ライフサイエンスコーパス: be necessary and sufficient for

1 Complement activation alone was necessary and sufficient for 2C7 function, evidenced

2 MCT1 is necessary and sufficient for 3-BrPA uptake by cancer

3 that the change in the neurons' selectivity was necessary and sufficient for a network of stochastic

4 and targets Boi2 to the site of abscission, is necessary and sufficient for abscission inhibition.

5 This peptide was necessary and sufficient for accelerated chemotaxis.

6 These signals are necessary and sufficient for accumulating phosphatid

7 in within the C-terminal 76 amino acids that is necessary and sufficient for accumulation as a single

8 c effects of Cdk5 and demonstrates that SynI is necessary and sufficient for achieving the effects of

9 of-function mutants demonstrated that MpMYCs are necessary and sufficient for activating the jasmonat

10 to the minimal modular elements of GIV that are necessary and sufficient for activation of Gi downst

11 ARF6 is necessary and sufficient for activation of both PI3K

12 This suggests that CnfR2 is necessary and sufficient for activation of the nifB2

13 hich links the NTD and the catalytic domain, is necessary and sufficient for activation.

14 ound that formation of an internal disulfide was necessary and sufficient for aggregation under physi

15 The viral protein Nef was necessary and sufficient for all HIV-1-mediated effe

16 ls, we show that HIFalpha in oligodendroglia is necessary and sufficient for angiogenesis independent

17 nce at the C terminus of the Acm1 D-box that was necessary and sufficient for APC/C inhibition.

18 C-terminal coiled-coil domain of Slik, which is necessary and sufficient for apical localization of t

19 iously that nuclear localization of PKCdelta is necessary and sufficient for apoptosis.

20 er of the ASCORBATE PEROXIDASE 2 (APX2) gene were necessary and sufficient for APX2 expression in con

21 Although Asap lacked Golgi enrichment, it was necessary and sufficient for Arf1 accumulation at th

22 all three compounds, and that these neurons are necessary and sufficient for attraction behavior in

23 Thus, MeCP2 in cholinergic neurons is necessary and sufficient for autonomic cardiac contro

24 oss of autophagy by upregulating NRF2, which is necessary and sufficient for autophagy-dependent cell

25 ere, we show that class I KNOX gene activity is necessary and sufficient for axis extension from an i

26 functions in SC development whereby the NTF is necessary and sufficient for axon sorting, whereas th

27 se infection, the deamidase activity of TecA is necessary and sufficient for B. cenocepacia-triggered

28 Human pDCs were necessary and sufficient for B cell activation indu

29 of the EGL-4 kinase that promotes adaption, is necessary and sufficient for behavioral adaptation.

30 The MDMX acidic domain and zinc finger are necessary and sufficient for binding and inhibition

31 at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylati

32 at serine 7 but not serine 12 and that this is necessary and sufficient for binding beta-TrCP and an

33 vage fragment of the cellular prion protein, is necessary and sufficient for binding early oligomeric

34 We found that this conserved region is necessary and sufficient for binding the SNARE protei

35 nt but distinct septin-associating elements, is necessary and sufficient for binding to septin filame

36 We show that dPARP16 catalytic activity is necessary and sufficient for both amino-acid starvati

37 CELF1 is necessary and sufficient for both mesenchymal transit

38 lly disordered protein (IDP) domain of LAF-1 is necessary and sufficient for both phase separation an

39 lycan binding, the fusion (F) protein, which is necessary and sufficient for both viral binding to th

40 ts indicated that such changes in microbiota were necessary and sufficient for both low-grade inflamm

41 n of AF10, and this region has been shown to be necessary and sufficient for CALM-AF10-mediated trans

42 nal coactivator Yes-associated protein (Yap) is necessary and sufficient for cardiomyocyte proliferat

43 op in cytosolic K(+) is the common step that is necessary and sufficient for caspase-1 activation.

