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2 dition, an HIF-1alpha Cys(520) serine mutant is resistant to 2-AAPA-induced HIF-1alpha stabilization.
3 amphotericin B, and 7% to echinocandins; 41% were resistant to 2 antifungal classes and 4% were resis
5 we investigated how several strains of HAstV are resistant to a virus-neutralizing monoclonal antibod
7 vitro and in vivo Acrolein-modified histones are resistant to acetylation, suggesting that the reduce
11 lethal phenotype, mice heterozygous for p32 are resistant to age- and high-fat diet-induced ailments
14 uggesting that a fraction of virus particles are resistant to antibody neutralization despite high an
17 of the underlying cause mediating G1 arrest, are resistant to apoptosis induced by the proteasome inh
18 cl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we ha
19 hils from patients with FMF during remission are resistant to autophagy-mediated NET release, which c
20 lenced cells or SLAMF1(lo) primary CLL cells were resistant to autophagy-activating therapeutic agent
21 ivity against chronic myeloid leukaemia that is resistant to available treatment, although it is asso
23 ain-of-function SHP2 mutation (SHP2(D61G/+)) were resistant to bleomycin-induced pulmonary fibrosis.
25 Mutant U1060A in 16S Escherichia coli rRNA is resistant to both antibiotics, whereas mutant U1052G
27 wed that the semi-arid steppe in north China was resistant to both daytime and nighttime warming, but
28 3, and interestingly M159W, V136E, and L122D were resistant to both isoflurane and TCE activation.
30 but is effective in killing WCR larvae that are resistant to Bt proteins produced by currently avail
31 DNA cleavage specificity is different and it is resistant to camptothecins (CPTs) and non-CPT Top1 in
32 GO (Spy1) proteins bind and activate Cdk but are resistant to canonical regulatory mechanisms that es
34 t primary CD4 T cells expressing GPI-scFv X5 were resistant to CCR5 (R5)-, CXCR4 (X4)-, and dual-trop
35 l stages, mouse embryonic stem cells (mESCs) are resistant to cell fate conversion induced by the mel
36 E-cadherin-expressing prostate cancer cells were resistant to cell death by chemotherapeutic drugs b
37 In the current study, a number of isolates were resistant to cephalosporins and fluoroquinolones.
38 a small fraction of cells in the cancer that are resistant to chemotherapy and radiation therapy and
40 BACKGROUND & AIMS: Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents
41 re hyperphagic under stressed conditions and are resistant to chemotherapy-induced anorexia and body
42 of cancer-related deaths and is reported to be resistant to chemotherapy caused by tumor-initiating
47 he viruses, with the exception that mallards were resistant to Ck/Pennsylvania/83 and Ck/Queretaro/95
49 detected (22%), and 62% and 36% of isolates were resistant to clindamycin and trimethoprim/sulfameth
50 nd and that RAC1-mutant human melanoma cells are resistant to clinical inhibitors of BRAF but are uni
53 athogen-free (SPF) mice, germ-free (GF) mice are resistant to Concanavalin A (ConA)-induced liver inj
55 al-like tumor cell populations in mCRPC that are resistant to conventional and targeted therapies can
56 tion promotes lysis of arterial thrombi that are resistant to conventional approaches such as recombi
57 ent a significant clinical challenge as they are resistant to conventional cancer therapies and play
63 , bioassays indicated that field populations were resistant to Cry3Bb1 maize and mCry3A maize, and th
66 rboring BRAF(V600E) and PTEN mutations often are resistant to current therapies, including BRAF inhib
69 development of A. suturalis populations and were resistant to damage caused by plant bug infestation
70 over, glucocorticoid induction of Klf13 mRNA was resistant to de novo protein synthesis inhibition, d
72 responsible for the control of eye movement) were resistant to degeneration in endstage SMA mice, as
75 st proteoliposomes have evolved naturally to be resistant to degradation and provide a supportive env
76 with activated sludge demonstrated that LMG is resistant to degradation and that its human metabolit
77 CP in the kidney, liver, and adipose tissues were resistant to developing high-fat diet-induced obesi
80 ed lipid storage and adipose tissue mass and were resistant to diet-induced obesity and insulin resis
81 tently, neither Akt1(-/-) nor Akt2(-/-) mice are resistant to diethylnitrosamine-induced hepatocarcin
82 odimer in human spinal cord homogenates that was resistant to dissociation by boiling, denaturants, o
88 riant of RAGE (RAGE splice variant 4), which is resistant to ectodomain shedding, inhibited RAGE liga
95 nkages, particularly from prokaryotes, which are resistant to enzymatic or chemical release, could al
99 o LDL or extracellular PCSK9, the LDLR-R410S was resistant to exogenous PCSK9-mediated degradation in
100 nsfer of WT platelets to CD40-KO mice, which are resistant to experimental cerebral malaria, partiall
103 While memory B-cells from cirrhotic patients were resistant to Fas-mediated apoptosis ex vivo, Toll-l
104 ce in the proportion of tested isolates that were resistant to fluconazole between the fluconazole an
105 sing stringent break points, 93% of isolates were resistant to fluconazole, 35% to amphotericin B, an
106 -derived tetracycline-like viridicatumtoxins are resistant to fungal biotransformation, providing che
109 strongly inhibited growth of CC, whereas SC was resistant to growth inhibition, and this was coupled
112 ich Mst1/Mst2 heterodimers are not possible, are resistant to H-ras-mediated transformation and maint
115 steroid receptor RNA activator (SRA) (SRAKO) are resistant to high fat diet-induced obesity with a ph
118 indicates that subsets of cellular proteins are resistant to host shutoff and continue to be synthes
121 AI mutants deficient in nucleic acid binding are resistant to IAV-triggered necroptosis and apoptosis
124 findings suggest that R. pseudoacacia growth is resistant to increased drought frequency because it e
125 mmation in imiquimod-induced dermatitis, and were resistant to induction of experimental autoimmune e
129 to fibrin contributes to clot stability and is resistant to inhibition by antithrombin/heparin while
132 mping studies revealed that ECSHIP2(Delta/+) was resistant to insulin-stimulated glucose uptake in ad
