ライフサイエンスコーパス: be unlikely to be

1 s, indicating that qualities of the provirus are unlikely to be a major driver of persistent inflamma

2 ential, yet empirical evidence suggests they are unlikely to be a valid proxy.

3 under physiological conditions, dissociation is unlikely to be a biologically relevant reaction.

4 We show that, although BWA is unlikely to be a ceramidase, it is a regulator of sph

5 ficantly associated with CVD risk, psoriasis is unlikely to be a clinically useful independent risk f

6 a formal data homogenization procedure, and is unlikely to be a data artefact.

7 However, c-Src is unlikely to be a direct kinase for IRF4.

8 Although Sox2 is unlikely to be a direct therapeutic target, these dat

9 parameter-DNA binding affinity, for example-is unlikely to be a dominant contributor to function.

10 RNP complex, indicating that this mechanism is unlikely to be a driver of viral latency in this cell

11 We show that ASG1 is unlikely to be a glue, but rather is part of a widesp

12 value determinations, demonstrating that it is unlikely to be a good approach to guiding food choice

13 ommon infections with antibiotics in infancy is unlikely to be a main contributor to childhood obesit

14 on of NAAG on oligodendrocyte NMDA receptors is unlikely to be a major contributor to white matter da

15 udy demonstrates that latent viral diversity is unlikely to be a major driver of persistent HIV-assoc

16 t of c-ring stability loss, so this property is unlikely to be a major factor in vivo.

17 that TFB1M 12S m(6) 2A rRNA hypermethylation is unlikely to be a pathogenic mechanism and may be an a

18 Thus, MadC is unlikely to be a photosensor, yet is a fundamental li

19 the traffic of misfolding rhodopsin mutants is unlikely to be a practical therapy, because of their

20 Indeed, NAD(+) synthetic activity is unlikely to be a primary mechanism underlying retinal

21 ptake is a major factor in resistance, hCTR1 is unlikely to be a productive target in attempts to enh

22 Our geographically extensive dataset is unlikely to be a random sample of marine coastal habi

23 that the higher eGFR among coffee consumers is unlikely to be a result of glomerular hyperfiltration

24 the reduction in perfusion in dependent lung is unlikely to be a result of lung volume related increa

25 n cannabis use and relapse of psychosis that is unlikely to be a result of self-medication or genetic

26 Given the slow change during 1 year, BCVA is unlikely to be a sensitive outcome measure for STGD1

27 Given the overall slow rate of VA loss, VA is unlikely to be a sensitive outcome measure for treatm

28 te prey suggest that fish fillet consumption is unlikely to be a significant source of REE to humans

29 Serious mental illness is unlikely to be a sole risk factor and risk of blood-b

30 Y and FliM, FliY does not bind FliG and thus is unlikely to be a substitute for FliM in the center of

31 mechanistic studies suggest that CRP itself is unlikely to be a target for intervention.

32 h Frost that flexible letter-position coding is unlikely to be a universal property of word recogniti

33 ministered at a dosage of 400 mg twice daily is unlikely to be a useful long-term intervention to red

34 d not correlate genetically with disease and is unlikely to be a useful surrogate endophenotype for P

35 Reducing sPLA2-IIA mass is unlikely to be a useful therapeutic goal for preventi

36 nia, suggesting that increased sequestration was unlikely to be a major contributor.

37 evation (i.e., "thermoneutral") summer range was unlikely to be a viable behavioral adaptation strate

38 es of this functional architecture, however, are unlikely to be able to accommodate the more rapid co

39 logical changes in porcine trauma models and are unlikely to be able to serve as useful trauma biomar

40 onic glycine receptors suggests pharmacology is unlikely to be able to selectively target each form o

41 This deeply rooted cultural tradition is unlikely to be abolished.

42 egration of viral transgenes into the genome is unlikely to be accepted.

43 for bimolecular pairing of nucleotides that are unlikely to be accessible for bimolecular structure.

44 epresentational and motivational factors and is unlikely to be accounted for by changes to any singul

45 te-stage cancers and incidence and mortality are unlikely to be achieved.

