ライフサイエンスコーパス: be essential to

1 ll molecule ligands that participate in, and are essential to a large number of biological processes.

2 Photochemical reactions are essential to a large number of important industrial

3 highly conserved transmembrane protein that is essential to a wide spectrum of cellular systems.

4 wed that the predicted cooperative movements are essential to accommodate intermolecular interactions

5 We show that cofactors are essential to achieve affinity beyond the equilibrium

6 s addressing socioenvironmental determinants are essential to achieve thriving populations.

7 Here we show that population codes can be essential to achieve long coding timescales.

8 The search for biomarkers is essential to achieve a better understanding of the mo

9 Evaluation of riparian condition is essential to achieve and maintain good stream health,

10 ture of WNT/beta-catenin signaling in tumors is essential to achieve maximal therapeutic benefit from

11 Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprint

12 inhibitor and higher doses of Metronidazole is essential to achieve such results.

13 benefits, and limitations of genetic testing is essential to achieve the best possible outcomes.

14 Thus, RADX is essential to achieve the proper balance of RAD51 acti

15 ssive membrane permeation of small molecules is essential to achieve the required absorption, distrib

16 hieved via disciplined lipophilicity changes was essential to achieve both high affinity binding and

17 Optimizing use of existing tools will be essential to achieving the ambitious 2030 elimination

18 tors (TFs) to repressed genes in euchromatin is essential to activate new transcriptional programs du

19 Thus, Skap2 is essential to activate the beta2 integrins, and loss o

20 trolytes, while enabling fast ion transport, are essential to address chemical instability of the ano

21 However, significant data gaps remain that are essential to address for biological relevance and ne

22 capacity-building educational collaborations are essential to address the global burden of surgical d

23 nal data generated by multiplex assays could be essential to addressing the variant-interpretation cr

24 Determining optimal dose and delivery is essential to advance the field, decipher mechanism(s)

25 he excitatory neurotransmitter glutamate and are essential to all aspects of brain function, includin

26 not a major driver of longevity, but rather is essential to allow the survival of older animals beyo

27 Ubiquitination, which is essential to almost all biological processes in eukar

28 Vortices are essential to angular momentum in quantum systems suc

29 ing the sternum and their imaging appearance is essential to arrive at an early diagnosis and also to

30 of health) that relevant stakeholders agree are essential to assess in all clinical research studies

31 Monitoring biodiversity is essential to assess the impacts of increasing anthrop

32 astal development near mangrove forests will be essential to avert this crisis.

33 anagement of hyperinsulinaemic hypoglycaemia is essential to avoid hypoglycaemic brain injury, especi

34 RATIONALE: Acute pulmonary oxygen sensing is essential to avoid life-threatening hypoxemia via hyp

35 Bacterial cell walls are essential to bacteria, thus making them unique targe

36 As a compound class, they are essential to basic metabolic processes including cel

37 n acting in a complex visual environment, it is essential to be able to flexibly allocate attention t

38 identifying parameters that alter onset age are essential to better understanding this locus and to

39 This refined knowledge is essential to better guide translational studies and e

40 suboxide structure below the copper surface is essential to bind the CO2 in the physisorbed configur

41 nstrate that holistic multiscale translation is essential to biomimetic design.

42 Neurogenesis is essential to brain development and plays a central ro

43 Adequate blood flow is essential to brain function, and its disruption is an

44 rooting behavior under water-deficit stress is essential to breed climate-robust rice (Oryza sativa)

45 d chromosomes to an unlinked monomeric state is essential to cell survival.

46 These results show that it is essential to characterize the directionality of motio

47 ity, and initiates memory B and T cells that are essential to combat various pathogens.

48 Motivation : Meta-analysis is essential to combine the results of genome-wide assoc

49 Finally, a non-myristoylated isoform is essential to complete cytokinesis by activating motil

50 ensue by c-NHEJ, but when executed, Artemis is essential to complete resection-dependent c-NHEJ.

