ライフサイエンスコーパス: be severely reduced

1 nd the production of outer membrane vesicles is severely reduced.

2 cerebellum is underdeveloped, and the vermis is severely reduced.

3 nal cord, although the extent of myelination is severely reduced.

4 wth, but survival during nitrogen starvation is severely reduced.

5 -18, the size of the readily releasable pool is severely reduced.

6 propagation when gap junctional conductance is severely reduced.

7 in the muscle at the neuromuscular junction is severely reduced.

8 formation is incomplete, and homolog pairing is severely reduced.

9 ymph-filled lumen of the semicircular canals is severely reduced.

10 at the muscle membrane and alpha-sarcoglycan is severely reduced.

11 In the absence of the CTD, pre-mRNA splicing is severely reduced.

12 AER is poorly stratified and FGF8 expression is severely reduced.

13 yl alcohol dehydrogenase (CAD; EC 1.1.1.195) is severely reduced.

14 limited flexibility, the antiviral activity is severely reduced.

15 chance of emerging during anti-SR-BI therapy is severely reduced.

16 s (GCPs) in response to Sonic hedgehog (SHH) is severely reduced.

17 al hemispheres and olfactory epithelium (OE) is severely reduced.

18 y reduced, but, paradoxically, not when they are severely reduced.

19 proteins examined, including OmpC and TolC, are severely reduced.

20 ding goosecoid, Xnot, Cerberus, and chordin, are severely reduced.

21 normal and stressed conditions, and lifespan are severely reduced.

22 the dentate gyrus, and the olfactory bulbs, are severely reduced.

23 d virulence factors elastase and rhamnolipid are severely reduced.

24 ertebrae, forelimbs are absent and hindlimbs are severely reduced.

25 ces suggest that midline signaling functions are severely reduced.

26 athways and the induction of gene expression are severely reduced.

27 ion of the outer plate constituent Ndc80HEC1 was severely reduced.

28 tch1 intracellular domain (N1ICD) expression was severely reduced.

29 acidic pHs, while the infectivity of VSIV-GI was severely reduced.

30 ty in patients' erythrocytes and fibroblasts was severely reduced.

31 lasts to form mineralized nodules in culture was severely reduced.

32 Fertility of transgenic females was severely reduced.

33 rotein, which is mediated by the F10 kinase, was severely reduced.

34 ancreatic morphogenesis and differentiation, was severely reduced.

35 e in wild-type mice, but neutrophil adhesion was severely reduced.

36 mutant, Glc-induced LR production/emergence was severely reduced.

37 binding was preserved, but kinase activation was severely reduced.

38 IV (lig4(+)), nonhomologous DNA end-joining was severely reduced.

39 activator in a transient transfection assay was severely reduced.

40 tion from the simple FNR-dependent promoters was severely reduced.

41 detectable and the yield of infectious virus was severely reduced.

42 al activity of A19-deficient virus particles was severely reduced.

43 ng immune complexes and EBV-gp350 to B cells was severely reduced.

44 auxin efflux facilitator PIN-FORMED 1 (PIN1) was severely reduced.

45 t HSD17B4 protein in a compound heterozygote was severely reduced.

46 e progression, although neurogenic divisions were severely reduced.

47 ting levels of cholesterol and triglycerides were severely reduced.

48 nfiltrates in ischemic limbs of apoE-/- mice were severely reduced.

49 b(F/F)/CD4-Cre mice, their arginase-1 levels were severely reduced.

50 matotrophs and POU1F1-dependent thyrotrophs, were severely reduced.

51 rs of CD71(+)Ter119(+) erythroid progenitors were severely reduced.

52 t intestine, NK cells and group 2 and 3 ILCs were severely reduced.

53 el of cardiac UCP-3 but not UCP-2 expression was severely reduced (20-fold) in PPARalpha-/- mice comp

54 in(-1) ; means +/- SEM; P < 0.0001) and FMVD was severely reduced (3.9 +/- 1.3% and 9.1 +/- 1.2%, res

55 and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency

56 Ossification is severely reduced after condensation of the palatal me

57 predators, and freshwater biodiversity will be severely reduced almost everywhere.

58 o unwind origin DNA and a helicase substrate was severely reduced, although they still had ATPase act

59 ish edn1 mutants, the ventral jaw structures are severely reduced and fused to their dorsal counterpa

60 euchromatic regions of polytene chromosomes are severely reduced and the chromosome arms condensed.