46 euroinflammation' or 'microglial activation' is unlikely to be achieved by the sole use of TSPO PET i

47 d into conjunctive representations, and this is unlikely to be achieved by unidirectional, sequential

48 However, whilst limb loss is unlikely to be adaptive, females with missing limbs m

49 AM with a common incidence correction factor is unlikely to be adequate.

50 each other: although a neuron of one subtype is unlikely to be adjacent to another of the same subtyp

51 ent by means of hand transfer and saliva but is unlikely to be aerosolized.

52 numbers and structure within hybrid genomes are unlikely to be affected by global change.

53 cause PCR also offers more rapid turnaround, is unlikely to be affected by storage and transport cond

54 nvironmental effects; and G x E interactions are unlikely to be an important aspect of normal develop

55 ptibility to aphids, indicating that SlSERK1 is unlikely to be an essential virulence target.

56 These findings suggest that vitamin D status is unlikely to be an important determinant of LTL, at le

57 Thus, reduced baseline ASL pH is unlikely to be an important pathobiological factor in

58 placement in women vaccinated against HPV 16 is unlikely to be an issue for the general population.

59 ndication that type replacement of HPV 16/18 is unlikely to be an issue in the general population pos

60 ng to the high cost of gold, these reactions are unlikely to be applicable in medium- or large-scale

61 &N's) theory suggests that these preferences are unlikely to be appropriate when applied to a differe

62 s instance, the immune-deficient mouse model is unlikely to be appropriate for testing medical counte

63 have broad benefits by reducing poverty, but is unlikely to be as effective or affordable for prevent

64 mily in which all known RP/LCA-related genes are unlikely to be associated with their disorder.

65 vide evidence that receiving ADHD medication is unlikely to be associated with greater risk of substa

66 prescribed as one capsule per day, disposal is unlikely to be at the patient level.

67 rmal differentiation after Par3 inactivation is unlikely to be attributed to increased perpendicular

68 fluctuations at usual breathing frequencies are unlikely to be baroreflex mediated, and disappear du

69 lude that the mechanism of specific activity is unlikely to be based simply on preferential recogniti

70 GF-beta, used in those with Marfan syndrome, are unlikely to be beneficial and could be detrimental.

71 the tolerability profile of pirfenidone, and is unlikely to be beneficial in IPF.

72 Treatment is unlikely to be beneficial, and could worsen outcomes.

73 ronary intervention in contemporary practice is unlikely to be beneficial.

74 y, a strategy proposed for cancer treatment, is unlikely to be beneficial.

75 ults, suggesting that directional pleiotropy was unlikely to be biasing the result (intercept 0.002;

76 ndicates that the majority of novel isoforms are unlikely to be both condition-specific and translata

77 kely to generalize across species, and which are unlikely to be broadly conserved.

78 on; (2) miRNAs with extreme sequence lengths are unlikely to be cancer-related; and (3) the miRNA seq

79 hereas effects of macronutrients such as fat are unlikely to be carried over to influence breeding in

80 tepwise procedure, we excluded variants that are unlikely to be causal, and identified 20 candidate g

81 accination observed in epidemiologic studies are unlikely to be causal.

82 ever, which might be early transient wheeze, is unlikely to be causal or familial.

83 Therefore, the presence of autoantibodies is unlikely to be causal, and their role in pathogenesis

84 en 25(OH)D concentration and type 2 diabetes is unlikely to be causal.

85 U more efficiently and that ICU readmissions are unlikely to be causally related to patient outcomes.

86 Albuminuria of any degree is unlikely to be causally related to diabetic cardiovas

87 ormations that accompany economic growth and is unlikely to be causally related to levels of partner

88 clinical manifestations of systemic anthrax are unlikely to be caused by the direct binding and entr

89 dings indicate that Abeta accumulation in AD is unlikely to be caused by ECE-2 deficiency.

90 to reward; therefore, proximate reward bias was unlikely to be caused by effort or delay discounting

91 rophthalmia and anterior segment dysgenesis, were unlikely to be caused by the microdeletion.

92 r stationary distribution while slow species are unlikely to be changed.

93 tments targeting the reconsolidation process are unlikely to be clinically effective unless methods a

94 ral access, although the 3 minute difference is unlikely to be clinically relevant.

95 time, although the 4- to 6-minute difference is unlikely to be clinically relevant.

96 e to 93.9%, with two misidentifications that were unlikely to be clinically relevant.

97 hiatus hernia, and the clinical differences were unlikely to be clinically significant.

