLPR) on CD4 T cells is required for OVA-induced lung inflammation, DCs have

180 Estrogen receptor alpha is required for oviductal transport of embryos.

181 e that Atf1 phosphorylation by the MAPK Sty1 is required for oxidative stress responses in fission ye

182 prevent BTP and targeting central sites may be required for pain relief once BTP has been initiated.

183 First, after DSB formation, Mer2 is required for pairing by mediating homolog spatial jux

184 We demonstrate that PABPN1 and MATR3 are required for paraspeckles, as well as for adenosine

185 ght to determine if intrinsic MAVS signaling is required for participation of Tregs in anti-WNV immun

186 o consensus sites within the PFKFB3 gene and was required for PFKFB3 mRNA and protein expression.

187 e data further demonstrated that Raf kinases are required for phosphate-induced ERK1/2 phosphorylatio

188 t signalling through the TrpA1 thermo-sensor is required for PMW, and that TrpA1 specifically impacts

189 by elevating extracellular [K(+)], and KCNQ2 was required for potentiation of SMIT activity by myo-in

190 Furthermore, RYBP is required for PRC1-independent recruitment of OCT4 to

191 how that Sema-1a-dependent R axon lamination is required for preventing the spread of synaptic inhibi

192 ined by its ATPase domain, that this binding is required for processing protein substrates in nucleop

193 re dispensable for myocarditis induction but were required for progression to DCMi.

194 Finally, we show that CCAR2 is required for proliferation in vitro and in establishe

195 trated that T-cell intrinsic MyD88 signaling is required for proliferation, protection from apoptosis

196 Thus, gp226 is required for promoter recognition by the AR9 nvRNAP a

197 The drl genes are required for proper leaf patterning, development and

198 We hypothesize that laminins are required for proper trans-synaptic alignment.

199 ether downregulation of COUP-TFII expression is required for proper muscle cell differentiation.

200 -specific EZH2 deficiency we found that EZH2 was required for proper development of adaptive, but not

201 vely, indicating that Sgo2 at the centromere is required for protection.In meiosis I centromeric cohe

202 hese results demonstrate that CD8(+) T cells are required for protective immunity against a naturally

203 its C-terminal 51 amino acids (CT51), which is required for PTS protein import.

204 ) cortical complex interacts with dynein and is required for pulling force generation, but the dynami

205 implicated in SNARE complex interaction that is required for rapid synchronization and Ca(2+) coopera

206 e required for DSB repair per se, while Sit4 was required for rapid inactivation of the DNA damage ch

207 The Tre1-NRY domain via G protein signaling is required for reading and responding to guidance and s

208 and ribosome recycling factor, are known to be required for recycling, but there is controversy conc

209 We verify that Vps34 is required for recycling of the beta2-adrenoceptor (bet

210 ence of a distinct pool of PA in the ER that is required for regulation of Opi1p localization and thu

211 gene products that respond to the pistil and are required for reproductive success; moreover, we find

212 t murine hepatitis virus (MHV) ExoN activity is required for resistance to the innate immune response

213 basic helix-loop-helix transcription factors are required for retinogenesis, as well as patterning, d

214 Functionally, Tet3 is required for robust axon regeneration of DRG neurons

215 F11, which localizes to the plasma membrane, is required for ROCK-mediated cell contraction from 2 hr

216 10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC.

217 Sufficient consumer demand is required for sanitation coverage to expand through pr

218 Although this activation is required for SCs to rapidly proliferate in response t

219 ly expressed on Tregs but not on Teff cells, was required for selective Treg proliferation.

220 In addition, the RB family is required for self-renewal and survival of human embry

221 has an unexpected nuclear role in hESCs that is required for self-renewal and that it acts with HIRA

222 voltage-gated sodium channel subtype NaV 1.7 is required for sensing acute and inflammatory somatic p

223 ts suggest that plasma membrane localization is required for Ser5 antiviral activity, and Ser5-001 is

224 nscription factor Atonal homologue 1 (Atoh1) is required for Shh-type medulloblastoma development in

225 ubdivisions or the specific RAR subtype that is required for somite patterning.

226 It is required for specification of the blood program durin

227 by a group of MYB transcription factors that are required for sperm release from the pollen tube to t

228 Drosophila, the translational repressor Bgcn is required for spermatogonia to stop mitosis and transi

229 Cdc48 complexes, Cdc48-Ufd1 and Cdc48-Rbd2, are required for SREBP activation and low-oxygen adaptat

230 how that the established Cdc48 cofactor Ufd1 is required for SREBP cleavage but does not interact wit

231 CPH1 contains ankyrin repeats that are required for structural integrity of the conoid, par

232 Stx4 activity, and here we show that Munc18c is required for Stx4-mediated invadopodium formation and

233 Js), where low-frequency Ca(2+) oscillations are required for synaptic refinement and the response to

234 g lymphocytes (TILs), however, MAPK activity is required for T cells function.

235 TDPs are required for tardigrade desiccation tolerance, and t

236 1, and ADAM10-mediated sEphrin-B2 generation is required for TGF-beta1-induced myofibroblast activati

237 Here, we show that IRF8 is required for Th9 differentiation in vitro and in vivo

238 omelas) and suggest different test paradigms are required for that species.

