ライフサイエンスコーパス: be severely compromised

1 formation of astrocytes in the white matter is severely compromised.

2 application in pharmaceuticals and cosmetics is severely compromised.

3 f sister chromatids within these chromosomes is severely compromised.

4 on factor broad), the encapsulation response is severely compromised.

5 lasia, in which steroid hormone biosynthesis is severely compromised.

6 ny embryonic structures, including the limb, is severely compromised.

7 cluster, and GABAergic synaptic transmission is severely compromised.

8 one deacetylase activity of the core complex is severely compromised.

9 and/or survival of the differentiated cells is severely compromised.

10 gc-1(c) pups, indicating that erythropoiesis is severely compromised.

11 a mutant's ability to cause invasive disease is severely compromised.

12 5750 to a preformed enzyme-substrate complex is severely compromised.

13 sensitized, but development of T-cell memory is severely compromised.

14 t pollen, indicating that chx21 chx23 pollen is severely compromised.

15 In contrast, Hsp40 interaction is severely compromised.

16 ed under conditions where global translation is severely compromised.

17 develop and function normally, gametogenesis is severely compromised.

18 lt, cardiomyocyte respiration and ATP output are severely compromised.

19 ATP hydrolysis and helicase II stimulation, are severely compromised.

20 ut that their subunit association properties are severely compromised.

21 ompetence and infectivity of nascent virions are severely compromised.

22 ditions where the dynamics of thermal motion are severely compromised.

23 ll as embryonic and postembryonic patterning are severely compromised.

24 bs with dynamic cytoskeletal properties that are severely compromised.

25 ests that one or more key cellular processes are severely compromised.

26 the competitive fitness of peripheral Tregs was severely compromised.

27 e/+) SRC-2(flox/flox) mouse uterine function was severely compromised.

28 atically disrupted and keratinocyte adhesion was severely compromised.

29 its ability to cause plant tissue maceration was severely compromised.

30 lular Ca(2+) ([Ca(2+)](o)), but its function was severely compromised.

31 ondividing cells, and plaque-forming ability was severely compromised.

32 o grow within this macrophage-like cell line was severely compromised.

33 lular metabolic substrates, NADPH generation was severely compromised.

34 to Apc(+/DeltaIEC) mice, and their survival was severely compromised.

35 of virulence proteins in the hha sepB mutant was severely compromised.

36 in low-inorganic-phosphate (P(i)) conditions was severely compromised.

37 d and that from alpha-granules and lysosomes was severely compromised.

38 deficient allele, however, allelic exclusion was severely compromised.

39 cell subsets or even when TH2 cell functions were severely compromised.

40 ever, hair cycle and wound healing processes were severely compromised.

41 me mice, virus-specific CD4 T cell responses were severely compromised.

42 rough 24 weeks, even though immune functions were severely compromised.

43 sphingolipids, and their lysosomal functions were severely compromised.

44 arization of antigen-specific CD4(+) T cells were severely compromised after treatment with a soluble

45 e capacity to form stable end-on attachments was severely compromised, all kinetochores nevertheless

46 c analyses demonstrate that the R303M mutant is severely compromised, although active, with k(cat) =

47 ses of CD40L-deficient mice to these viruses were severely compromised, although moderate titres of a

48 n, an assembly factor for MO15 and cyclin H) are severely compromised and display a significant furth

49 In disease states in which liver function is severely compromised and both zinc and vitamin A meta

50 epsilon-deficient cells, PER phosphorylation is severely compromised and nonrhythmic, and the PER pro

51 gest that neuronal mitochondrial respiration is severely compromised and there is a compensatory swit

52 Photoautotrophic growth of the double mutant is severely compromised, and its photosynthetic capacity

53 uced, but cell adhesion to ICAM-1 and ICAM-2 is severely compromised, and Jbeta2.7 cells expressing R

54 in primary cultures, induction of astrocytes was severely compromised, and the few astrocytes generat

55 es demonstrated that cytochrome b6f function was severely compromised, and the levels of transcripts

56 a/Pf4Delta) Mcl-1(Pf4Delta/Pf4Delta) embryos was severely compromised, and these animals exhibited ec

57 the function of proteins modified by HNE can be severely compromised as previously demonstrated for g

58 ncreasing mechanical demands, heart function is severely compromised as evidenced by the onset of car

59 lopment of long-term tumor immunity (memory) was severely compromised as reflected by diminished CD8

60 ine phosphorylation and calcium mobilization were severely compromised, as seen in Lyn-deficient cell