51 not required to initiate differentiation but were essential to complete the differentiation process a

52 apply and further develop these methods, it is essential to consider many practical concerns, includ

53 ce and move toward personalized medicine, it is essential to consider signaling network dynamics that

54 Such knowledge is essential to considering various mechanistic hypothes

55 It is essential to continue efforts to maintain resilient,

56 e commonplace in dermatological practice, it is essential to continuously review the accuracy of tele

57 elated transcription factors, Zic1 and Zic2, are essential to control the balance between two defined

58 n effective antifungal stewardship programme is essential to control drug resistance, and should inco

59 Multiple, independent time markers are essential to correlate sediment and ice cores from t

60 ity of ways in which sex can alter the brain is essential to crafting policies and treatments that ar

61 n neonatal immunology that immunosuppression is essential to dampen robust immune responses in the ne

62 e an optimal functional microenvironment, it is essential to define how simple is complex enough to t

63 Indeed, hemocyte migration is essential to deliver a subset of ECM components evenl

64 nst DFT-derived free energies; their details are essential to design host-guest pairs that direct alk

65 the molecular mechanism of Kgp zymogenicity is essential to design inhibitors blocking its activity.

66 s of spatial patterns of biodiversity change are essential to detect a signature of anthropogenic imp

67 In order to minimize the losses, it is essential to detect and identify the pathogens at an

68 We demonstrate that expression of PhoQ is essential to detect Mg(2+) and reduce the expression

69 lue and red pigments and gallic acid seem to be essential to determine these OCRs.

70 use and land-use changes (LULUC) information is essential to determine the environmental impacts of a

71 A thorough diagnostic evaluation is essential to determine the pathogenesis in cryptogeni

72 Therefore, it is essential to determine the physiological mechanisms t

73 It is essential to determine the possible culprit because t

74 enhanced magnetic resonance lymphangiography was essential to determine etiology.

75 te, and spatially fine-grained baseline data are essential to determining policy in favor of reducing

76 f CDK4/6; CDK4/6-mediated activation of DUB3 is essential to deubiquitinate and stabilize SNAIL1, a k

77 more detailed, system-specific studies that are essential to develop an improved understanding on th

78 sporidiosis and the correlates of protection are essential to develop effective and sustainable appro

79 ions single crystals are not suitable and it is essential to develop high-performance polycrystalline

80 h knowledge of the pCRP activation mechanism is essential to develop therapeutic strategies to minimi

81 ells (OPCs) during the remyelination process is essential to developing new therapeutic tools to inte

82 It is essential to diagnose the disease early and distingui

83 on of metal nitride complexes to ammonia may be essential to dinitrogen fixation.

84 hly conserved Tyr-86 residue in E. coli TrmD is essential to discriminate between 3',5'-cAMP and the

85 Thus, histone ChIP-seq experiments are essential to distinguish nucleosomes from other DNA-

86 that the neuromodulator acetylcholine (ACh) is essential to dlPFC working memory functions, but the

87 Prevalence estimates are essential to effectively prioritize, plan, and deliv

88 at identifying important fuelling sites will be essential to effectively conserve migratory species.

89 learning of relevant nonaversive information is essential to elicit the participation of the hippocam

90 ral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degene

91 esis is a long standing challenge thought to be essential to elucidating the origins of life on Earth

92 complexity of the modern global food system is essential to enable better prediction of human exposu

93 nderstand the reasons for these observations is essential to enable informed public health policy and

94 rporate the in vivo cell-matrix interactions are essential to enhance LEPC ex vivo-expansion and tran

95 ypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages.

96 Therefore, early and accurate diagnosis is essential to ensure appropriate treatment and monitor

97 Rapid identification of bacterial infection is essential to ensure early appropriate administration

98 olution to resolve microparticles in tablets is essential to ensure high quality and efficacy in cont

99 f individuals around the world, its analysis is essential to ensure its safety.

