ライフサイエンスコーパス: be well understood

1 , all aspects of their mode of action should be well understood.

2 decapping is thought, for the most part, to be well understood.

3 documented; however, the sources have yet to be well understood.

4 r sequential membrane targeting and assembly is well understood.

5 he genesis of short APs lasting milliseconds is well understood.

6 orm clathrin-coated vesicles, a process that is well understood.

7 on from growth-related activities to defence is well understood.

8 tau aggregation, although neither mechanism is well understood.

9 hich Tel1 contributes to telomere metabolism is well understood.

10 H3.3 recruitment nor its essential function is well understood.

11 architecture of the closed promoter complex is well understood.

12 eptors in directed migration of immune cells is well understood.

13 essing by the core of its chemotaxis pathway is well understood.

14 ortical targeting nor the regulation thereof is well understood.

15 hydroxyecdysone (20E), but not of JH action, is well understood.

16 Neither mechanism is well understood.

17 of CD8 T cells in adaptive immune responses is well understood.

18 its association with coronary heart disease is well understood.

19 palatogenesis nor the causes of cleft palate is well understood.

20 nation and form joint-molecule intermediates is well understood.

21 tical period for experience in visual cortex is well understood.

22 uired to trigger adverse behavioral outcomes is well understood.

23 ition by G Protein-Coupled Receptors (GPCRs) is well understood.

24 ce grating couplers have been developed that are well understood.

25 e stability of quadruplexes nor their repair are well understood.

26 trxG-mediated gene silencing and activation are well understood.

27 les that contribute to homeostasis in health are well understood.

28 sferases that are essential for this process are well understood.

29 ng systems and their steady-state properties are well understood.

30 al age on offspring's health and development are well understood.

31 ctories are determined by flagellar dynamics are well understood.

32 the effects, nor mechanisms, of isoflavones are well understood.

33 o inflammation nor its enduring consequences are well understood.

34 ith Clostridium difficile-associated disease are well understood.

35 lip morphogenesis nor the cause of cleft lip are well understood.

36 s ethical implications for clinical practice are well understood.

37 ween patterning mechanisms and morphogenesis are well understood.

38 and mobility of a few model group I introns are well understood.

39 iciency nor its precise molecular mechanisms are well understood.

40 ules, and activate target gene transcription are well understood.

41 all the essential components of the process are well understood.

42 to lethal cell damage under ion irradiation are well understood.

43 hydrolases at the trans-Golgi network (TGN) are well understood.

44 nor the cis-regulatory elements they govern are well understood.

45 nction, and role in the life cycle of a cell are well understood.

46 e relevant ecological mechanisms and drivers are well understood.

47 of surveillance of DNA and protein integrity are well understood.

48 at interest for the scientific community and are well-understood.

49 omposition and its potential causes have not been well understood.

50 rmed acoustic droplet vaporization, have not been well understood.

51 al modifications such as acetylation has not been well understood.

52 betic patients, but the pathogenesis has not been well understood.

53 ive immune responses to vaccination have not been well understood.

54 hough the function of LTBP-2 in vivo has not been well understood.

55 rsity in tissue-specific stem cells have not been well understood.

56 determined, their mechanistic roles have not been well understood.

57 their chromatin targeting mechanisms has not been well understood.

58 metabolic cues to stem-cell function has not been well understood.

59 e, its persistence for over 20 years has not been well understood.

60 -time-scale gene expression changes have not been well understood.

61 effect of chronic CaMKII inhibition has not been well understood.

62 tion, but the molecular basis for it has not been well understood.

63 f these unusually large differences have not been well understood.

64 The mechanism of MTF1 activation has not been well understood.

65 However, the underlying mechanisms have not been well understood.

66 and plasticity of effector Th cells have not been well understood.

67 onsequences for cellular physiology have not been well understood.

68 their precise roles in angiogenesis have not been well understood.

69 between plasmodial and mammalian ADA has not been well understood.

70 e origin of these seismic structures has not been well understood.

71 iological stimuli in primary T cells has not been well understood.

72 ls directed at tissue-restricted Ags has not been well understood.

73 ism(s) of regulation of CDM proteins has not been well understood.

74 hoGEF activity of these proteins has not yet been well understood.

75 bolites and metabolic pathways play have not been well understood.

76 rious tissues, such as liver and muscle, has been well understood.

77 nd the consequence of such violation has not been well understood.