61 vered a regime in which E. coli NO. defenses were severely compromised, as well as conditions that ex

62 could occur, but viability of these embryos was severely compromised at an early stage of developmen

63 ionally deficient mice after phenylhydrazine is severely compromised because of their inability to mo

64 bacteria, but Cox17-mediated copper transfer was severely compromised both in vitro and in a yeast cy

65 es where a resin's vibrational signature has been severely compromised, both the Raman and infrared b

66 orebrain-specific deletion of LMO4 (LMO4 KO) was severely compromised but could be restored by single

67 P1 and RP2 respectively, the kinase reaction was severely compromised but phosphotransferase activity

68 y of the NAM protection network is likely to be severely compromised by a changing climate.

69 of amyloid inhibition by these compounds can be severely compromised by background signals and compet

70 erties measured on as-prepared nanotubes may be severely compromised by extrinsic air exposure effect

71 In chemical gas sensors odor recognition can be severely compromised by poor signal stability, partic

72 er activation when the TcpP-binding site has been severely compromised by mutation.

73 ey clinical therapy, their effectiveness has been severely compromised by the development of drug res

74 In utero parthenote development is severely compromised by defective organogenesis and i

75 Pregnancy outcome is severely compromised by intrauterine infections and i

76 partner of the myogenic regulatory factors, is severely compromised by MEKK1-initiated signaling.

77 repair in human adult articular chondrocytes is severely compromised by minimal exposure to bFGF beca

78 5) by an independent HHCC domain (Cdelta232) was severely compromised by NEM modification of either s

79 f plo1(+) overexpression to induce septation was severely compromised by SIN inactivation.

80 Teeth were severely compromised by the presence of CAL loss of

81 ficient (NPCD) cells, wherein these pathways are severely compromised, causing massive accumulation o

82 pid kinetics but typically their performance is severely compromised compared to heterogeneous assay

83 e coimmunoprecipitation of Trt1 and Polalpha was severely compromised compared to those in the wild-t

84 learning abilities and exploratory behaviors were severely compromised compared with control males.

85 endogenous PER abundance and phosphorylation were severely compromised, demonstrating that CKIdelta/e

86 structure activity relationship studies has been severely compromised due to the uncertain compound

87 challenge in patients whose thymic function is severely compromised due to age or cytoreductive cond

88 During aging, adaptive immunity is severely compromised, due in part to decreased produc

89 Here we report that Rif1(-/-) mice are severely compromised for 53BP1-dependent class switc

90 to knock-down translation of GATA-6 protein, are severely compromised for heart development.

91 Furthermore, polyribosome association is severely compromised for both truncated proteins.

92 a mutant virus that does not express E4 ORF3 is severely compromised for replication.

93 nalysis reveals that one mutant, p53(25,26), is severely compromised for transactivation of most p53

94 One mutant, L314A, was severely compromised for replication and rapidly mut

95 afcat 14-3-3 binding mutant, B-Rafcat S728A, was severely compromised for the induction of PC12 cell

96 nsing cyclic guanine adenine synthase (cGAS) was severely compromised for the pUL25 mutant.

97 lity to cause mortality in a mouse model and were severely compromised for neuroinvasion.

98 n the hippocampus and cerebral cortex, which are severely compromised in Alzheimer's disease, showed

99 cell cycle arrest, and Rad55 phosphorylation are severely compromised in an FHA domain mutant of Dun1

100 urity 8 (eam8) mutations, also termed mat-a, are severely compromised in clock gene expression and cl

101 Learning and memory are severely compromised in dementias such as Alzheimer'

102 motif (ITAM)- and ITAM-like-mediated signals are severely compromised in FlnA-null platelets.

103 ETATION: Physical health and life expectancy are severely compromised in individuals who self-harm co

104 Mouse platelets that lack CalDAG-GEFI are severely compromised in integrin-dependent aggregati

105 or GDP-mannose transporter LPG2 lack PGs and are severely compromised in macrophage survival and indu

106 ondrocyte maturation and bone mineralization are severely compromised in Mia3-null embryos, leading t

107 that HDACi- and DNA damage-induced apoptosis are severely compromised in mouse embryonic fibroblasts

108 ial growth factor A, histamine, and thrombin are severely compromised in PPARbeta/delta-deficient mic

109 Hepatocyte function and regeneration are severely compromised in severe liver disease, and a

110 DA glutamatergic receptor (NMDAR) activities are severely compromised in synaptosomes prepared from A

111 able but fail to form a stable NuRD complex, are severely compromised in the ability to differentiate

