ライフサイエンスコーパス: be tightly regulate to

1 of vascular endothelial growth factor (VEGF) is tightly regulated to achieve normal angiogenesis.

2 erins with the underlying actin cytoskeleton is tightly regulated to achieve proper cell-cell adhesio

3 The stages at which this activity occurs are tightly regulated to allow activity-dependent develo

4 traits, and imply that SWEET16 activity must be tightly regulated to allow optimal Arabidopsis develo

5 e immune system, however their activity must be tightly regulated to allow pathogen clearance whilst

6 x regulation suggests that the cydA promoter is tightly regulated to allow its expression only at the

7 ctively, many studies suggest that uncoating is tightly regulated to allow nuclear import of the geno

8 a-vWF bond and suggest that this interaction is tightly regulated to allow rapid binding at sites of

9 The levels of Comm and Robo appear to be tightly regulated to assure that only certain growth

10 hage pro-inflammatory gene expression should be tightly regulated to avert host tissue damage.

11 ppa, pol is processive, implying that it may be tightly regulated to avoid deleterious mutagenesis.

12 uggests that (1) fibre type distribution may be tightly regulated to avoid large fibres with high oxi

13 ti-component inflammatory response that must be tightly regulated to avoid tissue damage.

14 T cell activation is tightly regulated to avoid autoimmunity.

15 Complement activation is tightly regulated to avoid excessive inflammatory and

16 The channel has a low open probability and is tightly regulated, to avoid decoupling of the membran

17 The different modes of stem cell division are tightly regulated to balance growth and differentiat

18 The expression of iNOS needs to be tightly regulated to balance the broad ranging proper

19 The liver immune environment is tightly regulated to balance immune activation with i

20 T cell responses in mammals must be tightly regulated to both provide effective immune pr

21 In contrast, DUT-N protein and mRNA levels are tightly regulated to coincide with nuclear DNA repli

22 morphogenetic protein (BMP) receptor kinases are tightly regulated to control development and tissue

23 Fc-FcgammaR interactions are tightly regulated to control IgG-mediated inflammati

24 ctal cancer (DCC) (frazzled) attraction must be tightly regulated to control midline axon guidance in

25 f branched actin filaments by Arp2/3 complex is tightly regulated to control actin assembly in cells.

26 ding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and

27 Antiviral responses must be tightly regulated to defend rapidly against infection

28 se receptor activation is required, but must be tightly regulated to direct ramifications of the term

29 cs and magnitude of cytokine gene expression are tightly regulated to elicit a balanced response to p

30 requires a lumen, the diameter of which must be tightly regulated to enable optimal lung function.

31 SMADs are tightly regulated to ensure balanced cellular respon

32 Immune responses are tightly regulated to ensure efficient pathogen clear

33 d that KC cell cycle and cell death programs are tightly regulated to ensure epidermal homeostasis.

34 Meiotic crossovers (COs) are tightly regulated to ensure that COs on the same chr

35 series of site-specific rearrangements that are tightly regulated to ensure that functional antibodi

36 It is proposed that these programs are tightly regulated to ensure that the cell maintains

37 The innate inflammatory response must be tightly regulated to ensure effective immune protecti

38 ophil trafficking to the infection site must be tightly regulated to ensure efficient microbial clear

39 re of uniporter subunit assembly, which must be tightly regulated to ensure proper mitochondrial resp

40 ility of activated T cells to apoptosis must be tightly regulated to ensure sufficient T cell progeny

41 is indicates that meiotic recombination must be tightly regulated to ensure that each chromosome pair

42 DNA replication must be tightly regulated to ensure that the genome is accura

43 the amount of cell proliferation, which must be tightly regulated to ensure the generation of properl

44 These motors must be tightly regulated to ensure the spatial and temporal

45 The number of neutrophils in the blood is tightly regulated to ensure adequate protection again

46 t is vital that chemokine receptor signaling is tightly regulated to ensure appropriate responses.

47 scence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal musc

48 tin occurs in diverse signaling pathways and is tightly regulated to ensure cellular homeostasis.

