ライフサイエンスコーパス: be well defined

1 p53 function in apoptosis in vivo remains to be well defined.

2 key clinical features of the disease may not be well defined.

3 of Itk in the T cell activation and function is well defined.

4 ound the 99.5% confidence level for which PI is well defined.

5 e cell and tissue architecture of this organ is well defined.

6 selected disorders in which the pathogenesis is well defined.

7 e molecular targets of several of these DMTs are well defined.

8 P-43 in the adult nor its downstream targets are well defined.

9 ns, such as the selectins and their ligands, are well defined.

10 ial pressure, and cerebrovascular reactivity are well defined.

11 ductive interactions underlying this process are well defined.

12 e identifiers so that the extracted entities are well defined.

13 tinct nucleoside-binding sites, two of which are well defined.

14 f the membrane-spanning part of this pathway are well defined.

15 actors to describe enzymatic activities that are well defined.

16 ial residues, including His 173 and Ser 172, are well-defined.

17 localized surface plasmon resonances (LSPRs) are well-defined.

18 tect bexB in 10 strains whose capsule status was well defined.

19 and adults for whom the timing of infection was well defined.

20 mediated control of M. tuberculosis have not been well defined.

21 rs in CRC such as the NLR, PLR, and mGPS has been well defined.

22 hierarchical assembly of ribosomes, have not been well defined.

23 onse to different environmental cues has not been well defined.

24 ticipation on postoperative outcomes has not been well defined.

25 tact activation in severe infections has not been well defined.

26 e-specific CD8(+) T cell populations has not been well defined.

27 lth care-associated infections (HAI) has not been well defined.

28 e orchestrated to initiate lactation has not been well defined.

29 r North African non-Jewish neighbors has not been well defined.

30 VD undergoing heart transplantation have not been well defined.

31 h no retinal or neurologic morbidity has not been well defined.

32 s, but its role during EBV infection has not been well defined.

33 tional significance of this process have not been well defined.

34 on on various different Z functions have not been well defined.

35 thology during acute viral infection has not been well defined.

36 regulation of pilin gene expression has not been well defined.

37 contributions to the DNA expansion have not been well defined.

38 or adipocyte retinoid metabolism has yet not been well defined.

39 ts role in adaptive immune responses has not been well defined.

40 biosynthetic mechanism of P-cluster has not been well defined.

41 gic neurons that modulate breathing have not been well defined.

42 ia during ACS in community practice have not been well defined.

43 the peripheral nervous system (PNS) has not been well defined.

44 and consumers, and quality of care have not been well defined.

45 its functional consequences in vivo have not been well defined.

46 d fibroblasts from nonneoplastic tissue have been well defined.

47 s that induce macrophage activation have not been well defined.

48 ogic roles of VEGF in tumorigenesis have not been well defined.

49 y often implicated in tumorigenesis, has not been well defined.

50 viduals have residual plasma viremia has not been well defined.

51 cking evidence of immunosuppression have not been well defined.

52 s and functions of CD4 memory cells have not been well defined.

53 e risk of NC in these patients has still not been well defined.

54 creening tool in asymptomatic adults has not been well defined.

55 its impact on viral fitness in vivo has not been well defined.

56 role and functional activity have not always been well defined.

57 sterile inflammation and oncogenesis has not been well defined.

58 ls that are provided by hemodialysis has not been well defined.

59 ergen-induced airway responsiveness have not been well defined.

60 rvivin-2B in regulation of apoptosis has not been well defined.

61 ve the generation of Th17 responses have not been well defined.

62 ugh the proximal signaling pathways have not been well defined.

63 cids, whose function and regulation have not been well defined.

64 mammalian epithelial carcinogenesis have not been well defined.

65 role of age on surveillance outcomes has not been well defined.

66 sm of regulation of these chemokines has not been well defined.

67 ole in Th2-mediated immune responses has not been well defined.

68 ovascular risk in the post-MI period has not been well defined.

69 sms of epithelial mucous regulation have not been well defined.

70 g events that are downstream of Akt have not been well defined.

71 other than renal papillary carcinoma has not been well defined.

72 disease, its prognostic significance has not been well defined.

73 terial systems its mechanistic basis has not been well defined.

74 the mitochondrial signaling pathway have not been well defined.

75 B, although the underlying mechanism has not been well defined.

76 italized for worsening heart failure has not been well defined.