98 a nitrate/nitrite exchanger and that protons are unlikely to be co-transported.

99 omenon in which the majority of young miRNAs are unlikely to be coexpressed with host genes; however,

100 tions may create a sensitized background but are unlikely to be completely penetrant.

101 Controlled trials are unlikely to be conducted, so prospective, observatio

102 etween birth weight and asthma in twins that is unlikely to be confounded by genetic or shared enviro

103 properties of the TCR/peptide/MHC interface are unlikely to be conserved causal factors for peptide

104 LRRK2 activity in vivo is unlikely to be constitutive but rather refined to spe

105 Because in the Western world, insects are unlikely to be consumed raw, it is important to know

106 tions in local pollution concentrations that is unlikely to be correlated with other causes of death,

107 e perspective, suggesting that silk garments are unlikely to be cost-effective using currently accept

108 Other scenarios are unlikely to be cost-effective.

109 sient THW-induced deterioration of HRQoL but is unlikely to be cost effective at its current price.

110 inistic sensitivity analysis showed that THP is unlikely to be cost effective even under the most fav

111 show that screening all admissions for MRSA is unlikely to be cost effective in England at the curre

112 cision making based on the 70-gene signature is unlikely to be cost effective in patients with NNBC.

113 with metastatic HER2-positive breast cancer is unlikely to be cost effective in the United States.

114 and biologics with similar cost and efficacy is unlikely to be cost-effective compared with using tri

115 munotherapy as compared with pharmacotherapy is unlikely to be cost-effective for asthma.

116 ed to have a minimal effect on mortality and is unlikely to be cost-effective.

117 patients with localized PC, as surgery alone is unlikely to be curative for most patients.

118 cancers may not understand that chemotherapy is unlikely to be curative, which could compromise their

119 an respond to visual input, but such signals are unlikely to be directly communicated to the LHb.

120 etermined by rare, long-range movements that are unlikely to be discerned during field observations.

121 These discorrelated molecular changes are unlikely to be drivers of pathology allowing an excl

122 However, we argue that these traits are unlikely to be driving diversification directly.

123 We show that enhancement is unlikely to be driving such oscillations but may be m

124 schizophrenia, are stable across the night, are unlikely to be due to antipsychotic medications, and

125 A associations observed in the current study are unlikely to be due to chance because they were a pri

126 These defects are unlikely to be due to defective ENS precursor migrat

127 t the differences in GABAA ergic sensitivity are unlikely to be due to differences in slice health.

128 more than 25% and increases of more than 33% are unlikely to be due to measurement variability.

129 t in the cutaneous nerves of naked mole-rats is unlikely to be due primarily to lack of skin hair fol

130 g responses to intradermal pruritogens, this is unlikely to be due to an effect at the nerve terminal

131 ion profiling suggests that this sensitivity is unlikely to be due to an indirect effect on gene expr

132 The data suggest that this observation is unlikely to be due to an unfavorable equilibrium but

133 risk of developing PD over 5 to 7 years that is unlikely to be due to confounding or reverse causatio

134 This behavior is unlikely to be due to electrostatic interactions and

135 difference between island and mainland sites is unlikely to be due to greater male-male competition f

136 Melanoma transformation is unlikely to be due to height per se; however, height-

137 This increase is unlikely to be due to the introduction of varicella v

138 targeted at lowering circulating cystatin C are unlikely to be effective in preventing CVD.

139 t restrictions imposed at the hospital level are unlikely to be effective unless coordinated with cam

140 t that conventional routes of administration are unlikely to be effective.

141 t that conventional routes of administration are unlikely to be effective.

142 ovel context (e.g., treatment facility), and is unlikely to be effective due to the context specifici

143 Conversely, inhibition of CSF-1R is unlikely to be effective in inflammatory disease but

144 Targeted therapy is unlikely to be effective in the absence of the target

145 n who are incontinent after prostate surgery is unlikely to be effective or cost effective.

146 hibit biofilm formation through this pathway are unlikely to be encountered by V. cholerae in aquatic

147 Investigators studying exposures that are unlikely to be eradicated given current prevention e

148 hat energetic or nitrogen use considerations are unlikely to be evolutionary drivers for CAM photosyn

149 athematical modeling suggest that these data are unlikely to be explained by the gradual accumulation

150 s we show statistically that these increases are unlikely to be explained solely by qPCR measurement

151 reduced K(ir) conductance within pacemakers is unlikely to be explained by an absence of particular

152 modality in sandy beach benthic communities is unlikely to be explained by any single hypothesis.