78 vades an attack by the immune system has not been well understood.

79 water and other resources scarcity have not been well understood.

80 and their hybrid progeny Tenera has not yet been well understood.

81 mining and processing facilities but has not been well understood.

82 es, and their activation mechanisms have not been well-understood.

83 ich, contrary to all-or-none efflux, has not been well-understood.

84 s nor functions of codon-mediated regulation were well understood.

85 holine receptors (nAChRs) are still far from being well understood.

86 le the underlying mechanism remains far from being well understood.

87 pite remarkable recent progress, is far from being well understood.

88 tial feature of living cells, it is far from being well-understood.

89 onents and biochemistry of the W/SRC pathway are well understood, a basic understanding of how cells

90 individual receptors regulate transcription are well understood, a quantitative perspective is less

91 Although many details of mTORC1 regulation are well understood, a systems-level, predictive framewo

92 ough catalytic mechanisms in natural enzymes are well understood, achieving the diverse palette of re

93 lular behaviors that underlie skeletogenesis are well understood and a complex transcriptional gene r

94 governing blood flow in the vascular system are well understood and can be solved with well-establis

95 Plant growth responses to RSLR are well understood and represented in century-scale for

96 The mechanisms of these ligases are well understood and the structures of all four of th

97 ugs used to treat Mycobacterium tuberculosis are well understood and therefore should be amenable to

98 al causes of many occupational lung diseases are well understood and they should be amenable to contr

99 ent changes of the thermoelectric properties are well-understood and correlate with complex phase tra

100 ects dominate the spectral variance and must be well understood and modeled before analyzing the very

101 Whilst resonant transmission is well understood and can be fully harnessed for crysta

102 a model polypeptide as its folding behavior is well understood and compatible with the sol-gel chemi

103 Activation of Rad53 is well understood and involves phosphorylation by the p

104 The induction of the SOS response is well understood and involves the cleavage of the LexA

105 While positioning of chlorophyll cofactors is well understood and rationalized by the principle of

106 profits can only be achieved if the fishery is well understood and the regulations are strategically

107 chemical mechanism of protein trans-splicing is well-understood and has been exploited to develop sev

108 Although the oxygen affinity of blood is well-understood and routinely assessed in patients by

109 so other brain areas where mechanisms of LTD are well understood, and where it is thought to have a f

110 The onset of a nova is well understood as driven by runaway thermonuclear fu

111 ther the stabilization nor the recent growth are well understood, as evidenced by multiple competing

112 While electric field doping is well understood, assessment of mobility and density a

113 nd morbidity, the aging of the brain has not been well understood at a molecular level.

114 Huntington's disease (HD) pathology is well understood at a histological level but a compreh

115 vindoline from the MIA precursor tabersonine is well understood at the molecular and biochemical leve

116 Although the biogenesis of these organelles is well understood at the morphological level, the machi

117 us (HCV) to infect human liver cells has not been well understood because of the number of cell surfa

118 The latter process is well understood because it can be studied in vitro, b

119 teins often occurs in a two-state manner and is well understood both experimentally and theoretically

120 and socio-economic effects of eutrophication are well understood but its effect on organic carbon (OC

121 the activation of mast cells and basophils, is well understood but the mechanisms related to prevent

122 ning enzymes.Catalytic mechanisms of enzymes are well understood, but achieving diverse reaction chem

123 sponses of forest foliar traits to elevation are well understood, but far less is known about trait d

124 and environmental determinants of loneliness are well understood, but its genetic basis is not.

125 ion of centrosome-derived microtubule arrays are well understood, but less is known about how acentro

126 IFN gamma) production during Th1 development are well understood, but mechanisms that silence this cy

127 es of vlPAG activation in fearful situations are well understood, but much less is known about the pa

128 Equilibria defining how such molecules act are well understood, but structural models for such bind

129 The evolution of many forms of mimicry are well understood, but the evolution of mimicry in the

130 ntiate between vein and intervein cell fates are well understood, but the genetic pathways underlying

131 chanisms leading to duplicate gene retention are well understood, but the long-term impacts of paralo

132 sive forces generated by muscles and tendons are well understood, but there has been little recogniti

133 odes of replication during infection has not been well understood, but we observe that the switch bet

134 The tertiary structure of the folded domains is well understood, but describing the dynamic inter-dom

135 'trans-splicing' process in lower eukaryotes is well understood, but events in higher eukaryotes are

