ライフサイエンスコーパス: be tethered to

1 h other because they can associate when they are tethered to a complex with flexible linkers.

2 Both of these elements are tethered to a Neutravidin surface with the TNB recog

3 ries within the nucleus and that chromosomes are tethered to a nuclear matrix.

4 al-associated protein 25 (SNAP-25), and they are tethered to a PEG-coated glass surface.

5 However, the individual peptides must be tethered to a tag that preserves their individual ide

6 hydrolysis, metal-coordinating peptides have been tethered to a DNA-intercalating rhodium complex to

7 Short peptides have been tethered to a DNA-intercalating ruthenium complex t

8 allowed to attach to RGDS peptides that had been tethered to a silicone surface utilizing a previous

9 complexes of TSG-6 with hyaluronan that had been tethered to a solid surface.

10 r trans-repression as it is inactive when it is tethered to a heterologous protein.

11 replication is only efficient if the plasmid is tethered to a host chromosome.

12 a nucleotide-binding switch domain, NB-ARC, is tethered to a LRR sensor domain.

13 A transcription factor is tethered to a membrane-bound receptor with a linker t

14 a dominant positive form of MyoD, one which is tethered to a partner, E47, activates muscle-specific

15 of cell cycle transcription factors--when Rb is tethered to a promoter through E2F, it not only block

16 omplex 3 was designed such that cytochrome c is tethered to a region of the peroxidase near Asp148 wh

17 oloenzyme reveals that a single PlyCA moiety is tethered to a ring-shaped assembly of eight PlyCB mol

18 ity due to avidity effects when the receptor is tethered to a surface.

19 domain establishes silent chromatin when it is tethered to a weakened HMR-E silencer, and it disrupt

20 h) receptor (nAChR), a rhodamine fluorophore was tethered to a Cys side chain introduced at the beta

21 ear matrix, and the hTSHbeta silencer region was tethered to a nuclear matrix of human cells in vivo,

22 Thus, even when p53 was tethered to a reporter gene by a heterologous DNA-bi

23 quences of PAP binding to mRNAs in vivo, PAP was tethered to a reporter mRNA in resting oocytes using

24 the approach used in this study, the protein was tethered to a surface, allowing a freely diffusing f

25 even when the activation/regulatory domains were tethered to a different DNA-binding domain.

26 Single cells of Escherichia coli were tethered to a glass coverslip by means of a single

27 ifferent orientations, and the ChlI subunits were tethered to a silica surface; the probability of su

28 polymerase I Klenow fragment (KF) molecules were tethered to a single-walled carbon nanotube field-e

29 ell's spectrin-actin network, nano-particles were tethered to actin nodes and their constrained therm

30 The cells were tethered to adhesive sites, smaller in diameter tha

31 activity may be inhibited when a GUS domain is tethered to an H(+)-ATPase complex.

32 cking (SPT), one end of the polymer molecule is tethered to an immobile substratum.

33 A P450 reductase domain is tethered to an oxygenase domain containing the heme,

34 ein, Hir3p, to repress transcription when it was tethered to an HTA1-lacZ reporter gene, and Hir1p an

35 Bases were tethered to an AFM probe and mica substrate via lon

36 nts that focused the matrix into a mass that was tethered to, and suspended above, the light organ po

37 yclin A and its binding substrate, cdk2, can be tethered to beta-TrCP, ubiquitinated, and effectively

38 are still made with extensive manual labor, are tethered to bulky control systems, and have cumberso

39 in the fusion assay depending on whether it is tethered to C2B.

40 mes into daughter cells during mitosis, they are tethered to cellular chromatin by the viral E2 prote

41 in of Ras homologue enriched in brain (Rheb) is tethered to cellular membranes through a prenylated c

42 The data indicate that LANA is tethered to chromosomes through two independent chrom

43 Being tethered to collagen mRNAs, STRAP prevents unrestr

44 e kinase receptor-associated protein (STRAP) is tethered to collagen mRNAs by interaction with LARP6.

45 ct configurations of a regulatory complex to be tethered to different promoters.

46 Much, but not all, of this complex is tethered to disk membranes by the transmembrane prote

47 Chromosomal DNA polymerases are tethered to DNA by a circular sliding clamp for high

48 Replicative polymerases are tethered to DNA by sliding clamps for processive DNA

49 A polymerases are multiprotein machines that are tethered to DNA during chain extension by sliding cl

50 tivator in such experiments requires that it be tethered to DNA, a requirement that cannot be overcom

51 and the GAL11P mutation such that the latter is tethered to DNA and the former is attached to the hol

52 ata strongly support a model in which EBNA3A is tethered to DNA through a BATF-containing protein com

53 es GRIP1 transcriptional activity when GRIP1 is tethered to DNA.