61 ed in a switching B cell line, DSB formation is severely reduced and CSR frequency is impaired.

62 mal opercle bone is usually absent when Edn1 is severely reduced and is usually enlarged when Edn1 is

63 , formation of the covalent homodimers of Rz is severely reduced and outer membrane disruption is sig

64 -deficient cells, the level of dE2F2 protein is severely reduced and the expression of dE2F2-dependen

65 Fourth, cytokine secretion was severely reduced and c-Jun N-terminal kinase activat

66 In treated eyes, staining of beam edges was severely reduced and was instead found in plaques.

67 cDNA yields obtained by RT-PCR amplification were severely reduced and no infectious virus was recove

68 n 7 d the number of antigen-specific T cells is severely reduced, and the residual T cells become unr

69 ial cybrids, hypoxic induction of HIF-1alpha was severely reduced, and HIF-1 DNA binding was diminish

70 ADelta11, POKADelta10/11, and POKADelta11/12 was severely reduced, and no virus was recovered from sk

71 The secretion rate was severely reduced, and the ion content of the secrete

72 he rate of ATP hydrolysis in BZ of MI hearts was severely reduced, and the severity of this reduction

73 mice, corticotectal and pontine projections were severely reduced, and Fezl-expressing neurons forme

74 In addition, facial motoneuron numbers were severely reduced, and there was virtually a complet

75 t the linker for activation of T cells (LAT) is severely reduced as monocytes differentiate into macr

76 Overall, Lama5 protein levels were severely reduced as a result of mRNA frameshift cau

77 vities in the sIL-15Ralpha-administered mice were severely reduced as determined by IFN-gamma release

78 (CENPF), a component of the nuclear matrix, are severely reduced at kinetochores in metaphase oocyte

79 P were strongly dependent on ionic strength, being severely reduced at 500 mM KCl compared with 100 m

80 Cgamma2-/- platelets to a collagen monolayer is severely reduced at a shear rate of 800 s-1, relative

81 ta-DI peptide across the blood-brain barrier is severely reduced because of the vasculotropic mutatio

82 SBE activity in the leaves of these plants was severely reduced, but tuber activity was largely una

83 nsity, bone volume, and bone formation rates were severely reduced, but osteoblast and osteoclast num

84 The stability of the portal monomer is severely reduced by a Cys --> Ser point mutation intr

85 This flat-cell inducing activity is severely reduced by cotransfection of the wild-type E

86 g is insensitive to SIR3 overexpression, but is severely reduced by overexpression of full-length Sir

87 e show that interneuronal cytosolic coupling is severely reduced by the mutant Cx36, without effect o

88 The thermal stability of the duplexes is severely reduced by the presence of the abasic residu

89 and fungal-derived chitosan oligosaccharides is severely reduced by two inhibitors (salicylic acid an

90 The rate of pore enlargement was severely reduced by mutation.

91 Transcriptional activation by TFII-I was severely reduced by overexpression of HDAC3.

92 ted (125)I-alpha(2)M* binding to macrophages was severely reduced by wortmannin, LY294002, PD98059, S

93 par, in seven contiguous northeastern states were severely reduced by a fungal pathogen.

94 pair-rule phenotypes when their transcripts were severely reduced by RNA interference.

95 the genital ridge in TIAR-deficient embryos are severely reduced compared to wild-type embryos by E1

96 r reactivity of TBI rats to acoustic stimuli was severely reduced compared to that of sham-injured ra

97 tion level of MA in defective mutant viruses was severely reduced compared to that of the wild type,

98 motactic protein-1, monocyte-targeted signal was severely reduced compared with wild-type mice (1.2+/

99 ligin measured in alcS strain culture fluids were severely reduced compared with the wild-type levels

100 ns of the MOB1 protein to interact with DBF2 was severely reduced, confirming that binding of DBF2 to

101 Visual function is severely reduced, consistent with significant loss of

102 hindbrain primordium (pax2.1, wnt1, krox20) are severely reduced, correlating with the neuroectoderm

103 ding, melanocyte and xanthophore populations are severely reduced, craniofacial cartilage is barely d

104 oving objects, especially with low-contrast, was severely reduced despite full visual fields; we have

105 ro integrase activity, but infectious titers are severely reduced, despite normal synthesis of viral

