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1 ar localization studies have shown that TILs are targeted to a variety of cell membranes and organell
3 in resulting from a horizontal gene transfer is targeted to a bacterial symbiont, further blurring th
6 point regions of the hGLUT proteins that can be targeted to achieve isoform selectivity, and show tha
7 have identified potential pathways that can be targeted to activate cancer immunogenicity via TEs in
10 e availability of Cas9 endonuclease that can be targeted to almost any genomic locus using so called
13 in, and highlight a trophic pathway that can be targeted to ameliorate dendrite loss in pathological
14 it that gates avoidance responses, which can be targeted to ameliorate maladaptive avoidance in psych
15 Autophagy is a cellular mechanism that could be targeted to ameliorate these side effects based on it
17 we find that when a GAL4-MOF fusion protein is targeted to an upstream-activating sequence linked to
22 rocess, as an isogenic M1T1 DeltaspeB mutant is targeted to autophagy and attenuated for intracellula
23 CD19(+) cells and CD19(-) precursors should be targeted to avoid CD19(-) relapses in patients with B
25 ent extracellular domains of her-2/neu could be targeted to B cells to generate Abs against particula
26 e ECP reached consensus regarding who should be targeted to be trained as faculty (including proficie
29 transgenic mouse model in which p53 deletion is targeted to biliary epithelia and CC induced using th
30 the epigenetic activator of ERalpha that can be targeted to block ERalpha gene expression is a critic
31 (Y382-384) within the P2X7 receptor that can be targeted to blunt the development of morphine analges
33 to produce specific output projections that are targeted to both similar and different target areas.
34 We found that Kir2.1 and Kir2.2 channels were targeted to both the surface and the transverse tub
35 hrinkage of junctions; the actomyosin pulses are targeted to breaks in the cell polarity protein Par3
36 oped a modular drug delivery system that can be targeted to cell types of therapeutic interest in the
38 usly we showed that newly synthesized CENP-A is targeted to centromeres exclusively during early G1 p
39 opose a mechanism whereby HsSAS-6 homodimers are targeted to centrosomes where the local environment
42 l SMT of Cbx7 mutants demonstrates that Cbx7 is targeted to chromatin by co-recognizing of H3K27me3 a
45 require distinct metabolic programs that can be targeted to control specific T cell populations in au
46 covery identifies novel molecules that might be targeted to correct defective repair during cirrhosis
48 sociate with PBs in the cytoplasm but rather is targeted to cytosolic insoluble protein deposits (IPO
50 ing programs are leadership hubs, and should be targeted to develop future presidents and influence t
54 of CD133 protein to the cell surface and can be targeted to disrupt CD133 regulation and function.
56 esis and osteogenesis in bone, and Cxcl9 can be targeted to elevate bone angiogenesis and prevent bon
59 ed that ENT-dependent adenosine uptake could be targeted to enhance adenosine-mediated lung protectio
60 XCR3 in CTL migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunothera
61 uman hematolymphoid cell development and may be targeted to enhance production of specific cell popul
62 among major cell stress pathways that could be targeted to enhance proliferation of CMs in ischemia
64 stem cell (CSC)-like populations that could be targeted to enhance the antitumor action of these dru
67 ATF4 and CHOP, suggesting that the UPR could be targeted to eradicate TSC1/2-null cells during patien
75 The enzymes and transporters they encode may be targeted to further construe the nature of NMDAR coag
78 CoV E has a single hydrophobic domain (HD), is targeted to Golgi complex membranes, and has cation c
80 insights into the control of Arc that could be targeted to harness neuroplasticity for clinical appl
82 n drugs for breast cancer prevention, should be targeted to high-risk groups to maintain a favourable
84 cytoplasmic receptors and their ligands can be targeted to improve clinical outcomes in periodontiti
88 Stroke identified several factors that might be targeted to improve the consistency and fairness of t
89 vidence suggesting that the microbiota could be targeted to improve therapy while attenuating adverse
90 dentified specific barriers to care that may be targeted to improve treatment delivery and potentiall
92 These data suggest that multiple lipids can be targeted to induce oligomerization of defensins durin
93 that the AR-DBD has a surface site that can be targeted to inhibit all forms of the AR, including en
94 novel TCR-CXCR4-signaling pathway that could be targeted to inhibit the aberrant cytokine secretion t
95 racterize a novel signaling pathway that can be targeted to inhibit the secretion of cytokines by mod
101 during IAV infection that could potentially be targeted to limit morbidity following IAV infection.
102 Thus, NpHR-mCherry or mCherry expression was targeted to lOFC neurons that project to the BLA or
104 engineered version of diphtheria toxin that is targeted to malignant cells via a fusion with interle
105 providing a regulatory mechanism that could be targeted to manage acid-related gastric diseases.