54 he archetypal protein context, as long as it is tethered to DNA.

55 trong gene activation when the GAL4 fragment is tethered to DNA.

56 onsistent with a model in which the machines are tethered to each other to form 'gene expression fact

57 munication arise more readily when the sites are tethered to each other, either in cis on the same mo

58 ill undergo minor structural changes when it is tethered to either surface, and the structures differ

59 re translationally repressed when human Ago2 was tethered to either the 5' or 3' UTR.

60 ng in approximately 50% fewer melanoma cells being tethered to endothelium and retained in lungs.

61 Each protein was tethered to Escherichia coli DNA adenine-methyltrans

62 l motif is presented: DNA or chromatin loops are tethered to "factories" through the transcription ma

63 DNA through its ribbon-helix-helix motif and is tethered to FitB, the toxin, to form a heterodimer by

64 1, 3-bis(pentaphenylphenyl)benzene subunits were tethered to form the final macrocycle.

65 sufficient to bind to FtsA, but only when it is tethered to FtsN(TM) or to a leucine zipper.

66 acts as a transcriptional repressor when it is tethered to Gal4 DNA-binding domain.

67 nd the filament, are known to rotate, having been tethered to glass or marked by latex beads, the rot

68 get of MAPK signaling in the Golgi, where it is tethered to GLUT4 vesicles by binding to IRAP.

69 It further implies that G alpha subunits are tethered to Golgi membranes by posttranslational mod

70 pite recent advances, soft robots must still be tethered to hard robotic control systems and power so

71 covered that ERalpha-bound regulatory depots are tethered to heterochromatin protein 1 (HP1) for coor

72 associated herpesvirus (KSHV) latent genomes are tethered to host histones to form a minichromosome a

73 This episome is tethered to host chromatin to ensure proper segregati

74 ependent adhesion was noted when the ligands were tethered to inert beads, simulating the physiologic

75 ata are consistent with a model in which Tpr is tethered to intranuclear filaments of the NPC by its

76 Fe(II) was tethered to L9 via cysteine residues introduced at p

77 A nicotinic acid mononucleotide derivative is tethered to Lys(184) and forms a tridentate pincer co

78 Although Rho1p has been shown to be tethered to membranes of the secretory pathway, we sh

79 A26p is tethered to MVs via interaction with the A27 protein

80 nensine analogues in which a mannose residue was tethered to N-1 of kifunensine via a two-, three-, o

81 Collectively, our findings reveal that SENP2 is tethered to NPCs through a complex interplay of inter

82 of 2-ketoglutarate, suggesting that once PII was tethered to NRII the active conformation was stabili

83 showed that at least some of these factories are tethered to nuclear pores.

84 When a rhodium complex is tethered to one of the arms of the four-way junction

85 n budding yeast mitosis, sister kinetochores are tethered to opposite poles and separated, stretching

86 habditis elegans protein kinase A (PKAI(CE)) is tethered to organelles in vivo.

87 ugh DNA response elements as well as when it was tethered to other transcription factors.

88 ride (SCWP), an acetylated carbohydrate that is tethered to peptidoglycan.

89 d essential for signaling uptake of ACs that are tethered to phagocytes via other receptors.

90 rrespond to these tracts, and that the forks are tethered to planes of cell division.

91 The parS/ParB chromosomal centromere is tethered to PopZ at one pole prior to the initiation

92 Cyclic AMP-dependent protein kinase is tethered to protein kinase A anchoring proteins (AKAP

93 The nuclear myosin II is tethered to recognition sequence AGCTCC (-39/-34) in

94 EBNA2 is tethered to responsive promoters through a cellular f

95 e spliceosome containing the 5' and 3' exons are tethered to RNAP II for splicing.

96 indicate that elongating nascent transcripts are tethered to RNAP II on the immobilized DNA template.