77 nder which RPV confers an advantage have not been well defined.

78 mechanisms regulating this process have not been well defined.

79 tion strategies confer an advantage have not been well defined.

80 t to myocardial cell specification, have not been well defined.

81 ed kinase (Pak), in oxidase function has not been well defined.

82 through a series of steps that have not yet been well defined.

83 s for Hes1 in early eye development have not been well defined.

84 the absence of lymphadenopathy on CT has not been well defined.

85 ological targets of Rad23 and Rpn10 have not been well defined.

86 acological effects on human melanoma has not been well defined.

87 the control of cytokine production have not been well defined.

88 c cell (DC) development and function has not been well defined.

89 immunoglobulin A nephropathy (IgAN) has not been well defined.

90 iagnosis of diabetes in this setting has not been well defined.

91 with before the initiation of HAART has not been well defined.

92 ing mechanisms leading to secretion have not been well defined.

93 target genes downstream of ERRalpha have not been well defined.

94 he ileal enterocyte plasma membrane have not been well defined.

95 e natural history of resected cases have not been well defined.

96 eir identity and axonal projections have not been well defined.

97 elopment of DC from precursor cells have not been well defined.

98 lar details of collagen recognition have not been well defined.

99 ill in its infancy and its niche has not yet been well defined.

100 mits for iodine intake in pregnancy have not been well defined.

101 hanisms that coordinate these steps have not been well defined.

102 BBB breakdown and ensuing pathology has not been well defined.

103 , the initial attachment receptor(s) has not been well defined.

104 t T cell activation in vitro and in vivo has been well defined.

105 subcellular localization had not previously been well defined.

106 (GFR) the year before and after OLT have not been well defined.

107 o-chaperones in autophagy regulation has not been well defined.

108 rtality, independent of FVC decline, has not been well defined.

109 n by broadly neutralizing antibodies has not been well defined.

110 ation with conventional risk factors has not been well defined.

111 and colonize the gastric epithelium have not been well defined.

112 ons and operative risk for mortality has not been well defined.

113 in antigen-specific T cells in vivo has not been well defined.

114 the immunopathology of periodontitis has not been well defined.

115 that regulates serotonergic neurons has not been well defined.

116 s capable of shaping Th17 responses have not been well defined.

117 also crucial during bone homeostasis has not been well defined.

118 fect of pseudomonas on BOS and death has not been well defined.

119 ading to cell exit from the bloodstream have been well defined.

120 mportant pathways of the system have not yet been well-defined.

121 in gastric carcinogenesis and injury has not been well-defined.

122 the role of neutralizing antibodies has not been well-defined.

123 t-infarction ventricular arrhythmias has not been well-defined.

124 esidue in carbon-metal bond cleavage has not been well-defined.

125 association between these disorders has not been well-defined.

126 ons (MICs) of amphotericin B and fluconazole were well defined.

127 were less organ parasites and the granulomas were well defined.

128 the functions of granzyme A (GzmA) and GzmB are well-defined, a number of orphan granzymes of unknow

129 Many stem cell niches are well defined anatomically, thereby allowing their ro

130 from specific functional group interactions are well defined and constant parameters.

131 ve life histories of human subjects and mice are well defined and describe a unique story of evolutio

132 of the acceptor stem and the UUCG tetraloop are well defined and effectively superimposable for the

133 se risk factors for disseminated candidiasis are well defined and frequently of limited duration, vac

134 Medical indications for mastectomy are well defined and present in a minority of patients,

135 tory distress syndrome and acute lung injury are well defined and readily recognised clinical disorde

136 using a yeast model, where prion attributes are well defined and readily tested.

137 ircuit analysis because its input and output are well-defined and accessible to physiological measure

138 The quantities, which are well-defined and characterized for spin models, are

139 atterns and electrostatic potential profiles are well-defined and distinctive features of activated v

140 anodiscs are native-like lipid bilayers that are well-defined and potentially monodisperse.

141 mplex than predicted by classical models but are well-defined and quantifiable.