153 ence of skin prick test positivity in Europe is unlikely to be explained by geographical variation in

154 We show that this pattern is unlikely to be explained by several nonadaptive mecha

155 CAT insulin sensitivity with morning fasting is unlikely to be explained by signalling proximal to Ak

156 ability over multidecadal time scales, which is unlikely to be explained by the Interdecadal Pacific

157 These relationships are unlikely to be exploitable for improving clinical te

158 d thus far on single-dimensional data inputs are unlikely to be expressive enough to accurately model

159 shed for 14 of the 33 (42%), suggesting they are unlikely to be false-positives.

160 children with severe traumatic brain injury are unlikely to be feasible.

161 cure, i.e., viral eradication from the host, is unlikely to be feasible.

162 However, this capacity limitation is unlikely to be fixed because behavioral models indica

163 thereby suggesting that such hydrogen bonds are unlikely to be formed en route from the denatured to

164 ry loads, as occurs during tuberculosis, and are unlikely to be found after M. tuberculosis exposure.

165 Such molecules are unlikely to be found through conventional drug scree

166 or Nestin-CreER and NG2-CreER, markers which were unlikely to be found in CFU-Fs.

167 For most of them, however, this wish is unlikely to be fulfilled, as only a small number of d

168 The results of this study are unlikely to be generalizable to a less healthy older

169 osts assessed in currently existing programs are unlikely to be generalizable to TasP programs for se

170 he US effect observed in behavioral research is unlikely to be generated by editorial biases.

171 tion, and we conclude that the GH61 proteins are unlikely to be glycoside hydrolases.

172 but C storage in live vascular plant biomass is unlikely to be greater than losses from deep soil C p

173 is awaiting a compatible organ, many of whom are unlikely to be have a transplant.

174 trols focused on a single transmission route are unlikely to be highly effective.

175 ore chronic medical conditions (a group that is unlikely to be hospitalized because of marathon parti

176 subclones, that may influence prognosis but are unlikely to be ideal therapeutic targets; (3) mutati

177 indicate that tuning of thalamic excitation is unlikely to be imparted by direction- or orientation-

178 y other sites where amino acid substitutions are unlikely to be important.

179 he course of 1 year even in older adults who are unlikely to be in a presymptomatic stage of AD.

180 of T2D (vi) methylation at these five sites was unlikely to be influenced by neighboring DNA sequenc

181 This saliency representation is unlikely to be inherited from fronto-parietal cortice

182 etic field, and that inward radial diffusion is unlikely to be inhibited by scattering by electromagn

183 eported expression of TrpA1 in clock neurons is unlikely to be involved in generating the summer loco

184 we also found that the role of Msh1p in BER is unlikely to be involved in the avoidance of large-sca

185 NO released from the irradiated embryos was unlikely to be involved in the bystander effect indu

186 orest plot on Barro Colorado Island, Panama, are unlikely to be large enough to detect deviations fro

187 many microorganisms at very high levels and is unlikely to be life limiting on an exoplanet.

188 Given that TAIL measures are unlikely to be limited by perceptual sensitivity, we

189 Simple cyst-appearing renal masses are unlikely to be malignant.

190 s suggests that this effect of excess weight is unlikely to be mechanical alone.

191 rogenic lipoproteins, and these associations are unlikely to be mediated by direct cholesterol effect

192 IL-7-induced proliferation of CD4(+) T cells are unlikely to be mediated by downregulation of CD127 e

193 sition to acrophobia in this genetic isolate is unlikely to be mediated by a small number of shared h

194 Map4k4 regulation of myogenesis is unlikely to be mediated by classic mitogen-activated

195 ion, the primary control of MC4R PVN neurons is unlikely to be mediated by leptin action on arcuate N

196 that ORF57 association with the viral genome is unlikely to be mediated exclusively by an RNA tether.

197 However, these increased energetic demands are unlikely to be met by adequate production at lower t

198 the capabilities of current electronics, and are unlikely to be met by isolated improvements in trans

199 equirements for older breastfed-only infants are unlikely to be met without the regular consumption o

200 Post-2015 targets are unlikely to be met without the use of novel diagnost

201 inhibition, Caco-2 permeability, and efflux are unlikely to be modulated by chirality.

