ライフサイエンスコーパス: be solved by

1 ix (TMH) to residue 20 of the first TMH, has been solved by (15)N,(1)H NMR in a monophasic chloroform

2 g equations for the electrokinetic transport are solved by a high-efficiency lattice Poisson-Boltzman

3 et article, we expect that this dilemma will be solved by a fixed individual strategy rather than a c

4 dual patient-level extrapolation may need to be solved by a future randomized controlled trial.

5 Here, we propose that this dilemma can be solved by a new diagnostic concept: liquid biopsy, th

6 non-homologous end-joining pathway, may have been solved by a greater tolerance to deletion errors.

7 We find that this dilemma is solved by a "collision release" process in which pol

8 constructed based on the new IP3R model and is solved by a hybrid Gillespie method with adaptive tim

9 The citation side challenge is solved by a new deep semantic representation, D2V-TFI

10 m the 6-deoxyerythronolide B synthase (DEBS) was solved by a combination of multiple isomorphous repl

11 The solution structure, which was solved by a combined NMR and intensity-refined compu

12 rate constants for the two-compartment model were solved by a simple graphic approach and a more comp

13 The crystal structure has been solved by ab initio procedures from powder XRD data

14 Analyte carryover problem encountered was solved by adding 20% acetonitrile to the solvent of

15 d spatial responses to the same gradient can be solved by additional inputs from complementary gradie

16 ifying an appropriate control treatment, can be solved by adhering to 2 principles: the control treat

17 This and other unexpected problems were solved by adjustments in pH and temperature during

18 The structure was solved by an ab initio approach that took advantage

19 The structures of 3-7 were solved by analysis of spectroscopic data including

20 ptimization problems so that the problem can be solved by any standard optimization algorithm.

21 The inconsistencies are solved by assuming an equilibrium between antiparall

22 nical problem that, at the farm level, is to be solved by better shrimp and management of ponds and b

23 sidues of Bacillus stearothermophilus S4 has been solved by both X-ray crystallography and NMR, that

24 The model is solved by both analytic theory and stochastic-growth

25 The structure was solved by both the traditional 3-D crystallographic

26 -synthesized borosilicate zeolite SSZ-87 has been solved by combining high-resolution X-ray powder di

27 from tetracycline-responsive promoters have been solved by constructing tetracycline-sensitive trans

28 f the resulting catalytic domain, CelB2, has been solved by conventional multiple isomorphous replace

29 exed with H16.U4 fragments of antibody (Fab) was solved by cryo-electron microscopy (cryo-EM) image r

30 The homo-tetrameric structure has been solved by cryoelectron microscopy.

31 This problem was solved by crystallization of an engineered heterodim

32 generated, and the structures of the mutants were solved by crystallography.

33 The genomic structure of CYP4F11 was solved by database searching and computer analysis.

34 derstand how similar biological problems may be solved by different molecular mechanisms of signal tr

35 cture-directing agent, and its structure has been solved by direct methods applied to the powder X-ra

36 The structure was solved by direct methods and showed significant diff

37 on in the parallel conformation is likely to be solved by distributing the stress over the helices th

38 sion cytotoxicity at the highest dose, which was solved by dose reduction.

39 This complex task has been solved by dragonflies, who intercept their prey in

40 were trained on a cross maze task that could be solved by either a place or a response strategy, and

41 ynthase from the fungus, Pichia angusta, has been solved by electron cryo-microscopy.

42 h the alpha,beta-tubulin dimer structure has been solved by electron crystallography, the 3.7 A resol

43 However, the problem was solved by equipping the sensor with a heating unit t

44 For small models, the problem can be solved by exhaustive enumeration of all state transit

45 lems for deployment in agriculture but could be solved by expressing genes for the biosynthesis of ph

46 This regiochemical control problem was solved by extension of a method we recently develope

47 A two-domain decomposition problem is solved by finding a bottleneck (or a minimum cut) of

48 ctures of the major product in each reaction were solved by GCEIMS and one- and two-dimensional (1H a

49 ucture of the central EH domain of Eps15 has been solved by heteronuclear magnetic resonance spectros

50 e 19-nortestosterone hemisuccinate (19-NTHS) was solved by heteronuclear multidimensional NMR methods

51 Several basic olfactory tasks must be solved by highly olfactory animals, including backgro

52 not all object and spatial recognition tasks are solved by hippocampal-dependent memory processes.

