ライフサイエンスコーパス: be substituted by

1 uded in the model, the final three compounds were substituted by 24-methylene-cholesterol/stigmastero

2 e ions adsorbed on the colloid nanoparticles are substituted by 4-ABT, the colloid aggregates, formin

3 Individual pyrimidine nucleosides were substituted by 4-thiouridine, O4-methyluridine, O2-

4 trate stem-loop, in which the target uridine is substituted by 5-fluorouridine (5-FU), reveals a cova

5 nd to the isolated stem-loop, in which U2604 is substituted by 5-fluorouridine to prevent catalytic t

6 ate is absent when one of the two G residues is substituted by 8-oxo-7,8-dihydroguanine, a modificati

7 Typically, such MVs are substituted by a minimum value, which may lead to di

8 were not clearly identified in teleosts and are substituted by a related ligand, TNF-New; 4) as many

9 he rhythmicity of heart contractions and can be substituted by a battery-operated device as a last re

10 quired for mobilization of pLV22a, but could be substituted by a C-terminal deletion mutant of the F

11 However, these motifs can be substituted by a heterologous H/ACA family RNA.

12 diate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine a

13 ve complexes behave as electrophiles and can be substituted by a wide range of heteroatom nucleophile

14 d RNA in which the ribose-phosphate backbone is substituted by a backbone held together by amide bond

15 nal ethynyl addition to 1,2-diethynylbenzene is substituted by a barrierless addition of a cyano (CN)

16 nt wherein the N-terminal nucleophile Thr152 is substituted by a cysteine.

17 talytic tetrad, His(120) (AKR1D1 numbering), is substituted by a glutamate in AKR1D1.

18 e residue (Phe-394) in SOAR1, which in SOAR2 is substituted by a leucine residue.

19 ng analog, in which the sulfur of methionine is substituted by a methylene group (-CH2-).

20 isostructural analogues where the boryl unit is substituted by a phenyl or amine donor, a phenomenon

21 However, when Leu-41 is substituted by a smaller side chain, either Ala or Va

22 al.mol(-1) when the catalytic water molecule is substituted by a sulfuric acid molecule or one of its

23 which a fragment of the endogenous sequence was substituted by a ccdB cassette flanked by two BsaI s

24 ve of HMPA in which one of the methyl groups was substituted by a CH2CH2OH unit was synthesized.

25 onding to the extra cysteine residue of 1Dx5 was substituted by a cysteine codon through site-directe

26 ized human IL-13 in which Glu at position 13 was substituted by a Lys residue.

27 bserved depending on whether the amino group was substituted by a phenyl or an alkyl (usually benzyl)

28 itiation codon for each of these viral genes was substituted by a translational termination codon or

29 and proposed channel lining sequence of Cx32 was substituted by a transmembrane sequence of the cysti

30 The helicene skeleton was substituted by a variety of O-, S-, N-, and C-center

31 carboxylate was critical, although it could be substituted by acid isosteres and amides.

32 androgen-producing fetal Leydig cells (FLC) are substituted by adult Leydig cells (ALC) during perin

33 tivity retention in a mutant where every Cys is substituted by Ala.

34 ctive site from solvent in the ground state, was substituted by Ala.

35 Ile-455, and Gly-457 of smooth muscle myosin were substituted by Ala, Met, and Ala, respectively, and

36 When these residues are substituted by alanine, the mutant CPSs produce ster

37 p53 in which Ser15 is substituted by alanine (S15A) fails to mediate p53-de

38 ng the FALS-linked mutation in which glycine is substituted by alanine at position 93.

39 e face of the FeMo-cofactor, and when valine is substituted by alanine at this position, the substitu

40 trogenase MoFe protein alpha-Val(70) residue is substituted by alanine or glycine, the resulting vari

41 affinity of a mutant TRH-R, in which Trp279 was substituted by alanine (W279A TRH-R), for most teste

42 A mutant form of ICER in which Ser-41 was substituted by alanine had a half-life 4-5 h longer

43 Ectopic expression of H2B in which Ser36 was substituted by alanine reduced transcription and RNA

44 Mutations were studied in which Asp 23 was substituted by alanine, asparagine, and nitrile alan

45 When Asp(374) was substituted by alanine, high affinity ligand binding

46 When the corresponding residues were substituted by alanine in native germinal and somat

47 Arginine or glutamine residues in the tail were substituted by alanine.

48 ational analysis in which 23 of 25 positions were substituted by alanine.