142 y, the only nuclear import sequence that had been well defined and characterized was the classical NL

143 However, the effect of SLD has not been well defined and no tool has been developed to esti

144 unctional motifs of ATPase and nuclease have been well defined and the ATPase atomic structure has be

145 usceptibility to young-onset type 1 diabetes is well defined and does not predispose to type 2 diabet

146 hese aspects, because cerebellar development is well defined and identified neurons in the circuitry

147 The main-chain of the peptide is well defined and makes a series of polar contacts wit

148 gainst nonfatal cutaneous leishmaniasis (CL) is well defined and mediated by rapidly recruited, IFN-g

149 re of the CYP3A4-MDZ complex, where the drug is well defined and oriented suitably for hydroxylation

150 and the time required for such communication is well defined and preserved.

151 d each interfacial potential within the cell is well defined and reproducible, so that the response o

152 ese link groups, indicating that the binding is well-defined and electronically selective.

153 ion of Lip/Gd/DiI-DS covering the tumor mass was well defined and monitored with MRI.

154 nsertion loops, and presensor 1 (PS1) loops, are well defined, and many of them interact extensively

155 egulating steroid receptor function have not been well defined, and so we examined in vivo the influe

156 growth factor (IGF) system in breast cancer is well defined, and inhibitors of this pathway are curr

157 ocial neuroscience because its genetic basis is well-defined, and the unique phenotype reflects dimen

158 The resulting glycopolymers were well-defined, and a range of molecular weights from

159 Whereas the entrance of the D-channel is well-defined as D132(I) (subunit I; Rhodobacter sphae

160 mediates of the Salmonella bacteriophage P22 are well defined but the molecular interactions between

161 w the inflammatory response is initiated has been well defined but relatively little is known about h

162 ckle red blood cell (RBC) life span have not been well-defined but may include both intrinsic factors

163 Regulation of Yops and LcrV is well defined but little is known about bacteriostasis

164 ally ideal phyllotactic patterns, the center is well defined but there has not been a precise definit

165 ses where catalytic protein film voltammetry is well-defined but nonturnover signals elusive.

166 Almost all are well defined, but how to determine before the fact w

167 Brain pathways that control song production are well defined, but little is known about the sites an

168 Clathrin-coated pits are well defined, but the identity, mechanism and functi

169 siological functions of cytoplasmic Akt have been well defined, but little is known about the nuclear

170 ying COPII-mediated protein trafficking have been well defined, but the extent of regulation of this

171 ets and gata factors in hemangioblasts have been well defined, but the significance of FoxH1 in vess

172 ion of autophagy by nutrient-sensing kinases is well defined, but longer-term transcriptional regulat

173 nflammatory markers in type 2 diabetes (T2D) is well defined, but the role of anti-inflammatory cytok

174 Anophelin residues 32-61 are well-defined by electron density, completely occupyi

175 Prinomastat binding is well defined by electron density maps with its pyridy

176 Helix III is well-defined by numerous NMR-derived distance restrai

177 Although there are well-defined clinical risk factors for AF, a signifi

178 The susceptibility of infants to infections is well defined clinically, and immunologic abnormalitie

179 cluster and cofactor cluster of nitrogenase are well-defined crystallographically.

180 , tertiary, and quaternary protein structure are well defined, details about the protein-matrix conta

181 Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction o

182 DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the

183 tures for alpha-RgIA and its three analogues were well defined, except at the chain termini.

184 at control the reactivity of these reactions are well-defined experimentally, but the mechanistic det

185 Protein complexes are well defined, experimentally derived, functional mod

186 Although its core elements are well defined, factors modulating Hippo transcription

187 Although integration profiles are well defined for members of the lentivirus, spumaret

188 Such environmental factors are well defined for smoking-induced lung cancer; howeve

189 ct physiologic and pathologic roles have not been well defined for this pathway.

190 tance of matching at the HLA C locus has not been well defined for unrelated umbilical-cord blood tra

191 The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is

192 ranscriptional gene silencing mechanism that is well defined genetically in Caenorhabditis elegans.

193 On ultrasound, there were well-defined, heterogeneous, predominantly hypoecho

194 em--this contains relatively few glia, which are well-defined histologically and amenable to powerful

195 pathogen-associated molecular patterns have been well defined, how allogeneic cellular stimuli evoke

196 Although endolysosomal trafficking is well defined, how it is regulated and coordinates wit

197 FGFR4) in regulating bile acid synthesis has been well defined; however, its reported role on glucose

198 C) self-renewal and oncogenic potential have been well defined; however, the comprehensive epigenetic

199 mechanism of action for UVB carcinogenicity is well defined; however, the mechanistic involvement of

200 in is incomplete; regions of the pocket that are well defined in high-affinity PX domains are highly

201 uce output beams of high modal purity, which are well defined in three dimensions.

