ライフサイエンスコーパス: be required to

1 RP inhibitor >1000-fold higher than the IC50 were required to ablate both ADP-ribosylation and XRCC1

2 s shown that only nineteen extension modules are required to accomplish twenty cycles of polyketide c

3 determined that age-contaminant corrections are required to accurately report contaminant trends due

4 A longer follow-up evaluation is required to accurately describe and assess specific r

5 We demonstrate that OFC is required to accurately represent the distribution of

6 accuracy and how many single-molecule tracks are required to achieve an accurate quantification of ra

7 HLH transcriptional activators that together are required to achieve precise neuronal specification d

8 -edge states, because of which multiexcitons are required to achieve the lasing regime.

9 NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-li

10 hing that stochastic conformational sampling is required to achieve reactive tunneling geometries.

11 A bright flash of illuminating light is required to acquire sufficient number of photons for

12 ey act synergistically and that both factors are required to activate Hoxd13 in limb mesenchymal cell

13 ylation of both the UBL domain and ubiquitin are required to activate parkin by releasing the UBL dom

14 idues within the intracellular domain of MPL are required to activate signaling.

15 e we show that histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers t

16 MUS81 nucleolytic activity is required to activate compensatory DNA synthesis durin

17 We found that OxyR2 is required to activate its divergently transcribed gene

18 , suggesting different prevention strategies are required to address their different risk profiles.

19 Our data indicate that low [Na(+)] is required to allow large agonist-induced structural ch

20 Moreover, CMBK was required to allow beneficial effects of both nitric

21 uitment to the nucleosome, however both PHDs are required to alter the NCP dynamics.

22 ce suggest that static crosslinking proteins are required to appropriately restrict microtubule movem

23 Future studies in patients are required to assess the potential of TNT009 for preve

24 Further studies are required to assess the viability of probiotics in yo

25 A larger study is required to assess the impact of this therapy on clin

26 We found that Lamin B receptor expression was required to attach centromeric and pericentromeric r

27 y, and that a length of about 20 amino acids is required to attain the maximum localization efficienc

28 d modulation of the inflammatory environment is required to attenuate the effector potential while bo

29 Neutrophil survival in ischemic tissue is required to attract monocytes that contribute to the

30 resholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.

31 esendoderm by keratin intermediate filaments is required to balance stresses within the tissue to reg

32 costly because the image analysis workflows are required to be executed several times to systematica

33 All hospitals were required to be level 2A county general hospitals an

34 H9N2 strains; further mutational changes may be required to become virulent for pigs.IMPORTANCE Swine

35 increase upon surface adhesion and that this is required to begin biofilm development.

36 Undoubtedly, further investigations are required to best inform future guidelines on NMD-spe

37 ng for several potential confounding factors are required to better characterize generic substitution

38 ith HbA1c, glycemic, and erythrocytic traits are required to better determine the biological action o

39 Robust, large-scaled studies are required to better quantify the indirect protection

40 However, more research is required to better define whether the Campylobacter d

41 tudy is the first demonstration that an SRRP is required to bind beta-1,4-linked galactose and the fi

42 Ub in the presence of CUL-1, and that CDC34 is required to build chains onto the Ub-primed substrate

43 se modes that, among the many possible ones, are required to capture all of the relevant experimental

44 surement of coherence both in space and time is required to characterize driven-dissipative phase tra

45 More studies are required to clarify the cost-effectiveness of roboti

46 Further studies are required to clarify the involvement of TBL1XR1 mutat

47 Further studies are required to clarify the possible roles and underlyin

48 ion can account for the emission source that is required to close the Amazon CH4 budget.

49 attachment to the extracellular matrix (ECM) is required to combat the induction of programmed cell d

50 oexpression of cyanobacterial cycI and ycf54 is required to complement the loss of acsF in Rvi.

51 endotherms indicating a greater temperature was required to completely melt all of the fat.

52 s to EC-like cells, whereas Sox17 expression is required to confer EC function.

