1 y after the Fontan operation appears to have
been well tolerated in 13 to 14 gravidas.
2 CA4P
was well tolerated in 14 of 16 patients at 52 or 68 mg/m
3 AZA and 6-MP
were well tolerated in 82% of patients; of these, predni
4 t in vivo antimyeloma activity at doses that
are well tolerated in a murine model, confirming our in
5 d in vivo antimyeloma activity at doses that
are well tolerated in a murine model.
6 Rhythm disturbances that may
be well tolerated in a normal heart often cause hemodyna
7 our results suggest that VX-765, a drug that
was well tolerated in a 6 wk-long phase II trial in pati
8 azine, a novel molecule that reduces chorea,
was well tolerated in a double-blind, placebo-controlled
9 humanised form of this antibody (ozanezumab)
was well tolerated in a first-in-human trial.
10 Accelerated conformal radiotherapy
was well tolerated in a high-risk population with clinic
11 d cognitive dysfunction in schizophrenia and
was well tolerated in a phase II clinical proof of conce
12 9-Methylation of 12, but not 19,
was well-tolerated in A(3) AR binding.
13 combination of IL-36beta with TT/Alum, which
was well tolerated in AD mice, proved toxic and even let
14 Treatment with BOS
was well tolerated in adolescent and young adult patient
15 dipasvir-sofosbuvir currently used in adults
was well tolerated in adolescents and had an appropriate
16 to standard therapy causes rapid benefit and
is well tolerated in adults with acute asthma.
17 adual PBA release by pancreatic lipases, and
is well tolerated in adults with cirrhosis, suggesting t
18 the selection of an alternative NMBA, which
was well tolerated in all 6 cases.
19 Carbon marking
was well tolerated in all cases.
20 BMS-790052
was well tolerated in all dose groups, with adverse even
21 (188)Re-P2045
was well tolerated in all dose groups, with no adverse c
22 THAL-PRED
was well tolerated in all enrolled patients, with 20 pat
23 Although TIV
was well tolerated in all groups, reactogenicity in chil
24 oxaliplatin to the maximum dose of 130 mg/m2
was well tolerated in all patient groups with a CrCL > o
25 Despite an increased RAL exposure, RAL
was well tolerated in all patients and no patient had to
26 sion of gene-modified autologous CD4 T cells
was well tolerated in all patients.
27 Testosterone
was well tolerated in all patients.
28 UDCA
was well tolerated in all patients.
29 uthpieces relative to placebo, and treatment
was well tolerated in all study groups.
30 (11)C-CURB
was well tolerated in all subjects, with no radiotracer-
31 The injection of (18)F-D4-FCH
was well tolerated in all subjects, with no radiotracer-
32 Injection of (18)F-ICMT-11
was well tolerated in all subjects, with no serious trac
33 drug-related adverse events, and the tracer
was well tolerated in all subjects.
34 Ventricular arrhythmias
were well tolerated in all patients except in cases of e
35 alpha-Gal A infusions
were well tolerated in all patients.
36 ate cancer cell detachment in vitro, that it
is well tolerated in an older cohort of men with prostat
37 FTase inhibitors have
been well tolerated in animal studies and do not produce
38 L-786,392
was well tolerated in animal safety studies and had sign
39 enetic or pharmacological means was found to
be well tolerated in animals in our studies and to resul
40 RhBGN
is well tolerated in animals dosed for as long as 3 mont
41 PTC124
was well tolerated in animals at plasma exposures substa
42 Reconstituted human HDL
was well tolerated in animals that had undergone hemorrh
43 Intravenous terbutaline
was well tolerated in asthmatic children for < or =305 c
44 PA101
was well tolerated in both cohorts.
45 Treatment
was well tolerated in both groups.
46 rFVIIIFc
was well tolerated in both species.
47 Stretches of 4'-thio-RNA
were well tolerated in both the antisense and sense stra
48 uryl]-m ethyl)-sulfanyl]ethyl]urea) (CAP-1),
is well tolerated in cell cultures, enabling in vivo ant
49 , and (c) additional negative sulfate groups
are well tolerated in certain cases, such as on C-6 of t
50 All
are well tolerated in children and can increase peak cou
51 Vbl and Mtx
are well tolerated in children with desmoid-type fibroma
52 Furthermore, the vaccine appears to
be well tolerated in children with a diagnosis of asthma
53 Cefixime administered with oral irinotecan
is well tolerated in children and allows greater dose es
54 We found that our paradigm
is well tolerated in children as young as 6 years, that
55 Prophylactic HDM oral immunotherapy
is well tolerated in children at high heredity risk.