49 Surprisingly, most IGF-I residues could be substituted by alanines, resulting in less than 5-fol

50 hich the two phosphorylation serine residues were substituted by alanines, was used as a bait, wherea

51 nding and second messenger generation, Arg46 was substituted by all other 19 encoded amino acids.

52 is experimentally restored or if glutathione is substituted by alternate cellular antioxidants, confi

53 where the piperazine of LDK1203 and LDK1222 are substituted by an alkyl group and a tosyl group, res

54 shed in the food-safety applications, should be substituted by an acquisition at fixed incubation tim

55 alpha1,3-fucose on the reducing terminus can be substituted by an alpha-linked galactose.

56 in the second, the general acid Asp residue is substituted by an Ala (e.g., PTP1B/D181A).

57 second novel one in which the aspartic acid is substituted by an asparagine (Ac-LPFFN-NH2).

58 Pyruvate and 2-oxoglutarate dehydrogenases are substituted by 'ancient' CoA-dependent pyruvate and

59 nd positioning and that this function cannot be substituted by another residue at a nearby position.

60 riants where one of the coordinating ligands is substituted by another side chain capable of coordina

61 s (1572-1651) of the conventional alpha1C,77 were substituted by another 81 amino acids due to altern

62 importance for child survival and could not be substituted by any category of kin or nonkin.

63 P3beta3A subunit, affected in HPS2 patients, is substituted by AP3beta3B in the neuron-specific heter

64 he N-terminal short AGP motif was assumed to be substituted by arabinogalactans.

65 mutant Factor X in which the activation site was substituted by Arg196 --> Gln to prevent the proteol

66 All other lysyl residues are substituted by argynyls.

67 itrite reductase in which the distal His has been substituted by Asn.

68 Using site-directed mutagenesis, Ser-309 was substituted by aspartic acid to mimic the presence o

69 d regions of the transmembrane regions could be substituted by at least one other residue.

70 this ternary complex requires ATP, which can be substituted by ATPgammaS, suggesting that ATP binding

71 To identify genes whose function can be substituted by Bcl-x(L) in a unicellular eukaryote, a

72 unction in cardiac development, which cannot be substituted by BMP9.

73 alogue of natrolite where all sodium cations are substituted by calcium and water molecules, reveal a

74 site-directed AS-B mutants in which Glu-348 is substituted by conservative amino acid replacements.

75 a-N-acetylgalactosamine (GalNAc) residues to be substituted by core 1 chains, a value in agreement wi

76 in which up to 50% of the sickle hemoglobin is substituted by cross-linked hemoglobin A, which does

77 to both onset and offset of plasticity, and was substituted by diazepam, which enhances GABA functio

78 ycine residues, in two canonical DTG triads, are substituted by different amino acid residues.

79 , where the naturally occurring FMN cofactor is substituted by different analogs, makes it possible t

80 iptional activation function of CONSTANS can be substituted by direct fusion of the EDLL activation m

81 or its interaction with BiP/GRP78 and cannot be substituted by E. coli DnaJ.

82 d to the B-cell lineage, a function that can be substituted by ectopic Bcl2 expression, and (2) to en

83 cription complexes in which E. coli RNAP had been substituted by either bacteriophage SP6 or T7 RNAP.

84 Thr229 of rat p70s6k was substituted by either a neutral amino acid Ala (T229

85 at loss of activity was observed when Lys172 was substituted by either Ala or Cys, or when Gly137 was

86 Individual nucleosides were substituted by either a 2'-deoxy-nucleoside, an aba

87 Dicistronic vectors in which ORF1 and ORF2 were substituted by either two different fluorescent pro

88 Importantly, Topo IIIalpha cannot be substituted by Escherichia coli Top3, and the Hollida

89 the synthesis of proteins with peptide bonds being substituted by ester bonds.