136 Topo IIalpha function is well understood, but how its expression is regulated

137 2D Rac-driven lamellipodial migration is well understood, but how these features apply to 3D m

138 The role of Cav channels during axon growth is well understood, but it is unclear whether Kv channel

139 he biosynthesis and physiology of anandamide is well understood, but its mechanism of uptake (resulti

140 The impact of transcription on DNA damage is well understood, but our research reveals that this a

141 lor sensory system controlling PC expression is well understood, but PE regulation has not been resol

142 surface Urban Heat Island (UHI) effect that is well understood, but the causes of the more recently

143 ombination-dependent restart of broken forks is well understood, but the consequence of replication t

144 as an indicator of cellular nitrogen status is well understood, but the function of ATP/ADP binding

145 itter signaling in the mature nervous system is well understood, but the functions of transmitters in

146 Cooper pairing instability in a Fermi liquid is well understood by the BCS theory, but pairing mechan

147 by thermal fluctuations at high temperatures are well understood, controversy remains over the role o

148 With only a few exceptions that are well understood, conventional superconductivity does

149 g of drug molecules to their protein targets are well understood, detailed experimental characterizat

150 The catalytic mechanism of Complex I has not been well understood, due to the complicated structure o

151 Their function is well-understood during passive stimulation but, under

152 in Escherichia coli and other enterobacteria is well understood, except for the events leading to mat

153 Whereas these fluctuations are well understood for flat membranes, curved shells sh

154 and twin boundaries in mechanical properties are well understood for metals and alloys.

155 Although these statistics are well understood for pairwise comparisons, there has

156 The pathogenesis of ETEC infections has been well understood for almost two decades, and there i

157 tant applications of information theory, and is well understood for channels modelled by classical ph

158 Filament turnover and dynamics are well understood from in vitro biochemical analyses a

159 The SM/SSM difference is well understood from molecular first principles.

160 However, it had not been well understood how the complex network of Myc targ

161 Although it is well understood how BRs are produced and how their si

162 While it is well understood how IdeR functions as a repressor, ho

163 It is well understood how mobile introns home to allelic si

164 enin in cell-cell adhesion and Wnt signaling are well understood, how beta-catenin is regulated at th

165 nitric oxide synthesis mechanisms in animals are well understood, how nitric oxide is synthesized and

166 any of the individual subunits of AB5 toxins are well understood, how they self-associate and the eff

167 STIM proteins and coupling to Orai1 channels is well understood, how mitochondria communicate with Or

168 the biochemical composition of peptidoglycan is well understood, how the peptidoglycan architecture c

169 Although the circuitry for selection is well understood, how these nuclei evaluate the outcom

170 T nectin-like protein-5 (necl-5) interaction is well understood, how TIGIT engages nectin-2, a recept

171 l assembly of the synaptic release machinery is well understood; however, how signalling factors modu

172 iveness of newly approved therapeutic agents is well understood; however, the strength of the clinica

173 The parameters of both domains are well understood in terms of the structural propertie

174 with which stimulus kinetics can be resolved are well understood in vision, audition, and somatosensa

175 ysical mechanism of bacterial chemotaxis has been well understood in individual cells, the role of co

176 Although the functions of J-proteins have been well understood in the context of Hsp70s, their add

177 Embryonic anterior-posterior patterning is well understood in Drosophila, which uses 'long germ'

178 Heat capacity is well understood in gases and solids but not in the th

179 between egg polarity and the adult body plan is well understood in many bilaterians.

180 Chemotaxis of the bacterium Escherichia coli is well understood in shallow chemical gradients, but it

181 wer colour influencing pollinator behaviour, is well understood in some species, but the genetic chan

182 tory traits on resource competition outcomes is well understood in the context of a constant resource

183 Neural cell fate specification is well understood in the embryonic cerebral cortex, whe

184 It is well understood in the medicinal chemistry community

185 While this property is well understood in unbounded space, it has not been s

186 ms that drive mitotic chromosome segregation are well understood, in oocytes of most species atypical

187 many aspects of the phenomenon are far from being well understood including what determines droplets

188 etails of antagonist-BIR domain interactions are well understood, it is not clear how this binding ev

189 global patterns in standing species richness are well understood, it is poorly known which environmen

190 While selection on early dispersal is well understood, it is less clear whether costs are a

191 f transcriptional regulatory networks (TRNs) is well understood, it is not clear what constrains gove

192 by transferrin receptor-mediated endocytosis is well understood, it is not completely clear how iron

193 mechanism for AHR induction of target genes is well understood, it is not known how AHR activation p

194 Although the physics of structural colours is well understood, it remains a challenge to create art

195 ic activities of the replicative DNA Pol III are well understood, its dynamics within the replisome a

196 chanisms controlling NtcA activity appear to be well understood, its regulon remains poorly defined.