53 classification model but this situation can be solved by implementing standardization methods such a

54 urs during visually guided eye movements and is solved by implementing Listing's law and the half-ang

55 tion bias and information bias, which cannot be solved by increasing the sample size, and the precisi

56 The structure was solved by integrated analysis of MS and 1D and 2D NM

57 reover, anion interference problem at low pH was solved by integration of all-solid-state ISE and int

58 The structure was solved by interpretation of NMR data obtained at 600

59 The structure was solved by interpreting NMR and MS data, and the rela

60 The crystal structure was solved by isomorphous replacement with the correspon

61 es of a mammalian protein structure that has been solved by isotopic labeling of the protein in a euk

62 The tasks he could perform can all be solved by learning the value of actions, while those

63 s, while those he could not perform can only be solved by learning the value of stimuli.

64 The homotetrameric structure of ES* was solved by MAD phasing with 52 Se-Met sites in an ort

65 iculty of luciferin diffusion into the cells was solved by making use of cell membrane leakage during

66 The structure of III was solved by maximum entropy analysis of XRD data coupl

67 The maximal clique problem has been solved by means of molecular biology techniques.

68 structure of a bacterial K+ channel pore has been solved by means of X-ray crystallography.

69 The problem of gliadin insolubility was solved by mild acid treatment, which renders an acid

70 The structure has been solved by molecular replacement and refined at 1.8

71 erase (CPDase) from Arabidopsis thaliana has been solved by molecular replacement and refined at the

72 le 5 domain of human plasminogen (K5HPg) has been solved by molecular replacement methods using K1HPg

73 UMT), which is encoded by the cobA gene, has been solved by molecular replacement to 2.7A resolution.

74 The OIH-1 structure was solved by molecular replacement and refined at 1.25

75 The structure was solved by molecular replacement and refined at 2.0 A

76 MMP-10cd at 1.9 A resolution; the structure was solved by molecular replacement and refined with an

77 e S-(2-oxo)pentadecyl-CoA, and its structure was solved by molecular replacement at 1.4 A resolution.

78 t Saccharomyces cerevisiae chorismate mutase was solved by molecular replacement at a resolution of 2

79 the structure of the complex with Mg(2+)*OSB was solved by molecular replacement in space group P2(1)

80 alcium-bound state at 2.03 A resolution that was solved by molecular replacement in the space group P

81 erminal catalytic domain joined by a linker, was solved by molecular replacement methods using indepe

82 The structure was solved by molecular replacement using rat serum mann

83 The structure was solved by molecular replacement using the coordinate

84 The structure was solved by molecular replacement using the crystal st

85 The structure was solved by molecular replacement using the crystal st

86 ynureninase were obtained, and the structure was solved by molecular replacement using the CsdB coord

87 m at pH 5.2 in the presence of 0.1 M Mg(2+), was solved by molecular replacement using the model of c

88 The native structure was solved by molecular replacement using the structure

89 The crystal structure was solved by molecular replacement using the unliganded

90 The structure was solved by molecular replacement with the Pseudomonas

91 The SM3-MUC1 peptide structure was solved by molecular replacement, and the current mod

92 The structure was solved by molecular replacement, using a composite o

93 al grown with Triton X-100 and the structure was solved by molecular replacement.

94 zed in space group P41212, and the structure was solved by molecular replacement.

95 essed to 4.0-A resolution, and the structure was solved by molecular replacement.

96 The structures were solved by molecular replacement and refined to 2.1

97 plex between glycogenin and UDP-glucose/Mn2+ were solved by molecular replacement to 1.9 A using the

98 The structures were solved by molecular replacement using Escherichia c

99 the opposition between these approaches has been solved by more unitary theoretical and experimental

100 ency virus-type 1 (HIV-1) capsid protein has been solved by multidimensional heteronuclear magnetic r

101 n the presence of a specific target RNA, has been solved by multidimensional heteronuclear NMR spectr

102 ligand for the CXCR4 G-coupled receptor, has been solved by multidimensional heteronuclear NMR spectr

103 the full-length holo-1.3S subunit of TC has been solved by multidimensional heteronuclear NMR spectr

104 cherichia coli phosphotransferase system has been solved by multidimensional NMR spectroscopy with ex

105 -helical form resembling PrPC, the structure was solved by multidimensional heteronuclear NMR, reveal

106 re of the human Rap30 DNA-binding domain has been solved by multinuclear NMR spectroscopy.