134 We found that Th-MYCN/Trp53(KI/KI) tumors were resistant to ionizing radiation (IR), as expected.
135 losis clinical isolates, including four that are resistant to isoniazid and one that is resistant to
136 of clinically relevant A. baumannii strains are resistant to killing by normal human serum (NHS), an
137 d amplitudes of their speed tuning functions are resistant to large changes in spatial frequency.
138 ddition, the growing prevalence of UPEC that are resistant to last-line antibiotic treatments, and mo
139 ave lower adenovirus titers in the lung, and are resistant to lethal herpes simplex virus-1 infection
140 lar and cytokine-based lung inflammation and were resistant to lethal influenza virus infection.
141 d IFN-beta (IFN-alpha/beta) in the serum and were resistant to lethal plasmodium yoelii YM infection.
142 ion and chemotaxis, and TIPE2-deficient mice were resistant to leukocyte-mediated neural inflammation
145 comprise an important clinical subtype that is resistant to many standard of care chemotherapeutics
146 ative in glioblastoma (GBM) tumor cells that is resistant to mechanistic target of rapamycin (mTOR) i
152 Carbapenem-resistant Enterobacteriaceae are resistant to most beta-lactam antibiotics due to the
156 larming increase of pathogenic bacteria that are resistant to multiple antibiotics is now recognized
159 ectivity of viruses harboring mutant PR that are resistant to multiple PR inhibitors or mutant Gag pr
160 s in a localized ligand radical species that is resistant to N coupling of the nitrides and is stable
163 -section within the microcolony 3D structure were resistant to neutralization (vs. upper and peripher
167 LTP is dependent upon APP since APP-KO mice were resistant to oAbeta- and oTau-induced defects in sp
168 GLUT4 promoter (i.e., transgenic [TG] mice) are resistant to obesity-induced insulin resistance.
169 inistered a sclerostin-neutralizing antibody are resistant to obesogenic diet-induced disturbances in
171 ive against several influenza A viruses that are resistant to one or both classes of Food and Drug Ad
175 ll isolates were beta-lactamase positive and were resistant to penicillin, tetracycline, and ciproflo
177 transfer), and cells harboring this mutation are resistant to peptidyl-transferase inhibitors (e.g.,
178 tiffness and hardness comparable to diamond, is resistant to perforation with a diamond indenter and
179 receptor 9 (TLR9)-deficient (TLR9(-/-)) mice are resistant to periodontitis, a disease characterized
180 ant breeders have developed crop plants that are resistant to pests, but the continual evolution of p
182 one or in combination with onion leaf lectin are resistant to Phenacoccus solenopsis (cotton mealybug
183 , the prosurvival phenotype of patient cells was resistant to phosphoinositide 3-kinase inhibition.