106 dependent antigens but serum antibody titers are severely reduced, despite unimpaired germinal center

107 own that proliferation of de2f1 mutant cells is severely reduced due to unchecked activity of the rep

108 o find and develop novel antimicrobials have been severely reduced during the past two decades, the i

109 nesis rates from hepatocytes lacking PEPCK-M are severely reduced for lactate, alanine, and glutamine

110 like protein (MCLP), and the cathelin B9; it is severely reduced for neutrophil collagenase (NC) and

111 Seed oil content is severely reduced for the regulatory mutant wrinkled1

112 The in vivo thrombosis response was severely reduced for both heterozygous mutants.

113 However, this efficiency was severely reduced for probes that overlapped multiple

114 Pitx3 transcript levels are severely reduced in ak/ak mice from E11.5 to newborn

115 ogous chromosomes, and crossover frequencies are severely reduced in both oocyte and spermatocyte mei

116 lation of Swe1, preludes to its destruction, are severely reduced in cells lacking either Hsl1 or Hsl

117 Tissues expressing tbl3 are severely reduced in cey mutants, including HSPCs, th

118 Cdc28 and Cln3-Cdc28 protein kinase activity are severely reduced in cks1-38 cell extracts.

119 e b and cytochrome oxidase subunit III genes are severely reduced in cyt-5 mutants, suggesting a like

120 vels of dynamin, synaptojanin and endophilin are severely reduced in dap160 mutant NMJs, suggesting t

121 espondingly, neocortical NOS1 protein levels are severely reduced in developing human FXS cases, but

122 Notably, PBX1 and NFE2L1 levels are severely reduced in dopaminergic neurons of the subs

123 af1), and XBP1 mRNAs, unspliced and spliced, are severely reduced in ELL2-deficient cells.

124 Given that the junctin levels are severely reduced in human failing hearts, we perform

125 Levels of mature BMP4 are severely reduced in mutants, although levels of prec

126 he linkage between SCs and the basal lamina, are severely reduced in nerves of PMP22-deficient mice.

127 elop normally, but pathogenic effector cells are severely reduced in number.

128 f I kappa B, NF-kappa B, ERKs, and cJun/AP-1 are severely reduced in RANKL-treated TNFr1-null osteocl

129 ors Nanog, Sox2, Cdx2, Eomes, Elf5 and Sox17 are severely reduced in the absence of Suds3.

130 In addition, the transfected cells are severely reduced in their growth in a serum-free med

131 ty of patient plasma Gc protein was found to be severely reduced in about 25% of this patient populat

132 this study, we found levels of MAIT cells to be severely reduced in circulation in patients with chro

133 lls (SMCs), this cysteine protease inhibitor is severely reduced in both atherosclerotic and aneurysm

134 Expression of the transcription factor Irf8 is severely reduced in Cbfb-deficient progenitors, and o

135 hesion under conditions of physiologic shear is severely reduced in cells expressing CX3CR1-M280.

136 hoprotein, but that phosphorylation of USF-1 is severely reduced in cells in culture.

137 the non-coding interval, Cdkn2a and Cdkn2b, is severely reduced in chr4(Delta70kb/Delta70kb) mice, i

138 ly, and in vivo stimulated parotid secretion is severely reduced in double-null mice.

139 Human frataxin (fxn) is severely reduced in Friedreich ataxia (FRDA), a frequ

140 This current is severely reduced in hiPSC-RPE cells derived from macu

141 We found that dendrite complexity is severely reduced in homozygous mice deficient in Reel

142 ent to the nuclear surface and spindle poles is severely reduced in Lis-1 male germ cells.

143 e-strand DNA breaks after P-element excision is severely reduced in mus3O9 mutants using an in vivo a

144 By contrast, dystrobrevin membrane staining is severely reduced in muscles of Duchenne muscular dyst

145 ilage-specific extracellular matrix proteins is severely reduced in mutant elements.

146 pex mutants of the yeast Pichia pastoris but is severely reduced in pex4 and pex22 mutants and modera

147 ed and maintained into adulthood, but the CN is severely reduced in size and the topographic specific

148 y two different assays, one-hybrid and ChIP, is severely reduced in strains lacking Sir3p.

149 Although crossover recombination is severely reduced in syp-3 mutants, the production of

150 ta3 and Lhx1 and their downstream target Ret is severely reduced in the caudal ND.