107 ulolyticus in complex with cellotetraose has been solved by multiple isomorphous replacement and refi

108 mandelate pathway of Pseudomonas putida, has been solved by multiple isomorphous replacement at 1.6 A

109 m the alkalophilic Bacillus agaradherans has been solved by multiple isomorphous replacement at 1.6 A

110 in farnesyltransferase crystal structure has been solved by multiple isomorphous replacement methods

111 The structure was solved by multiple anomalous diffraction phasing met

112 structure of the Erwinia chrysanthemi enzyme was solved by multiple isomorphous replacement and refin

113 The crystal structure was solved by multiple isomorphous replacement and refin

114 nase from Erwinia carotovora ssp. carotovora was solved by multiple isomorphous replacement and refin

115 re of flavin reductase P from Vibrio harveyi was solved by multiple isomorphous replacement and revea

116 The structure was solved by multiple isomorphous replacement at 3.0 A

117 The structure of apo OSBS was solved by multiple isomorphous replacement in space

118 The crystal structure of LpdA was solved by multiple isomorphous replacement with anom

119 3-dimensional structure of the native enzyme was solved by multiple isomorphous replacement, and refi

120 domain of TonB from Escherichia coli has now been solved by multiwavelength anomalous diffraction and

121 hich the structures of trapped intermediates are solved by NMR, indicating that they are well packed

122 a prototypic integrin alpha(IIb)beta(3) has been solved by NMR and reveals multiple hydrophobic and

123 GG(TTAGGG)3, antiparallel and parallel, have been solved by NMR and X-ray crystallography.

124 ich (CR) domain of Escherichia coli DnaJ has been solved by NMR methods.

125 The structures of both of these domains have been solved by NMR spectroscopy and x-ray crystallograph

126 cherichia coli phosphotransferase system has been solved by NMR using conjoined rigid body/torsion an

127 cherichia coli phosphotransferase system has been solved by NMR, including the use of conjoined rigid

128 cherichia coli phosphotransferase system has been solved by NMR.

129 f the DPBD, the first of a WRN fragment, has been solved by NMR.

130 tation of the active site Cys384 to Ser, has been solved by NMR.

131 Glc) of the glucose transporter IICBGlc, has been solved by NMR.

132 ng the consensus sequence CTA(A/T)(4)TAG has been solved by NMR.

133 the histidine phosphocarrier protein HPr has been solved by NMR.

134 cherichia coli phosphotransferase system has been solved by NMR.

135 mannose transporter of Escherichia coli have been solved by NMR.

136 ased on protease-activated receptor-1 (PAR1) was solved by NMR and found to closely resemble the i3 l

137 ferric state with intact vinyl substituents was solved by NMR methods.

138 The mutant fusion domain structure was solved by NMR spectroscopy in a lipid environment at

139 n structure of the R347K mutant of TNFR-1 DD was solved by NMR spectroscopy.

140 astoris, and the three-dimensional structure was solved by NMR.

141 f of the deposited RNA structures in the PDB were solved by NMR methods, the usefulness of NMR is sti

142 emma, common to most flowering plants, could be solved by not producing nectar and/or scent, thereby

143 The structure of EH(3) has been solved by nuclear magnetic resonance (NMR) spectros

144 nd of eukaryotic 16 S-like ribosomal RNA has been solved by nuclear magnetic resonance spectroscopy i

145 0) and the pre-mRNA bound (b L30) forms have been solved by nuclear magnetic resonance spectroscopy.

146 The structure of the modification was solved by nuclear magnetic resonance and shown to co

147 The solution structure of FSD-1 was solved by nuclear magnetic resonance spectroscopy an

148 op IIB of the Rev response element (RRE) RNA was solved by nuclear magnetic resonance spectroscopy.