112 Neonates are severely compromised in the ability to generate an i

113 s reveal that proprioceptive sensory neurons are severely compromised in the lumbar dorsal root gangl

114 suggest that cells from MDA5-deficient mice are severely compromised in the production of IFN-alpha

115 TH1 cells from GADD45gamma(-/-) mice are severely compromised in their abilities to activate

116 mice with targeted deletions in Ku70 or Ku86 are severely compromised in their ability to form coding

117 hat T. gondii tachyzoites depleted of TgAMA1 are severely compromised in their ability to invade host

118 Strikingly, however, cells expressing DM are severely compromised in their ability to present the

119 Escherichia coli strains lacking PriA are severely compromised in their ability to repair UV-d

120 in c-Rel, a member of the NF-kappaB family, are severely compromised in their ability to transcribe

121 HSCs from 12/15-LOX-deficient mice are severely compromised in their capacity to reconstitu

122 as Extra Vehicular Activity (EVA) suits has been severely compromised in the past as a result of dus

123 However, infectivity of BBS1 null parasites is severely compromised in a BALB/c mouse footpad model.

124 BQS is severely compromised in a human cancer cell line, sug

125 o induce p53 and its transcriptional targets is severely compromised in ARF-null cells, which remain

126 idol-induced apoptosis during S phase, which is severely compromised in cells homozygous for a nonfun

127 re we demonstrate that NK cell-mediated ADCC is severely compromised in chronic HIV infection.

128 onstrate that HR repair of conventional DSBs is severely compromised in DEK-deficient cells.

129 hat the presynaptic microtubule architecture is severely compromised in DVAP-33A mutants.

130 ing and/or transducing abiotic stress, which is severely compromised in flp-1 myb88 mutants.

131 these data, we conclude that gluconeogenesis is severely compromised in HCC by IL6-Stat3-mediated act

132 ecause FoxA2 bearing a mutation at this site is severely compromised in its ability to activate a rep

133 The mutated protein is severely compromised in its ability to form a stable

134 Indeed, a DC3000 catalase triple mutant is severely compromised in its ability to grow in planta

135 rowth suppressive activity, the R213Q mutant is severely compromised in its ability to induce p53-reg

136 h indicates that the K151L,K156Y derivative is severely compromised in its ability to interact with

137 on is enhanced at low pH, a mutant EnvA that is severely compromised in its ability to support infect

138 (D113E) exhibits reduced ATPase activity and is severely compromised in its DNA helicase activity.

139 However, male-typical sexual behavior is severely compromised in male and female ERalphaKOs.

140 and BDNF-inducible TrkB autophosphorylation is severely compromised in neurons lacking PS1.

141 as axon growth of Nkx6-positive motoneurons is severely compromised in Nkx6 mutant embryos.

142 Recruitment of TATA-binding protein (TBP) is severely compromised in the absence of functional Med

143 ween photoactivated rhodopsin and transducin is severely compromised in the absence of Gtbetagamma.

144 a major function of the Th2 response, which is severely compromised in the absence of IL-4, is to re

145 null mutant showed that resistance to TYLCV is severely compromised in the absence of TIP1:1.

146 Unexpectedly, mutant SRP(D251N) is severely compromised in the formation of an active SR

147 nding of high-affinity galactoside analogues is severely compromised in the mutants; the affinity of

148 multiplicity-dependent growth phenotype that is severely compromised in the rate of infectious-virus

149 e in LMO4 KO, confirming that CICR machinery is severely compromised in these neurons.

150 ptotic program induced by IGF-I but not PDGF is severely compromised in TSC2 null cells.

151 ls, viral capsid accumulation in the nucleus is severely compromised in UL92 mutant virus-infected ce

152 virus glycoprotein presented by Adhu5rab.gp was severely compromised in animals preexposed to the ho

153 genes of the psl cluster (PA2231 and PA2232) was severely compromised in biofilm initiation, as confi

154 e regulated secretion of milk-lipid droplets was severely compromised in both mutant mouse lines in c

155 g injection with allogeneic P815 tumor cells was severely compromised in CD154 knockout mice and wild

156 Regeneration was severely compromised in E2f1 null mice but not affec

157 The H71A Fpg mutant was severely compromised in enzyme turnover on the 8-oxo

158 ermore, induction of Nur77 expression by LPS was severely compromised in fibroblasts lacking the thre

159 However, the P216G mutant was severely compromised in folding into a catalytically

160 The in vivo cancer-initiating ability was severely compromised in HNSCC cells expressing phosp

161 -6 (-/-) SN pars compacta (pc), microgliosis was severely compromised in IL-6 (-/-) mice.