44 mutants, we mapped a C-terminal domain that is necessary and sufficient for Cdr1 node localization a

45 ys reveal that Hoxb4 and its paralogue Hoxd4 are necessary and sufficient for cell segregation, and f

46 that high-affinity Teb1 DNA-binding activity is necessary and sufficient for cell cycle-regulated tel

47 Our results showed that Wg signaling is necessary and sufficient for cell polarity disruption

48 PC-1 functions as an intrinsic agonist that is necessary and sufficient for channel activation.

49 pore helix, alone provides the trigger that is necessary and sufficient for channel gating.

50 id protein (p22) or its processed form (p18) is necessary and sufficient for CNC and likely encoded b

51 anocomplex with neuropilin-1 and VEGFR2 that is necessary and sufficient for conferring mechanosensit

52 , conserved across all group 4 LEA proteins, is necessary and sufficient for conformational transitio

53 expectedly, the extracellular domain of Fn14 is necessary and sufficient for constitutive turnover.

54 s revealed that GPR139 signaling via G(q/11) is necessary and sufficient for counteracting MOR-mediat

55 that elevation of the tumour suppressor p53 is necessary and sufficient for crowding hypersensitivit

56 and found the viral accessory protein Vif to be necessary and sufficient for CUL5-dependent proteasom

57 The AH domain is necessary and sufficient for curvature sensing both i

58 ike Stat92E and its targets ZFH1 and Chinmo, is necessary and sufficient for CySC renewal.

59 contractility, a key myofibroblast feature, is necessary and sufficient for deciliation, since const

60 e experiments show that PDF from these cells is necessary and sufficient for delaying the timing of t

61 We show that GPI modification is necessary and sufficient for delivering both BG_pap a

62 istinct binding modules within its IDRs that are necessary and sufficient for directing protein inter

63 nsps), three of which, nsp3, nsp4, and nsp6, are necessary and sufficient for DMV formation.

64 We found that zinc fingers 11-13 are necessary and sufficient for DNA binding and, in com

65 Activation of adenylyl cyclase is necessary and sufficient for down-regulation of Cb1 r

66 , actin-rich invadopodia in the pioneer axon are necessary and sufficient for DREZ entry.

67 ic mutation or heavy chain VDJ recombination are necessary and sufficient for Dsg3 binding.

68 entify a coiled-coil region within PxdA that is necessary and sufficient for early endosome localizat

69 loid-epithelial-reproductive tyrosine kinase was necessary and sufficient for efferocytosis of cardio

70 ) of the Parkin primary substrate human Miro is necessary and sufficient for efficient ubiquitination

71 ific oviposition descending neurons (oviDNs) is necessary and sufficient for egg laying, and is equal

72 Consistently, btd is necessary and sufficient for eliciting a type II neur

73 We test here whether aldosterone is necessary and sufficient for ENaC expression and acti

74 Whereas lateral OFC->BLA projections are necessary and sufficient for encoding of the positiv

75 rrow monocytes from B27-Tg rats was found to be necessary and sufficient for enhanced osteoclast form

76 t tumor-cell expression of the alarmin IL-33 was necessary and sufficient for eosinophil-mediated ant

77 We conclude that Sp-Eph signaling is necessary and sufficient for epithelial insertion.

78 O binding site functions as an operator that is necessary and sufficient for EUO-mediated repression

79 tain a carboxy-terminal signal sequence that is necessary and sufficient for export, although both tr

80 lacement strategy to identify sequences that are necessary and sufficient for Fab-7 boundary function

81 CarT expression in photoreceptors is necessary and sufficient for fly vision and behavior.

82 tonomous structural and functional unit that is necessary and sufficient for folding and partial acti

83 Ostalpha, demonstrating that the TM segment is necessary and sufficient for formation of a heteromer

84 on the hinge and the other on the appendage, are necessary and sufficient for functional clathrin eng

85 Stromal NNMT expression was necessary and sufficient for functional aspects of t

86 ivation of viral glycoproteins is thought to be necessary and sufficient for fusion, accumulating evi

87 in vivo demonstrated that both DLX1 and DLX2 are necessary and sufficient for Gad gene expression.