197 While its biosynthesis is well understood, its fate, once in circulation, is le

198 the pharmacokinetics of caffeine in the body is well-understood, its alertness-restoring effects are

199 Although terrestrial circadian clocks are well understood, knowledge of clocks in marine organ

200 the signals that contribute to Teff function are well understood, less is known about the signals con

201 Although RA-mediated gene activation is well understood, less is known about the mechanisms f

202 basic principles of conventional solar cells are well understood, little attention has gone towards m

203 t activate Igo/ENSA to bind and inhibit PP2A are well understood, little is known about how Igo/Ensa

204 erpinnings of animal and plant domestication are well understood, little is known about microbe domes

205 Although steps in the activation phase are well understood, little is known on how signal termi

206 ptibility to Clostridium difficile infection are well-understood, little is known about what drives d

207 While GA signalling is well understood, little is known about how GA is tran

208 the enzymatic activity of the MTHFD2 protein is well understood, little is known about its larger rol

209 ch auxin triggers changes in gene expression is well understood, little is known about the specific r

210 which arterial and venous fates are acquired is well understood, little is known about when during va

211 gulation of iron metabolism in Baker's yeast is well-understood, little is known about the apparent h

212 nate response against Listeria monocytogenes is well understood, making it a useful immune probe.

213 Whereas thermal effects in flat membranes are well understood, many natural and artificial microst

214 Although overall the mechanism of RNAi is well understood, many molecular details of this compl

215 Based on the few MDR loci that are well-understood, MDR is conditioned by diverse mecha

216 Although the biochemical action of DAPK1 is well understood, mechanisms that regulate its express

217 Although microcompartment structure is well understood, much less is known about their assem

218 ping in a fold bifurcation of an equilibrium is well understood, much less is known about tipping of

219 ochemistry of cyclic dinucleotide metabolism is well understood, much remains to be discovered about

220 gh several aspects of this regulatory system are well understood, no BirA superrepressor mutant strai

221 e the direct physical impact on seabed biota is well understood, no studies have defined thresholds t

222 ds by receptor-mediated Smad phosphorylation is well understood, nothing is known about Smad phosphat

223 While DNA G4s are well understood on structural and, to some extent, f

224 by laser irradiation, i.e., laser ablation, are well understood on the micrometer length scale, it w

225 they are targeted to specific loci have not been well understood on a genome-wide scale.

226 ell protrusion on two-dimensional substrates are well understood, our knowledge of the actin structur

227 biological functions of ephrin-Eph signaling are well understood, our mechanistic understanding remai

228 ic resistance genes (ARG) in the environment are well understood processes.

229 ics, biosynthesis and regulation of alginate are well understood, questions still remain concerning i

230 attachment protein receptor (SNARE) function are well understood, remarkably little detail is known a

231 While protein secondary structure is well understood, representing the repetitive nature o

232 While their theoretical properties are well-understood, specific methodology for their opti

233 While the steps in the activation phase are well understood, steps in the termination pathway ar

234 post-transcriptional regulation of IFN-gamma is well understood, subsequent modifications of secreted

235 It is well understood that antigen-presenting cells (APCs)

236 Although it is well understood that CD develops in genetically predi

237 In animals, it is well understood that exposing animals to a more stimu

238 It is well understood that intermolecular forces are direct

239 Although it is well understood that N(ICD) forms a transcriptional a

240 While it is well understood that nanoparticle (NP) physico-chemic

241 It is well understood that the brain integrates information

242 eneral steps of fatty acid (FA) biosynthesis are well understood, the individual enzymes involved in

243 hough many details of the signaling cascades are well understood, the initial mechanism and regulatio

244 d its role in initiating centriole formation are well understood, the mechanisms by which SAS-5 and i

245 g pathways involved in hepatic specification are well understood, the mechanisms through which FGFs i

246 characteristics of particular architectures are well understood, the properties of newly discovered