151 decreased in Klf7-/- trigeminal ganglia, it is severely reduced in the double mutant Brn3a-/-;Klf7-/

152 expression of the SAP4, SAP5, and SAP6 genes is severely reduced in the rim101-/rim101- mutant.

153 air development, including Foxn1 and Hoxc13, is severely reduced in the transgenic hair follicles.

154 We also report that cyclophilin A packaging is severely reduced in W23A and F40A virions, even thoug

155 ochrome c release, and caspase-3 activation) was severely reduced in 3T9 cells lacking either Bim or

156 Seedling growth was severely reduced in a T-DNA insertion mutant of ICE1

157 Activity was severely reduced in alanine point mutants of conserv

158 Calcium intake was severely reduced in allergic patients than in contro

159 We found that neuronal excitability was severely reduced in CA1 neurons but not in granule c

160 ly, expression of Notch primary target genes was severely reduced in DKO embryos.

161 tiple cardiac-specific transcription factors-was severely reduced in E9.5 Zic3 null hearts.

162 The catalytic activity was severely reduced in each mutant.

163 f DN cells from BrdUrd(high) to BrdUrd(low), was severely reduced in Fyn-/- compared with conventiona

164 Growth of these filaments was severely reduced in hipA+ strains.

165 not affect hyphal length but curve formation was severely reduced in mid1Delta and cch1Delta and abol

166 , and Est1p, a telomerase accessory protein, was severely reduced in mre11Delta and tel1Delta cells.

167 Nuclear accumulation of NFAT was severely reduced in ORAI1-deficient T cells, and exp

168 Manganese binding to PSII was severely reduced in pam71 thylakoids, particularly i

169 CFR was severely reduced in patients with chronic heart fail

170 rtening of the IPMD from diastole to systole was severely reduced in patients with moderate/severe is

171 RDH activity was severely reduced in Rdh8(-/-)Rdh12(-/-) retina extra

172 Consequently, RVFV replication was severely reduced in Skp1-depleted cells when PKR was

173 yte extravasation into the peritoneal cavity was severely reduced in St3Gal4(-/-) mice.

174 endogenous Vdelta6.3/6.4 chain, and its size was severely reduced in TCRdelta(-/-) Tg-gammadelta mice

175 ity observed in wild-type activated TH cells was severely reduced in TH cells from Jnk1-/- mice.

176 n of the p110gamma catalytic subunit of PI3K was severely reduced in the absence of Cox-2, leading to

177 s (i.e. granule-to-granule homotypic fusion) was severely reduced in the absence of Munc13-4.

178 x1, the earliest liver markers in zebrafish, was severely reduced in the liver region when Bmp or Fgf

179 arly, we found that the expression of BMPR1A was severely reduced in the lungs of patients with vario

180 owth and dissemination of the Schu S4 mutant was severely reduced in the murine model of pneumonic tu

181 tylcholine-activated single-channel currents was severely reduced in the neurons of superior cervical

182 ut not by common myeloid progenitors (CMPs), was severely reduced in the presence of MEK/ERK inhibito

183 Expression from the cbb(II) promoter was severely reduced in the PrrA mutants during chemoaut

184 This oligomerization was severely reduced in the RCL mutant.

185 Conversely, whereas CCAP-IR was severely reduced in the thoracic and subesophageal n

186 sion of the MEF2-regulated actin gene Act57B was severely reduced in these animals.

187 n of several chemokines, in particular CCL2, was severely reduced in TRPML2-knockout mice.

188 Phage phi 29 assembly was severely reduced in vitro in the presence of mutant

189 tor and cyclophilin ligand interactor (TACI) was severely reduced in XID B cells.

190 ained only 14 nucleotides of the 5' terminus were severely reduced in ability to replicate.

191 fear responses assessed 24 hr after training were severely reduced in BLA-lesioned animals but not in

192 t the levels of MCT1, MCT3, and MCT4 protein were severely reduced in Bsg(-/-) mice.