100 tched with respect to time of heading, which is essential to ensure plants put together will cross po

101 ation of both pools of Mps1 during metaphase is essential to ensure prompt and efficient SAC silencin

102 of BP measurement in the outpatient setting is essential to ensure proper monitoring and gauge the e

103 IGNIFICANCE STATEMENT Thyroid hormones (THs) are essential to establish the stereotypical layered str

104 For overall water-splitting systems, it is essential to establish O2 -insensitive cathodes that

105 issue selective negative feedback regulation is essential to establish sex-specific differences in mu

106 ly programmed heat-shock response (HSR) that is essential to establish short-term acquired thermotole

107 tifying mechanism(s) underlying PVI deficits is essential to establish treatments targeting in partic

108 Correct positioning of organelles is essential to eukaryotic cells.

109 rbital due to c-axis contraction is shown to be essential to explain the insulating phase.

110 her with their influence on phonon-transport is essential to explore and design crystalline solids wi

111 Improved communication strategies are essential to facilitate this complex decision-making

112 measurement within oral health care systems is essential to facilitate learning from variation in pr

113 rther show that myristoylation of Src kinase is essential to facilitate Src-induced and high-fat diet

114 ast three different classes of CESA proteins are essential to form the CSC However, while organizatio

115 lian desertification dynamics and its causes is essential to formulate an effective strategy for comb

116 Here, we show that the phosphatase Cdc14 is essential to fulfil recombinational DNA repair in bud

117 Lead optimization (LO) is essential to fulfill the efficacy and safety requirem

118 linical cases and standardization of methods are essential to fully quantify the total burden of NDI

119 tion and maintenance of high CD4 cell counts are essential to further reducing KS incidence worldwide

120 its high-temperature deformation mechanisms is essential to further optimize the microstructure and

121 is oocytes, where active transport processes are essential to generate developmental polarity.

122 This pathway is essential to generate a gradient of RanGTP on chromat

123 Reversibility in bond formation is essential to generate ordered networks, as it allows

124 readily be modeled in Drosophila Centrosomes are essential to give organization to the rapidly increa

125 dings indicate that ventral hippocampal trkB is essential to goal-directed action selection, counteri

126 , establishment of a phase-transfer protocol was essential to guarantee that the hydrogen bond-mediat

127 Estimates of HCV infection burden are essential to guide policy and programs to optimally

128 the agents of subcutaneous fungal infection is essential to guide appropriate antifungal therapy.

129 Precise diagnosis is essential to guide prompt, proper management.

130 e to mitigate infectious disease threats, it is essential to have an efficient epidemic surveillance.

131 In order to proceed in this direction, it is essential to have thermoelectric materials that are e

132 ction of pathogens present in food and water is essential to help ensure food safety.

133 rchitecture and organization of the two RRMs is essential to hnRNP A1 function.

134 Polyunsaturated fatty acids (PUFAs) are essential to human health and can be produced by enz

135 Biodiversity is essential to human well-being, but people have been r

136 Analyses of discarded organs are essential to identify barriers to organ utilization

137 n models for beige adipocyte differentiation are essential to implement such therapeutic strategies.

138 For this reason, it is essential to implement approaches to ensure accurate

139 re and nutrient production and its diversity is essential to improve present understanding of nationa

140 , identifying the mechanism of P4 resistance is essential to improve the therapies for endometrial ca

141 ntly, binding data from primary human tissue are essential to improving our understanding of in vivo

142 post-translational events in the human brain are essential to improving our understanding of its deve

143 scaled up support for the youngest children is essential to improving health, human capital, and wel

144 a minimum set of core outcome measures that are essential to include in all clinical research studie

145 across this heterogeneous patient population is essential to individualize care and design future cli

146 thin 3 months of discharge from the hospital is essential to individualize postdischarge plans.