56 Oral tipifarnib
is well tolerated in children receiving the drug twice d
57 Lapatinib
is well tolerated in children with recurrent CNS maligna
58 Continuous, orally administered everolimus
is well tolerated in children with recurrent or refracto
59 Depsipeptide
is well tolerated in children with recurrent or refracto
60 Bortezomib
is well tolerated in children with recurrent or refracto
61 Weekly intravenous temsirolimus
is well tolerated in children with recurrent solid tumor
62 Cixutumumab
is well tolerated in children with refractory solid tumo
63 usion Vinblastine administered once per week
is well tolerated in children with treatment naive PLGG.
64 Pazopanib
is well tolerated in children, with evidence of antiangi
65 notecan given with 12 days of oral gefitinib
is well tolerated in children.
66 Oral gefitinib
is well tolerated in children.
67 This protracted schedule
is well tolerated in children.
68 ATO
is well-tolerated in children at the recommended dose of
69 MK-0752
is well-tolerated in children with recurrent CNS maligna
70 Pemetrexed
is well-tolerated in children with refractory solid tumo
71 Moxifloxacin
was well tolerated in children treated for MDR tuberculo
72 Given that ampakines
are well tolerated in clinical trials and were effective
73 Conclusion Abexinostat
is well tolerated in combination with pazopanib, allowin
74 RAD001 at 5 or 10 mg/d
was well tolerated in combination with octreotide LAR, w
75 Erlotinib
was well tolerated in combination with WBRT, with a favo
76 Full doses of each agent
were well tolerated in combination, although in this pre
77 BRAF mutation at the doses of two drugs that
were well tolerated in combination.
78 Subcutaneous administration of r-metHuSCF
was well tolerated in conjunction with a multi-agent pre
79 s concluded that regarding safety, rofecoxib
is "well tolerated." In contrast, in April 2001, the com
80 d SVR12 in a high proportion of patients and
was well tolerated in Egyptian patients with HCV genotyp
81 atinum doublets had activity and appeared to
be well-tolerated in first-line ES-SCLC.
82 day with peginterferon alfa-2a and ribavirin
was well tolerated in HCV genotype 1-infected previous n
83 Inhalation of hyperpolarized (129)Xe
is well tolerated in healthy subjects and in those with
84 of CFs in amounts up to 2000 mg/d for 12 wk
was well tolerated in healthy men and women.
85 Glembatumumab vedotin
is well tolerated in heavily pretreated patients with br
86 ry heavy chain of immunoglobulin M (micros),
is well-tolerated in HeLa cells.
87 virulence in vivo The fusion also proved to
be well tolerated in herpes simplex virus.
88 HIVIG
is well-tolerated in HIV-infected pregnant women and the
89 p-defective strain, was recently reported to
be well tolerated in human volunteers, suggesting a role
90 Our results suggest that LPD/pAAVaspa
is well tolerated in human subjects and is associated wi
91 First-generation nanotherapies
are well tolerated in humans and evidence shows that the
92 ical trials have indicated that GPx mimetics
are well tolerated in humans, this study may have import
93 It is expected to
be well tolerated in humans and is available for clinica
94 losures from clinical trials confirm that it
is well tolerated in humans and elevates cGMP in cerebra
95 YF17D
is well tolerated in humans and vaccination induces robu
96 Since PK11195
is well tolerated in humans as a single agent, its furth
97 nation with a proteosome-based adjuvant that
is well tolerated in humans plus glatiramer acetate, an
98 FK506 crosses the blood brain barrier,
is well tolerated in humans, and is active in neurons an
99 ials have indicated that the M40403 molecule
is well tolerated in humans, this study may have importa
100 Clopidogrel
is well tolerated in infants and young children at this
101 Although rA2cp248/404/1030 Delta SH
was well tolerated in infants, only 44% of infants who r
102 PFT inhibitors (PFTIs)
are well tolerated in man, but are highly cytotoxic to P
103 inistration of phenylbutyrate, at doses that
are well tolerated in man, exerts significant neuroprote
104 results demonstrate that SSPN overexpression
is well tolerated in mdx mice and improves sarcolemma de
105 explain why prolonged hypercapnia appears to
be well tolerated in mechanically ventilated patients.
106 Moreover, CDDO-Im and TRAIL
are well tolerated in mice and the combination of CDDO-I
107 it proliferation of mammalian cell lines and
are well tolerated in mice.
108 tumor endothelial cells and tumor cells, and
is well tolerated in mice.