149 h a variable-volume double-pool model, which was solved by numerical integration (Runge-Kutta method)

150 The phase problem is solved by oversampling and iterative phase retrieval.

151 Such equilibria are solved by pCa Calculator, a computer program designe

152 This end-protection problem is solved by protein-DNA complexes called telomeres.

153 The puzzle may be solved by quantitative historical evidence that demon

154 as been proposed that this "binding problem" is solved by selective attention to the locations of the

155 The structure was solved by selenomethionine single-wavelength anomalo

156 from rat (rGSTK1-1) in complex with GSH has been solved by single isomorphous replacement with anoma

157 erase, cloned from Arabidopsis thaliana, has been solved by single isomorphous replacement with anoma

158 n (P domain) of the Escherichia coli Lon has been solved by single-wavelength anomalous dispersion an

159 The structure was solved by single isomorphous replacement, anamalous

160 while the structure of [Pb3(SC6H4S)3(en)2]n was solved by single-crystal X-ray diffraction.

161 The structure of BTA121 was solved by single-wavelength anomalous dispersion (SA

162 The structure was solved by single-wavelength anomalous dispersion usi

163 Both were solved by single crystal X-ray diffraction and the

164 st that complex dynamic routing problems can be solved by small-brained animals using simple learning

165 mensional solution structure of apo NosL has been solved by solution NMR methods.

166 ich leads to differential equations that can be solved by standard numerical techniques to obtain mor

167 The structure was solved by substituting seleno-methionine for natural

168 The structure was solved by sulfur and manganese single wavelength ano

169 tures of [Pb2(S2C6H2S2)(en)]n and [Pb3C6S6]n were solved by synchrotron X-ray powder diffraction, whi

170 This problem is solved by taking advantage of the fact that most of t

171 ion that the antibiotic pipeline problem can be solved by the collaboration of global leaders to deve

172 in, discovered 60 years ago, is removed, has been solved by the demonstration that the trafficking ch

173 erthermophilic archaeon Aeropyrum pernix has been solved by the multiple anomalous dispersion techniq

174 eins in the M. tuberculosis genome that have been solved by the TBSGC over the past few years.

175 With an increasing number of structures being solved by the structural genomics initiatives, the

176 aryotic systems studied so far, this problem is solved by the formation of a loop in the lagging stra

177 aryotic systems, this directionality problem is solved by the formation of a loop in the lagging stra

178 te two-parameter sub-problems, each of which is solved by the measurement of two different experiment

179 How this complex problem is solved by the nervous system remains poorly understoo

180 This conundrum is solved by the redox cycling of iron between Fe(III) a

181 y a second telomere replication problem that is solved by the shelterin component TRF1.

182 The crystal structure of hCBG was solved by the molecular replacement method and refin

183 The structure was solved by the molecular replacement method and refin

184 The structure was solved by the molecular replacement method and refin

185 The structure was solved by the molecular replacement method and refin

186 The structure was solved by the molecular replacement method and subse

187 The structure was solved by the molecular replacement method at 1.9 A

188 The crystal structure was solved by the molecular replacement method, and the

189 The structure was solved by the molecular replacement method, and the

190 The structure was solved by the multiple wavelength anomalous diffract

191 The structure was solved by the multiple-wavelength anomalous dispersi

192 The structure was solved by the multiwavelength anomalous diffraction

193 roxymethyl pyrimidine (HMP) salvage pathway, was solved by the multiwavelength anomalous dispersion (

194 iological roles of a protein whose structure was solved by the structural genomics project.

195 e of the enzyme/4-hydroxybenzoyl-CoA complex was solved by the techniques of multiple isomorphous rep

196 Both structures were solved by the molecular replacement method using di

197 The structures were solved by the molecular replacement method.

198 Theory has proposed that this ambiguity is solved by tracking head tilt through multisensory int

199 n, we show that the public goods dilemma may be solved by two very different mechanisms: cells can pr

200 f the Escherichia coli F0F1-ATP synthase has been solved by two-dimensional 1H NMR in a membrane mime

201 on is a challenge in mass spectrometry which is solved by two-dimensional (2D) Fourier transform ion

202 These problems were solved by two approaches.

203 .1.1.-), in complex with cofactor NADPH, has been solved by using x-ray crystallographic data to 2.1-

204 tion center from Rhodobacter sphaeroides has been solved by using x-ray diffraction at a 2.55-A resol