147 and limit the emergence of new variants, it is essential to induce broad protection and restrict pne

148 These data are essential to inform interventions, such as maternal

149 , our results indicate that while centrioles are essential to initiate cilia formation, they are disp

150 uencing data for immune repertoire profiling is essential to insure high quality input for downstream

151 for each serine/threonine phosphatase (PPP) are essential to investigate the biological actions of P

152 These mechanisms are essential to keep the physiological HSC numbers in c

153 Some vicinal disulfides are essential to large, functionally coupled motions, wh

154 This recruitment is essential to limit gene conversion tract lengths geno

155 interacts with aberrant nascent peptides and is essential to limit their accumulation and aggregation

156 In conclusion, BCO2 is essential to macronutrient and mitochondrial metaboli

157 modifications of the actin cytoskeleton that are essential to maintain cell shape during infection.

158 hagocytic uptake by specialized immune cells are essential to maintain host homeostasis.

159 In summary, this study suggests that PAPPA is essential to maintain a receptive endometrium by up-r

160 our environment, and a healthy immune system is essential to maintain adequate protection from fungal

161 The cell cortex is essential to maintain animal cell shape, and contract

162 cific (ETS) family transcription factor Etv5 is essential to maintain AT2 cell identity.

163 DNA replication-coupled nucleosome assembly is essential to maintain genome integrity and retain epi

164 IL-10 is essential to maintain intestinal homeostasis.

165 it is unknown whether glycolytic regulation is essential to maintain the balance between proliferati

166 periods of time showed that a water molecule is essential to maintain the decarboxylation and aromati

167 nerin as a critical protein whose expression is essential to maintain the pancreatic cancer vasculatu

168 These features are essential to maintaining cellular homeostasis and bl

169 ms of intestinal/hepatic and urinary disease is essential to make a meaningful impact in global reduc

170 aterials for future optical technologies, it is essential to make such chiroptical responses tunable

171 gametocyte stage transition, a process that is essential to malaria transmission between hosts.

172 ATEMENT The ability to guide actions in time is essential to mammalian behavior from rodents to human

173 Proteoform identification is essential to mapping proteoforms to their biological

174 ved in CPC protection against hypoxic stress is essential to maximize their cardioprotective and ther

175 Selective detection of signal over noise is essential to measurement and signal processing.

176 we found that the p38-MK2/3 signaling module is essential to mediate IL-33-induced cytokine productio

177 tate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlap

178 Atomic motion at grain boundaries is essential to microstructure development, growth and s

179 t the homonid-specific brain enzyme GDH2 may be essential to mitigate metabolic liabilities created b

180 of the bSTC, whereas high spatial resolution is essential to more accurately approach neuronal operat

181 Light cues are essential to most physiological and behavioural proc

182 r-regulated polarized cilia positioning that is essential to mouse embryo left-right asymmetry establ

183 The use of a validated method is essential to obtain reliable analytical results since

184 e that customized combination therapies will be essential to optimize cancer treatment regimens.

185 normous potential in device applications, it is essential to optimize epitaxial growth for the precis

186 ce, and so multidisciplinary team assessment is essential to optimize outcomes.

187 es one X chromosome in the female mammal and is essential to peri-implantation development.

188 The resulting intracellular Ca(2+) transient is essential to physiological and pathological processes

189 true burden and seasonality of disease that is essential to plan the optimal target groups, timing,

190 ification of autophagy regulatory components is essential to positively or negatively regulate autoph

191 Single-droplet control will be essential to power subsets of compartments within syn

192 mmune cell composition of a solid tumour may be essential to predict a patient's response to immunoth

193 uishing between sign (or speech) and gesture is essential to predict certain types of learning and al

194 The regulation of replication is essential to preserve genome integrity.

195 ltimately, a multidisciplinary approach will be essential to prevent or improve adverse neurodevelopm

196 Maintenance of genome integrity is essential to prevent cancer.

197 SIRT1 T530 phosphorylation is essential to prevent DNA breakage upon replication st

198 tion, whereas proper limitation of signaling is essential to prevent immunopathology and autoimmune d

199 e expression following microbial stimuli and is essential to prevent inflammatory disease; however, t

200 Our results reveal that POT1 C terminus is essential to prevent initiation of genome instability

201 The presence of PTX2 is essential to prevent internalization of FX by SR-AI,

202 rol of ssDNA accumulated during this process is essential to prevent its channeling into toxic struct

203 Proper segregation of chromosomes in meiosis is essential to prevent miscarriages and birth defects.

204 DNA repair is essential to prevent the cytotoxic or mutagenic effec

205 Disinfection of such wastewater is essential to prevent the spread of pathogens; however

206 apenemase-producing Enterobacteriaceae (CPE) is essential to prevent their dissemination within healt

207 for mechanical heart valves during pregnancy is essential to prevent thromboembolic events.