202 s that deleterious mito-nuclear interactions are unlikely to be much more prevalent in individuals bo

203 Single genetic changes are unlikely to be necessary or sufficient for metastasi

204 he metabolic activity of HCT1806 and HCT4918 is unlikely to be necessary for their role in suppressin

205 ta suggest that the putative benefits of LPD are unlikely to be observed in institutions performing <

206 M. catarrhalis, S. aureus, and P. jirovecii are unlikely to be of diagnostic value in clinical setti

207 ted HDAC5 phosphorylation and nuclear export are unlikely to be of major importance in regulating MEF

208 nnot be made, these results indicate that it is unlikely to be of benefit.

209 l infarction or stroke, but this improvement is unlikely to be of clinical importance.

210 in concentration and suggest that MT imaging is unlikely to be of clinical utility in differentiating

211 is small increase in discriminative accuracy is unlikely to be of diagnostic or predictive utility at

212 ation-calling is still challenging and there is unlikely to be one established caller that systematic

213 limination/beta-migratory insertion pathway) are unlikely to be operative.

214 ator-associated pneumonia prevention bundles are unlikely to be optimal insofar as pneumonia accounts

215 change negatively were also those who would be unlikely to be organ donors anyway, because they tend

216 e pathways present in advanced tumors, which are unlikely to be overcome by intervention at a single

217 iber orientation obtained from DWI data that is unlikely to be overcome by improvements in data acqui

218 dinucleotide substrates for deamination but is unlikely to be part of the higher level targeting mec

219 Hence, the disulfide bond itself is unlikely to be part of the homophilic binding site.

220 131, although generated from an MG patient, is unlikely to be pathogenic and may make it a potential

221 E218K is unlikely to be pathogenic based on segregation.

222 ved in interactions critical for priming but are unlikely to be phosphorylated during viral replicati

223 ncanonical stoichiometries observed in vitro are unlikely to be physiologically relevant.

224 es of baseline RGC density from cone density are unlikely to be precise and offer little advantage ov

225 Our results indicate that schizophrenia risk is unlikely to be predominantly influenced by variants j

226 ervation and indicates that internal tissues are unlikely to be preserved with fidelity if organicall

227 This indicates that conventional GlcNAc-mers are unlikely to be produced and/or accumulate in P. palm

228 ts to reduce emissions and biodiversity loss are unlikely to be realized without specific actions tha

229 e clusters of atoms, with Angstrom precision are unlikely to be realized.

230 ng genes, proteins and biochemical reactions is unlikely to be realized in the near future.

231 in newborns suggests that stunting in utero is unlikely to be reduced by supplemental food alone.

232 versity crisis, the impacts of these efforts are unlikely to be reflected in improved trends in the s

233 s to heat stress in healthy aged individuals are unlikely to be related to attenuated increases in sy

234 ial differences in diagnostic practices that are unlikely to be related to patient characteristics ar

235 Only 1% of clusters were unlikely to be related to Bluetongue.

236 Therefore, these CC units are unlikely to be reporting only sensory signals, but t

237 d States and China's large swine populations are unlikely to be representative of swIAV diversity in

238 e and complex but variable among regions and are unlikely to be represented by those observed in only

239 es indicates that these gamma-proteobacteria are unlikely to be responsible for previously reported B

240 ive amounts of these meibum components alone are unlikely to be responsible for the increased stabili

241 that the hyperaccumulation of salicylic acid is unlikely to be responsible for dwarfism in this mutan

242 nts between the human H3N2 and H1N1 lineages is unlikely to be restricted by packaging signal mismatc

243 kinase activity-dependent step, whose target is unlikely to be SAS-6, triggers cartwheel assembly.

244 While this debate is unlikely to be settled in the immediate future, impro

245 in earthworms, but that the associated risk is unlikely to be significant for essential metals such

246 rge very low-density lipoprotein composition are unlikely to be solely predictable by the action of A

247 Hence, although polysulfides are unlikely to be stable in the reducing intracellular

248 eople with solid cancers using this strategy is unlikely to be straightforward.