49 the bacterial inner and outer membranes (OM) is tightly regulated to ensure cellular integrity, maint

50 otein 1 (RAG1) and RAG2 endonuclease complex is tightly regulated to ensure ordered recombination of

51 g complex/cyclosome (APC/C) ubiquitin ligase is tightly regulated to ensure programmed proteolysis in

52 genetic protein (BMP) signaling through Smad is tightly regulated to ensure proper embryonic patterni

53 ive PrE cells, suggesting that FGF signaling is tightly regulated to ensure specification of the appr

54 Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of

55 Eukaryotic translation is tightly regulated to ensure that protein production o

56 The activity of Smad proteins must be tightly regulated to exert the biological effects of

57 ties of infiltrating macrophages (Mphi) must be tightly regulated to facilitate appropriate responses

58 Its activity is tightly regulated to facilitate K(+) efflux for stoma

59 great potential for self-renewal, which must be tightly regulated to generate appropriate cell number

60 genes whose temporal and spatial expression is tightly regulated to guide patterning of the anterior

61 thesized that its biological activity should be tightly regulated to limit IL-22 expression to the si

62 ne system of the gastrointestinal tract must be tightly regulated to limit pathologic responses towar

63 The adaptive immune response is tightly regulated to limit responding cells in an Ag-

64 the biosyntheses of fatty acids and lipid A are tightly regulated to maintain a balance between phos

65 Their abundance and composition are tightly regulated to maintain efficient photosynthes

66 s (IP3R) and ryanodine receptors (RyRs) must be tightly regulated to maintain cell viability, both ac

67 iety of resident leukocyte subsets that must be tightly regulated to maintain immune homeostasis.

68 a transcription factor whose expression must be tightly regulated to maintain normal cell growth and

69 They must be tightly regulated to maintain production of the prote

70 Intracellular heme levels must be tightly regulated to maintain proper mitochondrial re

71 SREBP activity is tightly regulated to maintain lipid homeostasis, and

72 This process of proliferation and shedding is tightly regulated to maintain the intestinal architec

73 Retinal angiogenesis is tightly regulated to meet oxygenation and nutritional

74 These late mitotic events are tightly regulated to occur only after the onset of a

75 DNA replication is tightly regulated to occur once and only once per cel

76 tion-triggering signaling process in T cells is tightly regulated to permit an immune response that i

77 Neutrophil numbers in the periphery are tightly regulated to prevent opportunistic infection

78 ese results suggest that levels of Mad1 must be tightly regulated to prevent aneuploidy and transform

79 r host defense against pathogens but need to be tightly regulated to prevent chronic inflammation.

80 ynthesis, the accompanying water losses must be tightly regulated to prevent dehydration and undesire

81 acterial infections, and its production must be tightly regulated to prevent excessive inflammation.

82 However, production of these cytokines must be tightly regulated to prevent immunopathology.

83 Synaptic assembly must be tightly regulated to prevent overgrowth of the synaps

84 Their proliferative capacity must be tightly regulated to prevent the emergence of unwante

85 r these processes, but their activities must be tightly regulated to prevent the generation of lethal

86 ival signals activated by Tpo must therefore be tightly regulated to prevent uncontrolled cell growth

87 GPVI signaling has to be tightly regulated to prevent uncontrolled intravascul

88 intracellular degradation pathway, autophagy is tightly regulated to prevent cellular dysfunction in

89 IRF7 activation is tightly regulated to prevent excessive inflammation a

90 Their expression is tightly regulated to prevent excessive inflammation w

91 sible mechanism of activation, PAR signaling is tightly regulated to prevent the uncontrolled stimula

92 rive genetic variation, yet their expression is tightly regulated to prevent unchecked amplification.

93 Actin polymerization by Arp2/3 complex must be tightly regulated to promote clathrin-mediated endocy

94 eplication from multiple origins, which must be tightly regulated to promote precise genome duplicati

95 ukocyte recruitment during inflammation must be tightly regulated to protect the host against pathoge

96 TLR4 signaling must be tightly regulated to provide both effective immune pr

97 T cell growth and function must be tightly regulated to provide protection against forei

98 Activation of the immune system needs to be tightly regulated to provide protection against infec

99 ling inflammatory responses to infection and are tightly regulated to rapidly mount responses to infe

100 In general, we found expression is tightly regulated to reflect availability of their co

101 Inflammation in the CNS must be tightly regulated to respond efficiently to infection

102 The complement system is tightly regulated to safeguard against tissue damage

103 RNA degradation is tightly regulated to selectively target aberrant RNAs

104 nate plasticity of hematopoietic progenitors is tightly regulated to supply blood cells during normal