88 GILZ has been shown to be necessary and sufficient for GC-induced tolerogenic D

89 mitochondrial dysfunction motif (MDM), which is necessary and sufficient for gene expression under va

90 active in regenerating progenitor cells and is necessary and sufficient for generating new scxa(+) c

91 CF ASL had a reduced pH, which was necessary and sufficient for genotype-dependent visc

92 diated by an inflammatory cascade, with IL-6 being necessary and sufficient for GLP-1 induction.

93 The PrLD is necessary and sufficient for granule formation and in

94 monstrates that ALDH2-catalyzed NO formation is necessary and sufficient for GTN bioactivation in VSM

95 An intraepidermal Wnt signal is necessary and sufficient for hair follicle initiation

96 tudies show that this down-regulation of p63 is necessary and sufficient for HBC activation.

97 Here we show that p62 is necessary and sufficient for HCC induction in mice an

98 ntagonist that coprecipitates with HDAC4 and is necessary and sufficient for HDAC4 degradation.

99 terochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochromatin protein

100 ication for each HHV studied, with caspase-3 being necessary and sufficient for HHV replication.

101 rmore, functional assays disclosed that ATF3 is necessary and sufficient for HSF1 regulation.

102 ription factors AhR and RORgammat in T cells was necessary and sufficient for IL-22 production.

103 We also found the N-terminal domain to be necessary and sufficient for immune antagonism.

104 TATA-binding protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription,

105 drial alanine transaminase GPT2 was found to be necessary and sufficient for increased alanine flux u

106 Downstream of calcium, NFAT activity is necessary and sufficient for inducible IL-33 expressi

107 ngly, although HH-independent FOXA2 activity is necessary and sufficient for inducing MFP-specific ge

108 GluRs) demonstrated that G1 mGluR activation is necessary and sufficient for inducing Z-LTD and Z-LTP

109 A G-box sequence in the JAZ2 promoter was necessary and sufficient for induction by MYC5 (as i

110 IL-13 was necessary and sufficient for induction of CD11c(+) M

111 ally blocking sodium pumps in the cerebellum was necessary and sufficient for induction of dystonia.

112 permissive cells, and that ANTXR1 expression is necessary and sufficient for infection in cell lines

113 ent (ICE)-encoded DNase, which we name IdeA, is necessary and sufficient for inhibiting natural trans

114 ermore, we found that a hexapeptide from F1L is necessary and sufficient for inhibiting the NLRP1 inf

115 ating AAD and show that IVIg-generated pTreg are necessary and sufficient for inhibition of allergen-

116 yses reveal that cFLIPL nuclear localization is necessary and sufficient for inhibitory function.

117 i3 to its repressor, Gli3R, and was shown to be necessary and sufficient for initiating this transiti

118 C-terminal domain (amino acids 852-876) that is necessary and sufficient for INM localization of the

119 A conserved I/L-X-C-X2-D/E motif was necessary and sufficient for iNOS-S100A8/A9-mediated

120 Protein kinase C (PKC) activation was necessary and sufficient for integrin- and Rac1-depe

121 ow that the N-terminal RUN domain of PLEKHM1 is necessary and sufficient for interaction with Arl8b a

122 he carboxy-terminal domain of N protein, N3, is necessary and sufficient for interaction with M prote

123 The Nanog tryptophan repeat region is necessary and sufficient for interaction with Sox2, w

124 g to the receptor tyrosine kinase PVR, which is necessary and sufficient for intestinal ERK responses

125 can-containing linker region of neuropilin-2 are necessary and sufficient for its polysialylation and

126 The End3 C-terminus is necessary and sufficient for its cortical localizatio

127 leotide region of the amphoterin mRNA 3'-UTR is necessary and sufficient for its localization into ax

128 dorsal closure, Steppke's coiled-coil domain was necessary and sufficient for junctional recruitment.