53 However, further longitudinal studies are required to confirm and further characterize a prote

54 Further studies are required to confirm that serum albumin can be used a

55 Further studies are required to confirm the usefulness of this device an

56 Randomized controlled trials are required to confirm these results.

57 Further studies are required to confirm this approach.

58 the assessment of HIV-SN, but larger studies are required to confirm this finding.

59 Further research is required to confirm these results and examine the dri

60 be mechanism-based although additional work is required to confirm this and determine clinical relev

61 vivo results further showed that neutrophils are required to control both phage-sensitive and emergen

62 lly, master regulatory transcription factors are required to control tissue-specific gene expression

63 ease activity of the CSN (COP9 signalosome), are required to control ubiquitin ligase assembly, funct

64 Intriguingly, increased forces were required to convert hypermethylated dsDNA into an e

65 In addition, BET proteins are required to coordinate an IL6-dependent AMPK nuclear

66 a indicate that vision and social experience are required to coordinate precise movements between pai

67 Further research in the field is required to corroborate our study.

68 propose that at RdDM target regions, PKL may be required to create a chromatin environment that influ

69 achieve the wide scope of understanding that is required to create a unified model across crystal typ

70 r investigation of the Pals1-linked networks is required to decipher the mechanisms underlying the pa

71 Constant comparison between the two acids was required to decipher the course of the reaction owin

72 rison with conventional pacing systems, will be required to define the proper clinical role of these

73 to increase liver utilization, but more work is required to define factors predicting good outcomes.

74 This was required to define the transition between proliferat

75 ights that intensified prevention strategies are required to delay or prevent avoidable vision loss r

76 turbulence generated by fine scale structure is required to deliver larvae to the substratum even in

77 ther bacterial consortia or single organisms are required to depolymerize highly complex glycans.

78 Operational research is required to design delivery of pre-exposure prophylax

79 nciples include positive feedback loops that are required to destabilize a spatially uniform state of

80 Additionally, sensitive analytical methods are required to detect small changes.

81 In several examples, large population sizes were required to detect GxEs.

82 Further studies are required to determine if this medication used at low

83 Further studies are required to determine optimal parameters of LT for P

84 Although further investigations are required to determine the degree to which these find

85 immunotherapies, although systematic studies are required to determine the magnitude of the effect be

86 Further studies are required to determine the mechanisms linking these c

87 Further studies are required to determine the sensory modalities of thes

88 Targeted genomic analyses are required to determine whether these differences are

89 Additional studies will be required to determine whether quantitative muscle ult

90 Further research is required to determine a core set of outcomes to be us

91 Follow-up in a cohort of children is required to determine how the observed associations m

92 Future work is required to determine if hypoxia can be used to preve

93 Prospective testing is required to determine the clinical utility of this as

94 Kras activation and p16 inactivation are required to develop pancreatic ductal adenocarcinoma

95 developing systems that can utilize O2, will be required to develop a practical process that can repl

96 Further research is required to develop a new valid nomogram for laser-as

97 ation and on which cell types its expression is required to do so.

98 hat 15-31 degrees C (1sigma) surface warming is required to double the continental weathering flux, v

99 88 and FcRgamma, presumably on myeloid APCs, were required to downregulate T cell help for the extraf

100 IS2 moiety while both ETO2 and GLIS2 domains are required to drive increased self-renewal properties.

101 an orphan receptor, death receptor 6 (DR6), is required to drive axon degeneration after axotomy in

102 in K+-containing solution a branched pathway is required to drive the wild type sequence to distribut

103 ety-related behavior, alternate mouse models are required to effectively analyze cognitive outcomes a

104 differences both at baseline and in disease is required to effectively consider and treat all patien

105 ease in the protein levels of ALIX and ALG-2 are required to elicit apoptosis by activating ER stress

106 Sucrose feeding, which is required to elicit fatty liver in KI mice, led to a m

107 rmational change in the viral F protein that is required to elicit membrane fusion.