106 iral interferon regulatory factor 1 (vIRF-1) is targeted to mDRM during virus replication and negativ
107 sms, ribosomes translating membrane proteins are targeted to membrane translocons early in translatio
108 here was no general gene location that could be targeted to minimize or maximize the number of off-ta
110 ed that Nodamura virus replication complexes are targeted to mitochondria, as evidenced in biochemica
112 tity (i) SLC25A33 and SLC25A36 were found to be targeted to mitochondria and (ii) the phenotypes of S
113 aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavag
116 eutrophils and suggest that therapies should be targeted to modulate autophagy and phagocytosis in ne
117 nterocyte urate metabolism could potentially be targeted to modulate or prevent metabolic syndrome.
119 ys to handle microbiota-derived products may be targeted to modulate Th17 responses in the context of
120 P platform, wherein avidin-decorated NPs can be targeted to multiple human DC subsets via biotinylate
121 d-mediated capture/release strategy, HyCCAPP is targeted to multiple genomic loci in parallel, and th
125 sinADeltaE and to uncover factors that might be targeted to offset defects associated with torsinADel
130 interstrand crosslinks (ICLs), yet how SLX4 is targeted to other functional contexts remains unclear
132 gests that multiple invasion ligands need to be targeted to overcome the capacity of P. falciparum fo
133 of MLL fusions in leukemogenesis that might be targeted to overcome the differentiation block associ
135 actors identified could allow the therapy to be targeted to patients most likely to benefit and not e
139 l-targeted to plastids and mitochondria; two are targeted to plastids, and five are targeted to mitoc
140 precursors containing Hsp70-binding elements were targeted to plastids, whereas none of the chimeric
141 ing transcriptional remodeling during stress are targeted to PQC sites to influence gene expression c
143 may contribute to disease, and how it might be targeted to prevent damage to the aging choriocapilla
145 Finally, we demonstrate that Car enzymes can be targeted to prevent human mast cell development.
147 human disease, including how metabolism may be targeted to prevent T cell dysfunction in inhospitabl
148 ining whether distinct cellular pathways can be targeted to prevent the development of inflammatory a
151 erial transporter for drug uptake that might be targeted to promote greater antibiotic influx to incr
152 mmunoregulatory circuits in B cells that may be targeted to promote long-lived humoral immunity and r
154 point, redox dysregulation has successfully been targeted to protect PVIs with antioxidants/redox re
156 iRNA regulators of ANP production that could be targeted to raise ANP levels, which may have applicat
157 ay inhibit immune surveillance, and it could be targeted to reactivate CIITA expression in SWI/SNF de
158 has been conserved for a billion years, can be targeted to rebalance the phosphatase's activities fr
159 present in late endosomes/lysosomes, ClC-3c is targeted to recycling endosomes via a novel N-termina
160 mation and injury in mice with AP, and might be targeted to reduce pancreatic tissue damage and infla
161 ydroxy-2-naphthoate prenyltransferase (MenA) was targeted to reduce methicillin-resistant Staphylococ
165 sstalk between macrophages and PSCs that can be targeted to reverse or halt pancreatic fibrosis progr
166 rm light-evoked firing when LiGluR-MAG0(460) was targeted to RGCs and robust but diverse activity pat
169 l and proliferation of cancer cells, and can be targeted to selectively trigger cancer cell apoptosis
171 y chains are a class of rotaxanes which have been targeted to serve as artificial molecular machines
172 cytosis, and demonstrate whether a toxin can be targeted to Siglec-8-bearing cells to kill these cell
174 the preparation of protein micelles that can be targeted to sites of activated platelets with broad p
177 the vertebrate CNS, afferent sensory inputs are targeted to specific depths or layers of their targe
178 ns express multiple neuroligin isoforms that are targeted to specific synapses, but their synaptic fu
179 ity through the use of microbubbles that can be targeted to specific biological processes is explored
181 elivery of Ags and adjuvants to APCs and can be targeted to specific cell types, such as dendritic ce
183 may be a vehicle by which RNA therapy could be targeted to specific cells for the treatment of kidne
184 The CRISPR-associated endonuclease Cas9 can be targeted to specific genomic loci by single guide RNA
185 Cas9, an RNA-guided DNA endonuclease, can be targeted to specific genomic sequences by engineering
186 ys that instruct HSPC behavior, yet how PRC2 is targeted to specific genomic loci within HSPCs remain
187 mRNA, and some noncoding RNAs (ncRNAs), can be targeted to stress granules, the targeting efficiency
192 ryotes, up to one-third of cellular proteins are targeted to the endoplasmic reticulum, where they un
193 which mitochondrial-derived vesicles (MDVs) are targeted to the endosomal compartment has remained u
197 oteins destined for the mitochondrial matrix are targeted to the inner membrane Tim17/23 translocon b
200 of membrane translocation for proteins that are targeted to the intermembrane space via the redox-dr
201 the VHHs with a GPI attachment signal, VHHs are targeted to the lipid rafts of the plasma membranes.