90 e enzyme from Pseudomonas stutzeri ATCC14405 were substituted by evolutionary conserved residues or a

91 find that the PGRP-SC1a amidase activity can be substituted by exogenous addition of free peptidoglyc

92 lp from CD4+ cells; this helper activity can be substituted by exogenous IL-2 or IL-4.

93 CLIP is substituted by exogenous peptidic fragments in an exc

94 injury depends on the generation of, and can be substituted by, exogenous CO.

95 are crucial for backbone hydrogen bonding), are substituted by fluorine atoms.

96 ayer perovskites in which some of the oxygen is substituted by fluorine.

97 ctures on model compounds, in which the TiPB are substituted by formate ligands, reveal that the HOMO

98 t ditetrelene R2 E=ER2 in which the E=E bond is substituted by four heteroatoms (other than Si) is de

99 gate the variants of this compound where tin is substituted by germanium or silicon and find that the

100 Glu275 was substituted by Gln, Asp, Ala, and Arg; none of these

101 D61 can be substituted by glutamate, but E63 appears to be invar

102 sidue at the conserved DXDXT signature motif was substituted by glutamic acid via site-directed mutag

103 orm for which the alpha-His(195) residue has been substituted by glutamine.

104 putative proton donor near the active site, is substituted by glutamine in combination with substitu

105 trate access channel of LiP, in which Glu146 was substituted by Gly (E146G LiPH8), showed substantial

106 Function of omega is known to be substituted by GroEL in omega-null strain, which thus

107 hors, where the conserved GPI core structure is substituted by heterogeneous sialylated branched poly

108 Further opioids should not be substituted by high dose NSAIDs in the management of

109 on, but loss of the zinc hook connection can be substituted by higher levels of the complex.

110 acid within the MoFe protein (beta-98(Tyr)) is substituted by His, the resulting MoFe protein suppor

111 mple is a missense mutation where ARG531 has been substituted by HIS531.

112 it easy to prepare nonracemic helicenes that are substituted by hydroxyl groups at their 1,omega-posi

113 otential cytochrome P450 hydroxylation site, was substituted by I, Br, Cl, and F to potentially enhan

114 combination site (resF) which allows Hbsu to be substituted by IHF, binding specifically between site

115 CD28 costimulation, noteworthy, cannot be substituted by IL-2 to induce proliferation of Treg c

116 Isotope-effect measurements, in which atoms are substituted by isotopes of different mass to systema

117 We observed that human mtSSB can be substituted by its Drosophila homologue, and vice ver

118 ation by cholesterol, endogenous cholesterol was substituted by its optical isomer, epicholesterol.

119 ue in EL2, whereas the R7.39 in TM7 seems to be substituted by K7.35.

120 ty that KCNE1 in the IKs channel complex can be substituted by KCNE2 when the latter is available.

121 The conserved Phe and Arg in P450BM-3 were substituted by Leu112 and Asp439, respectively in P

122 ue in the Golgi GDP-fucose transporter (GFR) is substituted by leucine in nac(1) flies, which abolish

123 conserved valine in the A chain (residue A3) is substituted by leucine.

124 sphotyrosine in all other known SH2 domains, is substituted by leucine.

125 requires a divalent cation, Mg2+, which can be substituted by Mn2+.

126 fts (PDXs) stromal cells of the human tumour are substituted by murine counterparts, here we deploy h

127 tion of a critical arginine residue that has been substituted by mutagenesis is restored by GdmHCl.

128 3, and Gly-575 from the large subunit of CPS were substituted by mutagenesis with bulkier amino acids

129 The Cys(52) sulfinic acid moiety was substituted by mutating this residue to Asp, leading

130 infects men if N-acetyllactosamine residues are substituted by Neu5Ac during infection in women.