108 Cytokine priming was required to elicit the unanticipated finding that Si

109 Further work will be required to elucidate the biological mechanism and tr

110 To determine how many and which tyrosines are required to enable EGF receptor-mediated signaling,

111 how these tumors escape immune surveillance is required to enhance antitumor immune responses.

112 for shearwaters, urgent conservation actions are required to ensure the viability of their population

113 s suggest that massive EV/exRNA uptake would be required to ensure functional impact of transferred R

114 capacity for alternative electron transport is required to ensure adequate redox state and lumen pH.

115 quivalents from the cytosol to the ER, which is required to ensure correct disulfide formation in pro

116 The coordinated action of both pathways is required to ensure efficient neuroblast migration alo

117 Optimization of sensing algorithms is required to ensure that the highest risk HCM patients

118 Regulatory T cells (Tregs) are required to establish immune tolerance to commensal

119 Further studies are required to establish the role of RKT for obese cand

120 pirical implementation in animals that would be required to establish a common biological basis.

121 expected that a more potent formulation will be required to establish antibody titers that persist fo

122 Further evidence may be required to establish that a mixed catheter package i

123 Additional investigation is required to establish a causal connection.

124 We found that BMP signaling is required to establish a posterior SATB2+ domain in de

125 A larger prospective study is required to establish the role of all tests, demograp

126 ss very slowly and quantitative measurements are required to evaluate cerebellar dysfunction.

127 ne kinase inhibitors to conventional therapy are required to evaluate the clinical utility of these a

128 Although faster-acting alleles of myo2 will be required to evaluate its contribution at 25 degrees C

129 e attenuation of beta-catenin, both of which are required to execute the osteoclast developmental pro

130 Further studies are required to expand the versatility of CRISPR/Cas9 as

131 lume of the present East Antarctic Ice Sheet is required to explain many of the approximately 110-ky

132 he extent to which random sensorimotor noise is required to explain the non-linear remnant.

133 Further work is required to explore the potential use of IgG FXa reac

134 binding protein (CREBBP)/EP300 bromodomains are required to facilitate the elucidation of biology as

135 In accordance, the receptor of CCL2, CCR2, is required to facilitate increased MDSC presence and tu

136 ow that ATM expression by peritoneal B cells is required to facilitate viral reactivation during long

137 Consequently, efficient algorithms are required to filter the tests that are performed and

138 further investigation on a large population is required to firmly establish their effects on breast

139 plexes is 4.3 ns and generally two lifetimes are required to fit the exponential decays.

140 ass wasting features, as much less water may be required to form such features than previously though

141 SMADs to activate a subset of ME genes that is required to form cardiac mesoderm.

142 othelial filopodia, demonstrating that Myo10 is required to form normal numbers of filopodia in vivo.

143 r monitoring TBECH exposure, further studies are required to fully understand the levels and toxicolo

144 Further biomechanical analysis of the RDT is required to fully define RDT functional roles.

145 d conclude that extensive molecular analysis is required to fully understand the structure of enginee

146 istal tip, implying that an integrated model is required to fully understand these processes.

147 Treatment with both drugs was required to fully suppress mechanistic target of rap

148 The double-ring assembly of GroEL is required to function with GroES, and a single-ring Gr

149 ory, evolutionary age, and growth conditions is required to gain insight into the evolution of land p

150 28), an increase in burst frequency (>50 Hz) was required to gain timing-dependent LTP.

151 d bidirectional tuning of interneuron inputs are required to generate the kinematic representations i

152 showed that 12-lipoxygenase (12-LOX), which is required to generate the PMN chemoattractant hepoxili

153 Patients were required to have early-stage disease and gadolinium

154 Further studies are required to identify barriers and facilitators to th

155 uorescence in situ hybridization (FISH) will be required to identify HGBL-DH and will reclassify a su

156 l antigen-specific immunotherapy will likely be required to impart durable therapeutic efficacy.