109 le genetic knockout (KO) of LRRK2 expression
is well-tolerated in mice and rats, a unique age-depende
110 proteasome or growth of mammalian cells, and
is well-tolerated in mice.
111 In vivo, DMF10.167.4 antibody
was well tolerated in mice and did not detectably bind t
112 Cambinol
was well tolerated in mice and inhibited growth of Burki
113 EGF-SubA
was well tolerated in mice and led to a significant tumo
114 frontrunner compound (5h) from these studies
was well tolerated in mice.
115 s in lymphoma xenografted mice at doses that
were well tolerated in mice, rats, and monkeys.
116 Thus, PG
is well tolerated in most tissues, but the eventual accu
117 Although the drug
was well tolerated in most patients, a previously unreco
118 Treatment
was well tolerated in most patients, though 10 withdrew
119 soluble, has favorable pharmacokinetics, and
is well tolerated in murine systems.
120 LMB-2
was well tolerated in nine patients at the maximum-toler
121 f allogeneic, bone marrow-derived human MSCs
was well tolerated in nine patients with moderate to sev
122 p38 MAPK inhibition with oral losmapimod
was well tolerated in NSTEMI patients and might improve
123 Initial clinical studies showed it to
be well-tolerated in older patients with relapsed/refrac
124 Herpes zoster vaccine
is well tolerated in older, immunocompetent adults.
125 ed in patients younger than 70, and 200 mg/d
was well tolerated in older patients.
126 TPE appears to be a promising treatment that
was well tolerated in our elderly patients.
127 DNA methyltransferase inhibitors
are well tolerated in outpatient settings, with azacitid
128 Such aneuploidy
is well tolerated in papillae, as it does not significan
129 Riociguat
was well tolerated in PATENT-2.
130 The toxicities of this regimen
are well tolerated in patients with a good PS.
131 plications, but also minimize bleeding risk,
are well tolerated in patients with organ dysfunction, a
132 In particular, these contrast media
are well tolerated in patients with renal insufficiency
133 splatin (ITP) was previously demonstrated to
be well tolerated in patients with advanced transitional
134 dministration of Ad(GV)VEGF121.10 appears to
be well tolerated in patients with clinically significan
135 gh in this study oral alendronate appears to
be well tolerated in patients with PBC, larger studies a
136 olymerized bovine hemoglobin and has already
been well tolerated in patients undergoing cardiopulmona
137 several reverse transcriptase inhibitors has
been well tolerated in patients with AIDS-related malign
138 The formulation
is well tolerated in patients over the age of 1 year for
139 Short-term treatment with rhIL-11
is well tolerated in patients with active Crohn's diseas
140 sured by objective response rate and PFS and
is well tolerated in patients with advanced pancreatic N
141 We conclude that GSNO
is well tolerated in patients with CF and improves oxyge
142 UDCA
is well tolerated in patients with CHF.
143 ive beta- and alpha-blockade with carvedilol
is well tolerated in patients with COPD who do not have
144 We conclude that ATRA
is well tolerated in patients with emphysema, and trials
145 without an abbreviated course of prednisone
is well tolerated in patients with myelofibrosis and act
146 reduces eosinophilic airway inflammation and
is well tolerated in patients with persistent moderate-t
147 TEC has significant antitumor activity and
is well tolerated in patients with progressive androgen-
148 CONCLUSION:Vorinostat monotherapy
is well tolerated in patients with recurrent GBM and has
149 CytoFab
is well tolerated in patients with severe sepsis, effect
150 r HbA1c reduction than does glimepiride, and
is well tolerated in patients with type 2 diabetes recei
151 or report we demonstrated that this approach
is well tolerated in patients with underlying immunodefi
152 ant and concomitant EV with high-dose 3D-CRT
is well tolerated in patients with unfavorable-risk pros
153 INTERPRETATION: Eltrombopag
is well-tolerated in patients with lower-risk myelodyspl
154 y of life and C-reactive protein levels, and
was well tolerated in patients with active Crohn's disea
155 Sorafenib plus dacarbazine
was well tolerated in patients with advanced melanoma an
156 Single-agent R115777
was well tolerated in patients with advanced NSCLC, but
157 Alectinib showed clinical activity and
was well tolerated in patients with ALK-positive NSCLC w
158 Idelalisib treatment
was well tolerated in patients with allergic rhinitis an
159 Although postprocedural AR>/=grade 2
was well tolerated in patients with AR>/=grade 2 at base
160 d overall survival compared with placebo and
was well tolerated in patients with castration-resistant
161 , or ineligible and intolerant patients, and
was well tolerated in patients with HCV genotype 1b infe
162 tions compared with placebo or ezetimibe and
was well tolerated in patients with hypercholesterolemia
163 Intravenous glyburide
was well tolerated in patients with large hemispheric st
164 PTX
was well tolerated in patients with NASH.