162 ines derived from knock-out mice, MyD88 S34Y was severely compromised in its ability to respond to al

163 lex substrates similar to wild-type BLM, but was severely compromised in its ability to unwind long D

164 However, Pho-20 was severely compromised in its ability to use iron pres

165 -erbalpha, Pgc1, Foxo1, Hnf4alpha, and Pck1) was severely compromised in Mc3r(-/-) mice during RF.

166 bine (2',2'-difluoro-2'-deoxycytidine; dFdC) was severely compromised in Mycoplasma hyorhinis-infecte

167 lication of a virus containing this mutation was severely compromised in peripheral blood mononuclear

168 a muris, in which IgA plays a dominant role, was severely compromised in pIgR-deficient mice despite

169 ytarabine to activate the S-phase checkpoint was severely compromised in Rad9(-/-) cells, whereas act

170 , virus from pHXB2(His-AC-TGT) with M184V RT was severely compromised in replication.

171 The mutant subcomplex was severely compromised in the ability of both UL5 and

172 reas the CD3-mediated proliferative response was severely compromised in the absence of Itk, the calc

173 However, its potency was severely compromised in the muscle, because antigen-

174 oncentration citrate-nAg treatment alone but was severely compromised in the presence of predators (d

175 ligands that engage the NLRP3 inflammasome, was severely compromised in these cells.

176 d to unwind a 92-base pair duplex region and was severely compromised in unwinding a 20-base pair dup

177 V(0) assembly was severely compromised in voa1 vma21QQ double mutants.

178 In contrast, murine mdr3 function was severely compromised in yeast mutants lacking the FK

179 The same mutants were the ones that were severely compromised in binding topo I.

180 Hdac3(-/-) stem cells were severely compromised in competitive bone marrow tra

181 (TNF-alpha), PMN adhesion and extravasation were severely compromised in HPK1-deficient mice.

182 ons in response to poly(I:C) stimulation and were severely compromised in immune defense against vira

183 eas NER-deficient XP-A, XP-C, and XP-F cells were severely compromised in their ability to repair chr

184 Purified mutant proteins were severely compromised in their GTPase activities, de

185 Rad54(-/-)Ku80(-/-) mice were severely compromised in their survival, such that f

186 L. monocytogenes prfA- and Deltahly mutants were severely compromised in this respect.

187 was inhibited, and that of the double mutant was severely compromised, indicating impairment of mitoc

188 ith disruption of pslA and pslB (DeltapslAB) was severely compromised, indicating that psl has a role

189 els, breathing, sighing, and neuromodulation are severely compromised, leading to early mortality.

190 identities, adaptive face-coding mechanisms are severely compromised, offering a new explanation for

191 ort DNA duplexes (</=71 base pairs (bp)) but is severely compromised on longer DNA duplexes (>/=259-b

192 d and dye coupling between these two neurons was severely compromised or absent.

193 In patients with multiple risk factors, TFS was severely compromised, regardless of the timing of S2

194 Once dissociated, the next cycle of loading is severely compromised, resulting in steady-state ATP h

195 ntenance in dicerex1/2 embryos and yolk sacs were severely compromised, suggesting a possible role fo

196 The embryos are severely compromised, surviving to the tenth day of

197 C, their vegetative and reproductive growth was severely compromised under chilling conditions.

198 oid lineages was also partially impaired and was severely compromised under competitive conditions.

199 The midcell localization of CrgA(MT) was severely compromised under conditions of FtsZ deplet

200 ermore, the random mobility of CTL on ICAM-1 was severely compromised using all three methods of disr

201 lysine 9 of histone H3 (H3-K9), its activity is severely compromised when compared to that of the ESE

202 ntation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limi

203 Synaptogenesis was severely compromised when agrin expression or functi

204 thermore, the production of infectious virus was severely compromised when IFN-alpha was present earl

205 n Mre11-D16A or Mre11-D16N and Rad50 or Xrs2 were severely compromised, whereas the mre11 alleles wit

206 mor-initiating ability of HPV-positive HNSCC is severely compromised with CH1 overexpression, in part

207 impaired at synapses and (2) AP propagation was severely compromised with >40% of axonal branches no

208 B- and T-cell development, however, was severely compromised with transitional block from pr

209 media containing select amino acids/peptides was severely compromised, with microscopic examination r

210 containing replication compartment formation was severely compromised, with the appearance of small r

211 chia coli survival under antibiotic pressure is severely compromised without adenine methylation at G