157 Efficient strategies are required to implement comprehensive suspect screenin

158 low-cost methods of removing aqueous Mn(II) are required to improve the quality of impacted groundwa

159 imisation of HBc particle yield from E. coli is required to improve laboratory-scale productivity for

160 Further risk stratification is required to improve outcomes and reduce late effects.

161 Coordinated action is required to improve the situation of this extremely v

162 Further studies are required to incorporate molecular biomarkers into su

163 Universities in the United Kingdom (UK) are required to incorporate values based recruitment (VB

164 ances and therefore no change in legislation is required to increase utilization of organs from HIV-i

165 red with young cells, such that higher doses are required to induce comparable signaling.

166 t that appropriate subimmunogenic conditions are required to induce Foxp3(+) regulatory T cell conver

167 All of the pro-TH2 cytokines are required to induce our model of FA, whereas any pro-

168 perties, but intratumoral administration has been required to induce an effective anti-tumor immune r

169 ngage the type I IFN pathway, but only STING is required to induce IL-1beta secretion, caspase-1 acti

170 Exogenous angiopoietin-1 was required to induce arteriolargenesis (8.6 +/- 1.3% o

171 Thus, a deconvolution step is required to infer the expression values of each gene.

172 More convincing data from randomized trials are required to inform the management of patients with t

173 t Sec22b-dependent cross-presentation in DCs is required to initiate CD8(+) T cell responses to dead

174 Aquarius is required to initiate small-RNA-induced heritable gene

175 the complexity of the APP proteolytic system is required to integrate available evidence.

176 one DNA strand suggesting that two complexes are required to introduce a double strand break.

177 er multi-institutional, longitudinal studies are required to investigate effect of delirium on long-t

178 ding as a monomer, additional flanking bases were required to invoke sequential dimerization of the b

179 ad to a signal activation model, where Arrow is required to localize Dsh to the membrane during canon

180 late cAMP, or if normal basal levels of cAMP are required to maintain cellular health needed for hyph

181 eas intakes of 6 and 14 mug/d, respectively, are required to maintain concentrations >/=30 nmol/L dur

182 lpain cleavage, in the sensory neuron and L7 are required to maintain each form of LTF.

183 F4 and RALF19, are pollen tube-expressed and are required to maintain pollen tube integrity.

184 hat extent additional compensatory mutations are required to maintain stability during affinity matur

185 T) have unique membrane specializations that are required to maintain the high-capacity ion transport

186 ross-feed on PVDPAO1 , production of PVDPf-5 is required to maintain a competitive advantage.

187 ysiological studies proved that SlCBL10 gene is required to maintain a proper low Na(+)/Ca(2+) ratio

188 Our analysis predicts that filament turnover is required to maintain active stress against external r

189 morphology, showing that cell contractility is required to maintain adherens junction integrity.

190 that the nuclear pore basket component Alm1 is required to maintain both the proteasome and its anch

191 Large-scale cooperation is required to maintain contiguous air contact across th

192 t al. present evidence that POT1, like SSB1, is required to maintain genomic stability.

193 Additionally, Notch1, but not Notch2, is required to maintain HBC dormancy after selective neu

194 The findings suggest that adult neurogenesis is required to maintain hippocampal volume but is not re

195 lator of single-cell metabolic dynamics that is required to maintain metabolic stability in prolifera

196 Our data suggest that endothelial SHIP2 is required to maintain normal systemic glucose homeosta

197 A signaling in the developing forebrain that is required to maintain the appropriate size of the dien

198 hat the transcriptional coactivator CBP/p300 is required to maintain the growth of castration-resista

199 Additionally, Tfh cell-derived IL-4 was required to maintain the Th2 response in the mesente

200 difference in k(0) of >3 orders of magnitude is required to make this distinction.

201 When 50% agreement was required to make a recommendation, all questions yie

202 MEK1 was required to make Xenopus pluripotent cells competent

203 elop drug resistance, alternative strategies are required to manage malaria infections.