202 These transitions are well-defined in terms of ion conductance, but their

203 Although these functions are well-defined in the context of tumorigenesis, recent

204 Overall, our results show that the RRP can be well defined in the mathematical sense, and support t

205 rve, and vagal afferent nerve terminals have been well defined in animals.

206 dy-state fluorescence properties of 2AP have been well defined in diverse settings, interpretation of

207 Disparities in stroke and heart disease have been well defined in many populations in the United Stat

208 t infection in surgical patients, it has not been well defined in medical patients.

209 y relevant immune responses to them have not been well defined in organ transplantation.

210 and type 2 diabetes mellitus (T2DM) has not been well defined in persons with the metabolic syndrome

211 portance of such additional interactions has been well defined in recent times to stabilize the foldi

212 hat establish and regulate pluripotency have been well defined in the mouse, it has been difficult to

213 ic rheumatic disease as osteoporosis has not been well-defined in children.

214 To date, an obesity/asthma link is well defined in adults; however, the nature of such a

215 Although tropomyosin is well defined in electron microscopy helical reconstru

216 ue, NAD(P)H:quinone oxidoreductase 1 (NQO1), is well defined in oxidative stress, neoplasia, and carc

217 for hydrolytic ALDHs, the nicotinamide ring is well defined in the electron density due to direct an

218 of GNLY-induced apoptosis of Jurkat T cells is well defined in vitro, no direct evidence for its in

219 The intricate production of ribosomal RNA is well defined in yeast, but its complexity in higher o

220 While the phosphate is well-defined in the electron density, the ethanolamin

221 Posterior tumor surface was well defined in 54% of SDOCT vs 100% in UBM images.

222 transmembrane helical segment of the protein was well defined in comparison with experiment and the a

223 s disordered: only the N-linked GlcNAc sugar was well-defined in the electron density map.

224 Soft-tissue masses were well defined in 91%-100% of cases and surrounded a

225 Colony boundaries in all populations were well defined, in spite of reports of a widespread b

226 Water-in-oil microdroplets in microfluidics are well-defined individual picoliter reaction compartme

227 pulation structure and evolutionary genetics are well defined, it is not clear whether pneumococci th

228 f the signaling pathways for radioresistance are well defined, it is now clear that Ras-dependent sig

229 he composition and function of VLVs have not been well defined, largely due to the inability to effic

230 echanisms that execute the apoptotic program are well defined, less is known about how cells decide w

231 chanisms of the receptor tyrosine kinase MET are well defined, less is known about its close relative

232 syndrome and the pathologic characteristics are well defined, little is known about its biology and

233 echanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecul

234 sequence and structure for CsrA binding have been well defined, little information exists concerning

235 the mechanism of RAG2 protein downregulation is well defined, little is known about the pathways and

236 tracellular functions of interleukin 33 have been well defined, many aspects of the regulation and se

237 he onset and offset of ictal-like discharges are well-defined mathematical events: a saddle-node and

238 However, in some professions, there are well-defined metrics that quantify career longevity,

239 rified Act d 12 and Act d 13 from kiwi seeds are well-defined molecules involved in in vitro IgE cros

240 revealed the nucleobase peptide assembles to be well-defined nanotubes with an outer diameter of 24.8

241 Although the responsible mechanisms have not been well defined, neurotoxic viral proteins, such as Ta

242 f anaplastic large-cell lymphoma (ALCL) have been well defined; nevertheless, the notion that ALK is

243 To this point, the field has not been well defined, nor have future options to promote su

244 exes (hereafter referred to as metallogrids) are well-defined oligonuclear metal ion complexes involv

245 a silicon p-n junction, where the interface is well defined on the nanoscale.

246 te that the majority of the C-terminal chain is well-defined on the SH3 surface.

247 The biochemistry of blood coagulation has been well defined over the past 50 years.

248 e of DNA triplex structures in the gas phase is well-defined over the experimental time scale, with t

249 ment and supplementation guidelines have not been well defined, practitioners should aim for a serum

250 The resulting beta-lactones are well-defined precursors for a wide variety of aldol-

251 role of CD36 in other vascular cells has not been well defined, previous studies have demonstrated th

252 stablish which short- and long-term outcomes are well-defined, reliable, and reflective of how patien

253 ation exposure and certain genetic syndromes are well-defined risk factors for malignant glioma.