131 Two of these ligands can be substituted by non-native cysteine residues introduce

132 tic residues that line the active site gorge are substituted by nonaromatic residues, corresponding t

133 ginine or lysine residues in the zinc module were substituted by norleucine, an isostere that maintai

134 l and tautomerizable phenol derivatives have been substituted by O-, S-, N-, and C-centered nucleophi

135 M-9) in which only residues 341-454 of OCTN2 were substituted by OCTN1 had markedly reduced carnitine

136 use model in which the endogenous Trp53 gene is substituted by one encoding p53ER(TAM), a p53 fusion

137 he p-cymene ring and/or the chloride ligands are substituted by other ligands to modulate the steric

138 tion function of the 9-nt sequence could not be substituted by other 5'-terminal sequences.

139 nctions in the virulent strain, which cannot be substituted by other kinases.

140 These arginines can be substituted by other residues, while still retaining

141 Then, commercial pectin was substituted by other gelling agents (pomegranate pee

142 f mutant enzymes in which this aspartic acid was substituted by other residues that change charge and

143 hat 22% of the reduction in firearm suicides was substituted by other suicide methods.

144 tex to induce polarity, but its function can be substituted by overexpressing Lgl.

145 ived from guanine in which the N(1)-nitrogen is substituted by oxygen.

146 nd polytellurophene, respectively, and N has been substituted by P and As in polypyrrole.

147 lmodulin, in which the four Ca(2+) ions have been substituted by Pb(2+), and a target peptide.

148 of the cocoa aspartic protease, which cannot be substituted by pepsin.

149 erence for mFRT11 is nearly lost when Tyr-82 is substituted by Phe.

150 e predicted site of tyrosine phosphorylation is substituted by phenylalanine.

151 ouble, or triple mutations in which tyrosine was substituted by phenylalanine.

152 Position 4 of Kdo is substituted by phosphoethanolamine, also present in p

153 l globular domains of BclA from both species are substituted by polysaccharide-like O-linked glycans

154 tituted by either Ala or Cys, or when Gly137 was substituted by Pro.

155 eriodontal therapy in these defects, and can be substituted by probing bone measurements.

156 ly metal-coordinating residues H207 and Y220 were substituted by residues that should not coordinate

157 a distinct role in heterocysts which cannot be substituted by respiratory O2 uptake in the protectio

158 y introduced when one strand of a DNA duplex is substituted by RNA we find that six restriction enzym

159 Specifically, S has been substituted by Se and Te in polythiophene, leading

160 fitness effects of beneficial mutations that are substituted by selection are key to our understandin

161 It has been substituted by sentinel node biopsy with dissection

162 ere an interior cysteine residue (C6 or C39) is substituted by serine, a normal solvent effect is obs

163 solvent accessible surface cysteine residue is substituted by serine, the S covalency decreases upon

164 sidues of IIBMtl are denoted in italic type) was substituted by serine to permit the formation of a s

165 state and the active site Cys-10 of IIB(Chb) was substituted by serine to prevent intermolecular disu

166 2-C21S, in which the NH(2)-terminal cysteine was substituted by serine, lost their ability to activat

167 Akt1/PKBalpha (C224S), in which cysteine 224 was substituted by serine, was resistant to NO donor-ind

168 e protein for which the alphaGly(69) residue was substituted by serine.

169 olin alpha in which the N-terminal cysteines were substituted by serines (Cys4, Cys24, and Cys4/Cys24

170 ally, the two native cysteines found in CheB were substituted by serines and a cysteine was substitut

171 analog, where the cysteines (36, 41, and 46) were substituted by serines, is monomeric on SDS-polyacr

172 or interacts with the coenzyme, Trp-139 has been substituted by several different types of amino aci

173 Twenty different amino acids were substituted by site-directed mutagenesis for wild-t

174 The four residues were substituted by site-directed mutagenesis.

175 tive site (Cys(284), Cys(330), and His(331)) were substituted by site-directed mutagenesis.