129 eplication and transcription activator (RTA) is necessary and sufficient for KSHV reactivation from l

130 at glycolytic suppression and ATP production are necessary and sufficient for LA effects.

131 e actin-related protein 2/3 (Arp2/3) complex is necessary and sufficient for Listeria actin tail asse

132 r-specific genes, indicating that Med1 alone is necessary and sufficient for liver cell proliferation

133 Although InlA-E-cadherin interaction is necessary and sufficient for Lm crossing of the intes

134 PtdIns4P was necessary and sufficient for localization of P4M, wh

135 opulation encodes locomotor state and speed, is necessary and sufficient for locomotion, and is selec

136 sory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance.

137 hat the endoplasmic reticulum-resident STIM1 is necessary and sufficient for LRC channel activation b

138 Our work suggests that neutrophils are necessary and sufficient for mAb-induced therapy of

139 ubstrate whose phosphorylation at serine 109 is necessary and sufficient for maintaining Xenopus oocy

140 Esr1+) cells are activated during mating and are necessary and sufficient for male sexual behaviors,

141 n-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development.

142 (Aap) from S. epidermidis has been shown to be necessary and sufficient for mature biofilm formation

143 show that a highly conserved domain of Rtf1 is necessary and sufficient for mediating a physical int

144 T3SS-dependent invasion of epithelial cells is necessary and sufficient for mediating immune cell in

145 We found that endothelial IL-1R1 was necessary and sufficient for mediating sickness beha

146 Post-AAI rAMs were necessary and sufficient for mediating these proinf

147 discover that only one phosphorylation event is necessary and sufficient for MEK1 activity.

148 sed of basic and hydrophobic residues, which is necessary and sufficient for membrane localization, b

149 g ETV4-mediated upregulation of MMP24, which is necessary and sufficient for metastasis.

150 Remarkably, the eMIC domain is necessary and sufficient for microexon splicing, and

151 ver, Dpp ligand and Tkv receptor interaction is necessary and sufficient for microtubule-based nanotu

152 Tailor is necessary and sufficient for mirtron hairpin uridylat

153 Vms1 contains a highly conserved region that is necessary and sufficient for mitochondrial targeting

154 roduct of apple RIN4 (MdRIN4) but not AtRIN4 is necessary and sufficient for MR5 activation.

155 The BCAS3 domain of Rudhira is necessary and sufficient for MT-IF cross-linking and

156 recipitation analysis to show that the M46RE was necessary and sufficient for MYB46-responsive transc

157 ine 739 in the NCX1 large intracellular loop is necessary and sufficient for NCX1 palmitoylation.

158 These assemblies are necessary and sufficient for neurotoxicity in a C. e

159 show that the cytoplasmic amphipathic helix is necessary and sufficient for NGC generation.

160 show that an early and transient BMP signal is necessary and sufficient for NMJ growth as well as fo

161 signaling in the pericycle and in the cortex is necessary and sufficient for nodulation, whereas cyto

162 l conditioning, and cAMP signaling molecules are necessary and sufficient for normal memory in intrin

163 As E cell and gDN1 activity is necessary and sufficient for normal evening locomotor

164 Yorkie is necessary and sufficient for NSC reactivation, growth

165 rate receptor of CRL4, Mahjong (Mahj), which is necessary and sufficient for NSC reactivation.

166 We show that Yap/Taz-Tead activity is necessary and sufficient for optic vesicle progenitor

167 t that degradation of the peptidoglycan (PG) was necessary and sufficient for osmotic bursting of the

168 egative regulator of the Yap oncoprotein and is necessary and sufficient for pancreatic cancer suppre

169 FGF1 is necessary and sufficient for paracrine regulation of

170 show experimentally that a single parS site is necessary and sufficient for ParB-DNA complex formati

171 of one receptor and its compatible pheromone is necessary and sufficient for perithecial development

172 ain within the nonstructural gene NS1/2 that is necessary and sufficient for persistence.

173 ed mutants, suggesting that raft association is necessary and sufficient for PM sorting of LAT.