249 This is because selection is unlikely to be strong enough to establish significant

250 Pests are unlikely to be strongly self-limited because they at

251 t irradiation it experiences, its atmosphere is unlikely to be substantially ablated over the lifetim

252 t and that individual educational programmes are unlikely to be successful in the face of widespread

253 ral LVOT (>75%) and lateral LVOT, whereas it was unlikely to be successful for idiopathic VAs origina

254 te mitigation policies, yet existing metrics are unlikely to be sufficient.

255 ssion of CtIP at double-strand breaks (DSBs) is unlikely to be sufficient for the generation of radia

256 Basic training is unlikely to be sufficient to support the behaviour ch

257 sessment of corticospinal tract damage alone is unlikely to be sufficient when considering patients w

258 Our results indicate that Rad-NSCs are unlikely to be suitable for neuronal replacement in

259 uggests that direct interactions between TFs are unlikely to be the main source of cooperativity betw

260 rved differences in pathogenicity, but these are unlikely to be the major determinant.

261 g body of evidence shows that Abeta peptides are unlikely to be the sole factor in AD etiology.

262 psilateral motoneurons suggests that Hb9 INs are unlikely to be the sole intrasegmental rhythm-genera

263 Pepper & Nettle show that this is unlikely to be the case.

264 We further imply that haploinsufficiency is unlikely to be the causative factor in C9ALS/FTD path

265 ffusion can speed up kinetochore capture, it is unlikely to be the dominant physical mechanism for ty

266 ercially available prosthesis; however, this is unlikely to be the global optimum for the physically

267 nt, our results indicate that its activation is unlikely to be the main source of LID.

268 ronment of the cell and suggest that PKMzeta is unlikely to be the mediator of synaptic plasticity or

269 creased transmission of TB during wintertime is unlikely to be the only cause of the seasonal peak in

270 influenced by pneumococcal capsule type but is unlikely to be the only important mechanism by which

271 ase trypsin I can activate ENaC in vitro but is unlikely to be the physiologically relevant activatin

272 Thus, carbon limitation is unlikely to be the primary cause of fungal death.

273 suggests that dopamine dysregulation per se is unlikely to be the primary cause underlying attention

274 ough pre-dispersal mortality is important it is unlikely to be the primary factor leading to low recr

275 et of metalloenzymes and that RNA polymerase is unlikely to be the primary target.

276 n, suggesting that direct regulation by CodY is unlikely to be the principal mechanism by which CodY

277 we demonstrate that this parental age effect is unlikely to be the result of changes in the environme

278 isk for suicide among mood disorder patients is unlikely to be the result of individual common varian

279 The circular orbit is unlikely to be the result of tides and therefore was

280 suggesting that the EBA175-GYPA interaction is unlikely to be the sole determinant of Laverania host

281 usion, these data suggest that proliferation is unlikely to be the sole mechanism underlying the rapi

282 ematizations of function) as a gold standard is unlikely to be the way forward.

283 nonoperative procedures and operations that were unlikely to be the proximate cause of mortality and

284 reduced stability, and we predict that they are unlikely to be transmitted from human to human and c

285 HA stability, we conclude that these viruses are unlikely to be transmitted from human to human by th

286 Therefore, these SNPs are unlikely to be under selective pressure driven by th

287 despite being susceptible to antibody, PfRH5 is unlikely to be under substantial immune selection pre

288 The function of the brain is unlikely to be understood without an accurate descrip

289 heterogeneous, and thus response to steroids is unlikely to be uniform in all patients.

290 a structural distortion to enhance function is unlikely to be unique to alphaLP family members and m

291 ly non-linear models based on these patterns are unlikely to be universal, because they would be inco

292 results show that these Vif-derived peptides are unlikely to be useful as tools to study A3G function

293 collected for drug resistance testing of HIV are unlikely to be useful in most forensic investigation

294 tructures of postcovalent complexes of PBP 5 are unlikely to be useful vehicles for the design of new

295 t is associated with a small effect size and is unlikely to be useful as a predictor of AD risk, it m

296 od or urine with currently available methods is unlikely to be useful for predicting PML risk in nata

297 roducible assessment with DW imaging, but it is unlikely to be useful in clinical practice.

298 sically attractive alternative approach, but is unlikely to be useful in routine management of idiopa

299 tribute but without strong clinical evidence are unlikely to be widely reimbursed.

300 no further resistance markers and therefore is unlikely to be XDR, or (iii) is identical to an isola