165 Dacetuzumab monotherapy
was well tolerated in patients with NHL in doses up to 8
166 The integrated treatment
was well tolerated in patients with predominantly prior
167 ons, inhibited radiographic progression, and
was well tolerated in patients with PsA.
168 Long-term treatment with tadalafil
was well tolerated in patients with pulmonary arterial h
169 nd point of the study was not met, riociguat
was well tolerated in patients with pulmonary hypertensi
170 Thalidomide at a dose of 400 mg/d
was well tolerated in patients younger than 70, and 200
171 G-CSF therapy
was well-tolerated in patients with active RA, and was n
172 Repeated subconjunctival sirolimus
was well-tolerated in patients with GA, although no posi
173 used in combination with standard treatments
was well-tolerated in patients with WG.
174 Both doses of atorvastatin
were well tolerated in patients with CKD.
175 Conclusion Perindopril and bisoprolol
were well tolerated in patients with HER2-positive early
176 Sixteen-week sildenafil monotherapy
is well tolerated in pediatric pulmonary arterial hypert
177 uzumab, a potent lymphocyte-depleting agent,
is well tolerated in pediatric renal transplantation.
178 Conclusion ATO consolidation cycles
were well tolerated in pediatric patients with APL and a
179 6n-2 was found to
be well-tolerated in phase 1 clinical studies and repres
180 stimulates angiogenesis in animal models and
was well tolerated in Phase I clinical trials.
181 as effectively converted recent-onset AF and
was well tolerated in placebo-controlled studies.
182 late-dependent reaction, i.e. that 5-CHO-THF
is well tolerated in plants.
183 This chemoradiotherapy regimen
is well tolerated in poor-risk patients and yields a med
184 search suggests that a higher PCO2 level may
be well tolerated in premature infants.
185 Whether anti-VEGF treatment
is well tolerated in preterm infants, however, has to be
186 Importantly, drug conjugates of 3A5
were well tolerated in primates at levels in excess of t
187 r of two large recombinant Hip1 polypeptides
was well tolerated in Ptch1+/- mice, induced B and T cel
188 that a 50muL suprachoroidal injection of TA
was well tolerated in rabbit eyes and demonstrated excel
189 Toxicity studies showed that cKK-E12
was well tolerated in rats at a dose of 1 mg/kg (over 10
190 VKA
were well tolerated in real-life, and the influences of
191 Temsirolimus
is well tolerated in recurrent GBM patients.
192 The combination of erlotinib and bevacizumab
is well tolerated in recurrent or metastatic squamous-ce
193 ZD1839 has single-agent activity and
is well tolerated in refractory SCCHN.
194 ibition/angiotensin-receptor blocker therapy
is well tolerated in renal allograft recipients with chr
195 ed as an oil-in-water emulsion, was found to
be well-tolerated in rodents (mice, hamsters, rats) foll
196 ith a >100 mg/kg concentration of this agent
is well tolerated in rodents, without any hematotoxicity
197 Compound 13a
was well tolerated in rodents (in mice, LD50 = 2326 mg/k
198 Spiroindane 42
was well tolerated in rodents in vivo, demonstrated effi
199 Toxicologic analysis showed that rBD1
was well tolerated in rodents with LD50 values of 40 mg/
200 tric embolization is feasible and appears to
be well tolerated in severely obese patients.
201 l ischemia at plasma concentrations known to
be well tolerated in stroke patients.
202 nsive suppression of ventricular growth that
was well tolerated in terms of both clinical outcome and
203 f hypercapnia and associated severe acidosis
are well tolerated in the absence of contraindications (
204 ring and following treatment, these regimens
are well tolerated in the AYA population.
205 Thus, 2'-F-modified nucleotides
are well tolerated in the guide (antisense) and passenge
206 g aroyl units including heterocyclic systems
are well tolerated in the present domino reaction protoc
207 Although the replacements
are well tolerated in the wild type, the mutations sever
208 cebo-controlled study, inhaled NO appears to
be well tolerated in the population of ARDS patients stu
209 The WIT appears to
be well tolerated in the rabbit eye, with no evidence of
210 acid (RNA) which showed the modification to
be well tolerated in the sequence contexts examined.