174 d dPix isoforms that contain a specific exon are necessary and sufficient for postsynaptic differenti

175 for the identified transcription factors and are necessary and sufficient for PRE activity.

176 shown that nuclear translocation of PKCdelta is necessary and sufficient for pro-apoptotic signaling.

177 tric and colorectal cancer cell lines, CCK2R was necessary and sufficient for progastrin binding and

178 A signal causes high cytosolic Ca(2+), which is necessary and sufficient for progenitor maintenance.

179 y, we show that signaling through stromal PR is necessary and sufficient for progesterone antitumor e

180 redicted N-terminal helical region of PstB2p was necessary and sufficient for promoting the interacti

181 egion of negatively charged amino acids that is necessary and sufficient for proper chromosome segreg

182 ; however, deletion of CTLA-4 on T reg cells was necessary and sufficient for protection from EAE.

183 between Hp and Sp in the nanos2 3'UTR which is necessary and sufficient for protein enrichment in th

184 n of Psk1 appears to be direct, in that Snf1 is necessary and sufficient for Psk1 activation by alter

185 in TGD4, amino acids 1-80 and 110-145, which are necessary and sufficient for PtdOH binding.

186 evidence demonstrates that IkappaK activity is necessary and sufficient for regulation of neuronal f

187 The Bvg(+) phase is necessary and sufficient for respiratory infection wh

188 lue of a reward, medial OFC->BLA projections are necessary and sufficient for retrieving this value f

189 an essential mediator of HDAC6 function, and is necessary and sufficient for RMS cell migration and i

190 ROOT HAIR DEFECTIVE SIX-LIKE4 (RSL4) is necessary and sufficient for root hair elongation in

191 n factor root hair defective 6-like 4 (RSL4) is necessary and sufficient for root hair growth(2).

192 rylation on Thr-166 of AtRIN4, an event that is necessary and sufficient for RPM1 activation.

193 We demonstrate that this osmosensory signal is necessary and sufficient for satiation during normal

194 ivates core stem cell transcription factors, is necessary and sufficient for self-renewal, and is sup

195 Finally, we show that brain neurons are necessary and sufficient for sensing all main dietar

196 hermore, we find that Cep4l and Cdc42 itself are necessary and sufficient for sensory neurogenesis in

197 ing HPF1 to in vitro PARP-1/PARP-2 reactions is necessary and sufficient for serine-specific ADPr of

198 Here, we show that beta-tubulin tails are necessary and sufficient for severing.

199 Expression of MHCII on CD11c(+) cells was necessary and sufficient for SFB-induced Th17 cell d

200 iew results demonstrating that S-locus genes are necessary and sufficient for SI signaling and for re

201 hat dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction.

202 enitor maintenance, and that Notch signaling is necessary and sufficient for Six2 downregulation.

203 in skeletal muscle Gadd45a expression, which is necessary and sufficient for skeletal muscle fiber at

204 IL-1alpha was necessary and sufficient for skin inflammation in vi

205 In human breast cancer cells, alphavbeta3 was necessary and sufficient for Slug activation, tumors

206 strate that the ~100-nucleotide T-box stem I is necessary and sufficient for specific, high-affinity

207 ular-based studies revealed the GR domain as being necessary and sufficient for SRBP1 cell-to-cell mo

208 Our findings reveal that the GEF Mon1-Ccz1 is necessary and sufficient for stabilizing prenylated Y

209 coded by the small, centrally located exon 6 are necessary and sufficient for stable membrane associa

210 Finally, leucine deprivation is shown to be necessary and sufficient for starvation-induced, IKK-

211 demonstrate that mTORC1-regulated autophagy is necessary and sufficient for starvation-induced LD bi

212 b meristem (RM) of the shoot apical meristem is necessary and sufficient for stem cell regulation.