254 ar layer (ONL) and Henle's fiber layer (HFL) were well defined, showing that the ONL ends before the

255 e of the GAAA tetraloop-receptor interaction is well defined solely from experimental NMR data, shows

256 ing phosphatidylserine and phosphoinositides are well defined, specific recognition of the headgroup

257 error terms proportional to q(i) and q(i)/v are well defined statistically, where q(i) is the heat f

258 These particles appear to be well-defined structures that package the RNA for tran

259 "Molecular flasks" are well-defined supramolecular cages that can encapsula

260 More advantageous for characterization are well-defined synthetic (hyper)-branched polymers.

261 ological features of transplant vasculopathy are well defined, the causative mechanisms are not compl

262 signalling pathways regulating CDK1 activity are well defined, the functional significance of epigene

263 al determinants important for entry into ECs are well defined, the molecular determinants regulating

264 e effector proteins secreted by this system, are well defined, the relative roles of each protein in

265 of binding site and channel gating machinery are well defined, the structural basis of the activation

266 controlling conventional T cell development are well defined, the transcription factors and genetic

267 echanism for recognition of H3K27me3 by PRC1 is well defined, the interaction of PRC2 with H2AK119u1

268 capacity of Plg/Pla to induce cell migration is well defined, the mechanism underlying this process i

269 Although gut microbiome composition is well defined, the mechanisms underlying community ass

270 ircadian rhythms regulating daily activities is well defined, the molecular basis for the photoperiod

271 ough the clinical progression of the disease is well defined, the molecular events responsible for gl

272 the physiological mechanism of this pathway is well defined, the molecular mechanism and the sites o

273 he end stage of this process, termed anergy, is well defined, the pathway by which naive T cells beco

274 p21-mediated G1 arrest induced by DNA damage is well defined, the role of p53 in the cell cycle in re

275 While the role of HA in malignancy is well-defined, the mechanisms driving its biosynthesis

276 a marker for Th2 cell and mast cell activity were well defined, the complexities of IL-33 regulation,

277 If performance criteria are well defined, theory allows one to predict the reopt

278 Despite the fact that apoptotic mechanisms are well defined, there is still no substantial therapeu

279 lthough the characteristics of these viruses are well defined, they are still unpredictable with incr

280 ifferentiation of the other major Th subsets are well defined, those responsible for Tfh cell respons

281 e and cellular pathways triggering arthritis are well defined, those responsible for the resolution o

282 to host plants, but their functions have not been well defined to date.

283 t from the first few residues, the structure is well defined up to around residue 35 and does adopt a

284 e of the TNF-alpha receptors (TNFRs) has not been well defined using in vivo models.

285 ting TCR diversity for antigenic recognition are well defined, what controls its surface expression i

286 Colony morphology and color have been well defined when CHROMagar Candida has been used t

287 atients and control subjects) are assumed to be well defined, when biologically they are often highly

288 l evolution are maximized when the selection is well defined, which enables linking genotype, phenoty

289 tag, the H2-H3 region of the AIM2(PYD) F27G is well defined with low B-factors.

290 The majority of the nodules were well defined with smooth margins (n = 7).

291 ee-dimensional structure was demonstrated to be well-defined, with an alpha-helix and two 3(10)-helic

292 f model compounds has shown the fractions to be well-defined, with classes of model compounds isolate

293 he final bundle of energy-refined structures is well-defined, with an average rmsd value to the mean

294 the charge before and after reaction should be well-defined within the operational pH range; (3) the

295 ecting kringle-2 to the A chain, but Arg-320 is well defined within the activation domain and is not

296 While the role of Nodal is well defined within the context of endoderm commitmen

297 Apoptotic caspase activation mechanisms are well defined, yet inactivation modes remain unclear.

298 ence to control cardiovascular disease (CVD) are well defined, yet multiple studies have identified p

299 A)-4 as a negative regulator of CD4+ T cells is well defined, yet CTLA-4 regulation of CD8+ T cells i

300 the role of the axial ligand in type 1 sites is well defined, yet its role in the binuclear mixed-val