211 e that the lifetime absence of ADAR1-editing
is well tolerated in the absence of MDA5.
212 Endoscopist-directed propofol sedation
is well tolerated in the appropriately selected patient.
213 The Bard Clamshell Septal Occluder
is well tolerated in the canine heart for at least 2 yea
214 hich is a major risk for acute liver injury,
is well tolerated in the context of chronic DDC-mediated
215 er found that loss of either component alone
is well tolerated in the developing brain, in contrast t
216 mouse transthyretin (TTR) indicated that GNA
is well tolerated in the seed region of both strands in
217 Bevacizumab with modified FOLFOX6
is well tolerated in the surgical adjuvant setting in th
218 We maintain that aneuploidy
is well tolerated in the wild strains of S. cerevisiae t
219 osteric substitution of sulfur for 4'-oxygen
was well tolerated in the catalytic site of HIV-1 revers
220 The WIT
was well tolerated in the eye and no overt signs of toxi
221 Ranpirnase
was well tolerated in the majority of patients, and ther
222 External-beam radiation therapy
was well tolerated in the posttransplantation setting in
223 All of the monomers
were well tolerated in the DNA duplexes and induced only
224 Microneedle patches
were well tolerated in the skin, with mild erythema, min
225 ous compared with placebo and etanercept and
were well tolerated in the treatment of patients with mo
226 y, markedly lowers LDL-C levels and seems to
be well tolerated in these patients.
227 ce-weekly alendronate improves bone mass and
is well tolerated in these patients, but there is a conc
228 was significantly increased; AVP antagonism
was well tolerated in these patients.
229 eutic doses of bioengineered miR-34a prodrug
were well tolerated in these animals.
230 It appears to
be well tolerated in this group of patients and can be s
231 Subconjunctival sirolimus appears to
be well tolerated in this pilot trial and shows promise
232 exercise tolerance or lung function, despite
being well-tolerated in this COPD population.
233 ncy suggests definitive endoscopic treatment
is well tolerated in this patient population.
234 combination of high-dose IFNalpha2b and GMK
is well tolerated in this patient population.
235 Meropenem
was well tolerated in this cohort of critically ill infa
236 retinal injection with pars plana vitrectomy
was well tolerated in this cohort.
237 Bevacizumab
was well tolerated in this heavily pretreated patient po
238 Therapy
was well tolerated in this patient population but myelos
239 Rituximab
was well tolerated in this patient population, with most
240 Overall FCM
was well tolerated in this pediatric population and appe
241 Rituximab
was well tolerated in this predominantly older adult pat
242 Natalizumab
was well tolerated in this study.
243 Lumacaftor/ivacaftor
was well tolerated in this young population; no new safe
244 However, both doses of ITI-007
were well tolerated in this patient population, as evide
245 Subsequently, 8 mg/m(2)/d
was well tolerated in three patients.
246 The results indicate that the modifications
are well tolerated in various positions of the passenger
247 LDK
is well tolerated in vertebrates and induces long-term r
248 in this case, which suggests that cilium can
be well tolerated in vitreous cavity for as long as 40 y
249 piperazine, piperidine, but not sulfonamide)
were well tolerated in vitro, and the hydrophilic linker
250 ve been widely used to study TG2 biology and
are well tolerated in vivo, but these compounds have onl
251 ngiogenic therapy, and that beta1 inhibition
is well tolerated in vivo as a tractable strategy to dis
252 Deficiency of the Pim kinase genes
is well tolerated in vivo, suggesting that PIM1 inhibiti
253 al nontumor-bearing mice indicated that T115
is well-tolerated in vivo (maximum total tolerated dose,
254 rate that pharmacological inhibition of CREB
is well-tolerated in vivo and indicate that such inhibit
255 fective than single-frequency ultrasound and
is well-tolerated in vivo.
256 diet to C57BL/6 mice, 2500 mg/kg/day OGT2378
was well tolerated in vivo and biologically active, depl
257 Under conditions where it
was well tolerated in vivo, this FOXO4 peptide neutraliz
258 ntravitreal delivery of LiGluR and MAG0(460)
was well tolerated in vivo.
259 Roscovitine and PIK-90, in combination,
were well tolerated in vivo and acted in a synthetic-let
260 CVD 908-htrA and CVD 906-htrA
were well tolerated in volunteers; mild diarrhea in 3 of
261 Live attenuated influenza vaccine
was well tolerated in young children in Senegal, but did
262 Quininib
is well tolerated in zebrafish, human cell lines, and mu