213 ion experiments, we show that FGF signalling is necessary and sufficient for stratification but not i

214 s in circulating ghrelin, a peptide hormone, are necessary and sufficient for stress-associated vulne

215 increased tonic activity of the LC-NE system is necessary and sufficient for stress-induced anxiety a

216 increased the specific activity of AMPK, and was necessary and sufficient for stress-dependent activa

217 ST PACAP, and BNST PACAP receptor activation was necessary and sufficient for stress-induced reinstat

218 Domains I and II are necessary and sufficient for substantial RRE functio

219 riptional level and that FtsA overproduction is necessary and sufficient for suppression of Deltapbp2

220 nc886 alone is necessary and sufficient for suppression of PKR via d

221 n of the transcription repressor ATF3, which is necessary and sufficient for suppression of type I IF

222 ility complex (MHC) class I molecule H2-D(b) is necessary and sufficient for synapse elimination in t

223 66-nt element in the 5' UTR of sensorin that is necessary and sufficient for synaptic mRNA localizati

224 otif is the core of a functional module that is necessary and sufficient for targeting of the transcr

225 ine a minimum recognition sequence (RS) that is necessary and sufficient for TclM activity.

226 The results demonstrate that the I(8) module is necessary and sufficient for TG2-binding in vitro, bu

227 atalytic, amino-terminal domain of p110gamma was necessary and sufficient for TGF-beta-induced TRPV4

228 s of postmitotic COUP-TFI (Nr2f1) expression are necessary and sufficient for the development of sens

229 2* nicotinic acetylcholine receptors (nAChR) are necessary and sufficient for the experience of both

230 These cells are necessary and sufficient for the formation of self-r

231 bacteria, just two subunits, BcsA and BcsB, are necessary and sufficient for the formation of the po

232 Thus, neuro-adipose junctions are necessary and sufficient for the induction of lipoly

233 ction manipulations to identify neurons that are necessary and sufficient for the initiation of reori

234 These data show that c-kit(pos) eCSCs are necessary and sufficient for the regeneration and re

235 m in the signaled thymocytes and is shown to be necessary and sufficient for the CD4 helper lineage c

236 ition to its known targets, Vpu was found to be necessary and sufficient for the downregulation of th

237 ocated in the spinal cord have been shown to be necessary and sufficient for the generation and contr

238 m of protein kinase C, has been suggested to be necessary and sufficient for the maintenance of long-

239 cific product of the doublesex gene (dsx(M)) is necessary and sufficient for the acquisition of the p

240 study demonstrates that interaction with p50 is necessary and sufficient for the anti-inflammatory pr

241 tored within the AON and that their activity is necessary and sufficient for the behavioural expressi

242 nd pluripotent stem cells, we show that DKK3 is necessary and sufficient for the correct differentiat

243 We report that exon 11 is necessary and sufficient for the damage-specific alte

244 pectrometry (MS) analyses revealed that TET2 is necessary and sufficient for the deposition of the hm

245 synaptic rhythmic activity of the heart tube is necessary and sufficient for the development and matu

246 Disease (AD) is whether the neuritic plaque is necessary and sufficient for the development of tau p

247 tion, we establish that a set of six enzymes is necessary and sufficient for the eight-step conversio

248 on of Rgt1 from Ssn6-Tup1, but not from DNA, is necessary and sufficient for the expression of its ta

249 The ETS transcription factor Etv2 is necessary and sufficient for the generation of hemato

250 addition, our results indicate that miR-125b is necessary and sufficient for the induction of fibrobl

251 ized by the scaffold protein mAKAPalpha that is necessary and sufficient for the induction of neurite

252 med RRCT), we find that the Prph2 C-terminus is necessary and sufficient for the initiation of OSs, w

253 We have also found that the HPR motif is necessary and sufficient for the intracellular target

254 (Tac2) pathway in the central amygdala (CeA) is necessary and sufficient for the modulation of fear m

255 ence of propionaldehyde dehydrogenase (PduP) is necessary and sufficient for the packaging of enzymes

256 ear the nucleotide-sensing switch-II domain, is necessary and sufficient for the polymerase activity

257 regulator of morphogenesis in Cryptococcus, is necessary and sufficient for the production of this s