97 We show that MetAP-2 can be tethered to SCF(beta-TRCP), ubiquitinated, and degrad

98 (IGF-1)-IGF-1 receptor system, and IGF-1 can be tethered to self-assembling peptide nanofibers (NF-IG

99 igands to the T Cell Receptor and LFA-1 that are tethered to separate, closely juxtaposed regions of

100 rates an N-sulfonyl imine functionality that is tethered to Ser195, in accordance with the postulated

101 nt reporter molecule, acridinium ester (AE), was tethered to single-stranded oligonucleotide probes a

102 tronic technique in which lysozyme molecules were tethered to single-walled carbon nanotube field-eff

103 lent chromatin at non-centric locations, HP1 was tethered to sites within euchromatic regions of Dros

104 smids containing active partitioning systems are tethered to specific regions of the cell, and the nu

105 s a recognizable DNA-binding motif, how they are tethered to specific target promoters remains unknow

106 FeBABE was tethered to specific sites of the final sigma(70) su

107 c activity of a fusion protein in which ExoI is tethered to SSB is nearly equivalent to that of SSB-s

108 eristics are upheld even when the DNA duplex is tethered to streptavidin or the mobility of the nitro

109 ure when binding substrate and suggest sHSPs are tethered to substrate at multiple sites that are loc

110 Deletion mapping confirmed that hRap1 is tethered to telomeres through interaction of its C te

111 of DNA chains requires that DNA polymerases are tethered to template DNA at primer ends.

112 ing bilayers from cochleate cylinderss which are tethered to the aggregate by biotin-streptavidin cou

113 These Hsp90-binding regions, however, are tethered to the C-terminal tail via a "molecular cla

114 scherichia coli chromosome replication forks are tethered to the cell centre.

115 is that their cognate ligands, the ephrins, are tethered to the cell surface, in contrast to other R

116 c fluid and on microtubules whose minus ends are tethered to the cortex.

117 h the leading and lagging strand polymerases are tethered to the DnaB helicase via dimeric tau.

118 fragmentation into individual elements that are tethered to the FTCD/vimentin fibers.

119 These domains are tethered to the homodimeric Core by ~30-residue link

120 arcoma-associated herpesvirus (KSHV) genomes are tethered to the host chromosomes and partitioned fai

121 gnals of both NF-kappaB p50 and p65 subunits are tethered to the IkappaBalpha amino-terminal ankyrin

122 The internalized Tat-QDs are tethered to the inner vesicle surfaces and are trapp

123 Multiple viral polymerases are tethered to the interior of a particle, each dedicat

124 skeleton consists of spectrin tetramers that are tethered to the lipid bilayer by ankyrin and by acti

125 ria involves synthesis of intermediates that are tethered to the lipid carrier undecaprenol-phosphate

126 (OM) lipoproteins in Gram-negative bacteria are tethered to the membrane via an attached lipid moiet

127 ents in the bundle and whether the filaments are tethered to the membrane.

128 loosely bundled FtsZ polymers, some of which are tethered to the membrane.

129 ovalves are based on [2]pseudorotaxanes that are tethered to the nanoparticle surfaces.

130 ers are based on azobenzene derivatives that are tethered to the nanopore interiors, while nanovalves

131 omosomal sites known as pairing centers that are tethered to the nuclear envelope.

132 Furthermore, exogenous insulator sequences are tethered to the nucleolus in a CTCF-dependent manner

133 to complex with RNA polymerase II, and they are tethered to the nucleoskeleton.

134 mechanism whereby biosynthetic intermediates are tethered to the peptidyl carrier protein SgcC2.

135 Many Galpha are tethered to the plasma membrane by covalent lipid mo

136 ed that in the absence of VPU, HIV-1 virions are tethered to the plasma membrane in BST2-expressing H

137 lso binds to nuclear estrogen receptors that are tethered to the plasma membrane, resulting in acute

138 It is found that the amine functionalities are tethered to the PMMA backbone through an alkane brid

139 of nuclear microtubules (MTs) are capped and are tethered to the SPB inner plaque, whereas the majori

140 unique fluorophores at opposite termini can be tethered to the cell surface and used to detect DNA c

141 Proteins bound to FEN1 could be tethered to the flap base by the interaction of FEN1

142 n the outer leaflet, and RcsF was thought to be tethered to the inner leaflet by its lipidated N term

143 a periplasmic lipoprotein that is thought to be tethered to the inner membrane of this organism.

144 s a means for the NH(2)-terminal fragment to be tethered to the membrane.

145 es polymers of the tubulin homologue FtsZ to be tethered to the membrane.