208 uracy and robustness of analytical pipelines are essential to progress in both research and applied s

209 s-signaling, but not IL-6 classic signaling, is essential to promote hepatocellular carcinogenesis by

210 r3 loss up-regulates surface P-cadherin that is essential to promote MC proliferation and phenotypic

211 aintenance of appropriate T-cell homeostasis is essential to promote protective immunity and limit au

212 cover change (LULCC) and on the carbon cycle is essential to provide guidance for environmental polic

213 MDA receptor activation, structural modeling is essential to provide presently missing information ab

214 Diversity in the physician workforce is essential to providing culturally effective care.

215 Our findings highlight that it is essential to quantify the effects of smoking from a l

216 Cell proliferation is essential to rapid tissue growth and repair, but can

217 These data are essential to rationalize eventual, different nutriti

218 tions to support early childhood development are essential to realising the vision of the Sustainable

219 ofluidic systems with integrated electronics is essential to realizing ubiquitous, compact, reliable,

220 multidecadal and multicentennial timescales is essential to reconciling model projections with obser

221 ayed accumulation of H3K27me3 on nascent DNA is essential to recruit pioneer transcription factors in

222 d for outer kinetochore assembly, we find it is essential to recruit tension indicators, such as BubR

223 mprehensive, and real-time surveillance data are essential to reduce the burden of antimicrobial resi

224 impact of transposition in somatic cells it is essential to reliably measure the frequency and map l

225 Wound healing is essential to repair the skin after injury.

226 key elements in the natural adhesive system is essential to replicate the strong, instant, and durab

227 spersion energy in density functional theory is essential to reproduce the experimental geometries.

228 her, our data suggest that SUMO modification is essential to restrain pathogenic bacterial entry by l

229 Moreover, MYCN was essential to retinoblastoma cell growth and tumor fo

230 ccessful working with primary care providers is essential to scaling-up AIT provision in Europe, but

231 Medical imaging is essential to screening, early diagnosis, and monitori

232 mediate global action to curb future warming is essential to secure a future for coral reefs.

233 Reliable data are essential to show how far warring parties have stray

234 mology with Kunitz-type protease inhibitors, is essential to SI in Nicotiana spp.

235 These microbial commensals are essential to skin health and can potentially lead to

236 orks of interactions and chemical components is essential to solving contemporary problems in modern

237 It was confirmed that the propylenic bridge is essential to stabilize the spirobis[chromene] species

238 ) indicate that increased lipid desaturation is essential to stem-like characteristics in ovarian can

239 Therefore, it is essential to study and understand the behavior of sel

240 nvestigated at precisely mapped genomic DSBs is essential to study this relationship.

241 photosynthesis-associated nuclear genes and are essential to successful chloroplast biogenesis.

242 a certain threshold level of STAT3 activity is essential to support activation of the COL1A2 enhance

243 These results demonstrate that PFKFB4 is essential to support anabolic metabolism in p53-defic

244 Egr2 and 3 were essential to suppress Th1 differentiation in Th2 an

245 Whereas blood vessel growth is essential to sustain organ health, chronic hyperperme

246 soform-dependent positive feedback loop that is essential to sustain PI3K/Akt signaling in breast can

247 ting a finely balanced expression range that is essential to sustaining the colicinogenic population.

248 While upregulation of both xCT and GLT-1 are essential to the ability of ceftriaxone to attenuate

249 The secreted Wnt signaling molecules are essential to the coordination of cell-fate decision

250 Cytoskeletal motor proteins are essential to the function of a wide range of intrace

251 distributions over external states (priors) are essential to the interpretation of sensory signals.