205 The phase problem is solved by using an iterative algorithm with a random

206 The MeSH side challenge is solved by using the 'learning to rank' framework of M

207 The solution structure of the complex was solved by using NMR restraints to guide distance geo

208 These technical difficulties were solved by using clavulanic acid, an irreversible in

209 re of an extradiol ring-cleaving dioxygenase was solved by utilizing the improved operation and chara

210 encoded by the Escherichia coli genome, has been solved by X-ray crystallographic analyses to a reso

211 n carbonic anhydrase II (CAII) variants have been solved by X-ray crystallographic methods to probe t

212 though the structure of the aporepressor has been solved by X-ray crystallographic techniques, no str

213 differences, three CYP158A1 structures have been solved by X-ray crystallography and have been compa

214 The structure of VanX from E. faecium has been solved by X-ray crystallography and reveals a Zn(2+

215 the Bacillus stearothermophilus protein have been solved by X-ray crystallography and the structure o

216 embrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution

217 by its natural regulatory zeta-protein, has been solved by X-ray crystallography at 4.0 A resolution

218 d transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstr

219 cture of the resulting variant, CVB3-RD, has been solved by X-ray crystallography to 2.74 A, and a cr

220 nase, casein kinase I delta (CKI delta), has been solved by X-ray crystallography to a resolution of

221 the Mycobacterium tuberculosis ortholog has been solved by x-ray crystallography, but details of how

222 l packing by loop-receptor interactions have been solved by X-ray crystallography, but not by NMR.

223 n associated with a portion of the shaft has been solved by X-ray crystallography, the in situ struct

224 leotide-binding (OB)-fold domain of TPP1 has been solved by X-ray crystallography, the molecular inte

225 While the structure of the O-layer has been solved by X-ray crystallography, there is no detail

226 ined, structures of inhibitor complexes have been solved by X-ray crystallography, with data up to 1.

227 structures of the most powerful mutants have been solved by X-ray crystallography.

228 main from the human trifunctional enzyme has been solved by X-ray crystallography.

229 tions of (beta-)arrestins that have recently been solved by X-ray crystallography.

230 elatively few protein-protein complexes have been solved by X-ray crystallography.

231 s gnavus (strain ATCC 29149) [PDB:4HYZ] have been solved by X-ray crystallography.

232 nsional structure of the IRES RNA, which has been solved by X-ray crystallography.

233 cosides, the structures of two of which have been solved by X-ray diffraction.

234 on channel from Synechocystis PCC 6803, have been solved by X-ray diffraction.

235 o the substrate analog UDP-glucose (UDP-Glc) was solved by X-ray crystallographic methods and refined

236 The three-dimensional structure of Phl p 3 was solved by X-ray crystallography and compared with th

237 sis protein At5g01750 from the DUF567 family was solved by X-ray crystallography and provides the fir

238 ic assembly of voltage-dependent K+ channels was solved by x-ray crystallography at 2.1 angstrom reso

239 e three-dimensional structure of the protein was solved by X-ray crystallography at 2.2A resolution a

240 e sulfur bacterium Marichromatium purpuratum was solved by X-ray crystallography to 2.75 A resolution

241 the extremely oxygen-sensitive CompA protein was solved by X-ray crystallography to 3 A resolution.

242 the structure of BFDC with the MBP inhibitor was solved by X-ray crystallography to a spatial resolut

243 ly, the high-resolution structure of ClC-ec1 was solved by X-ray crystallography.

244 i-idiotypic monoclonal antibody (mAb) GH1002 was solved by X-ray crystallography.

245 f one fragment and of a more active analogue was solved by X-ray crystallography.

246 E and IgG reactivity to the natural allergen was solved by x-ray crystallography.

247 nd (13)C NMR spectroscopy, and the structure was solved by X-ray crystallography.

248 A complex was crystallized and its structure was solved by X-ray crystallography.

249 to the native COOH terminus at position 319 was solved by x-ray diffraction to a resolution of 1.75A

250 cL homologue from Mycobacterium tuberculosis was solved by x-ray diffraction to a resolution of 3.5 A

251 res of the designed proteins CA01 and DA05R1 were solved by x-ray crystallography (2.2 angstrom resol

252 ctures of the I50Q, V241A, and E211S mutants were solved by X-ray crystallography to resolutions of 2

253 d 2,3,4,4'-tetramethoxy-1,1'-biphenyl (TMB), were solved by X-ray diffraction.