193 rite outgrowth and STAT3 activation in vitro were severely reduced in cultures in gp130-deficient cul

194 ural responses to noxious mechanical stimuli were severely reduced in Dmpiezo knockout larvae, wherea

195 riptional activities of these cytokine genes were severely reduced in FcepsilonRI-stimulated btk muta

196 with CX3CL1 or via Fcgamma receptor ligation were severely reduced in Hck(-/-) bone marrow-derived ma

197 Flight and jump abilities were severely reduced in homozygotes.

198 ntrast, SSeCKS/Gravin protein and RNA levels were severely reduced in human (PC-3, PPC-1, LNCaP, DU14

199 br2+ UBCs was Math1 dependent, as Tbr2+ UBCs were severely reduced in Math1-null cerebellum.

200 In the absence of Blm, thymocytes were severely reduced in numbers and displayed a develop

201 positive thymocytes from reconstituted mice were severely reduced in numbers and exhibited impaired

202 encode essential catecholaminergic enzymes, were severely reduced in postnatal adrenal glands.

203 All white fat depots and brown fat pads were severely reduced in size, and exhibited prominent f

204 phi for 30 min to saturate the entry process were severely reduced in the ability to internalize subs

205 ted, T4 DNA synthesis and progeny production were severely reduced in the double mutants as compared

206 ion; however, the numbers of CD19(+) B cells were severely reduced in the lungs of CD4(+) T-cell-depl

207 short-term and long-term synaptic plasticity were severely reduced in the synaptophysin/synaptogyrin

208 genes participating in chlorophyll synthesis were severely reduced in the tsv mutant under cold stres

209 uty2, a downstream target of Fgf signalling, were severely reduced in the ventral prostate of Sox9 mu

210 Knockout mutants of At5g63560 were severely reduced in their alkyl caffeate but not al

211 /F, NO synthesis and stomatal closure to ABA are severely reduced, indicating that endogenous H(2)O(2

212 ession of OMP is abolished and that of GAP43 is severely reduced, indicating that no mature and few i

213 The cellular reversal frequency, however, was severely reduced, indicating that CheA in T. dentico

214 l RNA component of the 60S ribosomal subunit is severely reduced, leading to an insufficiency of 60S

215 r, expression of the truncated MYO7A protein is severely reduced, leading to defects in hair cell dev

216 this receptor at the neuromuscular junction are severely reduced, may be caused by mutations within

217 , levels of the meiotic cohesin protein REC8 are severely reduced on chromosomes in oocytes from old

218 es of seedlings and saplings of canopy trees are severely reduced on herbivore-affected islands, prov

219 w that histone H3 and HMG-14 phosphorylation is severely reduced or abolished in mice lacking MSK1 an

220 Fluid-phase endocytosis is severely reduced or abolished in whi2Delta, siw14Delt

221 multimers to smaller forms in normal plasma is severely reduced or absent in most patients with TTP.

222 ne-rod pattern of dysfunction in 8 patients, was severely reduced or undetectable in 2 patients, and

223 s, and the unique monocytosis of BXSB males, were severely reduced or absent in the alphabeta+ T cell

224 When FGF8 signaling is severely reduced rather than eliminated, mesenchymal

225 ystem in which the replication of Delta(nef) is severely reduced relative to that of the wild type.

226 tion to alveoli during LPS-induced pneumonia was severely reduced relative to that in wild-type or TN

227 tion markers representing osteoclastogenesis were severely reduced, resulting in a net increase in bo

228 rs contralateral to the implant SG soma size was severely reduced several months after withdrawal of

229 ARES, lipid and soluble cargo transfer rates were severely reduced, suggesting that pores flickered.

230 Fecal BS excretion in Hrn mice was severely reduced to 7.6% +/- 1.8% of wild-type (WT),

231 Growth of a sitA mntH double mutant was severely reduced under Mn(2+) limitation and sitA an

232 their early accumulation in the lymph nodes was severely reduced unless the mice were treated with L

233 Immune responses were severely reduced upon Ebf1 inactivation, as GCs wer

234 When EOBII transcript levels are severely reduced using a stable RNAi (ir) approach i

235 These interactions are severely reduced when helix 12 of the FTZ-F1 activat

236 e number of differentiating myocardial cells is severely reduced whereas pericardial cell populations

237 (DC) expressing an active GSK3-beta knockin was severely reduced, whereas pharmacological or genetic

238 IL-6 production within the eye is severely reduced, which is consistent with the failur

239 of the V94M-hGALE protein expressed in yeast was severely reduced with regard to UDP-galactose and pa

240 was adjusted serially so that hyperemic flow was severely reduced yet always higher than the preocclu