146 it is concluded that the fluorophore should be tethered to the metal-binding part of the sensor, and

147 l interact with ORF69 in the nucleus and can be tethered to the nuclear membrane by virtue of its int

148 E1B 55K repression requires that 55K be tethered to the promoter by binding directly to DNA-b

149 L42 remained bound, suggesting that UL30 may be tethered to the replication fork by protein-protein i

150 ngside drug loading, functional proteins can be tethered to the surface utilizing bio-orthogonal "cli

151 Moreover, the coactivator HAT activity must be tethered to the template by Tax and CREB, since a p30

152 main of the glucocorticoid receptor (GR) has been tethered to the intercalating fluorophore thiazole

153 ss the physiological significance of primase being tethered to the eukaryotic replisome in this way.

154 rs of FokI interact strongly, as a result of being tethered to the same molecule of DNA, and sequeste

155 model in which the pseudosubstrate of aPKCs is tethered to the acidic surface on p62, locking aPKC i

156 The loop is mostly disordered but is tethered to the active site region by several electro

157 membrane anchored whereas the C-terminal end is tethered to the bacterial cell wall.

158 r 1,3-linked polyglycerolphosphate chain and is tethered to the bacterial membrane by a glycolipid (d

159 ed 2'-deoxyuridines in which the amino group is tethered to the base via a 3-carbon alkyl, Z- or E-al

160 (4:1 ratio), we show that, as expected, Kras is tethered to the bilayer surface by specific lysine-PO

161 R) molecule catalyzing methyl group transfer is tethered to the C terminus of a neighboring receptor.

162 e derivatives, the C-4 acetate of the taxane is tethered to the C-3' phenyl at ortho and meta positio

163 A single calmodulin (CaM) molecule is tethered to the C-terminal alpha(1C)-LA/IQ region and

164 e produces a large extracellular domain that is tethered to the C-terminal stalk by disulfide bridges

165 t proteins around the packaged genome, which is tethered to the capsid's inner surface by the DNA-bin

166 core region followed by a stalk region that is tethered to the cell membrane by a glycosyl-phosphati

167 s expressed as an N-terminal ectodomain that is tethered to the cell surface by a C-terminal transmem

168 sible roles of the complex cytoskeleton that is tethered to the cells' plasma membrane.

169 strate that the native HelX in R. capsulatus is tethered to the cytoplasmic membrane via its uncleave

170 a consequence of this interaction, RARalpha is tethered to the DNA sites that are recognized and bou

171 The structures show how the polymerase is tethered to the DNA through multiple contacts with th

172 t, suggesting that this multiprotein complex is tethered to the DNA via TEF-1.

173 When Dam is tethered to the DNA-binding domain of GAL4, targeted

174 that the cytosolic Hsc70-SGTA-Hsp105 complex is tethered to the ER membrane, where Hsp105 and SGTA fa

175 s a unique trypsin-like serine protease that is tethered to the extracellular membrane of cells throu

176 The membrane is tethered to the gold electrode and includes an ionic

177 y play a role in orienting ubiquitin when it is tethered to the HECT active site cysteine.

178 tR in which the core, inducer-binding domain is tethered to the helix-turn-helix, DNA-binding domain

179 One of the p160 proteins (GRIP1) is tethered to the HIV-1 long terminal repeat (LTR) thro

180 It is tethered to the inner chloroplast envelope membrane f

181 t are captured by an Fc-binding protein that is tethered to the inner membrane.

182 x show that the 60 residue C-terminal domain is tethered to the main body of the enzyme via a flexibl

183 hilin, which directly binds to myosin Va and is tethered to the melanosome membrane via Rab27a.

184 ng dual kinase/methyltransferase (WbdD) that is tethered to the membrane and recruits WbdA into an ac

185 is a cytoplasmic, N-terminal PAS domain that is tethered to the membrane by a 47-residue F1 linker.

186 Expressing alpha-bungarotoxin that is tethered to the membrane by a glycosylphosphatidylino

187 sterol C4-demethylation enzyme complex that is tethered to the membrane by Ergosterol biosynthetic p

188 nicotinic receptors (nAChRs); however, lynx1 is tethered to the membrane via a GPI anchor.

189 CB is tethered to the membrane via phosphoinositides.

190 The catalytic domain is tethered to the membrane, with which it interacts in

191 ssors when ERRalpha and AP1 bind and ERalpha is tethered to the MHRE.

192 The BAG2/Hsp70 complex is tethered to the microtubule and this complex can capt

193 Cox11 is tethered to the mitochondrial inner membrane by a sin

194 e E2 protein of bovine papillomavirus type 1 is tethered to the mitotic chromosomes via the cellular

195 he mRNA processing enzyme poly(A) polymerase is tethered to the much larger 3'-end processing complex

196 the C-terminus of the B chain (residue B30) is tethered to the N-terminus of the A chain (A1).