184 ic alterations, mesenchymal-like tumor cells are resistant to PI3K and MAPK pathway inhibitors, sugge
185 ssing a constitutively activated form of AKT were resistant to PI3Kdelta inhibition, suggesting that
186 tiple substrains of the 129 mouse background are resistant to pigmentation locus-negative (pgm(-)) Ye
187 Cys42Ser PKGIalpha knock-in (KI) mice, which are resistant to PKGIalpha oxidation, have diastolic dys
188 ith reversions detected in tumor-derived DNA were resistant to platin- or poly ADP ribose polymerase
190 t pandemic O1 Vibrio cholerae biotype El Tor is resistant to polymyxins, whereas a previous pandemic
191 sgenes containing natural or synthetic PATCs are resistant to position effect variegation and stochas
192 ommon phase in high-silica igneous rocks and is resistant to post-eruptive alteration, thus offering
194 ssemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery con
195 portunity to develop production animals that are resistant to PRRS, the costliest viral disease to ev
196 Remarkably, dominant jaz2Deltajas mutants are resistant to Pseudomonas syringae but retain unalter
198 ly populated regions in Malawi, An. funestus is resistant to pyrethroids, carbamates, and organochlor
199 at determining whether the infected strains were resistant to quinolone can be performed simultaneou
201 that Rs-cps transgenic N. benthamiana plants were resistant to R. similis and the transcription level
202 sive CD4 T cells engineered with GPI-scFv X5 are resistant to R5-, X4-, or dual-tropic virus infectio
203 mor cells initiate and sustain tumor growth, are resistant to radiation and drugs, and bear specific
206 ifferentiated HSPCs and that quiescent HSPCs are resistant to reactivation by histone deacetylase inh
210 as a model for culture of other viruses that are resistant to replication in conventional cell cultur
212 nscriptionally >100-fold upon Dicer loss and is resistant to resilencing by complete restoration of m
213 memories created with 10 tone-shock pairings are resistant to retrieval-dependent memory destabilizat
214 nal studies of essential noncoding RNAs that are resistant to RNAi and RNase H-based degradation.
215 HIV-1 RNA from infected DBR1 knockdown cells was resistant to RNase R that degrades linear RNAs but n
216 while hyperphosphorylated cdc24 mutants that were resistant to scaffold stimulation displayed a defic
220 y expressed RHBDL2 and that a subset of them is resistant to shedding by cell surface metalloprotease
221 Moreover, while their ability to self-renew was resistant to SHH inhibitors, as has been previously
222 Furthermore, the VIR165-dependent viruses were resistant to soluble CD4-induced Env destabilizatio
226 d tumors often contain hypoxic regions which are resistant to standard chemotherapy and radiotherapy.
230 Autoimmune diseases feature T cells that are resistant to suppression by Tregs, whereas in cancer
231 vity (TRPM7(KR) ), are not hyperallergic and are resistant to systemic magnesium (Mg(2+) ) deprivatio
233 ve against the parasite, they need to either be resistant to TbMTAP-mediated cleavage, which is the c
234 yers involves cell-to-cell transmission that is resistant to tetherin but that virion dissemination v
235 es, but not proximal nerves or dorsal roots, is resistant to tetrodotoxin and that, in mice, this eff
236 de of the dipeptide d-Hot horizontal lineTap is resistant to TFA and thus can serve as a bioorthogona
237 o analysis reveals that CD4(+) T(Pam3) cells are resistant to TGF-beta-mediated gene expression throu
239 d in vivo In addition many rotavirus strains are resistant to the actions of different IFN types.
240 However, a number of bacterial pathogens are resistant to the antimicrobial activities of macroph
241 that nTregs, unlike Teffs (CD3(+)FOXP3(-)), are resistant to the antiproliferative effects of AzaC.
245 Mice devoid of Smad7 specifically in DCs are resistant to the development of experimental autoimm
247 ol and PC/phosphatidylethanolamine ratio and are resistant to the hepatitis and fibrosis normally ind
248 (+)/PIK3CA(H1047R) transgenic mammary tumors are resistant to the HER2 antibodies trastuzumab and per
252 ins of human astrovirus serotype 2 (HAstV-2) are resistant to the potent HAstV-2-neutralizing monoclo
253 or predisposing gene for autoimmune disease, are resistant to the suppressive effects of TGFbeta.
254 embryonic fibroblasts deficient in Bax/Bak1 are resistant to the third major form of cell death asso
255 further demonstrate that tumor cells, which are resistant to the toxin when grown in vitro, become h
257 LPH2 is localized to the plant cell cytosol, is resistant to the classic serine/threonine phosphatase
260 ve malignancy associated with infection that is resistant to the majority of chemotherapeutic drugs.
266 d elevated numbers of pulmonary NK cells yet were resistant to the induction of allergic inflammation
268 inhibitors, we generated mutant viruses that were resistant to the inhibitory effects of Z-d-Phe-l-Ph
269 13 366 (51.1%) of 26 174 bacterial isolates were resistant to the Malawian first-line antibiotics am
273 cy of antifungal agents; however, fungi that are resistant to these treatments are regularly isolated
281 , which inherit mutations present in GSC and are resistant to traditional antiangiogenic therapies.
288 uced by catecholamine injections, TG animals were resistant to triggered ventricular arrhythmias.
291 cific homozygous or heterozygous Arid1a loss were resistant to tumor initiation while ARID1A overexpr
295 ablation of HCC, hepatic veins and arteries were resistant to vessel occlusion compared with portal
296 ion, our results indicated that some neurons are resistant to virus-mediated cell death and provide a
297 on in the p110delta gene (p110delta(D910A) ) are resistant to VL, due in part to impaired regulatory
299 report that TLR8-deficient (Tlr8(-/-)) mice were resistant to WNV infection compared with wild-type
300 lant Nicotiana benthamiana has been shown to be resistant to Xanthomonas and Pseudomonas due to an im
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