204 bout two in shallow-lower-mantle bridgmanite is required to match seismic data, implying the presence

205 Two conditions are required to maximize malonate-sensitive ROS producti

206 Strong decreases in greenhouse gas emissions are required to meet the reduction trajectory resolved w

207 Rigorous laboratory good practice was required to minimize bacterial DNA contamination.

208 r (DCIR), a key component in DC homeostasis, is required to modulate lung inflammation and bacterial

209 ses of Trl and Atro clones suggest that Atro is required to modulate the transcription activation by

210 Dietary assessment and modelling are required to monitor efficacy and safety of ongoing s

211 n the mechanism of mC flipping by SRA, tools are required to monitor in real time how SRA reads DNA a

212 Our work indicates that CCR7 is required to mount a robust immune response against en

213 function in biological systems, new methods are required to obtain atomic resolution structures from

214 p yield, and regular fertilizer applications are required to obtain high yields and to prevent soil d

215 n maternal, offspring, and paternal genotype are required to obtain more precise (and unbiased) causa

216 technologies both biorefineries would likely be required to obtain major source permits under the Cle

217 rm net CO2 uptake of >200 g CO2 m(-2) yr(-1) is required to offset the positive radiative forcing of

218 t that different vaccination strategies will be required to optimize protection mediated by T cells r

219 ns with 34-nm long, S-shaped Atg17 complexes are required to overcome a substantial kinetic barrier i

220 arrangement in the capsid coat proteins that is required to package the viral gRNA in its dominant co

221 Assessed individuals in CDDCs were required to participate in services such as counsel

222 International collaboration will be required to perform clinical studies to inform the tr

223 sk that a clinician and his or her staff may be required to perform.

224 all resistant clones and determined that ADK is required to phosphorylate and activate 6-ETI.

225 Ipo11) is a transport receptor for PTEN that is required to physically separate PTEN from elements of

226 In addition, we found that c-Myc is required to preserve CPC growth, suggesting that modu

227 membrane influx in infected macrophages, and is required to preserve Mtb phagosome integrity and cont

228 nd scrupulous attention to infection control are required to prevent additional MERS outbreaks.

229 whether macrophage-intrinsic IL10R signaling is required to prevent colitis in infancy is unknown.

230 Long-term antiviral prophylaxis is required to prevent hepatitis B recurrence for patien

231 ease, but optimization of treatment regimens is required to prevent the emergence of mmpT5 variants a

232 ly expressed in murine thymic epithelium and is required to prime thymic epithelial cells (TEC) for e

233 separation within the decision-making center is required to process variable temperature inputs from

234 m, two sequential cyclases, LcLCC and LcLCD, are required to produce alpha-onocerin in the N. bentham

235 euron subtypes by controlling the genes that are required to produce them.

236 lacio-eustatically controlled sea-level fall is required to produce the observed drops of (87)Sr/(86)

237 We show that AtBMI1 proteins are required to promote all developmental phase transiti

238 3ph depends on tension at the centromere and is required to promote bi-orientation of sister chromati

239 A borane (e.g., pinacolborane) is required to promote CAH.

240 Our results reveal that hPOT1 OB-folds are required to protect and prevent newly replicated tel

241 Increased gamma2-AMPK activity is required to protect against ischemia/reperfusion inju

242 nt removal of infected and dying neutrophils is required to protect the surrounding tissue from bioac

243 Further investigations are required to provide a better overall view of the Lao

244 d nursing qualifications from outside the UK are required to provide evidence of English language com

245 Future research is required to provide evidence of replication in a larg

246 ons corrected for exposure misclassification are required to quantify the public health burden possib

247 light in which protein import into plastids is required to rapidly complete chloroplast biogenesis.