197 Lipoylated Pal is tethered to the OM and binds the beta-propeller domai

198 we present evidence that the assembling coat is tethered to the outer forespore membrane by a 26-amin

199 The 'bound' form of the protein is tethered to the outer membrane (OM) by its N-terminal

200 vated serine/threonine phosphoprotein (FAST) is tethered to the outer mitochondrial membrane, where i

201 phoprotein (FAST) is a survival protein that is tethered to the outer mitochondrial membrane.

202 RGS9Gbeta5 is tethered to the outer segment membranes by its membra

203 The OM is tethered to the peptidoglycan via the lipoprotein, Lp

204 croscopy probe miniSOG indicated that smAKAP is tethered to the plasma membrane and is particularly d

205 While the majority of mature PrPC is tethered to the plasma membrane by a glycosylphosphat

206 on suggesting that this region of the genome is tethered to the poles of the cell at a specific time

207 e EM reconstruction shows that the B subunit is tethered to the polymerase domain through a structure

208 cyclodextrin (alpha-CD) ring on a stalk that is tethered to the pore openings on the nanosphere, is s

209 ctivate E2F, but also we show that when p107 is tethered to the promoter through binding to E2F it fu

210 model in which one terminus of the substrate is tethered to the protease and the other terminus is en

211 ocyte chemoattractant protein-1 (MCP-1) that is tethered to the proteoglycans on the luminal side of

212 Our data indicate that Rep is tethered to the RBE in a specific orientation during

213 ChIP experiments established that RIF1 is tethered to the regulatory region of the A1 promoter

214 or type II depending on how the diene motif is tethered to the rest of the substrate (type I are tet

215 It is tethered to the ribosomes through its interaction wit

216 periments, it could be shown that the ligand is tethered to the second extracellular loop by hydropho

217 The core polymerase is tethered to the template by beta, enabling processive

218 han 90% of G protein-coupled receptors, ECL2 is tethered to the third TM helix via a disulfide bond.

219 y homologous to the G protein alpha subunit, is tethered to the top of the beta-propeller domain by a

220 Hsp70 is tethered to the translocon via interaction with Tim44

221 The Fab1 complex is tethered to the vacuole via an interaction between th

222 s between a substrate where the alkoxy group was tethered to the acetal group by a five-membered ring

223 In each case, a ferrocene redox probe was tethered to the AuNP surface to evaluate electron tr

224 The anti-CD38 scFv was tethered to the C-terminus of the hemagglutinin (H)

225 en Galphai2 yellow fluorescent protein (YFP) was tethered to the carboxyl terminus of the alpha2A adr

226 d networks of VWF multimers, and each string was tethered to the cell surface by a limited number of

227 xperiments where a nearly full-length INCENP was tethered to the centromere.

228 The PM was tethered to the CL and SSC until, at a critical defo

229 changes in chromatin structure even when it was tethered to the HIV-1 core promoter upstream of the

230 The dye was tethered to the lipid via a 1,2,3-triazole in the li

231 2-terminal domain was retained in the ER and was tethered to the membrane by its own M1 transmembrane

232 When soluble tissue factor was tethered to the membrane surface via such metal-chel

233 ling copper ions to the mitochondrion, Cox17 was tethered to the mitochondrial inner membrane by a fu

234 s of whether or not the Fas-signaling domain was tethered to the plasma membrane.

235 ex was tethered to the surface and the other was tethered to the probe.

236 Sir1 was tethered to the ring following excision from the chr

237 mitotic cells, a portion of the mitochondria was tethered to the spindle-pole bodies and moved to the

238 In order to do this, one duplex was tethered to the surface and the other was tethered t

239 (NH(3))(2)Cl(2)(OH)(O(2)CCH(2)CH(2)CO(2)H)], was tethered to the surface of DNA-Au NPs through amide

240 ptor subunits NR2A and -B, as well as PSD95, were tethered to the complex.

241 hell design, in which carboxylic acid groups were tethered to the core and silanol to the shell inter

242 d be significantly enhanced when DNP haptens were tethered to the end of very long hydrophilic PEG li

243 rved to sway in the oscillating flow as they were tethered to the surface by a capture antibody.

244 Transport vesicles are tethered to their target membrane prior to the inter

245 Thus, these secretory granules are tethered to their target plasma membrane by a static

246 When TPP1 is tethered to TIN2/TRF1/TRF2, POT1a is thought to block

247 During mitosis, aggregates are tethered to well-anchored maternal mitochondria, whe