247 gh the effects of kinetics on crystal growth are well understood, the role of substrate curvature is

248 Although many aspects of blood production are well understood, the spatial organization of myeloid

249 rocesses governing this threshold in soil pH are well understood, the threshold has not been quantifi

250 r repairing several forms of genomic insults are well understood, the upstream signalling pathways th

251 ent autokinase and phosphotransfer reactions are well-understood, the mechanism by which sensors acce

252 dissociation and nascent peptide degradation are well-understood, the molecular sensors of aberrant m

253 eading to cell cycle arrest are beginning to be well understood, the regulation of the release from a

254 onse to foreign proteins can be expected and is well understood, the basis for the development of res

255 olecular pathogenesis of these fatty changes is well understood, the biochemical and pharmacological

256 Although the neuropathology of RTT is well understood, the cellular and molecular mechanism

257 rigger defense responses in resistant plants is well understood, the disease-promoting functions of t

258 ough pigment inactivation by phosphorylation is well understood, the enzyme(s) responsible for pigmen

259 Although the mechanism of homing is well understood, the evolutionary relationship betwee

260 e of these proteins in mitigating DNA damage is well understood, the function of AidB is less clear.

261 pathophysiology of hypothalamic POMC neurons is well understood, the genetic program that establishes

262 While the contribution of diffusion is well understood, the influence of density gradient-dr

263 the mechanism of hypoxia-driven angiogenesis is well understood, the link between inflammation-induce

264 Whereas the mechanism of class A is well understood, the molecular details of methylation

265 Although PMN programmed cell death is well understood, the observation that macrophages apo

266 Although the signalling pathway is well understood, the origin of the RNA molecules that

267 Although SA biosynthesis is well understood, the pathways by which SA is cataboli

268 sis of phosducin interaction with G proteins is well understood, the physiological significance of li

269 hough the lectin-oligosaccharide association is well understood, the polypeptide-based interaction is

270 the transcriptional regulation of Th17 cells is well understood, the posttranscriptional regulation o

271 individual reactions into metabolic networks is well understood, the principles that govern their glo

272 f glucose and glutamine in cancer metabolism is well understood, the relative contribution of acetate

273 While the role of chitin in plant infection is well understood, the role of beta-1,3-glucan is unkno

274 l significance of Ser(22/23) phosphorylation is well understood, the role of other cTnI phosphorylati

275 y have invaded and spread though populations are well understood, their subsequent dynamics within th

276 on-brownian suspensions in the dilute regime is well understood, their behavior in the dense limit re

277 identity in the fly Drosophila melanogaster is well understood, there are very few cases in which th

278 l and chemical basis for ocean acidification is well understood, there exist few field data of suffic

279 ch as diamond carbon, silicon, and germanium is well understood, there is a gap in knowledge regardin

280 fits of symbiotic species with small genomes are well understood, these issues remain poorly elucidat

281 the factors that maintain CD8 T cell memory are well understood, those responsible for CD4 memory ar

282 While immune specificity and memory are well understood to underpin immunisation in vertebra

283 Despite the fact that NOD2 is well understood to have a key role in regulating inna

284 d the effects of changes in connectivity can be well understood using a set of methods including nume

285 of antipsychotics (APs) on neuronal function are well understood, very little is known about their ef

286 inoic acid (RA) regulates gene transcription are well understood, very little is known on the signali

287 functional groups at the core of dendrimers is well-understood, very little is known about their int

288 CsA action in causing cancer was thought to be well understood via immunosuppression.

289 ugh the molecular origin of force generation is well understood, we currently lack an understanding o

290 This behavior is well understood when all subunits within a cluster ar

291 sicle fusion during neurotransmitter release are well understood, whereas little is known about the p

292 The role of the former in neovascularization is well understood, whereas the latter is capable of dir

293 Although it is well understood which individuals are at risk of radi

294 ansmission dynamics of adenovirus have never been well understood, which complicates prevention effor

295 r its exact role in the disease pathogenesis is well understood, which is largely due to limitations

296 the health risks of obesity were thought to be well understood, with a straightforward correlation b

297 e underlying controls of tooth size have not been well understood, with hypotheses ranging from morph

298 Proton reduction is well-understood, with catalysts achieving quantum yie

299 tal nature of 2D MoS2-metal contacts has not been well understood yet.

300 iosis in bacterial symbiont genome evolution is well understood, yet the ways that symbiosis shapes h