248 e observed, thus, matrix-matched calibration is required to reach good performances, i.e. 63% of comp

249 natives we used a task in which participants were required to reach to either a single target or towa

250 Thus, measures that control infection may be required to realize the full benefits of CFTR-targeti

251 ved diabetic macular edema (DME) at baseline were required to receive ranibizumab for center-involved

252 nd vesicle transport in pull-down assays and was required to reconstitute Golgi compaction in PAQR11-

253 hich system processes drive optimal outcomes is required to reduce the burden of injury worldwide.

254 Lower doses of the FLAP inhibitor MK886 were required to reduce LTB4 levels in exudates of femal

255 pt for galaxolide, for which further studies are required to refine conclusions, the OMP's chemical s

256 we show that WNT5A in the bone marrow niche is required to regenerate HSCs and leukemic cells with f

257 ne NK cells are the key source of IL-10 that is required to regulate DC phenotype and pregnancy succe

258 and (ii) the washing and elution steps that are required to remove these reagents and release DNA in

259 m architecture, whereas dimerization of BslA is required to render the community hydrophobic.

260 orporating sediment biogeochemical feedbacks is required to reproduce the observed postbreach interna

261 -binding and dynein-dynactin-binding modules are required to rescue focused, bipolar spindle organiza

262 ical autophagy targets phagosomes, xenophagy was required to restrict the growth of L. monocytogenes,

263 Thus more direct approaches are required to reveal potentially druggable binding sit

264 methodologies and high performance computing is required to scale these studies to large imaging data

265 Axon degeneration during development is required to sculpt a functional nervous system and is

266 The protease is required to select specific substrates for degradatio

267 dings indicate that a combination of factors is required to sensitize these regions.

268 Long-term studies are required to show if density-related insect behavior

269 hes potentially including rindopepimut might be required to show efficacy of immunotherapy in gliobla

270 n between the two groups, although more work is required to show this definitively.

271 erlaps at the onset of cytokinesis proved to be required to spatially confine membrane accumulation.

272 developing dorsal spinal cord, multiple BMPs are required to specify sensory interneurons (INs).

273 Future studies are required to specify the implications of our dataset

274 ctivated kinase 1 (TAK1)-mediating signaling were required to spur inflammatory disease.

275 capsids, revealed that both pUL17 and pUL25 are required to stabilize the capsid shells at the verti

276 esigns and delivery, technology advancements are required to study fundamental mechanisms of mRNA upt

277 presence of profilin, proline-rich sequences are required to support polymerase activity by (i) bring

278 y-limited conditions, alternative substrates are required to support respiration.

279 Interventions were required to support symptom management.

280 since overexpression of the cluster subunits was required to suppress the brush phenotype.

281 We have previously shown that GIGANTEA (GI) is required to sustain Suc-dependent circadian rhythms i

282 Further studies in different areas are required to test the impact of different IgE molecul

283 Additional studies are required to test the prognostic significance of CNA

284 Further study is required to test effects of agents that target the NO

285 ntaining 5 (ACBD5) and that this interaction is required to tether the two organelles together, there

286 tiff but well distributed networks of plates are required to transfer loads efficiently between neigh

287 ow that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRN

288 suggesting that combinations of agents will be required to treat these diseases effectively.

289 thquakes demonstrate that little dehydration is required to trigger embrittlement.

290 (eg, gene or pathway based) may, therefore, be required to uncover common variants contributing to t

291 rger sample sizes across ages and lifestyles are required to understand the full genetic architecture

292 Further study is required to understand E2 variability in this setting

293 he role of metabolites, metals, and proteins is required to understand normal cell function, and ulti

294 Precise dating of diamond growth is required to understand the interior workings of the e

295 onal enhancers and their biological contexts is required to understand the mechanisms by which variat

296 ticular, a history of grounding-line retreat is required to understand the relative roles of contempo

297 dual-level information about prisoner health is required to understand the substantial variations rep

298 perating within emission control areas (ECA) are required to use fuels with </=0.1 wt % sulfur.

299 Longitudinal information is required to validate the implied risk of vision loss

300 xity of the metabolic context, and new tools are required to visually represent integrated biocurated