239 Wild-type cells are required for the active elimination of mutant cells

240 irus-associated replication complexes, which are required for the amplification and subsequent spread

241 The former are required for the current generation, and the latter

242 Both new neurons and glucocorticoid hormones are required for the enhancement of fear generalization

243 cific interactions between Gag and viral RNA are required for the enhancement of particle production.

244 Recent studies have identified factors that are required for the inheritance of small RNAs and for h

245 re fundamental drivers of the cell cycle and are required for the initiation and progression of vario

246 ion assays showed that both cleaved products are required for the PDI phenotype although we could not

247 Our data demonstrate that neuroligins are required for the physiological organization of neuro

248 re we show that both the oxsA and oxsB genes are required for the production of OXT-A.

249 The BRCA and NHEJ pathways are required for the repair of CX-5461 and CX-3543-induc

250 ATPase site, we find that both ATPase sites are required for the stimulation by DNA.

251 d histone deacetylase (NuRD) complex binding are required for the zinc-finger transcription factor CA

252 pon binding of the correct peptide substrate is required for the active site to assume the proper con

253 Copper is required for the activity of cytochrome c oxidase (CO

254 t out to determine whether this modification is required for the binding of NS5A to other cellular pr

255 eper understanding of the metastatic process is required for the development of new therapies that im

256 ular guiding factor, Semaphorin 3c (Sema3c), is required for the development of the OFT, however, its

257 strate that the Wnt/ss-catenin effector Lef1 is required for the differentiation of anxiolytic hypoth

258 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular help

259 recruited to the cVAC in infected cells and is required for the efficient production of infectious v

260 A certain level of this is required for the faithful segregation of chromosomes,

261 transcription factor-encoding gene, nkx1-1, is required for the formation of circular fibres, orient

262 Kapbeta2 is required for the formation of Gli activator (GliA) in

263 we show that a time scale of hours (t>/=4 h) is required for the formation of platinum surface oxides

264 al component of axon-glial communication and is required for the function and maturation of OLs to pr

265 This is required for the induction of lipophagy, but not basa

266 tein, the heme chaperone HemW from bacteria, is required for the insertion of heme b into respiratory

267 t nuclear-encoded proteins, whereas the Oxa1 is required for the insertion of mitochondria-encoded me

268 ler but not the N-terminal domain of CrODA16 is required for the interaction with ODAs.

269 itro biochemical analyses, we show that She1 is required for the maintenance of metaphase spindle sta

270 KII activity during, but not after, training is required for the memory formation.

271 in vivo evidence that BMP signaling activity is required for the odontogenic differentiation of MSCs.

272 is suggests that the remaining normal allele is required for the phenotype.

273 ry and vestibular organs, the ribbon synapse is required for the precise encoding of a wide range of

274 vity of apurinic/apyrimidinic endonuclease 1 is required for the processing of miR-221/222 in regulat

275 of VDCCs and subsequent TrkB-Rac1 signaling is required for the rapid and sustained antidepressant e

276 electronics with very low power consumption is required for the reading of the optical responses and

277 ate that the RNA-binding protein YBX1, which is required for the sorting of selected miRNAs into exos

278 at holds homologous chromosomes together and is required for the stabilization of pairing interaction

279 ns a tightly bound FAD prosthetic group, and is required for the stereoselective epoxidation of compo

280 au-induced toxicity; however, their function is required for the suppression of tau toxicity by bas-1

281 that continued expression of oncogenic K-RAS is required for the survival of primary and metastatic c

282 We show that GLI3R is required for the therapeutic effect of SMO antagonist

283 While HIP1 was required for the coupling of cell surface GLP-1R act

284 c cells, but not in the hematopoietic cells, was required for the development of spontaneous skin inf

285 We showed that Fli1 was required for the HDMEC proliferation by transcriptio

286 at a lncRNA expressed across all progenitors was required for the myeloid lineage, whereas the other

287 est whether As3MT-mediated biotransformation was required for the proatherogenic effects of inorganic

288 uced early on after treatment with IL-27 and were required for the differentiation and function of Tr

289 of MYO6 on endosomes through binding to GIPC is required for this cellular activity and regulation of

290 nd that the extracellular domain of IL1RAPL1 is required for this effect, independently of the intera

291 Positive transmural pressure is required for this suction, providing the energy requi

292 (Ubls) harbor two catalytic activities that are required for Ub/Ubl activation: adenylation and thio

293 deeper defects and hence a higher field E th is required for unpinning.

294 MAD2 phosphorylation or CDK2 repression, but was required for upregulation of p21 and EMT indicating

295 ave and different polarization manipulations are required for varied optical applications.

296 re highly conserved in metazoans, where they are required for various processes in development, and m

297 n is not required for crescent formation, it is required for virion formation, suggesting that intera

298 We concluded that I2 is required for virion morphogenesis, release of the D13

299 on type 6 secretion system 1 (T6SS-1), which is required for virulence in animals.

300 It was found to be required for virus-mediated cell fusion, but only for