202 the VHHs with a GPI attachment signal, VHHs are targeted to the lipid rafts of the plasma membranes.
204 g of some low-molecular-weight proteins that are targeted to the membrane or secreted, cellular physi
210 ally unstable and aggregation-prone proteins are targeted to the ribosome assembly site in the nucleo
214 the cell division site in many bacteria, can be targeted to the middle of a cell-like compartment.
215 ls that allow precursors of such proteins to be targeted to the mycomembrane remain uncharacterized.
217 ptogenetic tools, however, requires light to be targeted to the right neurons at the right time.
219 onjugated with an antielastin antibody could be targeted to the site of an aneurysm in a rat model of
220 ximum effect pre-exposure prophylaxis should be targeted to the subpopulations that account for the l
224 with the ubiquitin receptor protein DSK2 and is targeted to the autophagy pathway during stress via t
225 N1 is expressed selectively in rods where it is targeted to the axonal terminals by the synaptic rele
229 teins, the HIV-1 envelope glycoprotein gp160 is targeted to the endoplasmic reticulum (ER) by its sig
236 a bona fide Ser/Thr protein phosphatase that is targeted to the mitochondrial intermembrane space (IM
237 heme enzyme, cytochrome c peroxidase (Ccp1) is targeted to the mitochondrial intermembrane space.
238 ogenase Fe protein when the NifH polypeptide is targeted to the mitochondrial matrix together with th
240 -815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for removing SUMO from spec
242 hat at least 1.6% of the total cellular LDHB is targeted to the peroxisome by a conserved hidden PTS1
247 P1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteasome for degradation (the canon
248 igned a modified form of nNOSmu (NOS-M) that is targeted to the sarcolemma by palmitoylation, even in
249 cular mechanism by which the G9a/GLP complex is targeted to the specific gene loci for H3K9 methylati
251 ein, which forms the virion nucleocapsid and is targeted to the surface of lipid droplets, correlated
252 m nucleotide sequence-an RNA 'barcode'-which is targeted to the synapse using engineered proteins.
254 cent of some other ion-channel subunits, and is targeted to the tips of the stereocilia in the sensor
256 which a membrane anchored MinC/MinD complex is targeted to the Z ring through the conserved carboxy
257 lease-sequencing revealed that the +60ZF-DBD was targeted to the adult beta-globin downstream promote
259 ext, we generated knockin mice in which LacZ was targeted to the endogenous mouse vWF locus in the ab
260 s, inducible PTEN ablation (Delta5PTEN(flx)) was targeted to the epidermis of mice expressing activat
261 approach where PHOT1-GFP (P1-GFP) expression was targeted to the hypocotyl apex of the phot-deficient
262 petent model in which anti-insulin Vkappa125 was targeted to the Igkappa locus and paired with anti-i
263 oxifen-inducible MerCreMer chimaeric protein was targeted to the Kit locus in mice and then bred with
264 ing import into isolated chloroplasts, Plsp1 was targeted to the membrane via a soluble intermediate
266 , in which Asn was restored at position 441, was targeted to the plasma membrane and exhibited approx
267 We found that ectopically expressed LpdA was targeted to the plasma membrane and Rab4- and Rab14-
270 pea genome and expression of the transporter was targeted to the sieve element-companion cell complex
271 overexpressed or antisense oligonucleotides were targeted to the C9orf72 hexanucleotide repeat expan
272 presence of AChR subunits, rapsyn molecules were targeted to the cell surface and formed aggregates
274 ically, acyl-CoA/acyl-ACP processing enzymes were targeted to the cytoplasm, peroxisome, or endoplasm
276 we engineered derivative GPx-1 proteins that were targeted to the mitochondria by the addition of a m
277 hat PS1-containing gamma-secretase complexes were targeted to the plasma membrane, whereas PS2-contai
280 tions of Cre-dependent adenoviral constructs were targeted to the ventrolateral hypothalamus of Foxb1
281 tochondrial proteins are nuclear-encoded and are targeted to their mitochondrial destination from the
282 vel molecular mechanisms that can eventually be targeted to therapeutically trigger HIV-1 reactivatio
285 omatin modifications such as DNA methylation are targeted to transposable elements by small RNAs in a
286 a specific receptor of the gut-lung axis can be targeted to treat airflow obstruction in asthma.
288 ation and suggest that EC Kir channels could be targeted to treat endothelial dysfunction, which is a
294 ur work identifies host responses that could be targeted to treat severe H7N9 influenza and identifie
298 aracterized in some detail, how proteins may be targeted to ubiquitin-independent proteasomal degrada
299 shares this allosteric site and likewise can be targeted to uncover inhibitors with high specificity.
300 e (FLEX)-Channelrhodopsin2 (ChR2) expression was targeted to VTA DA neurons in DA transporter (DAT)-c
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