176 Derivatives where CH units are substituted by sp(2) nitrogen atoms are rare but of

177 AT5 binding to a subset of mammary enhancers is substituted by STAT3.

178 The strontium-H332E mutant, in which calcium is substituted by strontium, confirms that strontium (ca

179 2), and X(3) residues of hCG-alpha and -beta were substituted by swapping their respective cystine kn

180 the P-TEFb-recruitment function of Brd4 can be substituted by that of HIV-1 Tat, which recruits P-TE

181 en the p53-binding sites in the p21 promoter are substituted by the Bax p53 site or by the region of

182 local wavelet coefficients of the PET image are substituted by the corresponding values of the MRI/C

183 for the enzyme (Kd = 0.5 muM) and could not be substituted by the acceptor ACP.

184 Interestingly, the Ttk69 BTB can be substituted by the BTB of the human Bcl-6 protein, su

185 s are lacking in most archaea where they may be substituted by the chaperone prefoldin.

186 he GABAergic neurons, a function that cannot be substituted by the classical form of the bHLH heterod

187 embrane-binding domain of Rnd3, which cannot be substituted by the equivalent Cdc42 CAAX sequence.

188 physical interaction with RPA because it can be substituted by the Escherichia coli single strand DNA

189 -binding property, the N-terminal domain can be substituted by the influenza virus hemagglutinin fusi

190 ain of c-Ski, which is missing in v-Ski, can be substituted by the leucine zipper domain of GCN4.

191 nt role in the mouse intestine, which cannot be substituted by the other family kinases Fyn and Yes.

192 The effect of Rac or Cdc42 can be substituted by the Pak kinase, which is a direct down

193 h behaves as a transcription terminator, can be substituted by the trp transcription terminator witho

194 ch the GTPase center of E. coli 23S rRNA had been substituted by the corresponding domain from Saccha

195 S-66271, in which the amino acids 22-31 have been substituted by the sequence E22-L-L-E-K-L-L-E-K-L31

196 103-105 to 104-106, and when the human tail is substituted by the C-terminal tail of murine S100A9.

197 s of the chicken ecto-ATP-diphosphohydrolase is substituted by the corresponding region of the human

198 s of the chicken ecto-ATP-diphosphohydrolase is substituted by the corresponding region of the human

199 eg1 becomes completely dispensable when Ceg1 is substituted by the mouse guanylyltransferase, which d

200 because it is reversed to activation when P2 is substituted by the P1 or p53 consensus sequences.

201 ry complexes in which the glucosyl component is substituted by the putative transition state analogue

202 anges dramatically when an "ideal" potential is substituted by the real one; (ii) the structures of s

203 f of the MADS domain of AP1, AP3, PI, and AG was substituted by the corresponding sequences of human

204 reporter enzyme in which the membrane anchor was substituted by the Escherichia coli chemotaxis recep

205 hNTS1-R212E mutant receptor, in which Arg212 was substituted by the negatively charged Glu residue.

206 along the A kinase binding domain of d-AKAP2 was substituted by the other 19 l-amino acids.

207 cted nonpolar residues on the surface of CAT were substituted by the corresponding polar residues in

208 se proband in which one of these isoleucines was substituted by threonine (I317T).

209 suggest a unique role for TRbeta that cannot be substituted by TRalpha in the T3-dependent feedback r

210 f RNAP active centre, the trigger loop (TL), is substituted by transcription factor Gre.

211 K14Cre;pNog mice, in which Wnt signaling can be substituted by transgenic activation of Pitx2.

212 is dependent on NF-kappaB signals, which can be substituted by transgenic expression of the prosurviv

213 th the magnitude of change increasing as Trp is substituted by Tyr, Ala, Gly, and Glu.

214 RNA, where C2518 (C2499 in Escherichia coli) was substituted by U.

215 ous beta(1) subunits in the lateral membrane were substituted by unglycosylated beta(1) subunits disp

216 eries of modified analogues in which Phe(13) was substituted by unnatural amino acids.

217 Fossil fuels can be substituted by using wood products in place of altern

218 idue contributed by glycerol kinase (Glu478) is substituted by using site-directed mutagenesis to con

219 e (NL) largely untapped (e.g. 'glutamic acid was substituted by valine at residue 6').

220 La and M sites can be substituted by various metal ions leading to Li-rich

221 in the second step, the benzotriazole group is substituted by various nucleophiles with or without t