252 Exchanges of matrix contents are essential to the maintenance of mitochondria.

253 ar DNA (eDNA) and associated DNABII proteins are essential to the overall architecture and structural

254 e phosphopantetheinyl transferases (PPTases) are essential to the production of these compounds via f

255 the complex shapes of brain structures which are essential to the understanding of the result statist

256 on transfer pathways has been established to be essential to the vectorial transport efficiency of Cc

257 that active site conformational flexibility is essential to the acquisition of broader substrate spe

258 N2 reduction to NH3 is essential to the chemical industry and to the Earth's

259 Although Gata2 is essential to the embryonic development and function o

260 opod response to experimental conditions and is essential to the interpretation of biological observa

261 Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere chromatin st

262 e environment, its diversity, and mechanisms is essential to the management of our existing and futur

263 ation of gustatory and olfactory information is essential to the perception of flavor.

264 representation of the CCN activation process is essential to the prediction of clouds in climate mode

265 membrane trafficking and actomyosin networks is essential to the regulation of cell and tissue shape.

266 Nucleic acids detection is essential to the study of biological processes and to

267 ding of the freezing stress on nanoparticles is essential to the successful preservation of original

268 rations in fluctuating external environments-is essential to the survival of most organisms.

269 Radiotherapy is essential to the treatment of most solid tumors and a

270 llenge in cell biology; yet such measurement is essential to the understanding of cell regulation and

271 Balancing growth and differentiation is essential to tissue morphogenesis and homeostasis.

272 to modulate epithelial cell fusion kinetics are essential to understand the highly tuned tropism of

273 ecreted during infection, yet such knowledge is essential to understand and combat crop disease.

274 rements in research and in clinical care, it is essential to understand differences and similarities

275 anisms influenced by cis-regulatory variants is essential to understand gene regulation and ultimatel

276 Quantifying stochastic processes is essential to understand many natural phenomena, parti

277 rstanding of RAS' interaction with membranes is essential to understand RAS action and to intervene i

278 n order to develop mitigation strategies, it is essential to understand the atomistic processes that

279 Single-cell analysis is essential to understand the physical and functional c

280 clarifying the origins of these differences is essential to understand the processes by which indivi

281 s in TRPC6 and corresponding protein kinases is essential to understand the regulation of TRPC6 activ

282 bring forth novel and useful phenotypes, it is essential to understand the relationship between geno

283 envisage present and future variability, it is essential to understand the specific microbial proces

284 non-trophic direct and indirect interactions is essential to understand the structure and dynamics of

285 These results are essential to understanding the electron transfer pat

286 identification of a host or counterpart has been essential to understanding the origins and physics

287 mical heterogeneity in biological structures is essential to understanding cellular-level function in

288 The idea of the coordination polyhedron is essential to understanding chemical structure.

289 ormation of materials at the nanometer scale is essential to understanding complex material propertie

290 information becomes integrated in the brain is essential to understanding higher cognitive functions

291 zation and energy transfer in phycobilisomes is essential to understanding photosynthesis in these or

292 the internal limiting membrane of the retina is essential to understanding the cause of rhegmatogenou

293 Historical land use information is essential to understanding the impact of anthropogeni

294 c analysis of mouse models of human diseases is essential to understanding the underlying disease mec

295 or greenhouse gas (GHG) emissions of nations is essential to understanding their importance to global

296 id evaluation of protective immune responses are essential to vaccine development as they can provide

297 based on the MHAP hashing algorithm, and it is essential to validate assemblies of repetitive loci.

298 The VEGF/VEGFR2/Akt/eNOS/NO pathway is essential to VEGF-induced angiogenesis.

299 SITIVE3 (VIN3) is induced by winter cold and is essential to vernalization response in Arabidopsis (A

300 ivery of tracers into populations of neurons is essential to visualize their anatomy and analyze thei