258 d in all available genomes of Variovorax and is necessary and sufficient for the reversion of root gr

259 VA2, which binds directly to L1CAM pre-mRNA, is necessary and sufficient for the skipping of L1CAM tr

260 Mesp-b is necessary and sufficient for the specification of a s

261 eplication and transcription activator (RTA) is necessary and sufficient for the switch from KSHV lat

262 tellite cells), we show that mTORC1 activity is necessary and sufficient for the transition of satell

263 -relevant way, we showed that this sprouting was necessary and sufficient for the acute compensation

264 ants demonstrated that S1916 phosphorylation was necessary and sufficient for the capture and assembl

265 that spatially confined expression of CCRL1 was necessary and sufficient for the creation of functio

266 cific in that CTLA-4 expression by Tfh cells was necessary and sufficient for the improved humoral in

267 TLR4 expression was necessary and sufficient for the protective effect o

268 sis Mediator, while their N-terminal domains are necessary and sufficient for their incorporation int

269 ariat branch point and 3' splice site, which is necessary and sufficient for their stabilization.

270 sent in the nucleus and nuclear localization was necessary and sufficient for their toxicity.

271 enome editing demonstrated that TAZ mutation is necessary and sufficient for these phenotypes.

272 Furthermore, glucose was necessary and sufficient for these effects.

273 human HOPS complex and that residues 642-736 are necessary and sufficient for this interaction, and w

274 tative changes to the activity of metabolism are necessary and sufficient for this phenotype.

275 mation and, furthermore, that p53 inhibition is necessary and sufficient for this activity.

276 The GAR-3 N-terminal extracellular domain is necessary and sufficient for this asymmetric distribu

277 th IN, and the C-terminal domain (CTD) of IN is necessary and sufficient for this binding.

278 )-mediated, glucose-induced TXNIP expression is necessary and sufficient for this effect, and electro

279 onstrating that in vivo monomeric arrestin-1 is necessary and sufficient for this function.

280 amming, and the disintegrin domain of ADAM29 is necessary and sufficient for this function.

281 terminal catalytic domain of ACT (AC domain) is necessary and sufficient for this inhibitory effect.

282 within the cleaved CLCA1 N-terminal fragment is necessary and sufficient for this interaction.

283 e show that HRI is the eIF2alpha kinase that is necessary and sufficient for this relay.

284 nt-specific transcription factor LEAFY (LFY) is necessary and sufficient for this transition.

285 ow that the mechanosensor protein, vinculin, is necessary and sufficient for this viscous response, d

286 FcgammaRIII and TLR4 dependent, and T cells were necessary and sufficient for this process to occur,

287 e that the N-terminal domain of CdiA-CT(536) is necessary and sufficient for toxin import.

288 STAT3-binding site on the GIV promoter that was necessary and sufficient for transcriptional activat

289 ese data demonstrate that GRP-GRPR signaling is necessary and sufficient for transmitting contagious

290 We also show that [pH]cyt acidification is necessary and sufficient for triggering several key h

291 tion, tumor-released Hsp70/90-expressing EVs are necessary and sufficient for tumor-induced muscle wa

292 tic structural damage, indicating that TRN-1 is necessary and sufficient for uncoating in vitro.

293 on of glutamate to skeletal myotomes in vivo is necessary and sufficient for up-regulation of membran

294 CS chain attachment to Ser(507) and Ser(525) is necessary and sufficient for versican proteolysis by

295 at the oxidized sterol, ergosterol peroxide, is necessary and sufficient for Vms1 localization to mit

296 ding studies confirm that this region of VP3 is necessary and sufficient for VP1 binding, while bioch

297 omposed of a putative loop-helix domain that is necessary and sufficient for WDR62 dimerization and i

298 itution with the purified enzyme, that PORCN is necessary and sufficient for Wnt acylation.

299 between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-

300 indicated that rises in postsynaptic Ca(2+) are necessary and sufficient for Z-LTD induction.